利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

44 条记录 (耗时 0.039 秒)

    Injectable cross-linked collagen implant material
    2.
    发明授权
    Injectable cross-linked collagen implant material 失效
    注射交联胶原植入材料

    公开(公告)号：US4582640A

    公开(公告)日：1986-04-15

    申请号：US663478

    申请日：1984-10-22

    申请人： Thomas L. Smestad ,  John McPherson ,  Donald G. Wallace

    发明人： Thomas L. Smestad ,  John McPherson ,  Donald G. Wallace

    IPC分类号： A61L27/24 ,  C07K14/78 ,  C08L89/06 ,  A61L15/04

    CPC分类号： A61L27/24 ,  C07K14/78 ,  Y10S128/08 ,  Y10S514/801

    摘要： Cross-linked atelopeptide collagen that is substantially free of residual cross-linking agent is prepared by: reconstituting atelopeptide collagen from solution by neutralizing the solution at a reduced temperature and a hypotonic ionic strength; cross-linking the reconstituted fibers in an aqueous medium at a concentration of 0.1 to 10 mg/ml with glutaraldehyde under conditions that produce cross-linked collagen that when in suspension in physiological saline at a concentration of 35 mg/ml exhibits a shear viscosity whose log varies linearly with the log of the shear rate and is approximated by the formulalog .eta..ltoreq.-0.96 log .gamma.+2.3where .gamma. is the shear rate in sec.sup.-1, log .gamma. is in the range of -6 to +2 and .eta. is the viscosity of the suspension in Pascal-sec; optionally quenching the cross-linking reaction with an amino acid; and separating the cross-linked atelopeptide collagen from the reaction mixture. This collagen is dispersed in an isotonic aqueous medium for use in soft tissue dermal augmentation and is injectable and forms implants that have excellent persistence.

    摘要翻译： 通过以下方法制备基本上不含残留交联剂的交联的atelopeptide胶原蛋白：通过在降低的温度和低渗离子强度下中和溶液来重构来自溶液的阿曲肽胶原; 在产生交联胶原的条件下，用浓度为0.1至10mg / ml的水性介质在水性介质中交联重构纤维，当在浓度为35mg / ml的生理盐水中悬浮时，表现出剪切粘度， 对数随着剪切速率的对数线性变化，并且通过公式log eta = 0.96logγ+ 2.3近似，其中γ是sec-1中的剪切速率，logγ在-6至+2的范围内 eta是悬浮液的粘度（Pascal-sec）; 任选地用氨基酸淬灭交联反应; 并从反应混合物中分离交联的阿肽肽胶原。 该胶原分散在等渗水性介质中，用于软组织皮肤增生，并且是可注射的并且形成具有优异持久性的植入物。

    FRAGMENTED POLYMERIC COMPOSITIONS AND METHODS FOR THEIR USE
    9.
    发明申请
    FRAGMENTED POLYMERIC COMPOSITIONS AND METHODS FOR THEIR USE 有权
    混合聚合物组合物及其使用方法

    公开(公告)号：US20110223231A1

    公开(公告)日：2011-09-15

    申请号：US13114784

    申请日：2011-05-24

    申请人： Donald G. Wallace ,  Cary J. Reich ,  Narinder S. Shargill ,  Felix Vega ,  A. Edward Osawa

    发明人： Donald G. Wallace ,  Cary J. Reich ,  Narinder S. Shargill ,  Felix Vega ,  A. Edward Osawa

    IPC分类号： A61M5/178

    CPC分类号： A61L24/0015 ,  A61L24/0031 ,  A61L27/52 ,  A61L27/54 ,  A61L31/145 ,  A61L31/16 ,  A61L2300/418 ,  A61L2300/604 ,  Y10S524/916

    摘要： Cross-linked hydrogels comprise a variety of biologic and non-biologic polymers, such as proteins, polysaccharides, and synthetic polymers. Such hydrogels preferably have no free aqueous phase and may be applied to target sites in a patient's body by extruding the hydrogel through an orifice at the target site. Alternatively, the hydrogels may be mechanically disrupted and used in implantable articles, such as breast implants. When used in vivo, the compositions are useful for controlled release drug delivery, for inhibiting post-surgical spinal and other tissue adhesions, for filling tissue divots, tissue tracts, body cavities, surgical defects, and the like.

    摘要翻译： 交联水凝胶包含各种生物和非生物聚合物，如蛋白质，多糖和合成聚合物。 这种水凝胶优选不含游离水相，并且可以通过在目标部位的孔口挤出水凝胶而将其施加到患者体内的靶位点。 或者，水凝胶可以被机械破坏并用于可植入制品，例如乳房植入物。 当在体内使用时，组合物可用于控释药物递送，用于抑制手术后脊柱和其他组织粘连，用于填充组织切口，组织束，体腔，手术缺陷等。