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公开(公告)号：US20060121602A1
公开(公告)日：2006-06-08
申请号：US11265110
申请日：2005-11-03
申请人： Jon Hoshizaki , Howard King , Johannes Sluis , Steven Boege , Mark Oldham
发明人： Jon Hoshizaki , Howard King , Johannes Sluis , Steven Boege , Mark Oldham
CPC分类号： G01N21/645 , F21V29/54 , F21V29/677 , F21V29/763 , G01N21/6452 , G01N2021/6439 , G01N2201/062 , G01N2201/1211 , G05D23/1919 , G05D23/20
摘要： Methods and optical systems for scanning of a target sample, including methods and systems using a low mass scan head. The present invention also relates to methods and systems for performing sample assays, and for producing and measuring optical responses and signatures.
摘要翻译： 用于扫描目标样品的方法和光学系统，包括使用低质量扫描头的方法和系统。 本发明还涉及用于进行样品测定以及用于产生和测量光学响应和特征的方法和系统。
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公开(公告)号：US20050151972A1
公开(公告)日：2005-07-14
申请号：US10758667
申请日：2004-01-14
申请人： Steven Boege , Jon Hoshizaki , Mark Oldham , Liana Ilkova
发明人： Steven Boege , Jon Hoshizaki , Mark Oldham , Liana Ilkova
CPC分类号： G01N21/6452 , G01N21/253 , G01N2021/6439 , G01N2021/6471 , G01N2021/6476 , G01N2021/6478 , G01N2201/0245
摘要： A fluorometry device and method adapted to determine concentration of spectrally distinguishable species in a biological sample with a plurality of movable optical devices.
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公开(公告)号：US06419827B1
公开(公告)日：2002-07-16
申请号：US09552301
申请日：2000-04-18
IPC分类号： B01D6300
CPC分类号： B01L3/50255 , B01D61/18 , B01L3/5025 , B01L2400/049 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102
摘要： The invention includes a filtration apparatus for processing a plurality of fluid samples into sample wells is provided. In one embodiment, the filtration apparatus includes a purification tray and a sample well tray with a plurality of sample wells. The purification tray includes a filter plate having a plurality of columns with discharge openings at the bottom thereof, at least one filter positioned in the columns of the filter plate for filtering the fluid samples as they pass therethrough, a heat plate positioned adjacent the columns of the filter plate, and a vent plate positioned below the heat plate. The heat plate is configured for transferring heat to the columns of the filter plate. The vent plate includes vents for permitting aerosols from the sample wells of the sample well tray to escape. A sample well tray with a plurality of the sample wells is positioned so that the sample wells align with the discharge openings of the filter plate columns to receive the liquid sample therein.
摘要翻译： 本发明提供了一种用于将多个流体样品加工成样品孔的过滤装置。 在一个实施例中，过滤装置包括净化盘和具有多个样品孔的样品井托盘。 净化盘包括一个过滤板，该过滤板具有多个在其底部具有排放口的柱，至少一个过滤器，定位在过滤板的列中，用于在流体样品通过过滤器时对其进行过滤， 过滤板和位于加热板下方的通风板。 加热板被配置为将热量传递到过滤板的列。 通风板包括用于允许来自样品井托盘的样品井的气溶胶逸出的通风口。 定位具有多个样品孔的样品孔盘，使得样品孔与过滤板柱的排出口对准以在其中接收液体样品。
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公开(公告)号：US20050194371A1
公开(公告)日：2005-09-08
申请号：US11120797
申请日：2005-05-03
申请人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.
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公开(公告)号：US07452510B2
公开(公告)日：2008-11-18
申请号：US11338254
申请日：2006-01-24
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A multi-well microfiltration apparatus and method are provided and feature a manual touch-off system for transferring pendent drops hanging from discharge-conduits of a discharge-conduit array to respective receiving wells or receiving holes of a corresponding receiving array, with minimum or no cross-contamination between the discharge conduits, or the receiving wells or receiving holes. The manual touch-off is achieved by manually shifting a carriage that supports one of the arrays, into a position whereat pendent drops of fluid hanging from the distal ends of the discharge conduits contact the inner sidewalls of the corresponding receiving wells or receiving holes of the receiving array.
摘要翻译： 提供了一种多孔微滤装置和方法，其特征在于一种手动触发系统，用于将从排放管阵列的排放管道悬挂的悬挂液滴转移到相应接收孔的相应接收孔或接收孔的最小或不 排放管道或接收井或接收孔之间的交叉污染。 手动触发是通过将支撑其中一个阵列的托架手动地移动到从排出管道的远端悬挂的悬挂液滴与相应的接收井的内侧壁接触的位置或接收孔的接收孔 接收阵列。
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公开(公告)号：US06906292B2
公开(公告)日：2005-06-14
申请号：US10359665
申请日：2003-02-06
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： B01L99/00 , B01D61/18 , B01L3/00 , B01L7/00 , G01N35/00 , G01N35/02 , G01N35/10 , C12M1/38 , H05B3/22
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.
摘要翻译： 描述了一种加热器模块，其包括配热板，该散热板包括具有第一和第二侧面的底部以及远离其中一个侧面延伸的多个突起。 提供了用于加热分布板的热源，并且可选地，加热盘可以用于接收热源和散热板。 加热器模块适于接合具有多个净化和/或排出柱的样品净化盘，其可以延伸穿过加热器模块中的开口并将样品引导到样品接收托盘中。 还描述了使用加热器模块加热样品的方法。
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公开(公告)号：US20060191893A1
公开(公告)日：2006-08-31
申请号：US11338254
申请日：2006-01-24
申请人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd Weinfield , Gary Lim , Donald Sandell , Kevin Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
IPC分类号： F27D11/00
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A multi-well microfiltration apparatus and method are provided and feature a manual touch-off system for transferring pendent drops hanging from discharge-conduits of a discharge-conduit array to respective receiving wells or receiving holes of a corresponding receiving array, with minimum or no cross-contamination between the discharge conduits, or the receiving wells or receiving holes. The manual touch-off is achieved by manually shifting a carriage that supports one of the arrays, into a position whereat pendent drops of fluid hanging from the distal ends of the discharge conduits contact the inner sidewalls of the corresponding receiving wells or receiving holes of the receiving array.
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公开(公告)号：US07019267B2
公开(公告)日：2006-03-28
申请号：US11120797
申请日：2005-05-03
申请人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
发明人： Todd A. Weinfield , Gary Lim , Donald R. Sandell , Kevin S. Bodner , Mark Borodkin , Mark Oldham , Jon Hoshizaki
CPC分类号： B01L3/50255 , B01D61/18 , B01J2219/00288 , B01J2219/00313 , B01J2219/00319 , B01J2219/00335 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01L7/52 , B01L2200/025 , B01L2200/0631 , B01L2200/0689 , B01L2200/141 , B01L2300/0829 , B01L2300/1805 , B01L2400/049 , G01N1/4077 , G01N35/0099 , G01N35/028 , G01N35/1074 , G01N2035/00485 , G01N2035/102 , Y10T436/25375
摘要： A heater module is described that includes a heat distribution plate including a bottom portion having first and second sides and a plurality of projections extending away from one of the sides. A heat source is provided for heating the heat distribution plate, and, optionally, a heating tray can be used to receive the heat source and heat distribution plate. The heater module is adapted to engage a sample purification tray having a plurality of purification and/or discharge columns which can extend through openings in the heater module and direct a sample into a sample receiving tray. Methods of heating samples using the heater module are also described.
摘要翻译： 描述了一种加热器模块，其包括配热板，该散热板包括具有第一和第二侧面的底部以及远离其中一个侧面延伸的多个突起。 提供了用于加热分布板的热源，并且可选地，加热盘可以用于接收热源和散热板。 加热器模块适于接合具有多个净化和/或排出柱的样品净化盘，其可以延伸穿过加热器模块中的开口并将样品引导到样品接收托盘中。 还描述了使用加热器模块加热样品的方法。
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公开(公告)号：US08934098B2
公开(公告)日：2015-01-13
申请号：US12873132
申请日：2010-08-31
申请人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
发明人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
IPC分类号： G01N21/25 , C12Q1/68 , B01F13/00 , B01F13/02 , B01J19/00 , B01L3/00 , G01N35/00 , G01N35/10 , G02B21/34
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要翻译： 本文提供了能够快速成像多个波长的样品的测序系统的各种实施例。 在一个实施例中，该系统包括具有多个激发和发射滤波器的快速分度滤光轮，该激发和发射滤光片能够快速旋转进入激发源（例如，弧光灯，激光器） 轮可以被配置成以大约40ms至大约60ms，优选为50ms的范围内的时间量进行索引。该系统还可以被配置为考虑快速启动和停止快速索引所产生的振动 滤光轮以及由其他光源产生的振动。本文还提供了在多个波长下快速成像样品的各种方法。
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公开(公告)号：US20110128545A1
公开(公告)日：2011-06-02
申请号：US12873132
申请日：2010-08-31
申请人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
发明人： David Cox , Marc Haberstroh , Patrick Kinney , Albert Carrillo , Jon Hoshizaki , Maryam Shariati , Howard King , Joe Lee , Matthew Chan
CPC分类号： C12Q1/6869 , B01F13/0059 , B01F13/0222 , B01J19/0046 , B01J2219/00317 , B01J2219/00466 , B01J2219/00527 , B01J2219/00576 , B01J2219/00596 , B01J2219/00648 , B01J2219/00659 , B01J2219/00722 , B01L3/502707 , B01L3/50273 , B01L2200/027 , B01L2200/0647 , B01L2200/0684 , B01L2200/16 , B01L2300/0819 , B01L2300/0822 , B01L2300/0867 , B01L2300/0877 , B01L2300/0887 , B01L2300/1822 , B01L2400/0427 , C12Q1/6874 , G01N35/00069 , G01N35/1002 , G01N35/1097 , G01N2035/00148 , G01N2035/00237 , G01N2035/1034 , G02B21/34 , Y10T436/11 , Y10T436/143333
摘要： Various embodiments of a sequencing system capable of rapidly imaging samples at multiple wavelengths are provided herein. In one embodiment, the system includes a fast-indexing filter wheel having a plurality of excitation and emission filters capable of being rapidly rotated into and out of communication with an excitation source (e.g., an arc lamp, a laser. For example, the filter wheel can be configured to index in an amount of time falling within a range of about 40 ms to about 60 ms, preferably 50 ms. The system can also be configured to account for vibrations resulting from the quick starts and stops of the fast-indexing filter wheel as well as vibrations resulting from other sources. Various methods of rapidly imaging a sample at multiple wavelengths are also provided herein.
摘要翻译： 本文提供了能够快速成像多个波长的样品的测序系统的各种实施例。 在一个实施例中，该系统包括具有多个激发和发射滤波器的快速分度滤光轮，该激发和发射滤光片能够快速旋转进入激发源（例如，弧光灯，激光器） 轮可以被配置成以大约40ms至大约60ms，优选为50ms的范围内的时间量进行索引。该系统还可以被配置为考虑快速启动和停止快速索引所产生的振动 滤光轮以及由其他光源产生的振动。本文还提供了在多个波长下快速成像样品的各种方法。
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