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1.发明授权Devices and methods for enrichment and alteration of circulating tumor cells and other particles 有权用于富集和改变循环肿瘤细胞和其他颗粒的装置和方法公开(公告)号：US08921102B2
公开(公告)日：2014-12-30
申请号：US11322791
申请日：2005-12-29
申请人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
发明人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
IPC分类号： C12N5/00 , C12N5/02 , C12N13/00 , A01N1/02 , B01L3/00 , G01N33/569 , G01N33/543 , G01N33/574 , B82Y10/00 , B82Y5/00
CPC分类号： G01N33/57484 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/54366 , G01N33/56966 , G01N33/57492 , G01N2333/705 , G01N2333/70589 , G01N2333/71 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
摘要翻译： 本发明的特征在于用于检测，富集和分析循环肿瘤细胞和其他颗粒的装置和方法。 本发明进一步具有通过分析来自受试者的细胞样品来诊断受试者中病症例如癌症的方法。
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2.发明申请DEVICES AND METHODS FOR ENRICHMENT AND ALTERATION OF CIRCULATING TUMOR CELLS AND OTHER PARTICLES 审中-公开循环肿瘤细胞和其他颗粒的增殖和改变的装置和方法公开(公告)号：US20110294186A1
公开(公告)日：2011-12-01
申请号：US13007477
申请日：2011-01-14
申请人： Martin FUCHS , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
发明人： Martin FUCHS , Ying-Xin Wang , Yi-Shuian Huang , Neil X. Krueger
CPC分类号： G01N33/57484 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/54366 , G01N33/56966 , G01N33/57492 , G01N2333/705 , G01N2333/70589 , G01N2333/71 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
摘要翻译： 本发明的特征在于用于检测，富集和分析循环肿瘤细胞和其他颗粒的装置和方法。 本发明进一步具有通过分析来自受试者的细胞样品来诊断受试者中病症例如癌症的方法。
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3.发明申请公开(公告)号：US20070026418A1
公开(公告)日：2007-02-01
申请号：US11324041
申请日：2005-12-29
申请人： Martin Fuchs , Mehmet Toner , Ying-Xin Wang , Yi-Shuian Huang , Neil Krueger , Lotien Huang
发明人： Martin Fuchs , Mehmet Toner , Ying-Xin Wang , Yi-Shuian Huang , Neil Krueger , Lotien Huang
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/574 , C12M3/00
CPC分类号： G01N33/5005 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/54366 , G01N33/57492 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
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4.发明申请公开(公告)号：US20070026419A1
公开(公告)日：2007-02-01
申请号：US11324108
申请日：2005-12-29
申请人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang
发明人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang
CPC分类号： G01N33/54366 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2300/0636 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
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5.发明申请公开(公告)号：US20070026469A1
公开(公告)日：2007-02-01
申请号：US11322791
申请日：2005-12-29
申请人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil Krueger
发明人： Martin Fuchs , Ying-Xin Wang , Yi-Shuian Huang , Neil Krueger
IPC分类号： G01N33/574 , C12M3/00
CPC分类号： G01N33/57484 , B01L3/502707 , B01L3/502746 , B01L3/502761 , B01L2200/0668 , B01L2400/0406 , B01L2400/0409 , B01L2400/0415 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , B82Y10/00 , G01N33/54366 , G01N33/56966 , G01N33/57492 , G01N2333/705 , G01N2333/70589 , G01N2333/71 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
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6.发明申请公开(公告)号：US20070026415A1
公开(公告)日：2007-02-01
申请号：US11323946
申请日：2005-12-29
申请人： Martin Fuchs , Mehmet Toner , Yi-Shuian Huang , Neil Krueger , Ying-Xin Wang
发明人： Martin Fuchs , Mehmet Toner , Yi-Shuian Huang , Neil Krueger , Ying-Xin Wang
IPC分类号： C12Q1/68 , G01N33/567 , C12M1/34
CPC分类号： B82Y10/00 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2300/0816 , B01L2300/0864 , B01L2400/0409 , B01L2400/0472 , B01L2400/0487 , B01L2400/086 , B82Y5/00 , C12Q1/6886 , C12Q2600/16 , C12Q2600/178 , G01N1/40 , G01N33/5005 , G01N33/5091 , G01N33/574 , G01N2035/00237 , G01N2800/52
摘要： The invention features devices and methods for detecting, enriching, and analyzing circulating tumor cells and other particles. The invention further features methods of diagnosing a condition, e.g., cancer, in a subject by analyzing a cellular sample from the subject.
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7.发明授权公开(公告)号：US09114399B2
公开(公告)日：2015-08-25
申请号：US13223290
申请日：2011-08-31
申请人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
发明人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
CPC分类号： B01L3/502746 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , C12Q1/686 , G01N21/77 , G01N35/08 , G01N35/1095 , G01N2021/7786 , C12Q2561/113 , C12Q2565/629
摘要： The present invention relates to systems and methods for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
摘要翻译： 本发明涉及用于在聚合酶链反应（PCR）和热熔体应用中实时处理核酸的系统和方法。 根据本发明的一个方面，提供了用于多重核酸测定的快速连续处理的系统。 在一个实施例中，该系统包括但不限于：具有微流体（流通）通道的微流控筒，荧光成像系统，温度测量和控制系统; 压力测量和控制系统，用于将可变气动压力施加到微流控筒; 用于容纳多个试剂（例如，孔板）的储存装置; 液体处理系统，包括至少一个用于将试剂混合物抽吸，混合和分配到微流控盒的机器人移液器; 用于数据存储，处理和输出的系统; 和一个系统控制器来协调各种设备和功能。
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公开(公告)号：US09061279B2
公开(公告)日：2015-06-23
申请号：US13221948
申请日：2011-08-31
CPC分类号： C12Q1/6806 , B01L3/50273 , B01L2200/10 , B01L2200/146 , B01L2200/147 , B01L2300/0816 , B01L2300/18 , B01L2400/0487 , Y10T137/0318
摘要： The present invention relates to compositions and methods for in-system priming of microfluidic devices. Aspects of the present invention relate to compositions and methods for in-system priming of microfluidic devices utilizing a priming solution comprising adding and/or increasing concentrations of surfactant in a buffer solution.
摘要翻译： 本发明涉及用于微流控装置的系统内引发的组合物和方法。 本发明的方面涉及使用引发溶液的微流体装置的系统内引发的组合物和方法，包括在缓冲溶液中加入和/或增加表面活性剂的浓度。
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公开(公告)号：US20120052560A1
公开(公告)日：2012-03-01
申请号：US13223290
申请日：2011-08-31
申请人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
发明人： Ivor T. Knight , Kenton C. Hasson , Johnathan S. Coursey , Hongye Liang , Sami Kanderian , Gregory H. Owen , Weidong Cao , Ying-Xin Wang , Scott Corey , Ben Lane , Conrad Laskowski , Alex Flamm , Brian Murphy , Eric Schneider , Takayoshi Hanagata , Hiroshi Inoue , Shulin Zeng , Brian Bean , Franklin Regan
IPC分类号： C12M1/40
CPC分类号： B01L3/502746 , B01L3/502784 , B01L7/52 , B01L7/525 , B01L2200/025 , B01L2200/027 , B01L2200/028 , B01L2200/10 , B01L2300/0663 , B01L2300/0816 , B01L2300/1822 , B01L2300/1827 , B01L2300/1844 , B01L2400/0487 , C12Q1/686 , G01N21/77 , G01N35/08 , G01N35/1095 , G01N2021/7786 , C12Q2561/113 , C12Q2565/629
摘要： The present invention relates generally to systems and methods for the rapid serial processing of multiple nucleic acid assays. More particularly, the present invention provides for the real time processing of nucleic acid during polymerase chain reaction (PCR) and thermal melt applications. According to an aspect of the invention, a system for the rapid serial processing of multiple nucleic acid assays is provided. In one embodiment, the system includes, but is not limited to: a microfluidic cartridge having microfluidic (flow-through) channels, a fluorescence imaging system, a temperature measurement and control system; a pressure measurement and control system for applying variable pneumatic pressures to the microfluidic cartridge; a storage device for holding multiple reagents (e.g., a well-plate); a liquid handling system comprising at least one robotic pipettor for aspirating, mixing, and dispensing reagent mixtures to the microfluidic cartridge; systems for data storage, processing, and output; and a system controller to coordinate the various devices and functions.
摘要翻译： 本发明一般涉及用于多重核酸测定的快速连续加工的系统和方法。 更具体地说，本发明提供了在聚合酶链反应（PCR）和热熔体应用中核酸的实时处理。 根据本发明的一个方面，提供了用于多重核酸测定的快速连续处理的系统。 在一个实施例中，该系统包括但不限于：具有微流体（流通）通道的微流控筒，荧光成像系统，温度测量和控制系统; 压力测量和控制系统，用于将可变气动压力施加到微流控筒; 用于容纳多个试剂（例如，孔板）的储存装置; 液体处理系统，包括至少一个用于将试剂混合物抽吸，混合和分配到微流控盒的机器人移液器; 用于数据存储，处理和输出的系统; 和一个系统控制器来协调各种设备和功能。
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公开(公告)号：US20120167988A1
公开(公告)日：2012-07-05
申请号：US13221948
申请日：2011-08-31
CPC分类号： C12Q1/6806 , B01L3/50273 , B01L2200/10 , B01L2200/146 , B01L2200/147 , B01L2300/0816 , B01L2300/18 , B01L2400/0487 , Y10T137/0318
摘要： The present invention relates to compositions and methods for in-system priming of microfluidic devices. Aspects of the present invention relate to compositions and methods for in-system priming of microfluidic devices utilizing a priming solution comprising adding and/or increasing concentrations of surfactant in a buffer solution.
摘要翻译： 本发明涉及用于微流控装置的系统内引发的组合物和方法。 本发明的方面涉及使用引发溶液的微流体装置的系统内引发的组合物和方法，包括在缓冲溶液中加入和/或增加表面活性剂的浓度。
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