公开(公告)号：US06387379B1

公开(公告)日：2002-05-14

申请号：US08202647

申请日：1994-02-28

Applicant: Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak ,  Theresa Rivero Erickson ,  James Seeger

Inventor： Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak ,  Theresa Rivero Erickson ,  James Seeger

IPC: A61L2716

CPC classification number: G02B1/041 ,  A61F2/0077 ,  A61F2/16 ,  A61F2002/0086 ,  A61F2002/009 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/16 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/0088 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  B05D3/142 ,  B05D7/02 ,  C03C17/32 ,  C03C23/0035 ,  C03C23/004 ,  C03C23/006 ,  C03C2218/31 ,  C04B41/48 ,  C08J7/18 ,  C08L39/06 ,  C23C8/36 ,  C23C26/00 ,  G02B1/043 ,  C08L51/00 ,  C08L51/06 ,  C08L33/14 ,  C08L5/08 ,  C08L1/28

Abstract: A method for modifying the surface of a material adapted for contact with tissue of a human or non-human animal to impart biofunctional, bioactive or biomimetic properties to the surface comprising: (a) exposing the surface to a solution comprising (1) an ethylenically unsaturated monomer or mixture thereof capable, via the ethylenic unsaturation, of gamma irradiation or electron beam induced polymerization, and (2) at least one biofunctional agent; and (b) irradiating the surface with gamma or electron beam irradiation in the presence of the solution to thereby form on the surface a graft polymerized coating, the coating having physically entrapped therein or chemically bonded thereto molecules of the at least one biofunctional agent which imparts biofunctional or biomimetic properties to the surface; wherein the gamma or electron beam irradiation induced polymerization is conducted under one of the following conditions: A. (i) monomer concentration in the solution in the range of from about 0.1% to about 50%, by weight; (ii) total gamma or electron beam dose in the range of from about 0.001 to less than about 0.50 Mrad; and (iii) gamma dose rate in the range of from about 10 to about 2,500 rads/min., or electron beam dose rate in the range of from about 10 to about 108 rads/min.; B. (i) hydrophilic monomer(s) graft under conditions which may include monomer pre-soak or plasma gamma surface modification (especially for metal or glass substrates in latter case); and (ii) graft polymerization of monomer(s) with bioactive/biofunctional molecules using (i) as substrate; C. (i) Hydrograft™ as in A or B above followed by dehydration and adsorption of bioactive/biofunctional molecules into the hydrophilic polymer graft; wherein the biological properties of the biofunctional agent are substantially maintained.

公开(公告)号：US5290548A

公开(公告)日：1994-03-01

申请号：US859016

申请日：1992-03-30

Applicant: Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak

Inventor： Eugene P. Goldberg ,  Ali Yahiaoui ,  Khalid Mentak

IPC: A61F2/00 ,  A61F2/16 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L33/00 ,  B05D3/06 ,  B05D7/02 ,  C08J7/18 ,  G02B1/04 ,  C08J7/06 ,  C08F291/18 ,  C08F220/26 ,  C08F226/08 ,  A61L27/00 ,  G02C7/04

CPC classification number: G02B1/043 ,  A61F2/0077 ,  A61F2/16 ,  A61F2/1613 ,  A61K31/727 ,  A61K31/728 ,  A61K31/79 ,  A61L27/16 ,  A61L27/34 ,  A61L31/10 ,  A61L33/0088 ,  B05D7/02 ,  C08J7/18 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  Y10S522/912 ,  Y10S522/915 ,  Y10S525/937 ,  Y10S623/92

Abstract: A method for modifying the plastic surface of an article adapted for contacting living tissue by the gamma or electron beam irradiation induced chemical graft coating thereon of:(1) a neutral or ionic water-soluble, hydrophilic vinylic monomer or salt thereof;(2) a mixture of at least two of said monomers, or(3) a mixture of (1) or (2) with up to about 50%, by weight, based on the total monomer weight, of a member selected from the group consisting of N-vinylpyrrolidone, 2-hydroxyethyl-methacrylate, and mixtures thereof; so as to form a hydrophilic graft polymer coating on the surface.

Abstract translation: 一种用于改变制品的塑料表面的方法，其适于通过伽马或电子束照射诱导化学接枝涂层将生物组织接触在其上：（1）中性或离子水溶性，亲水性乙烯基单体或其盐; （2）至少两种所述单体的混合物，或（3）（1）或（2）的混合物与基于总单体重量的至多约50重量％的选自 由N-乙烯基吡咯烷酮，2-羟乙基 - 甲基丙烯酸酯及其混合物组成的组; 以在表面上形成亲水接枝聚合物涂层。

公开(公告)号：US5804263A

公开(公告)日：1998-09-08

申请号：US362890

申请日：1994-12-23

Applicant: Eugene P. Goldberg ,  Ali Yahiaoui ,  James Burns

Inventor： Eugene P. Goldberg ,  Ali Yahiaoui ,  James Burns

IPC: A61M25/00 ,  A61B17/00 ,  A61F2/00 ,  A61F2/16 ,  A61L27/34 ,  A61L29/08 ,  A61L31/00 ,  A61M25/16 ,  B05D3/14 ,  B05D7/24 ,  B32B27/30 ,  C03C17/32 ,  C03C23/00 ,  C04B41/48 ,  C04B41/83 ,  C08F2/00 ,  C08F2/46 ,  C08F10/00 ,  C08F291/00 ,  C08J7/00 ,  C08J7/04 ,  C23C8/36 ,  C23C26/00 ,  B05D3/00 ,  A61M5/00

CPC classification number: B05D3/00 ,  A61L27/34 ,  A61L29/085 ,  B05D3/068 ,  B05D3/142 ,  C03C17/32 ,  C03C23/0035 ,  C03C23/004 ,  C03C23/006 ,  C04B41/48 ,  C04B41/83 ,  C08F10/00 ,  C08F2/46 ,  C23C26/00 ,  C23C8/36 ,  A61B2017/00831 ,  A61F2/0077 ,  A61F2/1613 ,  A61L2400/18 ,  A61M2025/0046 ,  B05D3/141 ,  C03C2218/31 ,  Y10T428/1321 ,  Y10T428/1352 ,  Y10T428/1355 ,  Y10T428/1393 ,  Y10T428/31678

Abstract: A material consisting of a hydrophobic material having a metallic, ceramic or glass surface which has been modified by exposing the surface to a glow discharge plasma to activate the surface, followed by exposing the activated surface to one or more ethylenically unsaturated monomers and irradiating the surface with gamma or electron beam radiation to induce polymerization thereon of the monomer(s) so as to form a hydrophilic polymeric coating on the surface of an article.

Abstract translation: 由具有金属，陶瓷或玻璃表面的疏水材料组成的材料，其通过将表面暴露于辉光放电等离子体以激活表面而被修饰，然后将活化表面暴露于一种或多种烯属不饱和单体并照射表面 用γ射线或电子束辐射诱导单体上的聚合，从而在物品的表面上形成亲水性聚合物涂层。

公开(公告)号：US5108776A

公开(公告)日：1992-04-28

申请号：US592478

申请日：1990-10-05

Applicant: Eugene P. Goldberg ,  Ali Yahiaoui

Inventor： Eugene P. Goldberg ,  Ali Yahiaoui

IPC: A61F2/00 ,  A61F2/16 ,  A61L27/16 ,  A61L27/34 ,  B05D3/06 ,  B05D7/02 ,  G02B1/04

CPC classification number: B05D3/068 ,  A61F2/14 ,  A61F2/16 ,  A61L27/16 ,  A61L27/34 ,  B05D7/02 ,  G02B1/043 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  Y10S623/901

Abstract: An improved method for modifying the surface of an ocular implant material by the gamma or electron beam irradiation induced chemical graft coating thereon of a monomer comprising N-vinly-pyrrolidone, 2-hydroxyethylmethacrylate or a mixture of the two to form a hydrophilic graft polymer coating, the improvement comprising pre-soaking the ocular implant material in a monomer or a solution comprising a monomer prior to conducting the gamma- or electron beam-irradiation induced graft polymerization in a second solution of a monomer.

Abstract translation: 一种用于通过γ或电子束照射来诱导眼睛植入材料表面的改进方法，其中包含N-乙烯吡咯烷酮，甲基丙烯酸2-羟乙酯或二者的混合物的单体，形成亲水性接枝聚合物涂层 改进之处包括在将单体或包含单体的溶液预先浸泡在单体的第二溶液中进行γ-或电子束照射诱导的接枝聚合之前。

公开(公告)号：US5130160A

公开(公告)日：1992-07-14

申请号：US592483

申请日：1990-10-05

Applicant: Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kunar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Richard Robinson

Inventor： Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kunar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Richard Robinson

IPC: A61F2/00 ,  A61F2/16 ,  A61L27/16 ,  A61L27/34 ,  B05D3/06 ,  B05D7/02 ,  G02B1/04

CPC classification number: A61F2/16 ,  A61F2/145 ,  A61F2/1613 ,  A61L27/16 ,  A61L27/34 ,  B05D7/02 ,  G02B1/043 ,  A61F2002/0086 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  B05D3/068 ,  Y10S623/901

Abstract: A method for modifying an ocular implant polymer surface by the gamma-irradiation or electron beam irradiation induced polymerization thereon of N-vinylpyrrolidone, 2-hydroxyethylmethacrylate or a mixture thereof while maintaining the following conditions:(a) monomer concentration in the range of from about 0.1% to about 50%, by weight;(b) total gamma dose in the range of from about 0.001 to less than about 0.50 Mrad; and(c) gamma dose rate in the range of from about 10 to about 2500 rads/minute or electron beam irradiation dose rate in the range of from about 10 to about 10.sup.8 rads/minute.

Abstract translation: 通过γ照射或电子束照射改性眼睛植入物聚合物表面的方法，其中在N-乙烯基吡咯烷酮，甲基丙烯酸2-羟乙酯或其混合物上进行聚合，同时保持以下条件：（a）单体浓度范围为约 0.1％至约50％; （b）在约0.001至小于约0.5Mrad范围内的总伽马剂量; 和（c）约10至约2500rad /分钟范围内的γ剂量率或约10至约108弧度/分钟范围内的电子束照射剂量率。

公开(公告)号：US5100689A

公开(公告)日：1992-03-31

申请号：US592482

申请日：1990-10-05

Applicant: Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kumar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Robinson, Richard

Inventor： Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kumar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Robinson, Richard

IPC: A61L27/00 ,  A61F2/00 ,  A61F2/16 ,  A61L27/16 ,  A61L33/00 ,  C08F291/00 ,  C08J7/18 ,  G02B1/04

CPC classification number: G02B1/043 ,  A61L27/16 ,  A61L33/0088 ,  C08J7/18 ,  A61F2/16 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  Y10S623/921

Abstract: Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma-irradiation or electron beam-irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue,the improvement comprising carrying out the graft polymerization in an aqueous solution under specific combinations of the following conditions:1) monomer concentration in the range of from about 0.1% to about 50%, by weight;2) total gamma or electron beam irradiation dose in the range of from about 0.001 to less than about 0.50 Mrad; and3) gamma dose rate in the range of from about 10 to about 2500 rads/min or electron beam-irradiation dose rate in the range of from about 10 to about 10.sup.8 rads/min.

Abstract translation: 通过改进的生产亲水性，γ射线照射或电子束照射的方法制备的改进的医疗装置和仪器，其诱导聚合和化学接枝的涂层或适于接触生物组织的制品的塑料表面，改进包括在水性 溶液在以下条件的特定组合下：1）单体浓度在约0.1％至约50％的范围内; 2）总伽马或电子束照射剂量在约0.001至小于约0.5Mrad范围内; 和3）在约10至约2500rad / min范围内的γ剂量率或约10至约108rad / min范围内的电子束照射剂量率。

公开(公告)号：US4961954A

公开(公告)日：1990-10-09

申请号：US304479

申请日：1989-02-01

Applicant: Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kumar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Richard Robinson

Inventor： Eugene P. Goldberg ,  James W. Burns ,  G. Sudesh Kumar ,  David C. Osborn ,  Jeffrey A. Larson ,  John W. Sheets ,  Ali Yahiaoui ,  Richard Robinson

IPC: A61F2/00 ,  A61F2/16 ,  A61L27/16 ,  C08J7/18

CPC classification number: A61L27/16 ,  A61F2/16 ,  C08J7/18 ,  G02C7/02 ,  A61F2002/009 ,  A61L2400/18 ,  A61L2430/16 ,  Y10S623/921 ,  Y10T428/265 ,  Y10T428/31507 ,  Y10T428/31544 ,  Y10T428/31663

Abstract: Improved medical devices and instruments prepared by an improved method of producing hydrophilic, gamma irradiation induced polymerized and chemically grafted coatings or plastic surfaces of articles adapted for contacting living tissue, the improvement comprising carrying out the graft polymerization in an aqueous solution under specific combinations of the following conditions:(1) monomer concentration in the range of from about 0.5% to about 50%, by weight;(2) total gamma dose in the range of from about 0.01 to less than about 0.50 Mrad;(3) gamma dose rate in the range of from about 10 to about 2500 rads/min; and(4) maintaining the molecular weight of the polymer in solution in the range of from about 250,000 to about 5,000,000.

Abstract translation: 改进的医疗装置和仪器通过改进的生产亲水性，γ照射诱导的聚合和化学接枝涂层或适于接触生物组织的制品的塑料表面的方法制备，改进包括在水溶液中进行接枝聚合， 以下条件：（1）单体浓度在约0.5％至约50％的范围内; （2）在约0.01至小于约0.5Mrad范围内的总伽马剂量; （3）γ剂量率在约10至约2500rad / min的范围内; 和（4）将聚合物在溶液中的分子量保持在约250,000至约5,000,000的范围内。

公开(公告)号：US5376400A

公开(公告)日：1994-12-27

申请号：US003682

申请日：1993-01-13

Applicant: Eugene P. Goldberg ,  Ali Yahiaoui ,  James Burns

Inventor： Eugene P. Goldberg ,  Ali Yahiaoui ,  James Burns

IPC: A61L27/00 ,  A61L27/34 ,  A61L29/08 ,  B05D3/06 ,  B05D3/14 ,  B05D7/24 ,  C03C17/32 ,  C03C23/00 ,  C04B41/48 ,  C04B41/83 ,  C23C8/36 ,  C23C26/00 ,  A61F2/02 ,  A61M1/00 ,  A61M25/00 ,  B05D3/04

CPC classification number: C08J7/123 ,  A61L27/34 ,  A61L29/085 ,  B05D1/60 ,  B05D3/068 ,  B05D3/142 ,  B05D3/144 ,  C03C17/32 ,  C03C23/0035 ,  C03C23/004 ,  C03C23/006 ,  C04B41/009 ,  C04B41/48 ,  C04B41/83 ,  C23C26/00 ,  C23C8/36 ,  A61L2400/18 ,  C03C2218/31 ,  C04B2111/00836

Abstract: A method for modifying the surface of a material by:a. exposing the surface to a glow discharge plasma to activate the surface;b. exposing the surface to an ethylenically unsaturated monomer or mixture of monomers; andc. irradiating the activated surface with gamma radiation or electron beam radiation in the presence of the ethylenically unsaturated monomer to form a graft polymerized coating thereon.

Abstract translation: 一种通过以下方式改变材料表面的方法：a。 将表面暴露于辉光放电等离子体以激活表面; b。 将表面暴露于烯属不饱和单体或单体混合物; 和c。 在烯键式不饱和单体的存在下用γ辐射或电子束辐射照射激活的表面，以在其上形成接枝聚合的涂层。

公开(公告)号：US08987544B2

公开(公告)日：2015-03-24

申请号：US12971741

申请日：2010-12-17

Applicant: Simon Poruthoor ,  Rebecca Griffin ,  Lei Huang ,  Balaji K. Kandadai ,  Suzanne Murray ,  Hue Scott Snowden ,  Herb Velazquez ,  Dean M. Wydeven ,  Ali Yahiaoui

Inventor： Simon Poruthoor ,  Rebecca Griffin ,  Lei Huang ,  Balaji K. Kandadai ,  Suzanne Murray ,  Hue Scott Snowden ,  Herb Velazquez ,  Dean M. Wydeven ,  Ali Yahiaoui

IPC: A61F13/494 ,  A61L15/42 ,  A61F13/472 ,  A61F13/475 ,  A61F13/00

CPC classification number: A61L15/42 ,  A61F13/00059 ,  A61F13/47263 ,  A61F13/475

Abstract: An absorbent article has a longitudinal direction, a transverse direction, a first major surface which forms a body-facing surface of the absorbent article, and a second major surface disposed distally from the first major surface which forms a garment-facing surface of the absorbent article. The article includes an absorbent core positioned between the first major surface and the second major surface. The article also includes at least one heat-activatable expandable structure. The at least one heat-activatable expandable structure is disposed on or below the first major surface. Application of heat to the heat-activatable expandable structure causes the heat-activatable expandable barrier structure to form distinctive designs, barriers and/or channels.

Abstract translation: 吸收性物品具有纵向方向，横向方向，形成吸收性物品的面向身体表面的第一主表面和从第一主表面向远侧设置的第二主表面，其形成吸收剂的面向衣服表面 文章。 该制品包括位于第一主表面和第二主表面之间的吸收芯。 该制品还包括至少一种可热激活的可膨胀结构。 至少一个可热激活的可膨胀结构设置在第一主表面上或下方。 将热量施加到可热激活的可膨胀结构上使热可活化的可扩张的阻挡结构形成独特的设计，阻挡层和/或通道。

公开(公告)号：US08778386B2

公开(公告)日：2014-07-15

申请号：US11847976

申请日：2007-08-30

Applicant: Kou-Chang Liu ,  David W. Koenig ,  Ali Yahiaoui ,  Alison Salyer Bagwell

Inventor： Kou-Chang Liu ,  David W. Koenig ,  Ali Yahiaoui ,  Alison Salyer Bagwell

IPC: A61F13/00 ,  A61K33/40

CPC classification number: A61K33/40 ,  A01N25/34 ,  A01N59/00 ,  A01N33/12 ,  A01N25/22 ,  A01N25/10

Abstract: An oxidizing anti-microbial treatment and products containing such treatment are described. The treatment involves, in part, preparing a substrate to accept an attachment of charged moieties, and a number of stabilized peroxide compounds on at least part of a surface of said substrate. When microbes, such as bacteria, having a net charge opposite to that of the charged moieties come in close proximity to the treated substrate surface, peroxide molecules from the substrate are activated and released to kill the microbes.

Abstract translation: 描述了氧化性抗微生物处理和含有这种处理的产品。 该处理部分地涉及制备底物以接受带电部分的附着物，以及在所述基材的至少部分表面上的许多稳定的过氧化物化合物。 当具有与带电部分的净电荷相反的净电荷的微生物与处理的底物表面紧密接近时，来自底物的过氧化物分子被活化并释放以杀死微生物。