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公开(公告)号：US07569189B2
公开(公告)日：2009-08-04
申请号：US11093606
申请日：2005-03-30
IPC分类号： B01L3/00
CPC分类号： G01N35/1002 , B01L3/50825 , G01N2035/0405 , Y10T436/11 , Y10T436/113332 , Y10T436/114998 , Y10T436/202499
摘要： An apparatus for opening and closing a container having a slidable shutter closure moving past the apparatus includes: a rotatable shaft having an axis perpendicular to the direction of travel of the slidable shutter, the shaft being biased against rotation in either direction; a driver for bidirectionally moving the shaft from a position away from the container to a position in the vicinity of the container for opening and closing; and an extension extending outwardly from the rotatable shaft along at least a portion of the shaft into a line of travel, whereby the extension is adapted to engage the shutter closure of the container and move the shutter closure from an open position to a closed position or from a closed position to an open position. A reagent source for an automated analyzer includes: a reagent source which includes a container having a shutter closure which slides between an open and closed position; an apparatus for opening and closing the container. The apparatus includes: a rotatable shaft having an axis perpendicular to the direction of travel of the slidable shutter, the shaft being biased against rotation in either direction; a driver for bidirectionally moving the shaft from a position away from the container to a position in the vicinity of the container for opening and closing; and an extension extending outwardly from the rotatable shaft along at least a portion of the shaft, whereby the extension is located to engage the shutter closure of the container as the container is transported past the extension; and a bidirectional conveyor for transporting the container into engagement with and past the apparatus for opening and closing.
摘要翻译： 一种用于打开和关闭具有移动通过设备的可滑动的快门盖的容器的装置包括：具有垂直于可滑动挡板的行进方向的轴的可旋转轴，该轴被偏压以防止在任一方向上的旋转; 用于将轴从远离容器的位置双向移动到用于打开和关闭的容器附近的位置的驱动器; 以及从所述可旋转轴沿着所述轴的至少一部分向外延伸到行进线的延伸部，由此所述延伸部适于接合所述容器的所述闸门盖并且将所述闸门闭合件从打开位置移动到关闭位置，或者 从关闭位置到打开位置。 用于自动分析器的试剂源包括：试剂源，其包括具有在打开和关闭位置之间滑动的快门闭合的容器; 用于打开和关闭容器的装置。 该装置包括：具有垂直于可滑动挡板的行进方向的轴的可旋转轴，该轴被偏压以抵抗任一方向上的旋转; 用于将轴从远离容器的位置双向移动到用于打开和关闭的容器附近的位置的驱动器; 以及沿着所述轴的至少一部分从所述可旋转轴向外延伸的延伸部，由此当所述容器被运送通过所述延伸部时，所述延伸部定位成与所述容器的所述闸门盖接合; 以及双向传送器，用于将容器运输到与开启和关闭装置接合并经过设备。
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2.发明授权公开(公告)号：US08329475B2
公开(公告)日：2012-12-11
申请号：US10417912
申请日：2003-04-17
IPC分类号： G01N33/00
CPC分类号： G01N1/40 , G01N2035/00564 , Y10T436/25 , Y10T436/25125 , Y10T436/25375 , Y10T436/255 , Y10T436/25625 , Y10T436/2575
摘要： A method for removing undesired component(s) from bound desired component(s) in an analysis including: (a) providing a container having a desired component bound thereto and an undesired component; (b) dispensing wash fluid in the container at a first level sufficient to contact a portion of the bound desired component; (c) oscillating wash fluid level in the container; and (d) removing a portion of the wash fluid from the container. A method for removing undesired components from bound desired components in an analysis including steps (a) and (b) above; (c) removing the wash fluid; (d) dispensing a wash fluid at a subsequent level lower than the first level and sufficient to wash the bound desired substrate; and (e) removing wash fluid. Preferably, the desired component is an analyte being measured. Another aspect of the invention provides a method for removing an undesired component from a bound desired component in an analysis by removing a surface portion of fluid containing a portion of the undesired component.
摘要翻译： 一种用于在分析中从结合的所需组分除去不需要的组分的方法，包括：（a）提供具有结合到其上的所需组分的容器和不期望的组分; （b）以足以接触所述结合的所需组分的一部分的第一水平分配所述容器中的洗涤流体; （c）在容器中振荡冲洗液面; 和（d）从容器中除去洗涤液的一部分。 一种用于在包括上述步骤（a）和（b）的分析中从结合的所需组分中除去不想要的组分的方法; （c）去除洗涤液; （d）在低于第一水平的后续水平处分配洗涤液体并足以洗涤结合的所需底物; 和（e）除去洗涤液。 优选地，所需组分是被测量的分析物。 本发明的另一方面提供了一种在分析中通过去除含有一部分不需要的组分的流体的表面部分从结合的所需组分中除去不需要的组分的方法。
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公开(公告)号：US08313713B2
公开(公告)日：2012-11-20
申请号：US10870107
申请日：2004-06-17
IPC分类号： G01N21/00
CPC分类号： G01N21/13 , G01N21/0303 , G01N21/253 , G01N2021/0357 , G01N2021/0367 , G01N2021/0371 , G01N2201/0438
摘要： A device and method solves the problems of improving precision, in particular in reducing movement of a cuvette, particularly lateral or side to side movement of a cuvette, during the measurement process. The device, which stabilizes a cuvette during a measurement read in an analyzer having a cuvette path of travel, includes: a fixed support located on a first side of the path of travel and abutting a side of the cuvette at a location that does not interfere with an optical window on the cuvette on which the measurement read takes place; and a movable support located on a second side of the path of travel and biased against a side of the cuvette at a location that does not interfere with the optical window on the cuvette on which the measurement read takes place, and which is opposite the side abutting the fixed support.
摘要翻译： 一种装置和方法解决了在测量过程中提高精度的问题，特别是在减小试管的运动，特别是比色杯的侧向或侧向运动。 在具有运动的比色皿路径的分析器中读取测量期间稳定比色杯的装置包括：位于行进路径的第一侧的固定支撑件，并且在不干扰的位置处邻接比色杯的一侧 在其上进行测量读取的比色皿上具有光学窗口; 以及可移动支撑件，其位于行进路径的第二侧，并且在不影响在其上进行测量读取的比色皿上的光学窗口的位置处抵靠所述比色皿的侧面偏压，并且与所述侧面相对的位置 抵靠固定支架。
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公开(公告)号：US06641993B1
公开(公告)日：2003-11-04
申请号：US09510928
申请日：2000-02-22
申请人： Merrit N. Jacobs , Zhong Ding , Ronald F. Brookes
发明人： Merrit N. Jacobs , Zhong Ding , Ronald F. Brookes
IPC分类号： C12Q100
CPC分类号： B01F11/0074 , B01F5/10 , B01F11/0071 , B01F13/002 , B01F2215/0037 , B01L3/0275 , G01N1/14 , G01N2035/106 , Y10S436/81
摘要： Apparatus and a method for mixing a liquid within a disposable aspirating probe tip so that most of the liquid is forced to move past a transition zone between two different inside diameters to cause rotational mixing. The apparatus and method can be used to provide agglutination of blood, which in turn can be used for blood typing. The probe tip can comprise a single integral piece, or two separate portions. The transition zone can comprise a sharp demarcation between inside diameters, or a smooth one.
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公开(公告)号：US5401467A
公开(公告)日：1995-03-28
申请号：US94668
申请日：1993-07-21
申请人： Merrit N. Jacobs
发明人： Merrit N. Jacobs
CPC分类号： G01N35/00029 , G01N1/4077 , G01N35/1095
摘要： A method and related apparatus for the dispensing of a biological liquid, such as whole blood, to a diagnostic test element is described, in which a quantity of patient sample is preferably added to a container having contained filters for separating and supporting a quantity of the sample. The container has an exterior surface wettable with the filtered sample, a cover to prevent significant evaporation of the wetted filter surface, and a movable transfer element for transferring filtered liquid from the wetted surface and delivering the liquid to a test element.
摘要翻译： 描述了一种用于将诸如全血的生物液体分配到诊断测试元件的方法和相关装置，其中优选地将一定数量的患者样品添加到包含用于分离和支撑一部分 样品。 该容器具有用过滤的样品可润湿的外表面，用于防止润湿的过滤器表面的显着蒸发的盖，以及用于从已浸湿的表面传送过滤的液体并将液体输送到测试元件的可移动的转移元件。
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6.发明授权Apparatus for transferring liquid out of a capped container, and analyzer utilizing same 失效用于将液体从封盖容器中转移的装置，以及使用其的分析仪
公开(公告)号：US4539855A
公开(公告)日：1985-09-10
申请号：US606489
申请日：1984-05-03
申请人： Merrit N. Jacobs
发明人： Merrit N. Jacobs
CPC分类号： G01N35/1083 , G01N35/00029 , G01N35/1079
摘要： Apparatus is disclosed for transferring liquid out of a container covered by a pierceable cap using a storage unit. The apparatus includes means for moving the storage unit into an aspirating position within the capped container, means for aspirating the liquid into the storage unit, means for moving the storage unit away from such aspirating position, and means for dispensing at least a fraction of the liquid out of the storage unit. The apparatus further includes means for holding such container during all movement of the storage unit away from its aspirating position.
摘要翻译： 公开了一种用于使用存储单元将液体从可刺穿盖覆盖的容器中移出的装置。 该装置包括用于将存储单元移动到被封盖的容器内的抽吸位置的装置，用于将液体吸入存储单元的装置，用于使存储单元远离这种抽吸位置移动的装置，以及用于分配至少一部分 液体从存储单元中取出。 该装置还包括用于在存储单元远离其抽吸位置的所有运动期间保持该容器的装置。
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公开(公告)号：US20100276445A1
公开(公告)日：2010-11-04
申请号：US12834088
申请日：2010-07-12
IPC分类号： G01F13/00
CPC分类号： B01L3/08 , B01L2200/026 , B01L2300/047 , G01N2035/00277
摘要： A foam reducing or eliminating container for containing a liquid includes: a container body having a top portion, a bottom portion and an opening for adding a liquid to or removing a liquid from the container body; and a hollow baffle located within the container with first and second openings therein. The first and second openings are covered with a pierceable seal, wherein the first opening of the baffle is at least partially aligned with the opening of the container. In a preferred embodiment, the container is a reagent supply container for an automated analyzer, which includes: a container as described above; and a closure which is movable away from the opening of the container to be in an open position and movable into contact with the opening to be in a closed position. In another preferred embodiment a reagent supply for an automated analyzer includes: the reagent supply container as described above; and a liquid reagent therein. The second opening of the baffle is submerged in liquid. A method for reducing or eliminating the aspiration of foam into a metering probe includes: providing a reagent supply as described above; providing a metering probe movable in a direction toward and away from the reagent supply; moving the closure away from the opening of the container; piercing both seals covering the first and second openings of the baffle allowing liquid to enter the baffle from the end of the baffle submerged in the liquid, wherein the seals may or may not be pierced with the metering probe; moving the metering probe into the first opening of the baffle and into contact with the liquid in the baffle; aspirating a selected amount of liquid in the baffle; and moving the metering probe out of the baffle.
摘要翻译： 用于容纳液体的泡沫减少或消除容器包括：具有顶部，底部和用于将液体添加到容器主体或从容器主体移除液体的开口的容器主体; 以及位于容器内的中空挡板，其中具有第一和第二开口。 第一和第二开口用可刺破的密封件覆盖，其中挡板的第一开口至少部分地与容器的开口对准。 在优选实施例中，容器是用于自动分析器的试剂供应容器，其包括：如上所述的容器; 以及能够远离容器的开口移动以使其处于打开位置并且能够与开口接触以处于关闭位置的闭合件。 在另一个优选的实施方案中，用于自动分析仪的试剂供应器包括：如上所述的试剂供应容器; 和其中的液体试剂。 挡板的第二个开口被浸没在液体中。 用于减少或消除泡沫进入计量探针的方法包括：提供如上所述的试剂供应; 提供可在朝向和远离所述试剂供应的方向移动的测量探针; 将盖子从容器的开口移开; 穿过覆盖挡板的第一和第二开口的两个密封件，允许液体从浸没在液体中的挡板的端部进入挡板，其中密封件可以或不可以用计量探头刺穿; 将测量探针移动到挡板的第一开口并与挡板中的液体接触; 在挡板中吸取选定量的液体; 并将测量探针移出挡板。
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公开(公告)号：US20080166740A1
公开(公告)日：2008-07-10
申请号：US11621797
申请日：2007-01-10
申请人： Merrit N. Jacobs
发明人： Merrit N. Jacobs
IPC分类号： G01N33/53
CPC分类号： G01N33/54386 , Y10S435/96 , Y10S435/969 , Y10S435/971 , Y10S435/973
摘要： A method of analyzing a sample for one or more analytes of interest includes: providing an element having a base layer; a layer containing streptavidin; a spreading layer, wherein the streptavidin may or may not be in the spreading layer; providing immunocomponents and labeled immunoreactants which may be in the spreading layer or may be combined with the sample; dispensing the sample, and optionally the immunocomponents and a labeled immunoreactant onto the spreading layer at three or more areas, wherein each center of the three or more areas is substantially equidistance to the center formed by the three or more areas, and wherein each area contacts an adjacent area such that wash fluid flow in any direction will contact sample; washing the sample and label by directing the wash fluid at the center formed by the three or more areas, whereby the wash fluid equally flows over each of the three or more areas; and taking a measurement at each three or more areas to determine the presence or concentration of the one or more analyte. In a preferred embodiment, the element is a dry slide used on a diagnostic analyzer.
摘要翻译： 分析一种或多种感兴趣分析物的样品的方法包括：提供具有基础层的元件; 含有链霉亲和素的层; 扩散层，其中链霉抗生物素蛋白可以或不在扩散层中; 提供可以在扩散层中或可以与样品组合的免疫组分和标记的免疫反应物; 将样品和任选的免疫组分和标记的免疫反应物分配到三个或更多个区域的扩散层上，其中三个或更多个区域的每个中心与由三个或更多个区域形成的中心基本上等距，并且其中每个区域接触 相邻区域使得洗涤流体沿任何方向流动将接触样品; 通过将洗涤流体引导到由三个或更多个区域形成的中心处洗涤样品和标签，由此洗涤流体均匀地流过三个或更多个区域中的每一个; 并在每个三个或更多个区域进行测量以确定一种或多种分析物的存在或浓度。 在优选实施例中，该元件是用于诊断分析器的干燥载玻片。
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9.发明授权公开(公告)号：US06913933B2
公开(公告)日：2005-07-05
申请号：US10005257
申请日：2001-12-03
IPC分类号： G01F11/16 , B01L99/00 , B67D7/02 , F04B7/06 , F04B9/02 , F04B13/00 , F04B49/06 , G01N35/10 , G05D7/06 , G01N1/10 , G01N15/06 , G01N21/00 , G01N35/00 , G01N35/08
CPC分类号： B01L3/0289 , B01L2200/0615 , B01L2400/0487 , F04B7/06 , F04B13/00 , G01N35/1016 , G01N2035/102 , G05D7/0676 , Y10T436/11 , Y10T436/119163 , Y10T436/2575
摘要： A method for improving the fluid dispense rate in a metering system utilizing speed includes the steps of modifying the fluid flow rate profile during a portion thereof so as substantially increase or decrease the speed of the motor during certain portions of a metering cycle in order to improve the efficiency of the metering system. For a variable speed pump producing a sinusoidal speed profile, the pump motor speed can be increased to increase the dispense velocity during the beginning and end of the dispense phase to reduce perfusion and improve metered volume precision or a motor speed profile can be applied which is inverted relative to that of the variable speed pump to produce a constant velocity flow. Alternately or in addition to the above, the home position of the variable speed pump can be shifted to produce fluid velocity during the entirety of a dispense portion of a metering system cycle.
摘要翻译： 用于改善计量系统利用速度的流体分配速率的方法包括以下步骤：在其一部分期间改变流体流速分布，以便在计量循环的某些部分期间大幅度地增加或减少电动机的速度，以改善 计量系统的效率。 对于产生正弦速度曲线的变速泵，可以增加泵电机速度，以在分配阶段的开始和结束期间增加分配速度，以减少灌注并提高计量体积精度或可应用电机速度分布 相对于变速泵的转速产生恒定的速度流。 或者除了上述之外，可以移动变速泵的原始位置以在计量系统循环的整个分配部分的整体期间产生流体速度。
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公开(公告)号：US5525514A
公开(公告)日：1996-06-11
申请号：US415262
申请日：1995-04-03
IPC分类号： G01N33/53 , G01N33/543 , G01N35/00 , G01N35/02 , G01N35/10
CPC分类号： G01N35/00029 , G01N33/54386 , G01N2035/00138 , G01N2035/1018 , G01N35/1016 , Y10S436/805 , Y10T436/11 , Y10T436/112499 , Y10T436/115831 , Y10T436/12 , Y10T436/25375
摘要： A method for verifying the effectiveness of a washing operation on a clinical dry chemistry slide element in which wash liquid is dispensed onto the surface of the slide element and then detection devices are used to verify the effectiveness of the wash by making an initial detection at an on center site followed by making a second detection at a second and off-center radial position. A comparison of the two readings provides verification of the wash. In addition, rate measurements can be made at each of the read positions to measure the effectiveness of the wash and to verify sample application for immunological assays.
摘要翻译： 一种用于验证洗涤操作对临床干化学滑动元件的有效性的方法，其中将洗涤液体分配到滑动元件的表面上，然后检测装置用于通过初步检测在 然后在第二和偏心径向位置进行第二次检测。 两个读数的比较提供了洗涤的验证。 此外，可以在每个读取位置进行速率测量，以测量洗涤的有效性并验证免疫测定的样品应用。
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