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公开(公告)号：US20190322963A1
公开(公告)日：2019-10-24
申请号：US16416318
申请日：2019-05-20
发明人： ROBERT DICOSIMO , Qiong Cheng , Rakesh Nambiar , Jayme L. Paullin , Mark S. Payne , Jahnavi Chandra Prasad , Zheng You
摘要： An enzymatically produced α-glucan oligomer/polymer compositions is provided. The enzymatically produced α-glucan oligomer/polymers can be derivatized into α-glucan ether compounds. The α-glucan oligomers/polymers and the corresponding α-glucan ethers are cellulose and/or protease resistant, making them suitable for use in fabric care and laundry care applications. Methods for the production and use of the present compositions are also provided.
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公开(公告)号：US20190292528A1
公开(公告)日：2019-09-26
申请号：US16381010
申请日：2019-04-11
发明人： Yougen Li , Mark S. Payne , Jared B. Parker , Slavko Kralj , Veli Alkan , Richard R. Bott , Robert Dicosimo , Qiong Cheng , Ellen D. Semke , Susan Marie Hennessey
摘要： Disclosed herein are glucosyltransferases with modified amino acid sequences. Such engineered enzymes exhibit improved alpha-glucan product yields and/or lower leucrose yields, for example. Further disclosed are reactions and methods in which engineered glucosyltransferases are used to produce alpha-glucan.
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公开(公告)号：US20170198323A1
公开(公告)日：2017-07-13
申请号：US15313285
申请日：2015-05-22
发明人： Qiong Cheng , Robert Dicosimo , Arthur Ouwehand , Zheng You , Mark S. Payne , Jahnavi Chandra Prasad
IPC分类号： C12P19/18 , A61K31/702 , A61K8/60 , A61Q19/00 , A23G1/40 , A23K20/10 , A23G9/34 , A23L2/52 , A23L7/139 , A23L27/30 , A23L33/10 , A23L33/21 , C07H3/06 , A23G3/42
CPC分类号： C12P19/18 , A23G1/40 , A23G3/42 , A23G9/34 , A23K20/10 , A23L2/52 , A23L2/60 , A23L5/00 , A23L7/00 , A23L7/139 , A23L9/00 , A23L21/00 , A23L27/30 , A23L29/30 , A23L29/37 , A23L33/10 , A23L33/105 , A23L33/115 , A23L33/125 , A23L33/17 , A23L33/18 , A23L33/21 , A23V2002/00 , A61K8/60 , A61K8/73 , A61K31/702 , A61K31/716 , A61K45/06 , A61K2800/10 , A61K2800/85 , A61Q19/00 , C07H3/06 , C08B37/0009 , C08L5/00 , C12P19/04 , C12P19/08 , C12Y204/01005 , C12Y301/01059 , C12Y302/01011 , C12Y302/01059 , A61K2300/00
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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公开(公告)号：US09278138B2
公开(公告)日：2016-03-08
申请号：US14191871
申请日：2014-02-27
IPC分类号： C07K7/04 , C07K7/08 , A61K38/04 , A61K38/16 , A61Q5/00 , A61K47/48 , C07K14/00 , G01N33/68 , G06F19/16 , A61K8/64
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US20140241999A1
公开(公告)日：2014-08-28
申请号：US14191871
申请日：2014-02-27
CPC分类号： A61K47/48338 , A61K8/19 , A61K8/64 , A61K2800/94 , A61Q5/00 , A61Q5/065 , C07K14/001 , C07K2319/70 , G01N33/6803 , G06F19/16
摘要： Short single chain peptides having affinity for a target surface often lack the binding durability required for certain commercial applications. One way to improve durability is to promote multivalent binding by linking together binding sequences using peptide linkers. However, the resulting single chain binding peptides often suffer from linker entropy. It has been discovered that the use of rigid peptide linkers when linking together multiple binding sequences enhances the binding affinity of the resulting single chain peptide.
摘要翻译： 对目标表面具有亲和性的短单链肽通常缺乏某些商业应用所需的结合耐久性。 提高耐久性的一种方法是通过使用肽接头连接在一起的结合序列来促进多价结合。 然而，所得到的单链结合肽通常具有接头熵。 已经发现，当将多个结合序列连接在一起时，使用刚性肽接头增强所得单链肽的结合亲和力。
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公开(公告)号：US20170218093A1
公开(公告)日：2017-08-03
申请号：US15313347
申请日：2015-05-22
发明人： Qiong Cheng , Robert Dicosimo , Arthur Ouwehand , Zheng You , Mark S. Payne , Jian Ping Lai , Kristin Ruebling-Jass , Steven Cary Rothman
IPC分类号： C08B37/00 , C12P19/08 , C12P19/04 , C12N9/10 , C12N9/44 , A61K31/716 , C08L5/00 , A23L29/30 , A23L33/21 , A23C9/13 , A23L2/52 , A23L7/126 , A21D13/45 , A21D13/80 , A23L7/135 , A23L21/10 , A23G3/36 , A23G9/32 , C12P19/18
CPC分类号： C08B37/0009 , A21D13/45 , A21D13/80 , A23C9/13 , A23G3/36 , A23G9/32 , A23L2/52 , A23L7/126 , A23L7/135 , A23L21/10 , A23L29/37 , A23L33/21 , A23V2002/00 , A61K31/716 , C08L5/00 , C08L2203/02 , C08L2203/12 , C08L2205/16 , C12N9/1051 , C12N9/246 , C12P19/04 , C12P19/08 , C12P19/18 , C12Y204/00 , C12Y204/01002 , C12Y204/01005 , C12Y302/01 , C12Y302/01068 , A61K2300/00
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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公开(公告)号：US10822383B2
公开(公告)日：2020-11-03
申请号：US15767689
申请日：2016-11-22
IPC分类号： C07K14/47 , A61K8/64 , A61K31/716 , C08B37/00 , C08L5/02 , C12N9/10 , C12P19/18 , A61K8/60 , A61K8/73 , A23L33/10 , C08L5/00 , A61Q19/00 , A23L33/135 , C12P19/04 , A23L33/21 , C11D3/22
摘要： Disclosed herein are proteins capable of forming glucans having alpha-1,2 linkages/branches, reactions and methods for producing such glucan, compositions comprising such glucan, and various applications thereof.
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公开(公告)号：US20180049457A1
公开(公告)日：2018-02-22
申请号：US15313238
申请日：2015-05-22
发明人： Qiong Cheng , Robert Dicosimo , Arthur Ouwehand , Zheng You , Supaporn Suwannakham , Kevin D. Nagy , Mark S. Payne , Jahnavi Chandra Prasad
IPC分类号： A23L29/269 , C12P19/08 , C12P19/18 , A61K8/73 , A61K31/716 , A61K8/36
CPC分类号： A23L29/269 , A61K8/36 , A61K8/73 , A61K31/716 , A61K2800/10 , A61Q19/00 , C08B37/0009 , C08L5/00 , C08L2205/16 , C12P19/04 , C12P19/08 , C12P19/18 , C12Y204/01 , C12Y302/01011 , C12Y302/01059
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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公开(公告)号：US20170198324A1
公开(公告)日：2017-07-13
申请号：US15313321
申请日：2015-05-22
发明人： Qiong Cheng , Robert Dicosimo , Arthur Ouwehand , Zheng You , Jian Ping Lai , Zheyong YU , Zhenghong ZHANG
IPC分类号： C12P19/18 , C12P19/08 , A61K31/721 , A61K8/73 , A61Q19/00 , A23L29/269 , A23L33/21 , A23L2/52 , A23C9/123 , A23L7/126 , A23L7/135 , A21D13/40 , A23L21/10 , A23G3/36 , A23G9/32 , C08B37/00
CPC分类号： C12P19/18 , A21D13/40 , A23C9/123 , A23G3/36 , A23G9/32 , A23L2/52 , A23L7/126 , A23L7/135 , A23L21/10 , A23L29/273 , A23L33/21 , A23V2002/00 , A61K8/73 , A61K31/716 , A61K31/721 , A61K2800/10 , A61K2800/85 , A61Q19/00 , C08B37/0009 , C08L5/00 , C08L2205/16 , C12P19/04 , C12P19/08 , C12Y204/01 , C12Y204/01005 , A23V2200/328 , A23V2250/5116 , A61K2300/00
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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公开(公告)号：US20170198322A1
公开(公告)日：2017-07-13
申请号：US15313263
申请日：2015-05-22
发明人： Qiong Cheng , Robert Dicosimo , Andrew C. Eliot , Arthur Ouwehand , Brian Michael Roesch , Steven Cary Rothman , Kristin Ruebling-Jass , Zheng You
IPC分类号： C12P19/18 , A61K31/702 , A61K8/60 , A23L33/21 , A23K20/163 , A23L2/52 , A23L29/269 , C07H3/06 , A61Q19/00
CPC分类号： C12P19/18 , A23K20/163 , A23L2/52 , A23L29/273 , A23L33/21 , A23V2002/00 , A61K8/60 , A61K8/66 , A61K8/73 , A61K31/047 , A61K31/7004 , A61K31/7016 , A61K31/702 , A61K31/716 , A61K2800/10 , A61K2800/85 , A61Q19/00 , C07H3/06 , C12N9/1051 , C12N9/2454 , C12P19/04 , C12P19/08 , C12Y204/01002 , C12Y302/01011 , A61K2300/00
摘要： An enzymatically produced soluble α-glucan fiber composition is provided suitable for use as a digestion resistant fiber in food and feed applications. The soluble α-glucan fiber composition can be blended with one or more additional food ingredients to produce fiber-containing compositions. Methods for the production and use of compositions comprising the soluble α-glucan fiber are also provided.
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