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公开(公告)号：US09511171B2
公开(公告)日：2016-12-06
申请号：US12951205
申请日：2010-11-22
CPC分类号： A61L27/3612 , A61F2/02 , A61F2/08 , A61F2310/0097 , A61L27/18 , A61L27/36 , A61L27/3616 , A61L27/3817 , A61L27/3895 , A61L27/58 , A61L2400/18 , A61L2430/06 , A61L2430/10 , A61L2430/34 , C12N5/0068 , C12N5/0655
摘要： A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译： 提供生物相容性组织修复植入物或支架装置，用于修复各种组织损伤，特别是软骨，韧带，腱和神经的损伤。 修复程序可以用包含有助于愈合或组织修复的生物成分的植入物进行。 生物相容性组织修复植入物包括生物相容性支架和活组织颗粒，使得组织和支架变得相关联。 活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。
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公开(公告)号：US20110091517A1
公开(公告)日：2011-04-21
申请号：US12951205
申请日：2010-11-22
IPC分类号： A61F2/00 , A61K35/12 , A61K35/32 , A61K35/36 , A61K35/34 , A61K35/30 , A61K35/23 , A61K35/28 , A61K35/407 , A61K35/22 , A61K35/39
CPC分类号： A61L27/3612 , A61F2/02 , A61F2/08 , A61F2310/0097 , A61L27/18 , A61L27/36 , A61L27/3616 , A61L27/3817 , A61L27/3895 , A61L27/58 , A61L2400/18 , A61L2430/06 , A61L2430/10 , A61L2430/34 , C12N5/0068 , C12N5/0655
摘要： A biocompatible tissue repair implant or scaffold device is provided for use in repairing a variety of tissue injuries, particularly injuries to cartilage, ligaments, tendons, and nerves. The repair procedures may be conducted with implants that contain a biological component that assists in healing or tissue repair. The biocompatible tissue repair implants include a biocompatible scaffold and particles of living tissue, such that the tissue and the scaffold become associated. The particles of living tissue contain one or more viable cells that can migrate from the tissue and populate the scaffold.
摘要翻译： 提供生物相容性组织修复植入物或支架装置，用于修复各种组织损伤，特别是软骨，韧带，腱和神经的损伤。 修复程序可以用包含有助于愈合或组织修复的生物成分的植入物进行。 生物相容性组织修复植入物包括生物相容性支架和活组织颗粒，使得组织和支架变得相关联。 活组织的颗粒含有一个或多个活细胞，其可从组织迁移并填充支架。
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公开(公告)号：US07163920B2
公开(公告)日：2007-01-16
申请号：US10674516
申请日：2003-09-30
申请人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
发明人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George A. Heavner , Xuanhan Lin , Chin-Feng Yi
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。
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公开(公告)号：US20060154367A1
公开(公告)日：2006-07-13
申请号：US11322003
申请日：2005-12-29
申请人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska
发明人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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公开(公告)号：US20050187162A1
公开(公告)日：2005-08-25
申请号：US10674516
申请日：2003-09-30
申请人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George Heavner , Xuanhan Lin , Chin-Feng Yi
发明人： Sridevi Dhanaraj , Anna Gosiewska , Ali Rezania , George Heavner , Xuanhan Lin , Chin-Feng Yi
CPC分类号： A61K38/08 , A61K31/375 , A61K31/573 , A61K31/661 , A61K35/32 , A61K38/18 , A61K45/06 , A61L27/227 , A61K2300/00
摘要： The present invention provides a composition including an isolated or recombinant peptide component that has osteogenic cell proliferative activity. The peptide, which promotes proliferation of osteoblasts, is useful for treatment of fractures, as a filler in deficient sites of bone, for inhibition of decrease in bone substance related to osteoporosis and periodontic diseases, and for prevention of fractures associated with osteoporosis and rheumatoid arthritis. The peptide, or cells that have been genetically engineered to produce the peptide, can be combined with a bone-compatible matrix to facilitate slow release of the peptide to a treatment site and/or provide a structure for developing bone.
摘要翻译： 本发明提供了包含具有成骨细胞增殖活性的分离或重组的肽组分的组合物。 促进成骨细胞增殖的肽可用于治疗骨折，作为骨缺损部位的填充物，用于抑制与骨质疏松症和牙周病相关的骨质减少，以及用于预防与骨质疏松症和类风湿性关节炎相关的骨折 。 已经经遗传工程化以产生肽的肽或细胞可以与骨相容性基质组合以促进肽缓慢释放到治疗部位和/或提供用于发展骨的结构。
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6.发明授权公开(公告)号：US08491883B2
公开(公告)日：2013-07-23
申请号：US13026995
申请日：2011-02-14
CPC分类号： C12N5/0605 , A61K35/12 , C12N5/0607 , C12N5/0622 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/11 , C12N2501/115 , C12N2501/119 , C12N2501/12 , C12N2501/13 , C12N2501/21 , C12N2501/23 , C12N2501/385 , C12N2501/41 , C12N2502/02 , C12N2502/03 , C12N2506/02 , C12N2506/025 , C12N2506/03 , C12N2509/00 , C12N2533/50
摘要： This invention relates to methods of treating amyotrophic lateral sclerosis. In particular, the invention provides for methods of treating amyotrophic lateral sclerosis by administering umbilical cord tissue-derived cells, an effective amount of a substantially homogenous population of umbilical cord tissue-derived cells or a pharmaceutical composition comprising umbilical cord tissue-derived cells to a patient.
摘要翻译： 本发明涉及治疗肌萎缩性侧索硬化症的方法。 特别地，本发明提供了通过施用脐带组织来源的细胞，有效量的基本上均匀的脐带组织来源的细胞群或包含脐带组织来源的细胞的药物组合物来治疗肌萎缩性侧索硬化的方法 患者。
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公开(公告)号：US20090275129A1
公开(公告)日：2009-11-05
申请号：US12432994
申请日：2009-04-30
申请人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
发明人： Kevin Cooper , Iksoo Chun , David C. Colter , Sridevi Dhanaraj , Anna Gosiewska , Agnieszka Seyda , Carrie H. Fang , Chunlin Yang
CPC分类号： C12N5/0691 , A61L27/18 , A61L27/3604 , A61L27/38 , A61L27/507 , C12M21/08 , C12M25/14 , C08L67/04
摘要： Compositions and methods of using tissue engineered blood vessels to repair and regenerate blood vessels of patients with vascular disease are disclosed.
摘要翻译： 公开了使用组织工程化血管修复和再生血管疾病患者血管的组合物和方法。
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公开(公告)号：US20060153815A1
公开(公告)日：2006-07-13
申请号：US11304091
申请日：2005-12-15
申请人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
发明人： Agnieszka Seyda , David Colter , Charito Buensuceso , Sridevi Dhanaraj , Anna Gosiewska , Jeffrey Geesin , Angelo Scopelianos
CPC分类号： C12N5/0068 , A61L27/3604 , A61L27/38 , C12N2533/40
摘要： Tissue engineering devices for use in the repair or regeneration of tissue made of support scaffolds and cell sheets.
摘要翻译： 用于修复或再生由支撑支架和细胞片组成的组织的组织工程装置。
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9.发明申请Cartilage and bone repair and regeneration using postpartum-derived cells 审中-公开使用产后来源的细胞进行软骨和骨修复和再生公开(公告)号：US20050019865A1
公开(公告)日：2005-01-27
申请号：US10876998
申请日：2004-06-25
申请人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
发明人： Anthony Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander Harmon , Ian Harris , Darin Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
CPC分类号： A61K35/51 , A01N1/0226 , A61K35/12 , A61K35/50 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/1833 , A61K38/1841 , A61K38/185 , A61K38/1858 , A61K38/1866 , A61K38/1891 , A61K38/19 , A61K38/204 , A61K38/2053 , A61K38/27 , A61K45/06 , C12N5/0605 , C12N5/0606 , C12N5/0607 , C12N2500/32 , C12N2500/34 , C12N2500/44 , C12N2500/90 , C12N2500/95 , C12N2501/12 , C12N2501/21 , C12N2501/23 , C12N2502/02 , C12N2506/02 , C12N2506/03 , C12N2509/00 , C12N2509/10 , C12N2533/50
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
摘要翻译： 源自产后组织的细胞及其分离和诱导分化成软骨形成或成骨表型细胞的方法由本发明提供。 本发明进一步提供产后来源细胞的培养物和组合物及其相关的产品。 本发明的产后衍生细胞及其相关产品具有多种用途，包括但不限于研究，诊断和治疗应用，例如用于治疗骨和软骨病症。
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公开(公告)号：US11191789B2
公开(公告)日：2021-12-07
申请号：US10876998
申请日：2004-06-25
申请人： Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
发明人： Anthony J. Kihm , Agnieszka Seyda , Sridevi Dhanaraj , Ziwei Wang , Alexander M. Harmon , Ian Ross Harris , Darin J. Messina , Sanjay Mistry , Anna Gosiewska , Chin-Feng Yi
IPC分类号： A61K48/00 , A61K35/51 , C12N5/074 , C12N5/073 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/27 , C12N5/0735 , A61K35/50 , A61K35/12
摘要： Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.
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