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公开(公告)号：US5417863A
公开(公告)日：1995-05-23
申请号：US269952
申请日：1994-06-30
申请人： Laszlo Varady , Noubar B. Afeyan , Robert Langer , Shmuel Shefer
发明人： Laszlo Varady , Noubar B. Afeyan , Robert Langer , Shmuel Shefer
CPC分类号： C12Q1/60 , G01N33/92 , G01N2800/044 , Y10T436/255
摘要： Disclosed is a method for the rapid quantitative determination of low density lipoprotein (LDL) in a biological fluid sample containing LDL, very low density lipoprotein (VLDL) and high density lipoprotein (HDL). The sample is first passed through a matrix to bind LDL to the matrix. The LDL is then eluted from the matrix differentially from VLDL and HDL. A parameter representative of the concentration of a solute exiting the matrix during the interval when LDL is eluted is then determined, wherein the parameter is proportional to the amount of the LDL in the sample. The parameter may be determined, e.g., by electronically integrating under a spectrophotometrically detected peak of eluted LDL.
摘要翻译： 公开了一种用于在含有LDL，极低密度脂蛋白（VLDL）和高密度脂蛋白（HDL））的生物液体样品中快速定量测定低密度脂蛋白（LDL）的方法。 样品首先通过矩阵将LDL结合到基质上。 然后将LDL从VLDL和HDL差异性地从基质中洗脱出来。 然后确定表示在洗脱LDL的间隔期间离开基质的溶质的浓度的参数，其中参数与样品中LDL的量成比例。 该参数可以例如通过在分光光度法检测的洗脱的LDL的峰上电子积分来确定。
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公开(公告)号：US09981068B2
公开(公告)日：2018-05-29
申请号：US14115451
申请日：2012-05-04
申请人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
发明人： Paul Williams , Morgan Russell Alexander , Martyn Christopher Davies , Robert Langer , Daniel Griffith Anderson
IPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L29/08 , A61L31/14 , A61L31/10 , A61L27/50 , A61L27/34 , A61L29/14 , C08F220/56 , C08F220/24 , C08F220/18 , C08F220/22 , C08F222/10
CPC分类号： A61L29/16 , A01N37/12 , A01N37/20 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , C08F220/18 , C08F220/22 , C08F220/24 , C08F220/56 , C08F222/1006 , C08L33/08 , C08L33/10 , C08L33/26 , A01N25/10 , A01N25/34
摘要： The invention provides a method for inhibiting bacterial attachment to a surface, the method comprising forming the surface from a polymer, or applying a polymer to the surface, wherein the polymer is a homopolymer formed from a (meth) acrylate or (meth) acrylamide monomer or a copolymer formed from one or more (meth) acrylate or (meth) acrylamide monomers, wherein the (meth) acrylate or (meth) acrylamide monomers are of formula (I) or (II): [H2C═CR′—C(═O)—O—]nR (I) [H2C═CR′—C(═O)—NH—]nR (II) wherein n is 1, 2 or 3, R′ is independently H or CH3, R is an organic group having a total of from 2 to 24 carbon atoms, wherein the organic group includes an aliphatic or aromatic hydrocarbon moiety and wherein the organic group does not include any hydroxyl groups.
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3.发明授权公开(公告)号：US09412476B2
公开(公告)日：2016-08-09
申请号：US13373139
申请日：2011-11-03
申请人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.
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4.发明授权公开(公告)号：US09144488B2
公开(公告)日：2015-09-29
申请号：US13495252
申请日：2012-06-13
申请人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
发明人： Edward S. Boyden , Gregory J. Della Rocca , Daniel Hawkins , Roderick A. Hyde , Robert Langer , Eric C. Leuthardt , Terence Myckatyn , Parag Jitendra Parikh , Dennis J. Rivet , Joshua S. Shimony , Michael A. Smith , Elizabeth A. Sweeney , Clarence T. Tegreene
CPC分类号： A61F2/12 , A61B5/0031 , A61B5/076 , A61B5/14546 , A61B5/4312 , A61B5/686 , A61B5/6867 , A61B2560/0219 , A61F2250/0085 , A61F2250/0096
摘要： Breast implants including sensor modules and related methods are described herein. Breast implants include those with: a shell configured to be substantially filled with a viscous material; and a plurality of sensor modules attached to the shell and positioned at a distance from each other, each of the plurality of sensor modules oriented to detect one or more analytes in a fluid adjacent to the shell, wherein each of the plurality of sensor modules includes a unique identifier and is configured to utilize energy transmitted from an external source.
摘要翻译： 本文描述了包括传感器模块和相关方法的乳房植入物。 乳房植入物包括具有：壳体被构造为基本上被粘性材料填充的植入物; 以及多个传感器模块，其附接到壳体并且彼此间隔一定距离，多个传感器模块中的每一个被定向成检测与壳体相邻的流体中的一种或多种分析物，其中多个传感器模块中的每一个包括 唯一的标识符并被配置为利用从外部源发送的能量。
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公开(公告)号：US09061075B2
公开(公告)日：2015-06-23
申请号：US11900776
申请日：2007-09-12
CPC分类号： A61K47/48776 , A61K9/0024 , A61K47/6901 , A61K2035/126 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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6.发明授权Systems, devices, methods, and compositions including fluidized x-ray shielding compositions 有权包括流化X射线屏蔽组合物的系统，装置，方法和组合物公开(公告)号：US09006694B2
公开(公告)日：2015-04-14
申请号：US13373135
申请日：2011-11-03
申请人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
发明人： Philip A. Eckhoff , William H. Gates, III , Peter L. Hagelstein , Roderick A. Hyde , Jordin T. Kare , Robert Langer , Erez Lieberman , Eric C. Leuthardt , Nathan P. Myhrvold , Michael Schnall-Levin , Clarence T. Tegreene , Lowell L. Wood, Jr.
摘要： Systems, devices, methods, and compositions are described for providing an x-ray shielding system including a flexible layer including a support structure having a plurality of interconnected interstitial spaces that provide a circulation network for an x-ray shielding fluid composition.
摘要翻译： 描述了用于提供包括柔性层的x射线屏蔽系统的系统，装置，方法和组合物，所述柔性层包括具有多个互连的间隙空间的支撑结构，所述多个互连间隙空间提供用于x射线屏蔽流体组合物的循环网络。
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公开(公告)号：US09005943B2
公开(公告)日：2015-04-14
申请号：US11906580
申请日：2007-10-02
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N11/00 , A61F13/00 , A61K9/52 , A61L27/36 , A61K9/00 , A61K47/48 , A61L27/38 , C12N5/077 , A61K35/12
CPC分类号： A61F2/00 , A61K9/0024 , A61K47/6901 , A61K2035/126 , A61L27/3608 , A61L27/3808 , B33Y80/00 , C12N5/0654 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08968274B2
公开(公告)日：2015-03-03
申请号：US12217873
申请日：2008-07-08
申请人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
发明人： Leroy E. Hood , Muriel Y. Ishikawa , Edward K. Y. Jung , Robert Langer , Clarence T. Tegreene , Lowell L. Wood, Jr. , Victoria Y. H. Wood
CPC分类号： A61M5/14276 , A61M5/145 , A61M5/172 , A61M5/1723 , A61M2005/14513 , A61M2205/0266 , A61M2205/0288 , A61M2205/3507 , A61M2205/3523 , A61M2205/3569 , A61M2205/36
摘要： Embodiments of a system including a remotely controlled substance delivery device and associated controller are described. Methods of use and control of the device are also disclosed. According to some embodiments, a delivery device or related device may be placed in an environment in order to pump a material into the environment or into an additional fluid handling structure within the device. Exemplary environments include a body of an organism, a body of water, or an enclosed volume of a fluid. The concentration of a substance in the fluid to be delivered may be modified by a remote control signal. In selected embodiments, an acoustic control signal may be used.
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公开(公告)号：US08962316B2
公开(公告)日：2015-02-24
申请号：US11451994
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N5/071 , C12N5/00 , C12N5/02 , A61K47/48 , A61K9/00 , A61L27/36 , A61L27/38 , C12N5/079 , C12N5/077 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
摘要翻译： 公开了骨笼，包括用于生物相容性植入的装置。 骨的结构可用于向受试者提供活细胞和组织以及生物活性分子。
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公开(公告)号：US08906687B2
公开(公告)日：2014-12-09
申请号：US11452019
申请日：2006-06-12
申请人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
发明人： Ed Harlow , Roderick A. Hyde , Edward K. Y. Jung , Robert Langer , Eric C. Leuthardt , Lowell L. Wood, Jr.
IPC分类号： C12N11/00 , C12N11/16 , C12N5/00 , C12N5/02 , A61F2/00 , A61L27/38 , A61K47/48 , A61L27/36 , C12N5/079 , C12N5/077 , A61K9/00 , A61K35/12
CPC分类号： C12N5/0691 , A61K9/0024 , A61K35/44 , A61K47/6901 , A61K2035/126 , A61L27/18 , A61L27/3608 , A61L27/3612 , A61L27/3808 , A61L27/3813 , A61L27/54 , A61L2300/64 , B33Y80/00 , C12N5/0618 , C12N5/0654 , C12N2502/13 , C12N2502/1305 , C12N2502/1311 , C12N2502/1317 , C12N2502/1323 , C12N2502/1329 , C12N2502/1335 , C12N2502/1341 , C12N2502/1347 , C12N2502/1352 , C12N2502/1358 , C12N2502/1364 , C12N2502/137 , C12N2502/1376 , C12N2502/1382 , C12N2502/1388 , C12N2502/1394 , C12N2510/00
摘要： Bone cages are disclosed including devices for biocompatible implantation. The structures of bone are useful for providing living cells and tissues as well as biologically active molecules to subjects.
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