公开(公告)号：US08227237B2

公开(公告)日：2012-07-24

申请号：US13174580

申请日：2011-06-30

Applicant: Nikos B. Reppas ,  Martha Sholl ,  Sriram Kosuri ,  Brian D. Green ,  Christian P. Ridley ,  Frank A. Skraly ,  Dan E. Robertson ,  David A. Berry ,  Noubar B. Afeyan

Inventor： Nikos B. Reppas ,  Martha Sholl ,  Sriram Kosuri ,  Brian D. Green ,  Christian P. Ridley ,  Frank A. Skraly ,  Dan E. Robertson ,  David A. Berry ,  Noubar B. Afeyan

IPC: C12N1/04 ,  C12N1/13 ,  C12N7/02 ,  C12N15/31

CPC classification number: C12P7/065 ,  C12N1/20 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/74 ,  C12P1/04 ,  C12P5/00 ,  C12P5/02 ,  C12P5/026 ,  C12P7/00 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463 ,  C12P7/6472 ,  C12P7/649 ,  C12P13/04 ,  C12R1/01 ,  C12Y103/03006 ,  Y02E50/13 ,  Y02E50/17 ,  Y02E50/18 ,  Y02E50/343

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract translation: 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些有机物用于商业生产乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体。

公开(公告)号：US08142756B1

公开(公告)日：2012-03-27

申请号：US12717372

申请日：2010-03-04

Applicant: Todd H. Gardner ,  David A. Berry ,  Dushyant Shekhawat

Inventor： Todd H. Gardner ,  David A. Berry ,  Dushyant Shekhawat

IPC: C01B3/26

CPC classification number: B01J23/83 ,  B01D53/864 ,  B01D53/944 ,  B01D2255/2042 ,  B01D2255/206 ,  B01D2255/2065 ,  B01D2255/20715 ,  B01D2255/20753 ,  B01D2255/2092 ,  B01D2257/702 ,  B01D2258/012 ,  B01J23/002 ,  B01J23/78 ,  B01J37/031 ,  B01J2523/00 ,  C01B3/326 ,  C01B3/386 ,  C01B3/40 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/0261 ,  C01B2203/1041 ,  C01B2203/1058 ,  C01B2203/1217 ,  C01B2203/1235 ,  Y02P20/52 ,  B01J2523/25 ,  B01J2523/31 ,  B01J2523/3712 ,  B01J2523/48 ,  B01J2523/847 ,  B01J2523/375

Abstract: A metal substituted hexaaluminate catalyst for reforming hydrocarbon fuels to synthesis gas of the general formula AByAl12-yO19-δ, A being selected from alkali metals, alkaline earth metals and lanthanide metals or mixtures thereof. A dopant or surface modifier selected from a transitions metal, a spinel of an oxygen-ion conductor is incorporated. The dopant may be Ca, Cs, K, La, Sr, Ba, Li, Mg, Ce, Co, Fe, Ir, Rh, Ni, Ru, Cu, Pe, Os, Pd, Cr, Mn, W, Re, Sn, Gd, V, Ti, Ag, Au, and mixtures thereof. The oxygen-ion conductor may be a perovskite selected from M′RhO3, M′PtO3, M′PdO3, M′IrO3, M′RuO3 wherein M′=Mg, Sr, Ba, La, Ca; a spinel selected from MRh2O4, MPt2O4, MPd2O4, MIr2O4, MRu2O4 wherein M=Mg, Sr, Ba, La, Ca and mixtures thereof; a florite is selected from M″O2.

Abstract translation: 一种用于将烃燃料重整成通式为AByAl 12-y O 19-δ的合成气的金属取代六铝酸盐催化剂，A选自碱金属，碱土金属和镧系金属或其混合物。 从过渡金属，氧离子导体的尖晶石中掺入掺杂剂或表面改性剂。 掺杂剂可以是Ca，Cs，K，La，Sr，Ba，Li，Mg，Ce，Co，Fe，Ir，Rh，Ni，Ru，Cu，Pe，Os，Pd，Cr，Mn， Sn，Gd，V，Ti，Ag，Au及其混合物。 氧离子导体可以是选自M'RhO3，M'PtO3，M'PdO3，M'IrO3，M'RuO3的钙钛矿，其中M'= Mg，Sr，Ba，La，Ca; 选自MRh 2 O 4，MPt 2 O 4，MP d 2 O 4，MIr 2 O 4，MRu 2 O 4的尖晶石，其中M = Mg，Sr，Ba，La，Ca及其混合物; 选自M“O2的花青石。

公开(公告)号：US08133463B1

公开(公告)日：2012-03-13

申请号：US12422346

申请日：2009-04-13

Applicant: David A. Berry ,  Dushyant Shekhawat ,  Daniel Haynes ,  Mark Smith ,  James J. Spivey

Inventor： David A. Berry ,  Dushyant Shekhawat ,  Daniel Haynes ,  Mark Smith ,  James J. Spivey

IPC: C01B31/18 ,  C01B3/26

CPC classification number: C01B3/40 ,  B01J23/002 ,  B01J23/63 ,  B01J23/83 ,  B01J37/0236 ,  B01J37/031 ,  B01J2523/00 ,  C01B3/326 ,  C01B2203/0233 ,  C01B2203/0238 ,  C01B2203/0261 ,  C01B2203/1011 ,  C01B2203/1023 ,  C01B2203/1041 ,  C01B2203/1047 ,  C01B2203/1082 ,  C01B2203/1088 ,  C01B2203/1217 ,  C01B2203/1235 ,  Y02P20/52 ,  B01J2523/24 ,  B01J2523/3706 ,  B01J2523/48 ,  B01J2523/847 ,  B01J2523/828 ,  B01J2523/822 ,  B01J2523/821 ,  B01J2523/22 ,  B01J2523/23 ,  B01J2523/25 ,  B01J2523/3712 ,  B01J2523/375 ,  B01J2523/3737 ,  B01J2523/36 ,  B01J2523/47

Abstract: A method of catalytically reforming a reactant gas mixture using a pyrochlore catalyst material comprised of one or more pyrochlores having the composition A2-w-xA′wA″xB2-y-zB′yB″zO7-Δ. Distribution of catalytically active metals throughout the structure at the B site creates an active and well dispersed metal locked into place in the crystal structure. This greatly reduces the metal sintering that typically occurs on supported catalysts used in reforming reactions, and reduces deactivation by sulfur and carbon. Further, oxygen mobility may also be enhanced by elemental exchange of promoters at sites in the pyrochlore. The pyrochlore catalyst material may be utilized in catalytic reforming reactions for the conversion of hydrocarbon fuels into synthesis gas (H2+CO) for fuel cells, among other uses.

Abstract translation: 使用由具有组合物A2-w-xA'wA“xB2-y-zB'yB”zO7-＆Dgr的一种或多种烧绿石组成的烧绿石催化剂材料催化重整反应气体混合物的方法。 催化活性金属在B位置的整个结构中的分布产生锁定在晶体结构中的活性和良好分散的金属。 这大大降低了在重整反应中使用的负载催化剂上通常发生的金属烧结，并减少了硫和碳的失活。 此外，通过在烧绿石中的位点处促进剂的元素交换也可以提高氧迁移率。 烧绿石催化剂材料可用于催化重整反应，用于将燃料转化为用于燃料电池的合成气（H 2 + CO）等。

公开(公告)号：US07981647B2

公开(公告)日：2011-07-19

申请号：US12867738

申请日：2009-03-03

Applicant: David A. Berry ,  Dan E. Robertson ,  Frank A. Skraly ,  Brian D. Green ,  Christian P. Ridley ,  Sriram Kosuri ,  Nikos B. Reppas ,  Martha Sholl ,  Noubar B. Afeyan

Inventor： David A. Berry ,  Dan E. Robertson ,  Frank A. Skraly ,  Brian D. Green ,  Christian P. Ridley ,  Sriram Kosuri ,  Nikos B. Reppas ,  Martha Sholl ,  Noubar B. Afeyan

IPC: C12P7/06 ,  C12N1/13 ,  A01H13/00

CPC classification number: C12P7/065 ,  C12N1/20 ,  C12N9/00 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/0083 ,  C12N9/1007 ,  C12N9/1029 ,  C12N9/88 ,  C12N15/74 ,  C12P1/04 ,  C12P5/00 ,  C12P5/02 ,  C12P5/026 ,  C12P7/00 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6436 ,  C12P7/6463 ,  C12P7/6472 ,  C12P7/649 ,  C12P13/04 ,  C12R1/01 ,  C12Y103/03006 ,  Y02E50/13 ,  Y02E50/17 ,  Y02E50/18 ,  Y02E50/343

Abstract: The present disclosure identifies pathways and mechanisms to confer production of carbon-based products of interest such as ethanol, ethylene, chemicals, polymers, n-alkanes, isoprenoids, pharmaceutical products or intermediates thereof in photoautotrophic organisms such that these organisms efficiently convert carbon dioxide and light into carbon-based products of interest, and in particular the use of such organisms for the commercial production of ethanol, ethylene, chemicals, polymers, alkanes, isoprenoids, pharmaceutical products or intermediates thereof.

Abstract translation: 本发明公开了确定感兴趣的碳基产物如乙醇，乙烯，化学品，聚合物，正烷烃，类异戊二烯，药物产品或其中间体在光自养生物体中生产的途径和机制，使得这些生物有效地转化二氧化碳和 特别是利用这些生物来商业生产乙醇，乙烯，化学品，聚合物，烷烃，类异戊二烯，药物产品或其中间体。

公开(公告)号：US07913618B2

公开(公告)日：2011-03-29

申请号：US11820827

申请日：2007-06-21

Applicant: Gregory S. Ferry ,  David A. Berry

Inventor： Gregory S. Ferry ,  David A. Berry

IPC: B44B5/00 ,  B44B5/02 ,  B41K3/10

CPC classification number: B44B5/026 ,  B21D28/12 ,  B44B5/0057 ,  Y10T83/9423

Abstract: A punch press tool for stamping successive multicharacter impressions into a workpiece such as a piece of steel, sheet metal, or other workpiece, includes a guide body in which a stamp driver is slidably mounted for being driven downwardly toward the workpiece by a punch press ram which is a standard part of a high speed commercial punch press. A multicharacter marking stamp is supported at the lower end of the stamp driver for reciprocal movement therewith. The marking stamp includes multicharacter wheels that are rotated automatically during operation for advancing characters in sequence responsive to the movement of a character advancing arm. At least one character stamp operating lever is operatively associated with the punch press tool for articulation responsive to motion imparted to the tool by the ram. The lever has an operating element that is operatively associated with the character advancing arm of the multicharacter stamp for indexing the arm to enable successive characters thereof to be placed in an operating position responsive to a stroke of the punch press ram.

Abstract translation: 用于将连续的多焦点印模冲压成诸如一块钢，金属片或其它工件的工件的冲压工具包括导向体，其中印模驱动器可滑动地安装，以便通过冲压压头向下朝向工件 这是高速商业冲压机的标准部件。 在印章驱动器的下端支撑多字符标记印章，用于与之相互移动。 标记印章包括多字符轮，其在操作期间自动旋转，以响应于字符前进臂的移动顺序前进字符。 至少一个字符印记操作杆与冲压工具可操作地相关联，用于响应于由冲头施加到工具的运动而进行铰接。 杠杆具有操作性地与多焦头印字机的字符前进臂相关联的操作元件，用于对臂进行分度，以使得其连续的字符能够响应于冲压压头的行程而被放置在操作位置。

公开(公告)号：US20100087634A1

公开(公告)日：2010-04-08

申请号：US12582432

申请日：2009-10-20

Applicant: David A. Berry ,  William H. Pearson

Inventor： David A. Berry ,  William H. Pearson

IPC: C09B29/00 ,  C07H19/10 ,  C07H19/20 ,  C07F9/02 ,  C07F9/06 ,  C07D311/02 ,  C07D207/46

CPC classification number: C07H21/00 ,  C07B63/00 ,  C07B2200/11 ,  C07C245/08 ,  C07F9/2408 ,  C07F9/6561 ,  C07H19/067 ,  C07H19/073 ,  C07H19/167 ,  C07H19/173 ,  C07H21/04 ,  C07H23/00

Abstract: Fluorous-tagged oligonucleotide reagents and an oligonucleotide purification methodology making use thereof, the method comprising: Synthesizing oligonucleotides using oligonucleotide reagents each bearing at least one fluorous group to yield a mixture of synthesis products and reagents, the mixture including at least one target synthesized oligonucleotide bearing at least one fluorous group; passing the mixture through a separation medium having an affinity for the at least one fluorous group so that the target synthesized oligonucleotide bearing at least one fluorous group is adsorbed by the separation medium; washing the separation medium with at least a first solvent to selectively dissociate therefrom substantially all synthesis products and reagents of the heterogenous mixture other than the at least one target synthesized oligonucleotide bearing at least one fluorous group; and subsequently dissociating the at least one synthesized oligonucleotide from the separation medium, with or without the fluorous group.

Abstract translation: 含氟标记的寡核苷酸试剂和利用其的寡核苷酸纯化方法，所述方法包括：使用各自携带至少一个氟基的寡核苷酸试剂合成寡核苷酸试剂以产生合成产物和试剂的混合物，所述混合物包含至少一种靶合成寡核苷酸轴承 至少一个氟团; 使混合物通过对至少一个氟族具有亲和力的分离介质，使得带有至少一个氟团的靶合成寡核苷酸被分离介质吸附; 用至少一种第一溶剂洗涤分离介质以选择性地从其中分离除了至少一种带有至少一个氟基的至少一种目标合成寡核苷酸之外的异质混合物的所有合成产物和试剂; 并随后使用或不与氟基离开分离介质中的至少一种合成的寡核苷酸。

公开(公告)号：US20090047295A1

公开(公告)日：2009-02-19

申请号：US12171923

申请日：2008-07-11

Applicant: David A. Berry ,  Eric J. Devroe ,  Noubar Boghos Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

Inventor： David A. Berry ,  Eric J. Devroe ,  Noubar Boghos Afeyan ,  Brett Chevalier ,  Sashank K. Reddy

IPC: A61K39/395 ,  C12N5/08 ,  A61K31/7105 ,  A61P31/00

CPC classification number: A61K39/39558 ,  A61K31/00 ,  A61K31/713 ,  A61K2300/00

Abstract: The invention provides methods and compositions for reducing the number of cancer stem cells in a mixed population of differentiated cells (for example, cancer cells) and cancer stem cells. The cancer stem cells, if present, can be more resistant to traditional drug-based therapies and can provide a source for new, differentiated cancer cells associated with the development of drug-resistance and more aggressive phenotypes. When combined with traditional cancer therapies, for example, drug-based therapies, the methods and compositions of the invention provide a more effective way for treating cancer and can provide a model system for developing new cancer therapies and new treatment modalities.

Abstract translation: 本发明提供了用于减少分化细胞（例如癌细胞）和癌干细胞的混合群体中的癌干细胞数目的方法和组合物。 癌症干细胞（如果存在）可以更好地抵抗传统的基于药物的疗法，并且可以为与耐药性和更具侵袭性的表型的发展相关联的新的分化癌细胞提供来源。 当与传统的癌症疗法结合时，例如基于药物的疗法，本发明的方法和组合提供了治疗癌症的更有效的方法，并且可以提供用于开发新的癌症疗法和新的治疗方式的模型系统。

公开(公告)号：US20080132713A1

公开(公告)日：2008-06-05

申请号：US11982811

申请日：2007-11-05

Applicant: David A. Berry

Inventor： David A. Berry

IPC: C07F9/28 ,  C07F9/655

CPC classification number: C07F9/117 ,  C12Q1/42 ,  Y02P20/55

Abstract: A myo-inositol derivative: R1, R2, R3 and R4 are identical, being selected from PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, H, COZ and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; R5 is one of H, benzyl, 4-methoxybenzyl, COZ, PO3H2, PO3Na2, PO3K2, PO3Li2, PO3Ca, PO3Mg, PO3(NH4)2, PO3(RNH3)2, PO3(R2NH2)2, PO3(R4N)2, PO(OR)2, and BHPP, where R is benzyl or alkyl of 1 to 6 carbon atoms and Z is an alkyl or arylalky group providing a cleavable protecting group; X is one of CH2, CH2CH2O, and CH2CH2CH2O; n is an integer from 1 to 8; L1 is a single bond or CH2; L2 is one of a single bond, CONH, CH2CONH, CH2CH2CONH, CH2CH2NHCO, CH2CH2NHCONH, CH2CH2NHCSNH, CH2CH2NHSO2, CH2CH2CH2NHCO, CH2CH2CH2NHCONH, CH2CH2CH2NHCSNH, CH2CH2CH2NHSO2, NHCO, NHCONH, NHCSNH, OCONH, CH2, CH2CH2, CH2CH2O, CH2CH2S, CH2CH2NH, CH2CH2CH2, CH2CH2CH2O, CH2CH2CH2S, CH2CH2CH2NH, and NH—SO2; and R6 is a UV-visible chromophore, a UV-chromophore, a fluorescent moiety, or a radiolabeled moiety.

公开(公告)号：US06793910B1

公开(公告)日：2004-09-21

申请号：US10261656

申请日：2002-10-02

Applicant: K. David Lyons ,  Robert James ,  David A. Berry ,  Todd Gardner

Inventor： K. David Lyons ,  Robert James ,  David A. Berry ,  Todd Gardner

IPC: C01B326

CPC classification number: B01J4/002 ,  B01J19/18 ,  B01J19/26 ,  B01J2208/00716 ,  B01J2219/00006 ,  C01B3/34 ,  C01B3/36 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/066 ,  C01B2203/0844 ,  C01B2203/1235 ,  C01B2203/142 ,  C01B2203/82 ,  F02M25/0227 ,  F02M25/038 ,  H01M8/0612 ,  H01M2008/1293 ,  Y02T10/121

Abstract: The invention provides a method and apparatus for producing a synthesis gas from a variety of hydrocarbons. The apparatus (device) consists of a semi-batch, non-constant volume reactor to generate a synthesis gas. While the apparatus feeds mixtures of air, steam, and hydrocarbons into a cylinder where work is performed on the fluid by a piston to adiabatically raise its temperature without heat transfer from an external source.

Abstract translation: 本发明提供了用于从各种烃生产合成气的方法和装置。 装置（装置）由用于产生合成气的半批量，非恒定体积的反应器组成。 当设备将空气，蒸汽和碳氢化合物的混合物进料到气缸中时，通过活塞对流体进行工作，以绝热地升高其温度而不会从外部源传热。

公开(公告)号：US4970324A

公开(公告)日：1990-11-13

申请号：US142151

申请日：1988-01-08

Applicant: James D. Hoeschele ,  David A. Berry ,  Luigi G. Marzilli

Inventor： James D. Hoeschele ,  David A. Berry ,  Luigi G. Marzilli

IPC: C07F15/00

CPC classification number: C07F15/0093

Abstract: Square-planar four-coordinate complexes of cis-platinum(II) with neutral bidentate aminoalkyl-substituted cycloalkylamine ligands and bromo-, chloro-, iodo-, nitrato-, oxalato-, or malanato-ligands possess antimicrobial activity as well as activity against transplanted L1210 and P388 murine leukemia cell lines.

Abstract translation: 顺式铂（II）与中性二齿氨基烷基取代的环烷基胺配体和溴 - ，氯 - ，碘 - ，硝基 - ，草酸 - 或马拉那那 - 配体的平面四坐标络合物具有抗菌活性和抗 移植L1210和P388鼠白血病细胞系。