公开(公告)号：US20130280523A1

公开(公告)日：2013-10-24

申请号：US13811787

申请日：2011-07-27

申请人： Martin Schwarz ,  Frank-Hendrik Wurm ,  Beate Heisterkamp ,  Ute Bergmann ,  Silvia Muehle ,  Hartmut Worch

发明人： Martin Schwarz ,  Frank-Hendrik Wurm ,  Beate Heisterkamp ,  Ute Bergmann ,  Silvia Muehle ,  Hartmut Worch

IPC分类号： C09D7/12

CPC分类号： C09D7/63 ,  C08L83/04 ,  C09D1/00 ,  C09D5/00 ,  C09D5/14 ,  C09D5/16 ,  C09D105/08 ,  C09D189/00 ,  Y10T428/265 ,  C01G23/047

摘要： The invention relates to a coating composition containing between 51 wt % and 99.9 wt % of a TiO2-producing agent, wherein the coating composition contains between 0.1 wt % and 49 wt %, relative to the total composition, of at least one further component which is selected from collagen, chitosans, phenols and/or substituted quaternary ammonium salts of alkylated phosphoric acid. The invention further relates to a nanoscale coating based on titanium dioxide, and to the production, further processing and use thereof.

摘要翻译： 本发明涉及包含51重量％至99.9重量％的TiO 2产生剂的涂料组合物，其中涂料组合物相对于总组合物含有0.1重量％至49重量％的至少一种其它组分， 选自烷基化磷酸的胶原蛋白，壳聚糖，酚类和/或取代的季铵盐。 本发明还涉及一种基于二氧化钛的纳米级涂层，以及其生产，进一步加工和使用。

公开(公告)号：US07763272B2

公开(公告)日：2010-07-27

申请号：US10799329

申请日：2004-03-12

申请人： Peter Offermann ,  Hartmut Worch ,  Wolfgang Pompe ,  Michael Gelinsky ,  Gerhilt Schmack ,  Gerald Hoffmann ,  Uwe Köckritz

发明人： Peter Offermann ,  Hartmut Worch ,  Wolfgang Pompe ,  Michael Gelinsky ,  Gerhilt Schmack ,  Gerald Hoffmann ,  Uwe Köckritz

IPC分类号： A61F2/02

CPC分类号： C12N5/0068 ,  A61F2/105 ,  A61F2/30756 ,  A61F2002/30062 ,  A61F2002/30225 ,  A61F2002/30448 ,  A61F2002/30602 ,  A61F2002/30762 ,  A61F2002/30766 ,  A61F2002/30892 ,  A61F2002/30971 ,  A61F2002/4648 ,  A61F2210/0004 ,  A61F2220/005 ,  A61F2230/0069 ,  A61F2310/00365 ,  A61F2310/00383 ,  A61L27/18 ,  A61L27/3633 ,  A61L27/38 ,  A61L27/3847 ,  A61L27/3852 ,  B33Y80/00 ,  C12N2533/40 ,  C12N2533/50 ,  C12N2533/54 ,  C12N2533/70 ,  C12N2533/72 ,  C08L67/04

摘要： A scaffold for tissue culture and cell culture and for producing implant materials, in particular bone, cartilage or skin replacements or extra-corporal organ replacements or for other applications in medicine or biotechnology is made of biocompatible materials. It has at least one base material which is electrostatically flocked with fibers on at least one side. Through the electrostatic flocking the fibers are arranged almost perpendicularly on the surface of the base material and exhibits a high fiber pull-out resistance. The scaffold provides an elastic growth lattice, which is stable against compression, for cell colonization in vitro or the ingrowth of cells in vivo. Implants or implant materials can be produced with the scaffold.

摘要翻译： 用于组织培养和细胞培养和用于生产植入材料，特别是骨，软骨或皮肤替代物或体外器官替代物或用于医学或生物技术中的其它应用的支架由生物相容性材料制成。 它至少有一种基材在至少一面被静电地植绒在纤维上。 通过静电植绒，纤维几乎垂直地布置在基材的表面上并表现出高的纤维拉出阻力。 支架提供弹性生长格子，其对于压缩是稳定的，用于体外细胞定植或体内细胞向内生长。 植入物或种植体材料可以用支架生产。

公开(公告)号：US08043627B2

公开(公告)日：2011-10-25

申请号：US12572884

申请日：2009-10-02

申请人： Dieter Scharnweber ,  Hartmut Worch ,  Susanne Bierbaum

发明人： Dieter Scharnweber ,  Hartmut Worch ,  Susanne Bierbaum

IPC分类号： A61K9/00 ,  C07K14/78

CPC分类号： A61L27/48 ,  A61L2430/02 ,  C08L89/06

摘要： The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibers produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibers.

摘要翻译： 本发明涉及由细胞外基质（ECM-组分）的胶原和非胶原组分组成的成骨复合基质，制备所述基质的方法，提供用于组织工程的植入物或支架的制备方法 具有由所述成骨复合基质形成的涂层，并且用于刺激和加速例如硬组织形成。 骨骼中的植入物骨整合。 本发明的成骨复合基质包括胶原蛋白和至少一种非胶原ECM组分或其衍生物，其中胶原组分由通过纤维发生产生的非交联胶原纤维组成，非胶原ECM组分或其衍生物被整合到 说胶原纤维。

公开(公告)号：US20050079198A1

公开(公告)日：2005-04-14

申请号：US10918743

申请日：2004-08-16

申请人： Berthold Nies ,  Andreas Sewing ,  Dieter Scharnweber ,  Hartmut Worch ,  Rene Beutner

发明人： Berthold Nies ,  Andreas Sewing ,  Dieter Scharnweber ,  Hartmut Worch ,  Rene Beutner

IPC分类号： A61L27/00 ,  A61L27/34 ,  A61L27/54 ,  C25D9/02 ,  A61N1/00 ,  A61F2/00

CPC分类号： C25D9/02 ,  A61L27/34 ,  A61L27/54 ,  A61L2300/232 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/426 ,  A61L2300/606 ,  C08L5/08

摘要： The invention describes an article made from chitosan-coated metal, where an impermeable chitosan layer having a barrier action is present on the metal through electrochemical polarisation in a chitosan-containing solution. The incorporation of biologically active components into the chitosan coating enables the coating to be matched to various applications and the bio-compatibility of correspondingly modified surfaces to be increased. Metallic articles or surfaces coated in this way are used, for example, as material for medical implants.

摘要翻译： 本发明描述了由壳聚糖涂覆的金属制成的制品，其中通过在含壳聚糖的溶液中的电化学极化，在金属上存在具有屏障作用的不可渗透的壳聚糖层。 将生物活性成分并入壳聚糖涂层中使得涂层能够匹配各种应用，并且相应改性表面的生物相容性增加。 以这种方式涂覆的金属制品或表面例如用作医疗植入物的材料。

公开(公告)号：US5723038A

公开(公告)日：1998-03-03

申请号：US718445

申请日：1996-12-02

申请人： Dieter Scharnweber ,  Henrike Bersch ,  Hartmut Worch ,  Jurgen Hofinger ,  Curt Kranz ,  Wolfgang Pompe

发明人： Dieter Scharnweber ,  Henrike Bersch ,  Hartmut Worch ,  Jurgen Hofinger ,  Curt Kranz ,  Wolfgang Pompe

IPC分类号： A61L27/00 ,  A61F2/00 ,  A61F2/28 ,  A61L27/32 ,  C25D9/04

CPC分类号： C25D9/04 ,  A61L27/32 ,  A61F2310/00796 ,  Y10S623/901

摘要： The invention concerns a process for producing a gradient coating of calcium phosphat phases and metal oxide phases on metallic implants, in particular made of titanium or titanium alloys, for use as dental, jaw or joint implants. A solution containing calcium ions and phosphate ions is used as electrolyte of which the pH is slightly acidic to approximately neutral. The substrate electrodes are alternately polarized cathodically and anodically. The layer deposited in a gratuated manner is adherent, has a fine structure and is distinguished by a high degree of biocompatibility.

摘要翻译： PCT No.PCT / DE96 / 00197 Sec。 371日期1996年12月2日第 102（e）日期1996年12月2日PCT PCT 1996年2月6日PCT公布。 公开号WO96 / 24391 日期1996年8月15日本发明涉及在用作牙科，颌骨或关节植入物的金属植入物，特别是由钛或钛合金制成的钙磷脂相和金属氧化物相的梯度涂层的方法。 使用含有钙离子和磷酸根离子的溶液作为电解质，其pH值略微为中性至酸性。 基板电极在阴极和阳极交替极化。 以令人满意的方式沉积的层是粘附的，具有精细的结构并且被高度的生物相容性区分开来。

公开(公告)号：US20130122067A1

公开(公告)日：2013-05-16

申请号：US13812497

申请日：2011-08-04

申请人： Sascha Heinemann ,  Christiane Heinemann ,  Hartmut Worch ,  Thomas Hanke ,  Wolfgang Pompe

发明人： Sascha Heinemann ,  Christiane Heinemann ,  Hartmut Worch ,  Thomas Hanke ,  Wolfgang Pompe

IPC分类号： A61F2/28

CPC分类号： A61L27/12 ,  A61F2/28 ,  A61L27/222 ,  A61L27/24 ,  A61L27/32 ,  A61L27/446 ,  A61L27/46 ,  A61L27/48 ,  A61L27/54 ,  A61L27/58 ,  A61L2300/10 ,  A61L2300/412 ,  A61L2300/604 ,  A61L2300/63 ,  A61L2400/18 ,  A61L2420/00 ,  A61L2430/02 ,  C01B25/32

摘要： The invention relates to growth-inhibited hydroxyapatite for improving bone healing. It differs from the apatites employed to date in that it releases calcium ions and phosphate ions in physiological solutions, which, unlike traditional hydroxyapatites, it does not bind. It thereby promotes bone regeneration and bone growth. The growth-inhibited hydroxyapatite contains in agglomerates of prestructured collagen templates on which hydroxyapatite crystals with a crystallite growth of below its critical nucleus radius are formed epitactically. It is prepared by the steps a) mineralization of prestructured collagen templates in supersaturated Ca- and phosphate-ion-containing solutions, where the prestructured collagen templates are capable of diffusion and/or migration, so that HAP crystallites grow epitactically on the collagen templates and the collagen templates grown together with HAP crystallites agglomerate due to their capability of diffusion and/or migration, b) separating off the agglomerates.

摘要翻译： 本发明涉及用于改善骨愈合的生长抑制型羟基磷灰石。 它与迄今为止使用的磷灰石的不同之处在于，它在生理溶液中释放钙离子和磷酸根离子，与传统的羟基磷灰石不同，它不结合。 从而促进骨再生和骨骼生长。 生长抑制羟基磷灰石含有预结构化胶原模板的附聚物，其上具有低于其临界核半径的微晶生长的羟基磷灰石晶体被外延形成。 它通过以下步骤制备：a）在过饱和的含Ca和磷酸根离子的溶液中预结构化胶原模板的成矿，其中预结构的胶原模板能够扩散和/或迁移，使得HAP微晶在胶原模板上上游生长， 与HAP微晶一起生长的胶原模板由于其扩散和/或迁移的能力而聚集，b）分离附聚物。

公开(公告)号：US20100119575A1

公开(公告)日：2010-05-13

申请号：US12572884

申请日：2009-10-02

申请人： Dieter SCHARNWEBER ,  Hartmut Worch ,  Susanne Bierbaum

发明人： Dieter SCHARNWEBER ,  Hartmut Worch ,  Susanne Bierbaum

IPC分类号： A61K9/00 ,  B05D3/00 ,  C12N5/077 ,  C07K14/78 ,  A61P43/00

CPC分类号： A61L27/48 ,  A61L2430/02 ,  C08L89/06

摘要： The invention relates to an osteogenic composite matrix consisting of collagen and non-collagen components of an extracellular matrix (ECM-components), to a method for producing said matrix, to a method for producing an implant or a scaffold for tissue engineering which is provided with a coating formed by said osteogenic composite matrix and is used for stimulating and accelerating a hard tissue formation such as, for example. The implant osseointegration in bones. The inventive osteogenic composite matrix comprises a collagen and at least one non-collagen ECM component or the derivatives thereof, wherein the collagen component consists of non-crosslinked collagen fibres produced by fibrillogenesis and the non-collagen ECM component or the derivatives thereof are integrated into said collagen fibres.

摘要翻译： 本发明涉及由细胞外基质（ECM-组分）的胶原和非胶原组分组成的成骨复合基质，制备所述基质的方法，提供用于组织工程的植入物或支架的制备方法 具有由所述成骨复合基质形成的涂层，并且用于刺激和加速例如硬组织形成。 骨骼中的植入物骨整合。 本发明的成骨复合基质包括胶原蛋白和至少一种非胶原ECM组分或其衍生物，其中胶原组分由通过纤维发生产生的非交联胶原纤维组成，非胶原ECM组分或其衍生物被整合到 说胶原纤维。

公开(公告)号：US20060035229A1

公开(公告)日：2006-02-16

申请号：US10519988

申请日：2003-07-04

申请人： Dieter Scharnweber ,  Rene Beutner ,  Sophie Roessler ,  Thomas Hanke ,  Hartmut Worch ,  Bernd Schwenzer ,  Jan Michael

发明人： Dieter Scharnweber ,  Rene Beutner ,  Sophie Roessler ,  Thomas Hanke ,  Hartmut Worch ,  Bernd Schwenzer ,  Jan Michael

IPC分类号： C12Q1/68 ,  C12M1/34

CPC分类号： A61K9/0024 ,  A61K9/1611 ,  A61K9/167 ,  A61L27/306 ,  B01J2219/00527 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00641 ,  B01J2219/00722 ,  C25D11/02 ,  C40B40/06

摘要： A metallic object has a coating made of a thin metal oxide layer and nucleic acids or nucleic acid derivatives bonded thereto. The nucleic acid compounds have 5′-terminal or 3′-terminal molecule areas that are incorporated stably into the metal oxide layer. The unincorporated areas of the nucleic acid compounds that are not incorporated into the metal oxide layer are freely accessible for subsequent interactions with other molecules such as complementary nucleic acids having active ingredients attached thereto.

公开(公告)号：US20110237552A1

公开(公告)日：2011-09-29

申请号：US13063469

申请日：2009-09-11

申请人： Sascha Heinemann ,  Hartmut Worch ,  Thomas Hanke

发明人： Sascha Heinemann ,  Hartmut Worch ,  Thomas Hanke

IPC分类号： A61K47/42 ,  A61K31/663 ,  C09D189/00

CPC分类号： A61L27/52 ,  A61L27/24 ,  A61L27/34 ,  A61L27/446 ,  A61L27/46 ,  A61L2420/04 ,  C08L89/06

摘要： The invention relates to novel composite materials based on a collagen matrix mineralised with silicate and calcium phosphate phases, to a method for the production thereof and use thereof as an implant material which can be shaped in a plurality of ways, a biological coating or active substance carrier. The claimed composite material comprises a collagen matrix which is mineralised with silicate and a calcium phosphate phase, said collagen being a recombinate collagen, collagen from Eumetazoa, sponge collagen from a sponge of the Demospongia class (horn sponges) or Calcarea (calcareous sponges), a synthetic collage analogue, a collagen derivative or a mixture of said collagens.

摘要翻译： 本发明涉及基于用硅酸盐和磷酸钙相矿化的胶原基质的新型复合材料，其生产方法和其可用作植入材料，其可以以多种方式成型，生物涂层或活性物质 载体 所要求保护的复合材料包括用硅酸盐和磷酸钙相矿化的胶原基质，所述胶原是重组胶原，来自Eumetazoa的胶原，来自Demospongia类海绵的海绵胶原（角海绵）或Calcarea（钙质海绵）， 合成拼贴模拟物，胶原衍生物或所述胶原蛋白的混合物。

公开(公告)号：US06524718B1

公开(公告)日：2003-02-25

申请号：US09297220

申请日：1999-06-21

申请人： Hartmut Worch ,  Michael Thieme ,  Dieter Scharnweber ,  Sophie Rössler ,  Martina Stölzel

发明人： Hartmut Worch ,  Michael Thieme ,  Dieter Scharnweber ,  Sophie Rössler ,  Martina Stölzel

IPC分类号： B32B1504

CPC分类号： C25D11/02 ,  A61F2310/00796 ,  A61L27/32 ,  B05D7/14 ,  C23C30/00 ,  Y10T428/12556

摘要： A metallic object, having a metallic substrate of a valve metal or a valve metal alloy inclusive of intermetallic phases, and a thin polyphase oxide coating, is disclosed. The polyphase oxide coating has a metal oxide phase and at least one other organic and/or inorganic phase. The polyphase oxide coating is produced by bringing the metallic substrate into contact with an organic and/or inorganic component to be integrated into the polyphase oxide coating such that the inorganic and/or organic phases are present at or in the direct vicinity of the substrate surface and by simultaneously or subsequently anodically polarizing the substrate material in an electrolytic solution.

摘要翻译： 公开了一种金属物体，其具有阀金属的金属基底或包括金属间相的阀金属合金和薄的多相氧化物涂层。 多相氧化物涂层具有金属氧化物相和至少一种其它有机和/或无机相。 多相氧化物涂层是通过使金属基材与有机和/或无机组分接触而制成的，以将其整合到多相氧化物涂层中，使得无机和/或有机相存在于基材表面的直接附近 并且通过同时或随后在电解液中阳极极化基板材料。