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    Systems and Methods for Cooling in a Thermal Cycler
    1.
    发明申请
    Systems and Methods for Cooling in a Thermal Cycler 审中-公开
    热循环器冷却系统和方法

    公开(公告)号：US20080050781A1

    公开(公告)日：2008-02-28

    申请号：US11767327

    申请日：2007-06-22

    申请人： Mark Oldham ,  Eric Henderson ,  Vinod Mirchandani ,  Eric Nordman ,  Marc Haberstroh ,  Johannes Sluis

    发明人： Mark Oldham ,  Eric Henderson ,  Vinod Mirchandani ,  Eric Nordman ,  Marc Haberstroh ,  Johannes Sluis

    IPC分类号： C12P19/34 ,  B01J19/00 ,  C12M1/38

    CPC分类号： B01L7/52 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0877 ,  B01L2300/1822 ,  B01L2300/1844 ,  B01L2300/185

    摘要： A device for performing polymerase chain reactions using cooling members not used in conventional thermal cyclers. A device for performing polymerase chain reactions may include a sample holder configured to receive a nucleic acid sample, a heating system configured to raise the temperature of the sample, a cooling system configured to lower the temperature of the sample, and a controller configured to operably control the heating system and the cooling system to cycle the device through a desired time-temperature profile. The cooling system may comprise at least one cooling member selected from a synthetic jet ejector array, a vibration-induced droplet atomization system, a vibrating diaphragm system, a piezo fan, a Cold Gun, a microchannel cooling loop, and a Cool Chip.

    摘要翻译： 使用不用于常规热循环仪的冷却部件进行聚合酶链反应的装置。 用于进行聚合酶链式反应的装置可以包括配置成接收核酸样品的样品架，配置成提高样品温度的加热系统，配置成降低样品温度的冷却系统，以及配置成可操作地 控制加热系统和冷却系统以使设备循环所需的时间 - 温度曲线。 冷却系统可以包括选自合成射流喷射器阵列，振动诱导液滴雾化系统，振动膜系统，压电风扇，冷枪，微通道冷却回路和冷却芯片中的至少一个冷却构件。

    DNA sequencing system
    5.
    发明授权
    DNA sequencing system 有权
    DNA测序系统

    公开(公告)号：US08384898B2

    公开(公告)日：2013-02-26

    申请号：US13442107

    申请日：2012-04-09

    申请人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  Janice Shigeura

    发明人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    DNA sequencing system
    7.
    发明授权
    DNA sequencing system 有权
    DNA测序系统

    公开(公告)号：US08169610B2

    公开(公告)日：2012-05-01

    申请号：US13153902

    申请日：2011-06-06

    申请人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura, legal representative

    发明人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

    摘要翻译： 提供了一种用于检测标记珠粒的装置。 该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

    Electrophoretic system with multi-notch filter and laser excitation source
    8.
    发明申请
    Electrophoretic system with multi-notch filter and laser excitation source 有权
    具有多陷波滤波器和激光源的电泳系统

    公开(公告)号：US20050036142A1

    公开(公告)日：2005-02-17

    申请号：US10887528

    申请日：2004-07-08

    申请人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    发明人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    IPC分类号： G01N21/00 ,  G01N21/63 ,  G01N27/27

    CPC分类号： G01N21/6456 ,  B82Y10/00 ,  B82Y20/00 ,  G01N27/44721 ,  G01N2021/6417 ,  G01N2021/6419 ,  G01N2021/6471 ,  G01N2201/0628

    摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.

    摘要翻译： 提供了用于检测样品中分析物的装置和方法。 该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。 各种实施例提供具有多陷波滤波器的装置。 各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

    Time-delay integration in a flow cytometry system
    9.
    发明申请
    Time-delay integration in a flow cytometry system 有权
    流式细胞术系统中的延时整合

    公开(公告)号：US20050030534A1

    公开(公告)日：2005-02-10

    申请号：US10887486

    申请日：2004-07-08

    申请人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    发明人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    IPC分类号： G01N21/00 ,  G01N21/63 ,  G01N27/27

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.

    摘要翻译： 提供了一种用于检测样品中分析物的装置。 该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。 还提供了检测样品中分析物的方法。

    Time-delay integration in a flow cytometry system
    10.
    发明申请
    Time-delay integration in a flow cytometry system 有权
    流式细胞术系统中的延时整合

    公开(公告)号：US20080094627A1

    公开(公告)日：2008-04-24

    申请号：US11644412

    申请日：2006-12-22

    申请人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    发明人： Mark Oldham ,  Eric Nordman ,  Richard Reel ,  John Shigeura ,  Janice Shigeura

    IPC分类号： G01N21/00

    CPC分类号： G01N27/44721 ,  B82Y10/00 ,  B82Y20/00 ,  G01N2015/149 ,  G01N2015/1497

    摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.

    摘要翻译： 提供了一种用于检测样品中分析物的装置。 该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。 还提供了检测样品中分析物的方法。