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公开(公告)号：US09562888B2
公开(公告)日：2017-02-07
申请号：US13637861
申请日：2011-03-31
IPC分类号： G01N33/497 , G01N29/02
CPC分类号： G01N33/497 , G01N29/022
摘要： A composite, analyte sensor includes a substrate; a micro- or nano-electro-mechanical (MEMS; NEMS) resonator that is coupled to the substrate at least two edge locations (i.e., it is at least doubly-clamped) of the resonator, wherein the resonator is in a statically-buckled state near a buckling transition point of the resonator; and a chemically-responsive substance covering at least a portion of the surface of the resonator that will undergo a conformational change upon exposure to a given analyte. The resonator may be a double-clamped, statically-buckled beam (or bridge), a multiply-clamped, statically-buckled dome (or crater), or other resonator geometry. The sensor may include two or more at least double-clamped, statically-buckled, composite MEMS or NEMS resonators each operating near a buckling transition point of the respective resonator, and each characterized by a different resonant frequency. A method for sensing an analyte in ambient air.
摘要翻译： 复合分析物传感器包括基底; 谐振器的至少两个边缘位置（即，它至少被双钳位）耦合到衬底的微机械或纳米机电（MEMS; NEMS）谐振器，其中所述谐振器处于静态弯曲 在谐振器的屈曲转变点附近; 以及覆盖谐振器表面的至少一部分的化学响应物质，其在暴露于给定的分析物时将经历构象变化。 谐振器可以是双夹紧，静态弯曲梁（或桥），多夹紧，静态弯曲的圆顶（或火山口）或其他谐振器几何形状。 传感器可以包括两个或更多个至少双夹紧，静态弯曲的复合MEMS或NEMS谐振器，每个谐振器在相应谐振器的屈曲转变点附近操作，并且每个谐振器的特征在于不同的谐振频率。 用于感测环境空气中的分析物的方法。
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公开(公告)号：US20130118228A1
公开(公告)日：2013-05-16
申请号：US13637861
申请日：2011-03-31
IPC分类号： G01N33/497
CPC分类号： G01N33/497 , G01N29/022
摘要： A composite, analyte sensor includes a substrate; a micro- or nano-electro-mechanical (MEMS; NEMS) resonator that is coupled to the substrate at least two edge locations (i.e., it is at least doubly-clamped) of the resonator, wherein the resonator is in a statically-buckled state near a buckling transition point of the resonator; and a chemically-responsive substance covering at least a portion of the surface of the resonator that will undergo a conformational change upon exposure to a given analyte. The resonator may be a double-clamped, statically-buckled beam (or bridge), a multiply-clamped, statically-buckled dome (or crater), or other resonator geometry. The sensor may include two or more at least double-clamped, statically-buckled, composite MEMS or NEMS resonators each operating near a buckling transition point of the respective resonator, and each characterized by a different resonant frequency. A method for sensing an analyte in ambient air.
摘要翻译： 复合分析物传感器包括基底; 谐振器的至少两个边缘位置（即，它至少被双钳位）耦合到衬底的微机械或纳米机电（MEMS; NEMS）谐振器，其中所述谐振器处于静态弯曲 在谐振器的屈曲转变点附近; 以及覆盖谐振器表面的至少一部分的化学响应物质，其在暴露于给定的分析物时将经历构象变化。 谐振器可以是双夹紧，静态弯曲梁（或桥），多夹紧，静态弯曲的圆顶（或火山口）或其他谐振器几何形状。 传感器可以包括两个或更多个至少双夹紧，静态弯曲的复合MEMS或NEMS谐振器，每个谐振器在相应谐振器的屈曲转变点附近操作，并且每个谐振器的特征在于不同的谐振频率。 用于感测环境空气中的分析物的方法。
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公开(公告)号：US20100331196A1
公开(公告)日：2010-12-30
申请号：US12819766
申请日：2010-06-21
CPC分类号： C12Q1/6874 , B01J2219/00511 , B01J2219/00524 , B01J2219/00576 , B01J2219/00596 , B01J2219/00657 , B01J2219/00666 , B01J2219/00702 , B01J2219/00722 , C07H1/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/14 , D01D5/0007 , G01N2021/6432 , G01N2021/7723 , G01N2021/773 , G01N2021/7786 , H01J47/00 , Y10T428/298
摘要： The present invention relates to compositions, methods, and uses for obtaining sequence information from nucleic acid molecules.
摘要翻译： 本发明涉及从核酸分子获得序列信息的组合物，方法和用途。
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公开(公告)号：US20090136932A1
公开(公告)日：2009-05-28
申请号：US12049149
申请日：2008-03-14
IPC分类号： C12Q1/68 , C07H21/00 , C07H21/02 , C07H21/04 , C07K2/00 , C07C53/00 , B32B5/02 , C40B40/04 , B01J19/00 , G01N21/00 , B29C47/00 , C07H1/00 , C07K1/00
CPC分类号： C12Q1/6874 , B01J2219/00511 , B01J2219/00524 , B01J2219/00576 , B01J2219/00596 , B01J2219/00657 , B01J2219/00666 , B01J2219/00702 , B01J2219/00722 , C07H1/00 , C07H21/00 , C07H21/02 , C07H21/04 , C07K1/14 , D01D5/0007 , G01N2021/6432 , G01N2021/7723 , G01N2021/773 , G01N2021/7786 , H01J47/00 , Y10T428/298
摘要： The present invention relates to compositions, methods, and uses for isolated biomolecule-containing fibers. The invention also relates to isolated, elongated biopolymers such as nucleic acids, polypeptides, lipids, and carbohydrates within fibers. The invention relates to methods of detecting and analyzing biomolecules in fibers using light, electrons, and neutrons. The invention further relates to methods of determining the sequence, structure, and properties of isolated, elongated biopolymers fixed within fibers.
摘要翻译： 本发明涉及用于分离的含有生物分子的纤维的组合物，方法和用途。 本发明还涉及分离的细长生物聚合物，例如纤维内的核酸，多肽，脂质和碳水化合物。 本发明涉及使用光，电子和中子检测和分析纤维中生物分子的方法。 本发明还涉及确定固定在纤维内的分离的细长生物聚合物的顺序，结构和性质的方法。
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公开(公告)号：US08486348B2
公开(公告)日：2013-07-16
申请号：US12914675
申请日：2010-10-28
CPC分类号： B81C1/00071 , B01L3/502707 , B01L3/502761 , B01L2300/0816 , B81B2201/0214 , B81B2201/051 , B81B2203/0338 , B81C2201/034
摘要： A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.
摘要翻译： 通过在基底模具上形成牺牲纤维来制造器件。 纤维和模具被第一材料覆盖。 去除基底模具，然后除去覆盖的纤维以在第一材料中形成通道。
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公开(公告)号：US20120107194A1
公开(公告)日：2012-05-03
申请号：US12914675
申请日：2010-10-28
CPC分类号： B81C1/00071 , B01L3/502707 , B01L3/502761 , B01L2300/0816 , B81B2201/0214 , B81B2201/051 , B81B2203/0338 , B81C2201/034
摘要： A device is made by forming sacrificial fibers on a substrate mold. The fibers and mold are covered with a first material. The substrate mold is removed, and the covered fibers are then removed to form channels in the first material.
摘要翻译： 通过在基底模具上形成牺牲纤维来制造器件。 纤维和模具被第一材料覆盖。 去除基底模具，然后除去覆盖的纤维以在第一材料中形成通道。
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7.发明授权公开(公告)号：US09458357B2
公开(公告)日：2016-10-04
申请号：US13410600
申请日：2012-03-02
IPC分类号： C09F1/04 , C09D193/02 , A61L27/14 , A61L27/56 , C09D189/06
CPC分类号： C09F1/04 , A61L27/14 , A61L27/56 , A61L2400/08 , C09D189/06 , C09D193/02
摘要： Methods for microfabricating composite materials and composite materials prepared there from are described herein. The sacrificial material can be etched or patterned to create a two-dimensional and/or three-dimensional sacrificial material structure. The resulting sacrificial material structure can be embedded in one or more embedding materials. The sacrificial material(s) are materials whose solubility can be altered by application of a stimulus typically pH, and/or temperature, light, pH, pressure, presence of absence of ions, and combinations thereof. The embedding materials can contain one or more additives that modify one or more properties of the embedding materials, such as degradation properties, porosity, mechanical properties, viscosity, conductive properties, and combinations thereof. The composite materials can be used in tissue engineering, drug screening, toxin detection, drug delivery, filtrations, bioseparations, and as microfluidic devices for fluid mixing and structural repair.
摘要翻译： 本文描述了在此制备的复合材料和复合材料的微加工方法。 牺牲材料可以被蚀刻或图案化以产生二维和/或三维牺牲材料结构。 所得到的牺牲材料结构可嵌入一种或多种嵌入材料中。 牺牲材料是其溶解度可以通过施加通常为pH，和/或温度，光，pH，压力，不存在离子的组合和其组合而改变的材料。 嵌入材料可以包含一种或多种改性嵌入材料的一种或多种性质的添加剂，例如降解性能，孔隙率，机械性能，粘度，导电性能及其组合。 复合材料可用于组织工程，药物筛选，毒素检测，药物递送，过滤，生物分离和用作流体混合和结构修复的微流体装置。
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公开(公告)号：US09242027B2
公开(公告)日：2016-01-26
申请号：US13054450
申请日：2009-07-16
IPC分类号： A61F2/02 , B29C69/02 , B29C47/06 , A61M31/00 , A61L27/38 , A61L27/54 , A61L27/56 , A61L27/58
CPC分类号： A61L27/3808 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/602
摘要： The first aspect of the present invention is directed to a method of producing a vascular network preform (VNP). This method involves forming a network of elongate fibers and at least one elongate structure from a sacrificial material. The diameter of the elongate structure is greater than that of the elongate fibers. The network of elongate fibers is placed in contact with at least one elongate structure either following or during forming the network of elongate fibers or forming the at least one elongate structure. A matrix is applied around the network of elongate fibers, in contact with the at least one elongate structure. The network of elongate fibers and elongate structure, within the matrix is sacrificed to form a preform. The resulting preform contains a vascular network of fine diameter tubes in contact with at least one elongate passage having a diameter greater than that of the fine diameter tubes. The resulting solid preform and methods of using it are also disclosed.
摘要翻译： 本发明的第一方面涉及一种生产血管网预制件（VNP）的方法。 该方法包括从牺牲材料形成细长纤维网络和至少一个细长结构。 细长结构的直径大于细长纤维的直径。 细长纤维的网络放置成在形成细长纤维的网络或形成至少一个细长结构之间或之后的至少一个细长结构接触。 矩阵围绕细长纤维的网络施加，与至少一个细长结构接触。 处于基体内的细长纤维和细长结构的网络以形成预制件。 所得到的预制件包含与直径大于细直径管的直径的至少一个细长通道接触的细直径管的血管网络。 还公开了所得到的固体预制件及其使用方法。
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公开(公告)号：US20130066045A1
公开(公告)日：2013-03-14
申请号：US13410600
申请日：2012-03-02
IPC分类号： C09F1/04
CPC分类号： C09F1/04 , A61L27/14 , A61L27/56 , A61L2400/08 , C09D189/06 , C09D193/02
摘要： Methods for microfabricating composite materials and composite materials prepared there from are described herein. The sacrificial material can be etched or patterned to create a two-dimensional and/or three-dimensional sacrificial material structure. The resulting sacrificial material structure can be embedded in one or more embedding materials. The sacrificial material(s) are materials whose solubility can be altered by application of a stimulus typically pH, and/or temperature, light, pH, pressure, presence of absence of ions, and combinations thereof. The embedding materials can contain one or more additives that modify one or more properties of the embedding materials, such as degradation properties, porosity, mechanical properties, viscosity, conductive properties, and combinations thereof. The composite materials can be used in tissue engineering, drug screening, toxin detection, drug delivery, filtrations, bioseparations, and as microfluidic devices for fluid mixing and structural repair.
摘要翻译： 本文描述了在此制备的复合材料和复合材料的微加工方法。 牺牲材料可以被蚀刻或图案化以产生二维和/或三维牺牲材料结构。 所得到的牺牲材料结构可嵌入一种或多种嵌入材料中。 牺牲材料是其溶解度可以通过施加通常为pH，和/或温度，光，pH，压力，不存在离子的组合和其组合而改变的材料。 嵌入材料可以包含一种或多种改性嵌入材料的一种或多种性质的添加剂，例如降解性能，孔隙率，机械性能，粘度，导电性能及其组合。 复合材料可用于组织工程，药物筛选，毒素检测，药物递送，过滤，生物分离和用作流体混合和结构修复的微流体装置。
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公开(公告)号：US20110270412A1
公开(公告)日：2011-11-03
申请号：US13054450
申请日：2009-07-16
CPC分类号： A61L27/3808 , A61L27/54 , A61L27/56 , A61L27/58 , A61L2300/412 , A61L2300/414 , A61L2300/426 , A61L2300/602
摘要： The first aspect of the present invention is directed to a method of producing a vascular network preform (VNP). This method involves forming a network of elongate fibers and at least one elongate structure from a sacrificial material. The diameter of the elongate structure is greater than that of the elongate fibers. The network of elongate fibers is placed in contact with at least one elongate structure either following or during forming the network of elongate fibers or forming the at least one elongate structure. A matrix is applied around the network of elongate fibers, in contact with the at least one elongate structure. The network of elongate fibers and elongate structure, within the matrix is sacrificed to form a preform. The resulting preform contains a vascular network of fine diameter tubes in contact with at least one elongate passage having a diameter greater than that of the fine diameter tubes. The resulting solid preform and methods of using it are also disclosed.
摘要翻译： 本发明的第一方面涉及一种生产血管网预制件（VNP）的方法。 该方法包括从牺牲材料形成细长纤维网络和至少一个细长结构。 细长结构的直径大于细长纤维的直径。 细长纤维的网络放置成在形成细长纤维的网络或形成至少一个细长结构之间或之后的至少一个细长结构接触。 矩阵围绕细长纤维的网络施加，与至少一个细长结构接触。 处于基体内的细长纤维和细长结构的网络以形成预制件。 所得到的预制件包含与直径大于细直径管的直径的至少一个细长通道接触的细直径管的血管网络。 还公开了所得到的固体预制件及其使用方法。
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