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    METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH LIGHT
    1.
    发明申请
    METHODS AND DEVICES FOR ACTIVATING BROWN ADIPOSE TISSUE WITH LIGHT 审中-公开
    用于用光激活褐色扁桃体组织的方法和装置

    公开(公告)号：US20140088487A1

    公开(公告)日：2014-03-27

    申请号：US13977536

    申请日：2011-12-21

    申请人： Jason L. Harris ,  Lee M. Kaplan ,  David N. Plescia ,  Taylor W. Aronhalt ,  James W. Voegele ,  Nicholas Stylopoulos

    发明人： Jason L. Harris ,  Lee M. Kaplan ,  David N. Plescia ,  Taylor W. Aronhalt ,  James W. Voegele ,  Nicholas Stylopoulos

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0613 ,  A61M5/14276 ,  A61M2230/06 ,  A61M2230/201 ,  A61N5/062

    摘要： Methods and devices are provided for activating brown adipose tissue (BAT) with light. Generally, the methods and devices can activate BAT to increase thermogenesis, e.g., increase heat production in the patient, which over time can lead to weight loss and/or improved metabolic function. In one embodiment, a medical device is provided that activates BAT by using light to stimulate nerves that activate the BAT and/or to stimulate brown adipocytes directly, thereby increasing thermogenesis in the BAT and inducing weight loss and/or improved metabolic function through energy expenditure. The light can be configured to directly or indirectly stimulate the nerves and/or the brown adipocytes. The light can be configured to indirectly stimulate the nerves and/or the brown adipocytes by activating a light activatable medium administered to a patient and configured to respond to the light to cause activation of the brown adipose tissue.

    摘要翻译： 提供了用于用光激活棕色脂肪组织（BAT）的方法和装置。 通常，方法和装置可以激活BAT以增加产热，例如增加患者的热产生，其随着时间推移可导致体重减轻和/或改善的代谢功能。 在一个实施方案中，提供了一种医疗装置，其通过使用光来刺激BAT来激发BAT，和/或直接刺激棕色脂肪细胞，从而增加BAT中的产热，并通过能量消耗引起体重减轻和/或改善的代谢功能来激活BAT 。 光可以配置成直接或间接刺激神经和/或棕色脂肪细胞。 光可以被配置为通过激活施用于患者的光可激活介质并配置为响应于光以引起棕色脂肪组织的激活来间接刺激神经和/或棕色脂肪细胞。

    Brown adipocyte modification
    8.
    发明授权
    Brown adipocyte modification 有权
    棕色脂肪细胞修饰

    公开(公告)号：US09381219B2

    公开(公告)日：2016-07-05

    申请号：US13977543

    申请日：2011-12-21

    申请人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

    发明人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

    IPC分类号： A61K35/12 ,  C12N15/85 ,  A61K35/35 ,  A61K48/00 ,  C07K14/47

    CPC分类号： A61K35/35 ,  A61K38/177 ,  A61K48/005 ,  C07K14/47 ,  C07K14/705 ,  C12N5/0653 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2506/1392 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2830/002

    摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.

    摘要翻译： 提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。 通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。 在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色 脂肪细胞 这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。

    BROWN ADIPOCYTE MODIFICATION
    9.
    发明申请
    BROWN ADIPOCYTE MODIFICATION 有权
    棕色ADIPOCYTE修改

    公开(公告)号：US20140199278A1

    公开(公告)日：2014-07-17

    申请号：US13977543

    申请日：2011-12-21

    申请人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

    发明人： Lee M. Kaplan ,  Nicholas Stylopoulos ,  Jason L. Harris ,  Dwight Henninger ,  Taylor W. Aronhalt ,  James W. Voegele

    IPC分类号： A61K35/12 ,  C12N15/85

    CPC分类号： A61K35/35 ,  A61K38/177 ,  A61K48/005 ,  C07K14/47 ,  C07K14/705 ,  C12N5/0653 ,  C12N7/00 ,  C12N15/85 ,  C12N15/86 ,  C12N2506/1392 ,  C12N2750/14143 ,  C12N2799/025 ,  C12N2830/002

    摘要： Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.

    摘要翻译： 提供了通过增加棕色脂肪组织活化来治疗代谢紊乱的方法和治疗。 通常，方法和治疗可以增加棕色脂肪组织的活化以增加能量消耗并引起体重减轻。 在一个实施方案中，增加棕色脂肪组织活化的方法包括修饰棕色脂肪细胞以表达激活棕色脂肪细胞的基因，例如解偶联蛋白1.在另一个实施方案中，增加棕色脂肪组织活化的方法包括增加褐色 脂肪细胞 这可以通过在体内诱导脂肪细胞的增殖或离体扩展脂肪细胞，将脂肪细胞移植到棕色脂肪组织贮库或其他地方并诱导脂肪细胞祖细胞如MSC，脂肪细胞祖细胞，前脂肪细胞和脂肪细胞前体细胞的分化来实现。