摘要:
Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.
摘要:
The present invention is directed to a compound of formula I, and pharmaceutically acceptable salts, solvates, hydrates or stereoisomer thereof, which are useful in treating Syndrome X, Type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to Syndrome X as well as cardiovascular diseases.
摘要:
The present invention is directed to a compound of Formula (I): and pharmaceutically acceptable salts, solvates, hydrates or stereoisomers thereof, which are useful in treating or preventing disorders mediated by a peroxisome proliferator activated receptor (PPAR) such as syndrome X, type II diabetes, hyperglycemia, hyperlipidemia, obesity, coagaulopathy, hypertension, arteriosclerosis, and other disorders related to syndrome X and cardiovascular diseases.
摘要:
An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.
摘要:
An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.
摘要:
A vehicle information system operating method performs operations comprising determining an operational period, determining a movement period, determining a modification factor, determining a fuel economy value and determining an adjusted fuel economy value. The determining of the operational period determines the operational period during which a vehicle is running. The determining of the movement period determines the movement period during which the vehicle is in motion. The determining of the modification factor determines the modification factor based on respective durations of the operational period and the movement period. The determining of the fuel economy value determines the fuel economy value associated with the operational period. The determining of the adjusted fuel economy value determines the adjusted fuel economy value based on the fuel economy value and the modification factor.
摘要:
The present invention provides compounds and pharmaceutical compositions that act as antagonists at metabotropic glutamate receptors, and that are useful for treating neurological diseases and disorders. Methods of preparing the compounds also are disclosed.
摘要:
An ergonomic support device is provided for accommodating the weight of a user and allowing the user to perform various tasks with reduced effort. The support device is adapted for use in connection with various settings, such as bathtubs, and allows the user to work in or around a space while in a supported position.
摘要:
A vehicle information system operating method performs operations comprising determining an operational period, determining a movement period, determining a modification factor, determining a fuel economy value and determining an adjusted fuel economy value. The determining of the operational period determines the operational period during which a vehicle is running. The determining of the movement period determines the movement period during which the vehicle is in motion. The determining of the modification factor determines the modification factor based on respective durations of the operational period and the movement period. The determining of the fuel economy value determines the fuel economy value associated with the operational period. The determining of the adjusted fuel economy value determines the adjusted fuel economy value based on the fuel economy value and the modification factor.
摘要:
A vehicle occupant information controller includes a fuel volume determining section, a fuel economy determining section, a first distance determining section, a traveled distance determining section and a second distance determining section. The first distance determining section determines a first obtainable travel distance based on a remaining fuel volume from the fuel volume determining section and a fuel consumption rate from the fuel economy determining section. The traveled distance determining section determines a vehicle traveled distance between two locations. The second distance determining section determines a second obtainable travel distance based on a difference between a previous obtainable travel distance value and an adjusted vehicle traveled distance value, with the adjusted vehicle traveled distance value being equal to a product of the vehicle traveled distance and a distance adjustment factor that is selectively adjusted based on a ratio of the second obtainable travel distance to the first obtainable travel distance.