专利检索 ap:("Muthiah Manoharan" OR "Kallanthottathil G. Rajeev" OR "Takeshi Yamada" OR "David Butler" OR "Narayanannair K. Jayaprakash" OR "Muthusamy Jayaraman" OR "Shigeo Matsuda" OR "Rajendra K. Pandey" OR "Chang Geng Peng") AND inv:"Muthiah Manoharan" 第 1 页

1.

发明授权
Chemical modifications of monomers and oligonucleotides with cycloaddition 有权
标题翻译：具有环加成的单体和寡核苷酸的化学修饰

公开(公告)号：US08962580B2

公开(公告)日：2015-02-24

申请号：US13120389

申请日：2009-09-23

申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Takeshi Yamada , David Butler , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Shigeo Matsuda , Rajendra K. Pandey , Chang Geng Peng

发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Takeshi Yamada , David Butler , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Shigeo Matsuda , Rajendra K. Pandey , Chang Geng Peng

IPC分类号： A61K48/00 , H04L29/06 , C07H21/00 , H04L29/08

CPC分类号： C12N15/113 , A61K31/713 , A61K47/544 , A61K47/64 , C07H21/00 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2310/3515 , H04L65/602 , H04L67/36 , Y02A50/465

摘要： The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

摘要翻译： 本发明的特征在于式I或II化合物：在一个实施方案中，本发明涉及将配体与寡核苷酸缀合的化合物和方法。本发明还涉及治疗各种病症和疾病如病毒感染，细菌感染，寄生虫感染，癌症，过敏症，自身免疫疾病，免疫缺陷和免疫抑制的方法。

2.

发明申请
CHEMICAL MODIFICATIONS OF MONOMERS AND OLIGONUCLEOTIDES WITH CYCLOADDITION 有权
标题翻译：单体和二聚体的化学修饰与循环

公开(公告)号：US20120035115A1

公开(公告)日：2012-02-09

申请号：US13120389

申请日：2009-09-23

申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Takeshi Yamada , David Butler , K. Narayanannair Jayaprakash , Muthusamy Jayraman , Shigeo Matsuda , Rajendra K. Pandey , Chang Geng Peng

发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Takeshi Yamada , David Butler , K. Narayanannair Jayaprakash , Muthusamy Jayraman , Shigeo Matsuda , Rajendra K. Pandey , Chang Geng Peng

IPC分类号： A61K38/14 , C07H19/10 , C07F9/6561 , C07H21/02 , A61K31/7072 , A61K31/675 , C07H1/00 , A61P31/12 , A61P31/04 , A61P33/00 , A61P35/00 , A61P37/08 , A61P37/06 , A61P37/04 , C07K9/00 , A61K31/7088

CPC分类号： C12N15/113 , A61K31/713 , A61K47/544 , A61K47/64 , C07H21/00 , C12N2310/14 , C12N2310/141 , C12N2310/3513 , C12N2310/3515 , H04L65/602 , H04L67/36 , Y02A50/465

摘要： The invention features compounds of formula I or II: In one embodiment, the invention relates compounds and processes for conjugating ligand to oligonucleotide. The invention further relates to methods for treating various disorders and diseases such as viral infections, bacterial infections, parasitic infections, cancers, allergies, autoimmune diseases, immunodeficiencies and immunosuppression.

摘要翻译： 本发明的特征在于式I或II化合物：在一个实施方案中，本发明涉及将配体与寡核苷酸缀合的化合物和方法。本发明还涉及治疗各种病症和疾病如病毒感染，细菌感染，寄生虫感染，癌症，过敏症，自身免疫疾病，免疫缺陷和免疫抑制的方法。

3.

发明授权
Biodegradable lipids for the delivery of active agents 有权
标题翻译：用于递送活性剂的生物可降解脂质

公开(公告)号：US09012498B2

公开(公告)日：2015-04-21

申请号：US13153200

申请日：2011-06-03

申请人： Muthiah Manoharan , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie

发明人： Muthiah Manoharan , Martin Maier , Muthusamy Jayaraman , Shigeo Matsuda , Narayanannair K. Jayaprakash , Kallanthottathil G. Rajeev , Akin Akinc , Thomas A. Baillie

IPC分类号： A61K31/265 , A61K31/13 , C07C229/00 , C07C229/12 , C12N15/88

CPC分类号： C07C229/12 , A61K31/713 , A61K39/0005 , A61K47/44 , C12N15/113 , C12N15/88 , C12N2310/14 , C12N2320/30

摘要： The present invention relates to a cationic lipid having one or more biodegradable groups located in the mid- or distal section of a lipidic moiety (e.g., a hydrophobic chain) of the cationic lipid. These cationic lipids may be incorporated into a lipid particle for delivering an active agent, such as a nucleic acid. The invention also relates to lipid particles comprising a neutral lipid, a lipid capable of reducing aggregation, a cationic lipid of the present invention, and optionally, a sterol. The lipid particle may further include a therapeutic agent such as a nucleic acid.

摘要翻译： 本发明涉及一种阳离子脂质，其具有位于阳离子脂质的脂质部分（例如，疏水链）的中间或远端部分中的一个或多个可生物降解基团。这些阳离子脂质可以掺入用于递送活性剂（例如核酸）的脂质颗粒中。本发明还涉及包含中性脂质，能够减少聚集的脂质，本发明的阳离子脂质和任选的固醇的脂质颗粒。脂质颗粒可以进一步包括治疗剂如核酸。

4.

发明授权
Lipid containing formulations 有权
标题翻译：含脂质配方

公开(公告)号：US08642076B2

公开(公告)日：2014-02-04

申请号：US13211094

申请日：2011-08-16

申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier

发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Akin Akinc , Narayanannair K. Jayaprakash , Muthusamy Jayaraman , Martin Maier

IPC分类号： A61K9/48

CPC分类号： C07C219/06 , A61K9/1272 , A61K9/1273 , A61K31/325 , A61K47/34 , C07C209/78 , C07C233/36 , C07C271/10 , C07C323/25

摘要： Compositions and methods useful in administering nucleic acid based therapies, for example association complexes such as liposomes and lipoplexes are described.

摘要翻译： 描述了用于施用基于核酸的疗法，例如缔合复合物如脂质体和脂质复合物的组合物和方法。

5.

发明授权
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components 有权
标题翻译：通过将靶向配体与内体分解组分结合来进行核酸的位点特异性递送

公开(公告)号：US08575123B2

公开(公告)日：2013-11-05

申请号：US12936961

申请日：2009-04-10

申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Muthusamy Jayaraman

发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , David Butler , Muthusamy Jayaraman

IPC分类号： A61K48/00 , C12N15/11 , C12N15/00 , A01N63/00 , A01N65/00

CPC分类号： A61K47/554 , A61K47/545 , A61K47/549 , A61K47/551 , A61K48/0008 , C12N15/111 , C12N15/1137 , C12N15/87 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/322 , C12N2310/346 , C12N2310/351 , C12N2310/3513 , C12N2320/32 , C12Y304/21021

摘要： The invention relates to compositions and methods for site-specific delivery of nucleic acids by combining them with targeting ligands and endosomolytic components.

摘要翻译： 本发明涉及通过将它们与靶向配体和内体分解组分组合而用于位点特异性递送核酸的组合物和方法。

6.

发明申请
LIPID COMPOSITIONS 有权
标题翻译：脂肪组合物

公开(公告)号：US20120128760A1

公开(公告)日：2012-05-24

申请号：US13318600

申请日：2010-05-05

申请人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Michael E. Jung

发明人： Muthiah Manoharan , Kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Michael E. Jung

IPC分类号： A61K31/7088 , A61K31/713 , A61P35/00 , A61K47/42 , C07D295/13 , C07D295/14 , A61K9/127 , A61K47/34

CPC分类号： A61K47/22 , A61K9/1272 , C07D295/13 , C12N15/113 , C12N15/1137 , C12N2310/14 , Y02A50/463

摘要： Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is (F). Also disclosed are methods of producing the cationic lipid of formula (I).

摘要翻译： 本文公开了包含式（I）的阳离子脂质，中性脂质，固醇和PEG或PEG修饰的脂质的脂质组合物，其中式（I）是（F）。还公开了制备式（I）的阳离子脂质的方法。

7.

发明申请
NOVEL LIPIDS AND COMPOSITIONS FOR THE DELIVERY OF THERAPEUTICS 有权
标题翻译：用于输送治疗药物的新型脂肪和组合物

公开(公告)号：US20110311583A1

公开(公告)日：2011-12-22

申请号：US13128287

申请日：2009-11-10

申请人： Muthiah Manoharan , kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu

发明人： Muthiah Manoharan , kallanthottathil G. Rajeev , Muthusamy Jayaraman , David Butler , Jayaprakash K. Narayanannair , Martin Maier , Laxman Eltepu

IPC分类号： A61K39/12 , A61K47/08 , C07J41/00 , A61K47/28 , C07C211/22 , A61K47/16 , C07C211/21 , C07D211/72 , A61K47/22 , C07C251/78 , C07C279/12 , C07C271/12 , A61K48/00 , A61K31/713 , C12N5/00 , A61K39/39 , A61K39/00 , A61K39/02 , A61P37/04 , A61P31/12 , A61P31/04 , A61P33/00 , C07C49/203

CPC分类号： A61K47/44 , A61K9/1272 , A61K31/7088 , A61K31/713 , A61K39/00 , A61K39/39 , A61K47/10 , A61K47/18 , A61K47/20 , A61K47/28 , A61K2039/55555 , A61K2039/55561 , C07C229/08 , C07C229/30 , C07C237/16 , C07C251/38 , C07C251/78 , C07C271/12 , C07C271/20 , C07C323/25 , C07D203/10 , C07D317/28 , C07D317/44 , C07D317/46 , C07D317/72 , C07D319/06 , C07D405/12 , C07D491/056 , C07D491/113 , C12N15/111 , C12N15/113 , C12N2310/14 , C12N2310/3515 , C12N2320/32 , Y02A50/464

摘要： (A1) Translate this text The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ?-aminoalkyls, ?-(substituted)aminoalkyls, ?-phosphoalkyls, ?-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(0)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ?-aminoalkyl, ?-(substituted)aminoalky, ?-phosphoalkyl or ?-thiophosphoalkyl.

摘要翻译： （A1）翻译本发明本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3是H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代磷酸烷基酯，硫代磷酸烷基酯，磷酸二烷基酯，烷基膦酸酯，烷基胺，羟烷基，α-氨基烷基，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q）），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，α-氨基烷基，β-（取代）氨基烷基，α-磷酸烷基或α-硫代磷酰烷基。