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公开(公告)号：US20110100293A1
公开(公告)日：2011-05-05
申请号：US12892783
申请日：2010-09-28
Applicant: Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
Inventor： Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
CPC classification number: C08F2/48 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/10 , A61L2420/02 , C08J7/18 , C08L33/08 , C09D4/00 , C09D133/08
Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.
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公开(公告)号：US11058749B2
公开(公告)日：2021-07-13
申请号：US15140885
申请日：2016-04-28
Applicant: Frank DiCosmo
Inventor： Frank DiCosmo
Abstract: A bioactive collagen biomaterial according to the invention that is biocompatible with cells and tissues and distinguished by containing certain cryptic and non-cryptic peptide constituents to stimulate cellular responses and further made to incorporate a variety of agents to provide a desired characteristic, such as antimicrobial properties. The bioactive collagen biomaterial can be provided as a variety of configurations and as various matrices and devices for use in medical applications such as in biotechnology, basic research, tissue engineering and in wound repair as a wound dressing or cell/tissue scaffold.
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公开(公告)号：US08840927B2
公开(公告)日：2014-09-23
申请号：US10468438
申请日：2002-02-26
Applicant: Valerio DiTizio , Frank DiCosmo
Inventor： Valerio DiTizio , Frank DiCosmo
CPC classification number: A61L31/10 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/606
Abstract: The present invention is a method for the modification of the surfaces of polymeric materials with polymer coatings that may be subsequently treated to be lubricious and anti-microbial. The method comprises incubating a photo-initiator-coated polymeric material with an aqueous monomer that is capable of free radical polymerization and exposing the incubating polymeric material to UV light creating a modified surface on said polymeric material. The method may additionally comprise adding a silver component to the modified surface. The silver component may be provided as a silver salt coating or a silver salt contained within a hydrogel bonded to the acrylate modified polymeric material surface.
Abstract translation: 本发明是一种用聚合物涂层改性聚合物材料的表面的方法，聚合物涂层可以随后被处理成润滑和抗微生物。 该方法包括将光引发剂涂覆的聚合物材料与能够进行自由基聚合的水性单体一起孵育，并将孵育的聚合物材料暴露于UV光，从而在所述聚合物材料上产生改性的表面。 该方法可另外包括向改性表面添加银组分。 银组分可以作为银盐包衣或包含在与丙烯酸酯改性的聚合物材料表面结合的水凝胶中的银盐提供。
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公开(公告)号：US08746168B2
公开(公告)日：2014-06-10
申请号：US12892783
申请日：2010-09-28
Applicant: Hamed Abbasian , Pamela Chan , Valerio Ditizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
Inventor： Hamed Abbasian , Pamela Chan , Valerio Ditizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
IPC: B05C3/02 , C09D4/00 , A61L27/34 , A61L29/08 , C09D133/08 , C08F2/48 , A61L31/10 , C08J7/18 , C08L33/08
CPC classification number: C08F2/48 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/10 , A61L2420/02 , C08J7/18 , C08L33/08 , C09D4/00 , C09D133/08
Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.
Abstract translation: 提供了一种用于将涂层聚合物光刻接到医疗器械表面上的系统和方法。 该系统包括多个站，包括一个新颖的移植站。 本发明的系统和方法既时间又资源有效。 该系统包括几个站，每个站包括一个浸渍槽。 该系统允许根据需要以特定的顺序将医疗装置自动化，半自动化或手动地浸入浸渍罐中，其中至少一个站是用于将涂层聚合物光刻接合到表面上的接枝站 的医疗器械。 该系统是模块化的，这允许根据需要修改过程，具体取决于用户的需求。 该系统可以包括用于将抗微生物剂并入涂层中的站和/或用于使涂层润滑的站。
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公开(公告)号：US06475516B2
公开(公告)日：2002-11-05
申请号：US09818649
申请日：2001-03-28
Applicant: Frank DiCosmo , Valerio DiTizio
Inventor： Frank DiCosmo , Valerio DiTizio
IPC: A61K9127
CPC classification number: A61L27/52 , A61K9/127 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/43 , A61L2300/436 , A61L2300/626
Abstract: The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
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Patent Agency Ranking
公开(公告)号：US08967077B2
公开(公告)日：2015-03-03
申请号：US12892799
申请日：2010-09-28
Applicant: Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
Inventor： Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
IPC: B05C3/02 , C09D4/00 , A61L27/34 , A61L29/08 , A61L31/10 , C08F2/48 , C08J7/18 , C09D133/08 , C08L33/08
CPC classification number: C08F2/48 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/10 , A61L2420/02 , C08J7/18 , C08L33/08 , C09D4/00 , C09D133/08
Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.
Abstract translation: 提供了一种用于将涂层聚合物光刻接到医疗器械表面上的系统和方法。 该系统包括多个站，包括一个新颖的移植站。 本发明的系统和方法既时间又资源有效。 该系统包括几个站，每个站包括一个浸渍槽。 该系统允许根据需要以特定的顺序将医疗装置自动化，半自动化或手动地浸入浸渍罐中，其中至少一个站是用于将涂层聚合物光刻接合到表面上的接枝站 的医疗器械。 该系统是模块化的，这允许根据需要修改过程，具体取决于用户的需求。 该系统可以包括用于将抗微生物剂并入涂层中的站和/或用于使涂层润滑的站。
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公开(公告)号：US20110212152A1
公开(公告)日：2011-09-01
申请号：US12982178
申请日：2010-12-30
Applicant: Valerio Ditizio , Frank DiCosmo
Inventor： Valerio Ditizio , Frank DiCosmo
CPC classification number: A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/452 , A61L2400/18
Abstract: Methods for making modified surfaces and in particular, surfaces that may be lubricious and may be further treated to be anti-microbial are disclosed. Devices comprising modified surfaces prepared by the methods are also disclosed. An exemplary method comprises incubating a photo-initiator-coated substrate in an aqueous monomer solution that is capable of free radical polymerization, exposing the incubating substrate to ultraviolet (UV) light creating a modified surface on the substrate. An anti-microbial agent may be added to the modified surface.
Abstract translation: 公开了制备改性表面，特别是可能是光滑的并可进一步处理为抗微生物的表面的方法。 还公开了包含通过该方法制备的改性表面的装置。 一种示例性方法包括将能够进行自由基聚合的单体水溶液中的光引发剂涂布的基材孵育，将培养基材暴露于紫外线（UV）光，从而在基材上产生改性表面。 可以将抗菌剂添加到改性表面。
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公开(公告)号：US20070009580A1
公开(公告)日：2007-01-11
申请号：US11169481
申请日：2005-06-29
Applicant: Frank DiCosmo , Valerio DiTizio
Inventor： Frank DiCosmo , Valerio DiTizio
CPC classification number: A61K47/42 , A61F13/00063 , A61F13/00991 , A61F2013/00157 , A61F2013/00221 , A61F2013/00268 , A61F2013/00519 , A61F2013/00885 , A61F2013/0091 , A61K9/0014 , A61K9/06 , A61K9/7015 , A61K31/00 , A61K33/38 , A61L15/14 , A61L15/32 , A61L15/325 , A61L15/42 , A61L15/60 , A61L26/0033 , A61L26/0038 , A61L26/0061 , A61L26/008 , C08J3/28
Abstract: Substantially non-adhesive hydrogels are useful as wound dressings, wound barriers, therapeutic drug delivery devices and the like. The substantially non-adhesive hydrogels are synthesized by a method that comprises irradiating a solution comprising a biological polymer that is biodegradable and biocompatible, using ionizing radiation, whereby free radicals of the biological polymer are formed and cross-linking occurs between the biological polymer radicals to provide the hydrogel.
Abstract translation: 基本上不粘合的水凝胶可用作伤口敷料，伤口，治疗药物递送装置等。 基本上不粘合的水凝胶是通过一种方法合成的，该方法包括使用电离辐射照射包含可生物降解和生物相容的生物聚合物的溶液，由此形成生物聚合物的自由基，并在生物聚合物自由基之间发生交联 提供水凝胶。
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公开(公告)号：US20060068013A1
公开(公告)日：2006-03-30
申请号：US11152367
申请日：2005-06-15
Applicant: Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
Inventor： Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
CPC classification number: A61K47/42 , A61K9/7007 , A61K47/10 , A61K47/36 , A61L15/225 , A61L15/325 , A61L15/425 , A61L31/041 , A61L31/045 , A61L31/146 , C08L5/00 , C08L5/04 , C08L5/08 , C08L71/00 , C08L89/00 , C08L89/06 , C08L2205/02 , C08L2666/26 , C08L2666/14 , C08L2666/02
Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
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公开(公告)号：US06228393B1
公开(公告)日：2001-05-08
申请号：US09412584
申请日：1999-10-05
Applicant: Frank DiCosmo , Valerio DiTizio
Inventor： Frank DiCosmo , Valerio DiTizio
IPC: A61K9127
CPC classification number: A61L27/52 , A61K9/127 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/43 , A61L2300/436 , A61L2300/626
Abstract: The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Abstract translation: 本发明涉及一种用于从固体基质进行药物递送的载体。 装载有脂质体治疗剂如抗生素的水凝胶共价结合到诸如植入物，导管等的诸如住院医疗装置的底物表面。 本发明特别可用于治疗和预防通常与使用住院医疗器械有关的生物膜介导的感染。
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