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公开(公告)号:US20110006007A1
公开(公告)日:2011-01-13
申请号:US12746961
申请日:2008-12-19
申请人: Gokhan Kuruc , Marjorie Bucholz , Todd E. Arnold , Robert T. Fitzsimons, JR. , Kannan Seshadri , Steven M. Heilmann , Andrew W. Rabins , Catherine A. Bothof
发明人: Gokhan Kuruc , Marjorie Bucholz , Todd E. Arnold , Robert T. Fitzsimons, JR. , Kannan Seshadri , Steven M. Heilmann , Andrew W. Rabins , Catherine A. Bothof
CPC分类号: B01J20/26 , B01D39/1653 , B01D2239/086 , B01J20/2803 , B01J20/285 , B01J2220/58 , B01J2220/66 , C02F1/285 , C02F2103/343
摘要: Provided are filtration media, matrixes, and systems for liquid purification that utilize functional polymer particles. The functional polymer particles can comprise a cationic charge. Exemplary functional polymer particles comprise comprise [3-(methacryloylamino)propyl]-trimethylammonium chloride (MAPTAC) polymerized with trimethylolpropane trimethacrylate (TMPTMA).
摘要翻译: 提供了使用功能性聚合物颗粒的过滤介质,基质和用于液体纯化的系统。 功能性聚合物颗粒可以包含阳离子电荷。 示例性功能性聚合物颗粒包含由三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)聚合的[3-(甲基丙烯酰氨基)丙基] - 三甲基氯化铵(MAPTAC)。
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公开(公告)号:US09056316B2
公开(公告)日:2015-06-16
申请号:US13703267
申请日:2011-06-17
申请人: Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, Jr. , Andrew W. Rabins , Taib K. Ansera
发明人: Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, Jr. , Andrew W. Rabins , Taib K. Ansera
IPC分类号: B01J41/14 , B01J39/20 , C08J3/24 , C08L33/26 , C08L101/00
CPC分类号: B01J41/14 , B01J39/20 , B01J39/26 , B01J41/20 , C08J3/246 , C08J2333/26 , C08J2400/00 , C08L23/06 , C08L33/26 , C08L77/00 , C08L101/00 , C08L2205/04 , C08L2205/16 , C08L2205/22 , C08L2312/00
摘要: Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.
摘要翻译: 描述了半互穿聚合物网络。 更具体地说,半互穿聚合物网络包括至少两种紧密相关的聚合物。 第一聚合物是不交联的离子聚合物。 第二聚合物是可以是另一离子聚合物或非离子聚合物的交联聚合物。 还描述了制备半互穿聚合物网络的方法,含有半互穿聚合物网络的制品以及使用半互穿聚合物网络的方法。 半互穿聚合物网络可用作离子交换树脂。
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公开(公告)号:US20130090397A1
公开(公告)日:2013-04-11
申请号:US13703267
申请日:2011-06-17
申请人: Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, JR. , Andrew W. Rabins , Taib K. Ansera
发明人: Del R. Lawson , James I. Hembre , Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , Robert T. Fitzsimons, JR. , Andrew W. Rabins , Taib K. Ansera
CPC分类号: B01J41/14 , B01J39/20 , B01J39/26 , B01J41/20 , C08J3/246 , C08J2333/26 , C08J2400/00 , C08L23/06 , C08L33/26 , C08L77/00 , C08L101/00 , C08L2205/04 , C08L2205/16 , C08L2205/22 , C08L2312/00
摘要: Semi-interpenetrating polymeric networks are described. More specifically, the semi-interpenetrating polymeric networks include at least two polymers that are closely associated. The first polymer is an ionic polymer that is not crosslinked. The second polymer is a cross-linked polymer that can be either another ionic polymer or a non-ionic polymer. Methods of making the semi-interpenetrating polymeric networks, articles containing the semi-interpenetrating polymeric networks, and methods of using the semi-interpenetrating polymeric networks are also described. The semi-interpenetrating polymeric networks can function as ion exchange resins.
摘要翻译: 描述了半互穿聚合物网络。 更具体地说,半互穿聚合物网络包括至少两种紧密相关的聚合物。 第一聚合物是不交联的离子聚合物。 第二聚合物是可以是另一离子聚合物或非离子聚合物的交联聚合物。 还描述了制备半互穿聚合物网络的方法,含有半互穿聚合物网络的制品以及使用半互穿聚合物网络的方法。 半互穿聚合物网络可用作离子交换树脂。
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公开(公告)号:US20110217752A1
公开(公告)日:2011-09-08
申请号:US13026331
申请日:2011-02-14
申请人: Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, JR. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
发明人: Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, JR. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
CPC分类号: C07K1/14 , B01D21/01 , C08F120/60 , C08F126/02 , C08G69/10 , C08G73/0206 , C08G73/022 , C08G73/028 , C08L77/04 , C08L79/02 , C08L83/08 , C12N7/02 , C12N11/08 , G01N33/54393 , G01N33/545 , Y10T428/249978 , Y10T428/249991 , Y10T428/2935 , Y10T428/2998 , Y10T442/20
摘要: Ligand functionalized substrates, methods of making ligand functionalized substrates, and methods of using functionalized substrates are disclosed.
摘要翻译: 配体功能化底物,制备配体官能化底物的方法,以及使用官能化底物的方法。
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公开(公告)号:US09272246B2
公开(公告)日:2016-03-01
申请号:US13353413
申请日:2012-01-19
申请人: Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, Jr. , George W. Griesgraber , Yi He
发明人: Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, Jr. , George W. Griesgraber , Yi He
IPC分类号: C12N9/00 , B01D67/00 , B01D71/56 , C09D179/02
CPC分类号: C07K1/22 , B01D67/0093 , B01D71/56 , B01D2323/30 , B01D2323/385 , C07H1/08 , C07K14/765 , C09D179/02 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31928
摘要: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
摘要翻译: 提供了包含交联聚合物底漆层并接枝到配体官能化聚合物上的底物。 在接近或低于生物材料的pI的pH值下,接枝聚合物对结合中性或带负电荷的生物材料如细胞,细胞碎片,细菌,孢子,病毒,核酸和蛋白质具有必要的亲和力。
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公开(公告)号:US08435776B2
公开(公告)日:2013-05-07
申请号:US13026331
申请日:2011-02-14
申请人: Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, Jr. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
发明人: Jerald K. Rasmussen , Kannan Seshadri , Robert T. Fitzsimons, Jr. , James I. Hembre , Catherine A. Bothof , Erin A. Satterwhite , George W. Griesgraber , Yi He , Louis C. Haddad
CPC分类号: C07K1/14 , B01D21/01 , C08F120/60 , C08F126/02 , C08G69/10 , C08G73/0206 , C08G73/022 , C08G73/028 , C08L77/04 , C08L79/02 , C08L83/08 , C12N7/02 , C12N11/08 , G01N33/54393 , G01N33/545 , Y10T428/249978 , Y10T428/249991 , Y10T428/2935 , Y10T428/2998 , Y10T442/20
摘要: A method of separating a target biological species from a fluid is disclosed comprising contacting the fluid with a ligand-functionalized polymer comprising: a water soluble or water dispersible aminopolymer functionalized with guanidinyl groups; whereby a complex comprising the functionalized substrate and the target biological species is formed.
摘要翻译: 公开了一种从流体中分离目标生物物种的方法,包括使所述流体与配体官能化聚合物接触,所述配体官能化聚合物包含:用胍基基团官能化的水溶性或水分散性氨基聚合物; 从而形成包含官能化底物和靶生物物质的复合物。
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公开(公告)号:US20120252091A1
公开(公告)日:2012-10-04
申请号:US13353413
申请日:2012-01-19
申请人: Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, JR. , George W. Griesgraber , Yi He
发明人: Jerald K. Rasmussen , Catherine A. Bothof , Kannan Seshadri , James I. Hembre , Robert T. Fitzsimons, JR. , George W. Griesgraber , Yi He
IPC分类号: B32B27/08 , C07H1/06 , C08F220/60 , C08F220/40 , C12N1/20 , B32B27/28 , B32B27/36 , B32B27/34 , C12N9/00 , C12N7/02 , C07K1/32 , C08F226/02
CPC分类号: C07K1/22 , B01D67/0093 , B01D71/56 , B01D2323/30 , B01D2323/385 , C07H1/08 , C07K14/765 , C09D179/02 , Y10T428/31663 , Y10T428/31721 , Y10T428/31725 , Y10T428/31855 , Y10T428/31928
摘要: A substrate comprising a crosslinked polymer primer layer, and grafted thereto a ligand-functionalized polymer is provided. The grafted polymer has the requisite affinity for binding neutral or negatively charged biomaterials, such as cells, cell debris, bacteria, spores, viruses, nucleic acids, and proteins, at pH's near or below the pI's of the biomaterials.
摘要翻译: 提供了包含交联聚合物底漆层并接枝到配体官能化聚合物上的底物。 在接近或低于生物材料的pI的pH值下,接枝聚合物对结合中性或带负电荷的生物材料如细胞,细胞碎片,细菌,孢子,病毒,核酸和蛋白质具有必要的亲和力。
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公开(公告)号:US08328023B2
公开(公告)日:2012-12-11
申请号:US12620754
申请日:2009-11-18
申请人: Douglas E. Weiss , Clinton P. Waller, Jr. , Michael R. Berrigan , Andrew W. Rabins , Jeffrey A. Lucas , Kannan Seshadri , Catherine A. Bothof
发明人: Douglas E. Weiss , Clinton P. Waller, Jr. , Michael R. Berrigan , Andrew W. Rabins , Jeffrey A. Lucas , Kannan Seshadri , Catherine A. Bothof
CPC分类号: B01D39/163 , C08F255/00 , C08F289/00 , C08F291/00 , C08L51/08 , C08L2666/02
摘要: A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture.
摘要翻译: 公开了接枝非织造基材,其平均纤维尺寸为0.7-15微米,空隙体积为50至95%,以及包含接枝到非织造基材表面的阳离子氨基烷基(甲基)丙烯酰基单体单元的聚合物。 该制品可以用作过滤元件以从流体混合物纯化或分离靶物质,例如寡核苷酸或单克隆抗体(MAb)。
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公开(公告)号:US20100155323A1
公开(公告)日:2010-06-24
申请号:US12620754
申请日:2009-11-18
申请人: Douglas E. Weiss , Clinton P. Waller, JR. , Michael R. Berrigan , Andrew W. Rabins , Jeffrey A. Lucas , Kannan Seshadri , Catherine A. Bothof
发明人: Douglas E. Weiss , Clinton P. Waller, JR. , Michael R. Berrigan , Andrew W. Rabins , Jeffrey A. Lucas , Kannan Seshadri , Catherine A. Bothof
CPC分类号: B01D39/163 , C08F255/00 , C08F289/00 , C08F291/00 , C08L51/08 , C08L2666/02
摘要: A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising cationic aminoalkyl(meth)acryloyl monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as oligonucleotides or monoclonal antibodies (MAb), from a fluid mixture.
摘要翻译: 公开了接枝非织造基材,其平均纤维尺寸为0.7-15微米,空隙体积为50至95%,以及包含接枝到非织造基材表面的阳离子氨基烷基(甲基)丙烯酰基单体单元的聚合物。 该制品可以用作过滤元件以从流体混合物纯化或分离靶物质,例如寡核苷酸或单克隆抗体(MAb)。
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公开(公告)号:US20100320138A1
公开(公告)日:2010-12-23
申请号:US12819261
申请日:2010-06-21
CPC分类号: B01D67/0093 , B01D39/1623 , B01D39/1692 , B01D63/00 , B01D63/10 , B01D63/14 , B01D67/009 , B01D69/10 , B01D69/105 , B01D2239/0421 , B01D2239/0464 , B01D2239/065 , B01D2239/069 , B01D2239/10 , B01D2239/1216 , B01D2239/1225 , B01D2239/1266 , B01D2239/1291 , B01D2323/385 , D04H1/42 , D04H1/4334 , D04H1/4382 , D04H1/56 , D06M14/26 , D06M14/28 , Y10T442/2008
摘要: A grafted nonwoven substrate is disclosed having average fiber sizes of 0.7 to 15 microns, and a void volume of 50 to 95%, and a polymer comprising anionic monomer units grafted to the surface of the nonwoven substrate. The article may be used as a filter element to purify or separate target materials, such as monoclonal antibodies (MAb), from a fluid mixture.
摘要翻译: 公开了接枝非织造基材,其平均纤维尺寸为0.7至15微米,空隙体积为50至95%,以及包含接枝到非织造基材表面的阴离子单体单元的聚合物。 该制品可以用作过滤元件以从流体混合物中纯化或分离靶物质,例如单克隆抗体(MAb)。
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