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    Process for synthesizing peptides or peptide derivatives
    2.
    发明授权
    Process for synthesizing peptides or peptide derivatives 失效
    合成肽或肽衍生物的方法

    公开(公告)号：US4572894A

    公开(公告)日：1986-02-25

    申请号：US461307

    申请日：1983-01-26

    申请人： Kazutomo Imahori ,  Hiroshi Nakajima ,  Tatsuo Iwasaki ,  Isao Tomioka ,  Keiichi Yamamoto

    发明人： Kazutomo Imahori ,  Hiroshi Nakajima ,  Tatsuo Iwasaki ,  Isao Tomioka ,  Keiichi Yamamoto

    IPC分类号： C12P21/02 ,  C12P21/00 ,  C12N9/00

    CPC分类号： C12P21/02

    摘要： A process for synthesizing peptides or peptide derivatives is disclosed. The process involves using aminoacyl-tRNA synthetase as a condensing agent when synthesizing peptides or peptide derivatives from amino acids. According to the process, peptides or peptide derivatives which are useful as various hormones such as bradykinin having antihypertensive activity or somatostatin having an internal or external secretion controlling function and other biologically active substances such as antibiotic peptides or seasoning peptides can be produced at a moderate price without using protective groups.

    摘要翻译： 公开了合成肽或肽衍生物的方法。 当从氨基酸合成肽或肽衍生物时，该方法包括使用氨酰-tRNA合成酶作为缩合剂。 根据该方法，可以以适度的价格生产可用作各种激素的肽或肽衍生物，例如具有抗高血压活性的缓激肽或具有内部或外部分泌控制功能的生长抑素和其他生物活性物质如抗生素肽或调味肽 不使用保护组。

    Process for producing physiologically active substance
    3.
    发明授权
    Process for producing physiologically active substance 失效
    生产生理活性物质的方法

    公开(公告)号：US5001055A

    公开(公告)日：1991-03-19

    申请号：US862731

    申请日：1986-05-13

    申请人： Kazutomo Imahori ,  Isao Tomioka ,  Hiroshi Nakajima ,  Senji Kitabatake

    发明人： Kazutomo Imahori ,  Isao Tomioka ,  Hiroshi Nakajima ,  Senji Kitabatake

    IPC分类号： C07H19/20 ,  C12P1/00 ,  C12P13/00 ,  C12P13/04 ,  C12P13/14 ,  C12P19/02 ,  C12P19/32

    CPC分类号： C12P13/001 ,  C07H19/20 ,  C12P1/00 ,  C12P13/00 ,  C12P13/04 ,  C12P13/06 ,  C12P13/14 ,  C12P13/20 ,  C12P19/02 ,  C12P19/32 ,  Y10S435/813

    摘要： A process for producing a physiologically active substance by a combined enzymatic method is disclosed. In the combined enzymatic method, a reactant solution containing a precursor or precursors for the physiologically active substance, AXP, and a divalent metal ion is supplied at one end of a reactor incorporating either the combined enzymatic reaction system (a) or (b), wherein (a) is a reaction system including an enzyme for converting AMP to ADP, an enzyme for converting ADP to ATP, and an enzyme which catalyzes the synthesis of the physiologically active substance as it converts ATP to AMP; and (b) is a reaction system including an enzyme for converting ADP to ATP and an enzyme which catalyzes the synthesis of the physiologically active substance as it converts ATP to ADP, wherein the concentration of the divalent metal ion supplied into the reactor is held at a level no higher than 30 mM while the concentration of the AXP is held below that of that of the precursor or precursors for the physilogically active substance, and the physiologically active substance produced is withdrawn from the other end of the reactor.

    摘要翻译： 公开了通过组合的酶法生产生理活性物质的方法。 在组合的酶法中，在包含组合的酶反应体系（a）或（b）的反应器的一端提供含有生理活性物质前体或前体的反应物溶液AXP和二价金属离子， 其中（a）是包含用于将AMP转化成ADP的酶的反应体系，用于将ADP转化为ATP的酶，以及当ATP转化成AMP时催化生理活性物质合成的酶; 和（b）是包含用于将ADP转化为ATP的酶的反应体系，以及当ATP向ADP转化时催化生理活性物质的合成的酶，其中供给到反应器中的二价金属离子的浓度保持在 水平不高于30mM，而AXP的浓度低于物理活性物质的前体或前体的浓度，生成的生理活性物质从反应器的另一端排出。

    Hydraulic torque wrench
    5.
    发明授权
    Hydraulic torque wrench 失效
    液压扭矩扳手

    公开(公告)号：US4785693A

    公开(公告)日：1988-11-22

    申请号：US78936

    申请日：1987-07-29

    申请人： Toshimasa Minamiyama ,  Masaaki Ohkubo ,  Isao Tomioka

    发明人： Toshimasa Minamiyama ,  Masaaki Ohkubo ,  Isao Tomioka

    IPC分类号： B25B21/02 ,  B25B19/00

    CPC分类号： B25B21/02

    摘要： A communication passageway is formed to extend from the end surface of a cover member opposed to the axial end surface of the shoulder portion of a main shaft and through the main shaft so that in only one of the two particular phase conditions obtained per revolution of an oil cylinder, it establishes the communication between high and low pressure chambers to thereby equalize their pressures.The communication passageway establishes the communication between high and low pressure chambers in only one of the two particular phase conditions obtained per revolution of the oil cylinder and makes it possible to produce percussion torque in the other particular phase condition.

    摘要翻译： 连通通道形成为从与主轴的肩部的轴向端面相对的盖构件的端面延伸并且穿过主轴，使得在每转一次获得的两个特定相位条件中只有一个 油缸，它建立高压和低压室之间的连通，从而使其压力平衡。 通信通道仅在油缸每转获得的两个特定相位条件中的一个中建立高压室和低压室之间的连通，并且可以在另一特定相位条件下产生冲击转矩。

    Granular material of polyimide precursor, mixture comprising the material and process for producing the material
    6.
    发明授权
    Granular material of polyimide precursor, mixture comprising the material and process for producing the material 失效
    聚酰亚胺前体的颗粒材料，包含该材料的混合物和用于生产该材料的方法

    公开(公告)号：US5463016A

    公开(公告)日：1995-10-31

    申请号：US193887

    申请日：1994-02-09

    申请人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo

    发明人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo

    IPC分类号： B29C55/02 ,  B29K79/00 ,  C08G73/10 ,  C08J3/12 ,  C08J3/14 ,  C08L79/08 ,  C09D179/08 ,  H01B3/30 ,  C08G77/10 ,  C08G69/26

    CPC分类号： C08G73/1032 ,  C08J3/12 ,  C08J3/14 ,  C08J2379/08

    摘要： This invention provides (1) a granular material of a polyimide precursor, which has excellent solubility in solvents and excellent moldability and from which a polyimide molding having excellent mechanical properties can be produced, (2) a mixture of a granular material of a polyimide precursor with a solvent, in which the polyimide precursor shows excellent storage stability and (3) a process for the production of a granular material of a polyimide precursor, in which a solvent can be easily removed. Particularly provided are a polyimide precursor granular material having an intrinsic viscosity of 0.7 or higher and a polyimide precursor mixture which consists of a polyimide precursor granular polyimide having an intrinsic viscosity of 0.7 or higher and a solvent that does not exhibit a strong-mutual interaction with the polyimide precursor, as well as a process for the production of the polyimide precursor granular material. The granular material of a polyimide precursor can be obtained by allowing a tetracarboxylic dianhydride to undergo polymerization reaction with a diamine in a solvent that does not exhibit a strong mutual interaction with the polyimide precursor.

    摘要翻译： 本发明提供（1）聚酰亚胺前体的粒状材料，其在溶剂中的溶解性优异，成型性优异，可以制造出具有优异的机械性能的聚酰亚胺成型体，（2）聚酰亚胺前体的粒状材料 与聚酰亚胺前体显示优异的储存稳定性的溶剂和（3）可以容易地除去溶剂的聚酰亚胺前体的粒状材料的制造方法。 特别提供特性粘度为0.7以上的聚酰亚胺前体粒状材料和由特性粘度为0.7以上的聚酰亚胺前体粒状聚酰亚胺构成的聚酰亚胺前体混合物和不显示与 聚酰亚胺前体，以及聚酰亚胺前体粒状材料的制造方法。 聚酰亚胺前体的粒状材料可以通过使四羧酸二酐与不与聚酰亚胺前体表现出强相互作用的溶剂中的二胺进行聚合反应来获得。

    Poly(amic acid) solution and polyimide film or polymide-coated material obtained therefrom
    7.
    发明授权
    Poly(amic acid) solution and polyimide film or polymide-coated material obtained therefrom 失效
    聚（酰胺酸）溶液和由其获得的聚酰亚胺膜或聚酰亚胺涂层材料

    公开(公告)号：US5719253A

    公开(公告)日：1998-02-17

    申请号：US539740

    申请日：1995-10-05

    申请人： Yoshiaki Echigo ,  Shoji Okamoto ,  Hiroshi Yamada ,  Isao Tomioka ,  Yoshiaki Iwaya

    发明人： Yoshiaki Echigo ,  Shoji Okamoto ,  Hiroshi Yamada ,  Isao Tomioka ,  Yoshiaki Iwaya

    IPC分类号： C08G73/10 ,  C09D179/08 ,  H05K1/03 ,  C08K5/17

    CPC分类号： C08G73/1007 ,  C08G73/1032 ,  C09D179/08 ,  H05K1/0346

    摘要： This invention provides a poly(amic acid) solution which does not contain aprotic polar solvents such as DMF, NMP, DMAc, DMSO, as well as a polyimide film obtained therefrom having appropriate flexibility and a small coefficient of linear thermal expansion and a coated material in which the polyimide film is formed on a substrate. More particularly, it provides a poly(amic acid) solution which has an aromatic poly(amic acid) and a tertiary amine as the solute and a water soluble alcohol compound and/or a water soluble ether compound as the solvent and contains substantially no aprotic polar solvent, as well as a polyimide film obtained from the poly(amic acid) solution and a coated material obtained by forming the film on a substrate.

    摘要翻译： 本发明提供不含非质子极性溶剂如DMF，NMP，DMAc，DMSO的聚（酰胺酸）溶液，以及由其获得的具有适当柔性和小的线性热膨胀系数的涂覆材料 其中聚酰亚胺膜形成在基底上。 更具体地，它提供了具有芳族聚（酰胺酸）和叔胺作为溶质的聚（酰胺酸）溶液和水溶性醇化合物和/或水溶性醚化合物作为溶剂，并且基本上不含非质子 极性溶剂，以及由聚（酰胺酸）溶液获得的聚酰亚胺膜和通过在基材上形成膜得到的涂布材料。

    Polyimide precursor solution, process for producing the solution and moldings and coatings obtained therefrom
    8.
    发明授权
    Polyimide precursor solution, process for producing the solution and moldings and coatings obtained therefrom 失效
    聚酰亚胺前体溶液，用于制备溶液的方法和由其获得的模制品和涂料

    公开(公告)号：US5466732A

    公开(公告)日：1995-11-14

    申请号：US217767

    申请日：1994-03-25

    申请人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo

    发明人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo

    IPC分类号： B29C55/02 ,  B29K79/00 ,  C08G73/10 ,  C08J3/09 ,  C08J3/12 ,  C08J3/14 ,  C08L79/08 ,  C09D179/08 ,  H01B3/30 ,  C08J3/11 ,  C08K5/15

    CPC分类号： C08J3/095 ,  C08G73/1032 ,  C08J3/12 ,  C08J3/14 ,  C08J2379/08

    摘要： A polyimide precursor solution which comprises a polyimide precursor and a solvent wherein the polyimide precursor and the solvent are not solated strongly. A process for the production of the polyimide precursor solution, as well as moldings and coatings obtained from the solution.The polyimide precursor solution of the present invention has excellent storage stability, and the solvent can be removed easily at the time of the production of moldings or coatings. According to the process of the present invention, the polyimide precursor solution can be produced easily using simple apparatus and an inexpensive solvent(s) having low toxicity. The polyimide molding obtained from the polyimide precursor solution has excellent uniformity and no residual solvent. The polyimide coating obtained from the polyimide precursor solution has excellent uniformity, no residual solvent and excellent adhesiveness to a base material.

    摘要翻译： 一种聚酰亚胺前体溶液，其包含聚酰亚胺前体和溶剂，其中聚酰亚胺前体和溶剂不能很强地溶剂化。 用于生产聚酰亚胺前体溶液的方法，以及从溶液获得的模制品和涂料。 本发明的聚酰亚胺前体溶液具有优异的储存稳定性，并且在制造模制品或涂料时可以容易地除去溶剂。 根据本发明的方法，可以使用简单的装置和廉价的低毒性溶剂容易地制造聚酰亚胺前体溶液。 由聚酰亚胺前体溶液获得的聚酰亚胺模塑制品具有优异的均匀性和无残留溶剂。 由聚酰亚胺前体溶液获得的聚酰亚胺涂层具有优异的均匀性，无残余溶剂和对基材的优异粘附性。

    Process for producing diadenosine tetraphosphate and derivatives thereof
    9.
    发明授权
    Process for producing diadenosine tetraphosphate and derivatives thereof 失效
    二腺苷四磷酸及其衍生物的制备方法

    公开(公告)号：US4886749A

    公开(公告)日：1989-12-12

    申请号：US54975

    申请日：1987-05-28

    申请人： Munehiko Dombou ,  Isao Tomioka ,  Senji Kitabatake ,  Hiroshi Nakejima

    发明人： Munehiko Dombou ,  Isao Tomioka ,  Senji Kitabatake ,  Hiroshi Nakejima

    IPC分类号： C12N9/00 ,  C12P19/36

    CPC分类号： C12N9/93 ,  C12P19/36 ,  Y10S435/822 ,  Y10S435/832

    摘要： A process for producing diadenosine tetraphosphate or derivatives thereof in very high yields with little formation of undesired by-products is disclosed. The process comprises reacting adenosine-5'-triphosphate or a derivative thereof with an amino acid under the catalytic action of an aminoacyl-tRNA synthetase in the presence of an enzyme that converts adenosine-5'-diphosphate to adenosine-5'-triphosphate. The formation of by-products can be substantially completely inhibited if the last-mentioned enzyme is used in combination with an enzyme that converts adenosine-5'-monophosphate to adenosine-5'-diphosphate.

    摘要翻译： 公开了以非常高的产率生产二腺苷四磷酸或其衍生物的方法，几乎​​没有形成不需要的副产物。 该方法包括在氨基-5'-二磷酸腺苷转化为腺苷-5'-三磷酸的酶存在下，在氨基-tRNA合成酶的催化作用下使腺苷-5'-三磷酸或其衍生物与氨基酸反应。 如果最后提到的酶与将腺苷-5'-单磷酸腺苷转化为腺苷-5'-二磷酸的酶组合使用，副产物的形成可以基本上完​​全被抑制。

    Polyimide precursor fibrid, polyimide paper, polyimide composite paper and polyimide composite board obtained therefrom, and process for producing the fibrid and the paper products
    10.
    发明授权
    Polyimide precursor fibrid, polyimide paper, polyimide composite paper and polyimide composite board obtained therefrom, and process for producing the fibrid and the paper products 失效
    聚酰亚胺前体纤维原料，聚酰亚胺纸，聚酰亚胺复合纸和由其制得的聚酰亚胺复合板，以及制备纤条体和纸制品的方法

    公开(公告)号：US06294049B1

    公开(公告)日：2001-09-25

    申请号：US08428497

    申请日：1995-04-27

    申请人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo ,  Masato Wada

    发明人： Isao Tomioka ,  Takeshi Nakano ,  Mikio Furukawa ,  Yoshiaki Echigo ,  Masato Wada

    IPC分类号： D21M1326

    CPC分类号： C08G73/1028 ,  D01D5/40 ,  D01F6/74 ,  D21H13/26

    摘要： A polyimide precursor fibrid material which comprises a polyimide precursor that forms a polyimide having a property of no thermal melting when subjected to a ring closure reaction and which is substantially free from aprotic polar organic solvents, and polyimide paper, polyimide composite paper and polyimide composite board obtained therefrom. Since the inventive polyimide precursor fibrid material does not contain aprotic polar organic solvents, a polyimide paper product having excellent strength can be obtained from the polyimide precursor fibrid material, and a polyimide composite paper product and a polyimide composite board both consisting of uniformly dispersed components and having excellent strength can be obtained from the polyimide precursor fibrids and other staple fibers.

    摘要翻译： 一种聚酰亚胺前体纤条体，其包含聚酰亚胺前体，该聚酰亚胺前体在进行闭环反应时形成不具有热熔性质并且基本上不含非质子极性有机溶剂的聚酰亚胺，聚酰亚胺纸，聚酰亚胺复合纸和聚酰亚胺复合板 由此获得。 由于本发明的聚酰亚胺前体纤条体不含非质子极性有机溶剂，所以可以从聚酰亚胺前体纤条体材料和聚酰亚胺复合纸制品和聚酰亚胺复合板获得具有优异强度的聚酰亚胺纸制品，它们均匀分散的组分和 可以从聚酰亚胺前体纤条体和其它短纤维获得优异的强度。