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    Method for determining at least one hemoglobin related parameter of a whole blood sample
    1.
    发明授权
    Method for determining at least one hemoglobin related parameter of a whole blood sample 有权
    用于确定全血样品的至少一种血红蛋白相关参数的方法

    公开(公告)号：US08472693B2

    公开(公告)日：2013-06-25

    申请号：US13051705

    申请日：2011-03-18

    申请人： Graham Davis ,  Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten Lalpuria ,  Paul G. Mitsis

    发明人： Graham Davis ,  Stephen C. Wardlaw ,  Robert A. Levine ,  Darryn W. Unfricht ,  Niten Lalpuria ,  Paul G. Mitsis

    IPC分类号： G06K9/00

    CPC分类号： G01N33/726 ,  G01N15/1475 ,  G01N2015/0073

    摘要： A method and apparatus for determining at least one hemoglobin related parameter of a whole blood sample is provided. The method includes the steps of: a) depositing the sample into an analysis chamber adapted to quiescently hold the sample for analysis, the chamber defined by an interior surface of a first panel, and an interior surface of a second panel, and the chamber has a height extending between the interior surfaces of the panels, wherein the chamber is configured to increase the oxygenation state of the sample to a substantially oxygenated state within a predetermined amount of time after entry into the chamber; b) imaging the at least one red blood cell contacting the interior surfaces, and producing image signals; c) determining an optical density of at least a portion of the imaged red blood cell contacting both interior surfaces; and d) determining the at least one hemoglobin related parameter of the red blood cell contacting the interior surfaces, using the determined optical density and a molar extinction coefficient for oxygenated hemoglobin.

    摘要翻译： 提供了一种用于确定全血样品的至少一种血红蛋白相关参数的方法和装置。 该方法包括以下步骤：a）将样品沉积到适于静态保持样品进行分析的分析室中，所述室由第一面板的内表面和第二面板的内表面限定，并且所述室具有 在所述面板的内表面之间延伸的高度，其中所述腔被配置为在进入所述腔室之后的预定量的时间内将所述样品的氧合状态增加到基本上氧合状态; b）对与内表面接触的至少一个红细胞进行成像，并产生图像信号; c）确定接触两个内表面的成像红细胞的至少一部分的光密度; 以及d）使用确定的光密度和氧合血红蛋白的摩尔消光系数来确定与内表面接触的红细胞的至少一种血红蛋白相关参数。

    Reducing leukocyte interference in competitive immunoassays
    2.
    发明授权
    Reducing leukocyte interference in competitive immunoassays 有权
    减少竞争性免疫测定中的白细胞干扰

    公开(公告)号：US08389293B2

    公开(公告)日：2013-03-05

    申请号：US12620230

    申请日：2009-11-17

    申请人： John Lewis Emerson Campbell ,  Graham Davis

    发明人： John Lewis Emerson Campbell ,  Graham Davis

    IPC分类号： G01N33/53 ,  G01N1/00

    CPC分类号： G01N33/54313 ,  G01N33/54393 ,  Y10T436/25125

    摘要： The invention is directed to methods and devices for reducing interference from leukocytes in competitive analyte immunoassays. In one embodiment, the invention is to a method comprising the steps of (a) amending a biological sample such as a whole blood sample with sacrificial beads opsonized for leukocytes; and (b) performing a competitive immunoassay on the amended sample to determine the concentration of said analyte in said sample. Preferably, the sample is amended with IgG-coated sacrificial beads.

    摘要翻译： 本发明涉及减少竞争性分析物免疫测定中白细胞干扰的方法和装置。 在一个实施方案中，本发明涉及一种方法，包括以下步骤：（a）用生物样品（例如全血样品）修饰用于白细胞调理的牺牲珠; 和（b）对经修改的样品进行竞争性免疫测定以确定所述样品中所述分析物的浓度。 优选地，用IgG涂覆的牺牲珠改变样品。

    Apparatus and Methods for Analyte Measurement and Immunoassay
    4.
    发明申请
    Apparatus and Methods for Analyte Measurement and Immunoassay 有权
    用于分析物测量和免疫测定的装置和方法

    公开(公告)号：US20110290669A1

    公开(公告)日：2011-12-01

    申请号：US13198253

    申请日：2011-08-04

    申请人： Graham Davis ,  Imants R. Lauks ,  Chao Lin ,  Cary James Miller

    发明人： Graham Davis ,  Imants R. Lauks ,  Chao Lin ,  Cary James Miller

    IPC分类号： G01N27/327 ,  G01N27/40 ,  G01N33/50 ,  G01N27/28

    CPC分类号： G01N33/543 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N35/08 ,  G01N2035/0436

    摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

    摘要翻译： 本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。 特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。 该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器 能够适应不同的分析物测量。 所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。 所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

    Apparatus and methods for analyte measurement and immunoassay
    5.
    发明授权
    Apparatus and methods for analyte measurement and immunoassay 有权
    用于分析物测量和免疫测定的装置和方法

    公开(公告)号：US08017382B2

    公开(公告)日：2011-09-13

    申请号：US12165925

    申请日：2008-07-01

    申请人： Graham Davis ,  Imants R. Lauks ,  Chao Lin ,  Cary James Miller

    发明人： Graham Davis ,  Imants R. Lauks ,  Chao Lin ,  Cary James Miller

    IPC分类号： C12M3/00

    CPC分类号： G01N33/543 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N35/08 ,  G01N2035/0436

    摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

    摘要翻译： 本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。 特别地，本发明涉及一种设计成适用于各种实时测定方案的一次性盒，优选使用免疫传感器或其它基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。 该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器 能够适应不同的分析物测量。 所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。 所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术，疗养院，重症监护病房和非医疗环境中的使用。

    Amphibious vehicle
    6.
    发明授权
    Amphibious vehicle 失效
    两栖车

    公开(公告)号：US06971931B2

    公开(公告)日：2005-12-06

    申请号：US10692998

    申请日：2003-10-24

    申请人： Graham Davis

    发明人： Graham Davis

    IPC分类号： B60F3/00 ,  B63B43/14 ,  B63B1/00

    CPC分类号： B63B43/14 ,  B60F3/0038

    摘要： An amphibious vehicle for land and water use comprises a main mono hull section and a pair of port and starboard sponsons which are movable from a stowed position under a main vehicle deck adjacent to the mono hull and a fully deployed position in which the sponsons are spaced apart from the mono hull by at least one hull width. The sponsons are each pivotally connected to the main hull by means of a pair of respective arms which together with the sponson and the hull define a parallel type four bar linkage. The sponsons stabilise the vehicle on water and are readily stowed to allow vehicle mobility on land.

    摘要翻译： 用于陆地和水的水陆两用车辆包括主单体船体部分和一对端口和右舷支架，其可以从邻近单体船体的主车辆甲板下方的收起位置移动，并且完全展开位置，在该位置上， 至少一个船体宽度除了单体船体外。 支架各自通过一对相应的臂枢转地连接到主船体，这些臂与支架和船体一起限定了平行的四杆连杆。 赞助商将车辆稳定在水面上，并且容易收起，以允许在陆地上的车辆行驶。

    Strip electrode with screen printing
    8.
    发明授权
    Strip electrode with screen printing 失效
    带电极丝网印刷

    公开(公告)号：US5727548A

    公开(公告)日：1998-03-17

    申请号：US469205

    申请日：1995-06-06

    申请人： Hugh Allen Oliver Hill ,  Irving John Higgins ,  James Michael McCann ,  Graham Davis

    发明人： Hugh Allen Oliver Hill ,  Irving John Higgins ,  James Michael McCann ,  Graham Davis

    IPC分类号： A61B5/00 ,  C12Q1/00 ,  C12Q1/68 ,  G01N27/403 ,  G01N33/487 ,  G01N33/543

    CPC分类号： G01N33/5438 ,  A61B5/1486 ,  A61B5/6848 ,  C12Q1/001 ,  C12Q1/004 ,  C12Q1/6825 ,  G01N27/4035 ,  A61B2560/0418 ,  Y10T29/4914 ,  Y10T29/49153 ,  Y10T29/49169 ,  Y10T29/49224

    摘要： A sensor system that detects a current representative of a compound in a liquid mixture features a two-electrode strip adapted for releasable attachment to signal readout circuitry. The strip comprises an elongated support (preferably flat) adapted for releasable attachment to the readout circuitry; a first conductor and a second conductor each extend along the support and comprise means for connection to the circuitry. An active electrode, positioned to contact the liquid mixture and the first conductor, comprises a single layer deposit of an enzyme capable of catalyzing a reaction involving the compound, a conductive material, and an electron mediator, capable of transferring electrons between the enzyme-catalyzed reaction and the first conductor. A reference electrode is positioned to contact the mixture and the second conductor. The system includes circuitry adapted to provide an electrical signal representative of the current. The two-electrode strip is manufactured, e.g., by screen printing, an admixture of an enzyme a conductive material, and a mediator as a single layer onto the substrate.

    摘要翻译： 检测液体混合物中的化合物的当前代表的传感器系统具有适于可释放地附接到信号读出电路的双电极条。 条带包括适于可释放地附接到读出电路的细长支撑件（优选是平坦的）; 第一导体和第二导体各自沿着支撑件延伸并且包括用于连接到电路的装置。 定位成接触液体混合物和第一导体的活性电极包括能够催化涉及化合物，导电材料和电子介体的反应的酶的单层沉积物，其能够在酶催化的 反应和第一个导体。 定位参考电极以接触混合物和第二导体。 该系统包括适于提供代表电流的电信号的电路。 双电极条例如通过丝网印刷，酶导电材料的混合物和作为单层的介体制成在基底上。