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    Heterogeneous membrane electrodes
    1.
    发明授权
    Heterogeneous membrane electrodes 有权
    异质膜电极

    公开(公告)号：US07767068B2

    公开(公告)日：2010-08-03

    申请号：US10856929

    申请日：2004-06-01

    申请人： Imants Lauks ,  Anca Varlan ,  Alexandra Oussova ,  Michael Bales

    发明人： Imants Lauks ,  Anca Varlan ,  Alexandra Oussova ,  Michael Bales

    IPC分类号： G01N27/26

    CPC分类号： G01N27/307 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/0683

    摘要： The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and inexpensive construction, preferably with only a single membrane coating on an electrode. The invented devices are potentiometric salt-bridge reference electrodes and dissolved gas sensors constructed with a heterogeneous membrane coating of a conductor. The heterogeneous membrane, which is an intimate admixture of a hydrophobic and a hydrophilic compartment, concurrently supports constrained transport of non-volatile species through its hydrophilic compartment and rapid gas and water vapor transport through its hydrophobic compartment.

    摘要翻译： 本发明涉及具有用于进行化学分析的膜涂层的平面电化学传感器。 本发明的目的是提供非常简单和便宜的结构的单元使用一次性传感器，优选地在电极上仅具有单个膜涂层。 本发明的器件是电位计的盐桥参考电极和由导体的非均相膜涂层构成的溶解气体传感器。 疏水隔离层和亲水隔室的紧密混合物的非均相膜同时支持非挥发性物质通过其亲水隔室的受限运输，并通过其疏水隔室快速的气体和水蒸汽输送。

    Lateral flow diagnostic devices with instrument controlled fluidics
    5.
    发明授权
    Lateral flow diagnostic devices with instrument controlled fluidics 有权
    具有仪器控制流体学的侧流诊断装置

    公开(公告)号：US07722817B2

    公开(公告)日：2010-05-25

    申请号：US10649683

    申请日：2003-08-28

    申请人： Imants Lauks ,  Raymond J. Pierce ,  James Wojtyk ,  Benoit R. Bergevin

    发明人： Imants Lauks ,  Raymond J. Pierce ,  James Wojtyk ,  Benoit R. Bergevin

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0418 ,  F04B19/006 ,  Y10T436/2575

    摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.

    摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。

    Lateral flow diagnostic devices with instrument controlled fluidics
    6.
    发明申请
    Lateral flow diagnostic devices with instrument controlled fluidics 有权
    具有仪器控制流体学的侧流诊断装置

    公开(公告)号：US20050047972A1

    公开(公告)日：2005-03-03

    申请号：US10649683

    申请日：2003-08-28

    申请人： Imants Lauks ,  Raymond Pierce ,  James Wojtyk ,  Benoit Bergevin

    发明人： Imants Lauks ,  Raymond Pierce ,  James Wojtyk ,  Benoit Bergevin

    IPC分类号： B01L3/00 ,  F04B19/00 ,  G01N1/28

    CPC分类号： B01L3/50273 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0418 ,  F04B19/006 ,  Y10T436/2575

    摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.

    摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。

    Lateral flow diagnostic devices with instrument controlled fluidics
    7.
    发明授权
    Lateral flow diagnostic devices with instrument controlled fluidics 有权
    具有仪器控制流体学的侧流诊断装置

    公开(公告)号：US08124026B2

    公开(公告)日：2012-02-28

    申请号：US12718139

    申请日：2010-03-05

    申请人： Imants Lauks ,  Raymond J. Pierce ,  James Wojtyk ,  Benoit R. Bergevin

    发明人： Imants Lauks ,  Raymond J. Pierce ,  James Wojtyk ,  Benoit R. Bergevin

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50273 ,  B01L2200/0673 ,  B01L2200/10 ,  B01L2300/0816 ,  B01L2400/0406 ,  B01L2400/0418 ,  F04B19/006 ,  Y10T436/2575

    摘要： Devices with lateral flow elements and integral fluidics are disclosed. The integral fluidics consist of injector pumps comprised of fluidic elements under instrument control. The fluidic element of an injector pump is fluidically connected to lateral flow elements and can be used to control fluid entry into containment chambers referred to as micro-reactors. The lateral flow elements comprise conductor elements that can be used for sample application and transport of analyte contained in the sample to the micro-reactor. Fluidic transport through the fluidic element of the injector pump is under instrument-control. Both the lateral flow element and the fluidic element may contain chemical entities incorporated along their length. The chemical reactions that can be used for analyte detection using the devices are described. Also described are methods of manufacture of these devices.

    摘要翻译： 公开了具有侧向流动元件和整体流体的装置。 积分流体由在仪器控制下由流体元素组成的喷射泵组成。 注射器泵的流体元件流体连接到侧向流动元件，并且可以用于控制流体进入称为微反应器的容纳室中。 横向流动元件包括导体元件，其可以用于将样品中包含的分析物的样品应用和运送到微反应器。 通过注射泵的流体元件的流体传输是在仪器控制下。 侧流元件和流体元件都可以包含沿其长度并入的化学物质。 描述了可用于使用装置进行分析物检测的化学反应。 还描述了这些装置的制造方法。

    HETEROGENEOUS MEMBRANE ELECTRODES
    8.
    发明申请
    HETEROGENEOUS MEMBRANE ELECTRODES 有权
    异质膜电极

    公开(公告)号：US20060137980A1

    公开(公告)日：2006-06-29

    申请号：US10307481

    申请日：2002-12-02

    申请人： Imants Lauks ,  Andrzej Maczuszenko

    发明人： Imants Lauks ,  Andrzej Maczuszenko

    IPC分类号： G01N27/26

    CPC分类号： B01L3/502715 ,  B01L3/5027 ,  B01L2200/025 ,  B01L2200/148 ,  B01L2300/0645 ,  B01L2300/0825 ,  B01L2300/0883 ,  B01L2300/0887 ,  B01L2400/0487 ,  B01L2400/0683 ,  G01N27/301

    摘要： The present invention relates to planar electrochemical sensors with membrane coatings used to perform chemical analyses. The object of this invention is to provide unit-use disposable sensors of very simple and economical construction, preferably with only a single membrane coating on an electrode. The invented devices are potentiometric salt-bridge reference electrodes constructed with a heterogeneous membrane coating of a conductor. The heterogeneous membrane is a formulation that concurrently supports non-volatile species transport through an electrolyte compartment and gas transport through a hydrophobic compartment.

    摘要翻译： 本发明涉及具有用于进行化学分析的膜涂层的平面电化学传感器。 本发明的目的是提供非常简单和经济的结构的单元使用一次性传感器，优选地在电极上仅具有单个膜涂层。 本发明的器件是由导体的非均相膜涂层构成的电位盐基参比电极。 非均相膜是同时支持非挥发性物质通过电解质隔室传输并通过疏水隔室输送气体的制剂。

    Apparatus and methods for analyte measurement and immunoassay
    9.
    发明授权
    Apparatus and methods for analyte measurement and immunoassay 有权
    用于分析物测量和免疫测定的装置和方法

    公开(公告)号：US08679827B2

    公开(公告)日：2014-03-25

    申请号：US13495224

    申请日：2012-06-13

    申请人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

    发明人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

    IPC分类号： C12M3/00

    CPC分类号： G01N33/543 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N35/08 ,  G01N2035/0436

    摘要： The present invention relates to methods for measuring an amount of an analyte using an electrochemical assay in a conduit comprising a sensor, wherein said sensor comprises an electrode having a surface layer of immobilized antibody that binds said analyte, and a counter/reference electrode disposed within said conduit. A solution comprising a substrate for said enzyme and at least one air segment contacts the sensor to remove unbound analyte and labeled antibody from a region of the sensor. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

    摘要翻译： 本发明涉及用于在包括传感器的导管中使用电化学测定来测量分析物的量的方法，其中所述传感器包括具有结合所述分析物的固定化抗体表面层的电极，以及设置在 说导管。 包含用于所述酶的底物和至少一个空气区段的溶液与传感器接触以从传感器的区域去除未结合的分析物和标记的抗体。 所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。

    Apparatus and methods for analyte measurement and immunoassay
    10.
    发明授权
    Apparatus and methods for analyte measurement and immunoassay 有权
    用于分析物测量和免疫测定的装置和方法

    公开(公告)号：US08222024B2

    公开(公告)日：2012-07-17

    申请号：US13198253

    申请日：2011-08-04

    申请人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

    发明人： Graham Davis ,  Imants Lauks ,  Chao Lin ,  Cary James Miller

    IPC分类号： C12M3/00

    CPC分类号： G01N33/543 ,  B01L3/502723 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2200/10 ,  B01L2300/0663 ,  B01L2300/0816 ,  B01L2300/087 ,  B01L2400/0421 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0683 ,  G01N33/54366 ,  G01N35/08 ,  G01N2035/0436

    摘要： The present invention relates to an apparatus for conducting a variety of assays for the determination of analytes in liquid samples, and relates to the methods for such assays. In particular, the invention relates to a single-use cartridge designed to be adaptable to a variety of real-time assay protocols, preferably assays for the determination of analytes in biological samples using immunosensors or other ligand/ligand receptor-based biosensor embodiments. The cartridge provides novel features for processing a metered portion of a sample, for precise and flexible control of the movement of a sample or second fluid within the cartridge, for the amending of solutions with additional compounds during an assay, and for the construction of immunosensors capable of adaptation to diverse analyte measurements. The disclosed device and methods of use enjoy substantial benefits over the prior art, including simplicity of use by an operator, rapid in situ determinations of one or more analytes, and single-use methodology that minimizes the risk of contamination of both operator and patient. The disclosed invention is adaptable to the point-of-care clinical diagnostic field, including use in accident sites, emergency rooms, surgery, nursing homes, intensive care units, and non-medical environments.

    摘要翻译： 本发明涉及一种用于进行各种测定液体样品中分析物测定的装置，并涉及这种测定方法。 特别地，本发明涉及一种设计成能够适用于各种实时测定方案的单次使用的盒，优选使用免疫传感器或其他基于配体/配体受体的生物传感器实施方案来测定生物样品中分析物的测定。 该盒提供用于处理样品的计量部分的新颖特征，用于精确和灵活地控制盒内样品或第二流体的运动，用于在测定过程中用附加化合物修饰溶液以及用于构建免疫传感器 能够适应不同的分析物测量。 所公开的装置和使用方法相对于现有技术具有实质性的益处，包括操作者的简单使用，一种或多种分析物的快速原位测定，以及使操作者和患者的污染风险最小化的一次性方法。 所公开的发明适用于临床诊断领域，包括在事故现场，急诊室，手术室，疗养院，重症监护室和非医疗环境中的使用。