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    METHOD FOR FABRICATING A MICROARRAY OF SOFT MATERIALS
    1.
    发明申请
    METHOD FOR FABRICATING A MICROARRAY OF SOFT MATERIALS 有权
    微软材料制作方法

    公开(公告)号：US20130136863A1

    公开(公告)日：2013-05-30

    申请号：US13814588

    申请日：2012-03-27

    申请人： Satoshi Hiyama ,  Kaori Kuribayashi ,  Hiroaki Onoe ,  Shoji Takeuchi

    发明人： Satoshi Hiyama ,  Kaori Kuribayashi ,  Hiroaki Onoe ,  Shoji Takeuchi

    IPC分类号： B05D1/32

    CPC分类号： B05D1/325 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00206 ,  C12N15/09 ,  G01N33/543 ,  G01N37/00

    摘要： A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.

    摘要翻译： 一种制备多种软材料的微阵列的方法包括：在基材上蒸镀第一层聚（对二甲苯）树脂，在聚（对二甲苯）树脂中形成第一微图案; 获得包括通过倾倒第一软质材料溶液形成的第一微阵列的基板，冷冻干燥第一软质材料以获得冷冻干燥的第一软质材料的微阵列基板; 在冷冻干燥的第一软质材料的微阵列基底上气相沉积第二层聚（对二甲苯）树脂，通过穿透聚（对二甲苯）树脂形成不同于第一微图案的第二微图案 的第一和第二层，通过倾倒第二软材料溶液在基底上形成第二微阵列; 以及通过剥离第一层和第二层的聚（对二甲苯）树脂，在基材上形成第一和第二软材料的微阵列。

    Method for fabricating a microarray of soft materials
    3.
    发明授权
    Method for fabricating a microarray of soft materials 有权
    软材料微阵列的制造方法

    公开(公告)号：US08999443B2

    公开(公告)日：2015-04-07

    申请号：US13814588

    申请日：2012-03-27

    申请人： Satoshi Hiyama ,  Kaori Kuribayashi ,  Hiroaki Onoe ,  Shoji Takeuchi

    发明人： Satoshi Hiyama ,  Kaori Kuribayashi ,  Hiroaki Onoe ,  Shoji Takeuchi

    IPC分类号： C23C16/00 ,  B05D1/32 ,  C12N15/09 ,  G01N37/00 ,  G01N33/543 ,  B81C1/00

    CPC分类号： B05D1/325 ,  B01J2219/00317 ,  B01J2219/00529 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00722 ,  B01J2219/00725 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00206 ,  C12N15/09 ,  G01N33/543 ,  G01N37/00

    摘要： A method for fabricating a microarray of plural soft materials includes: vapor-depositing a first layer poly(para-xylylene) resin on a substrate, forming a first micro pattern in the poly(para-xylylene) resin; obtaining a substrate including a first microarray formed by pouring a first soft material solution, freeze-drying the first soft material to obtain a micro-arrayed substrate of the freeze-dried first soft material; vapor-depositing a second layer poly(para-xylylene) resin on the micro-arrayed substrate of the freeze-dried first soft material, forming a second micro pattern placed differently from the first micro pattern by penetrating the poly(para-xylylene) resin of the first and second layers, forming a second microarray on the substrate by pouring a second soft material solution; and forming a microarray of the first and second soft materials on the substrate by peeling off the poly(para-xylylene) resin of the first and second layers.

    摘要翻译： 一种制备多种软材料的微阵列的方法包括：在基材上蒸镀第一层聚（对二甲苯）树脂，在聚（对二甲苯）树脂中形成第一微图案; 获得包括通过倾倒第一软质材料溶液形成的第一微阵列的基板，冷冻干燥第一软质材料以获得冷冻干燥的第一软质材料的微阵列基板; 在冷冻干燥的第一软质材料的微阵列基底上气相沉积第二层聚（对二甲苯）树脂，通过穿透聚（对二甲苯）树脂形成不同于第一微图案的第二微图案 的第一和第二层，通过倾倒第二软材料溶液在基底上形成第二微阵列; 以及通过剥离第一层和第二层的聚（对二甲苯）树脂，在基材上形成第一和第二软材料的微阵列。

    INSTRUMENT AND METHOD FOR TREATING MINOR AMOUNT OF BIOLOGICAL MATERIAL
    7.
    发明申请
    INSTRUMENT AND METHOD FOR TREATING MINOR AMOUNT OF BIOLOGICAL MATERIAL 审中-公开
    用于处理少量生物材料的仪器和方法

    公开(公告)号：US20100279398A1

    公开(公告)日：2010-11-04

    申请号：US12812332

    申请日：2009-01-09

    申请人： Shoji Takeuchi ,  Hiroaki Onoe

    发明人： Shoji Takeuchi ,  Hiroaki Onoe

    IPC分类号： C12N5/00 ,  C12M1/00

    CPC分类号： C12M25/08 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/5088 ,  B01L2200/0668 ,  B01L2300/0819

    摘要： Provided is a technique for handling a minor amount of a biological material with the purpose of observing selectively the interaction between single cells by controlling cell number and two- or three-dimensional configurations of each of the different cell types. The present invention provides an instrument and a method for handling a minor amount of a biological material. The instrument of the present invention for handling a minor amount of a biological material comprises a construct and a base, wherein: the base holds the construct in a releasable manner; the construct is held on a surface of the base in such a manner that a part of the construct is exposed externally on the outer face of the instrument; and at least a part of a surface of the constructs is exposed externally on the outer face of the instrument being fabricated so as to allow the adhesion of the minor amount of the biological material thereto.

    摘要翻译： 提供了一种用于处理少量生物材料的技术，其目的是通过控制每种不同细胞类型的细胞数量和二维或三维构型来选择性地观察单细胞之间的相互作用。 本发明提供了一种用于处理少量生物材料的仪器和方法。 用于处理少量生物材料的本发明的仪器包括构建体和基底，其中：所述基座以可释放的方式保持构造; 构造体以使得构件的一部分在仪器的外表面外部暴露的方式被保持在基座的表面上; 并且所述构造体的表面的至少一部分在外部暴露在被制造的器械的外表面上，以便允许少量的生物材料粘附到其上。

    Microchip for forming emulsion and method for manufacturing the same
    8.
    发明授权
    Microchip for forming emulsion and method for manufacturing the same 有权
    用于形成乳液的微粒及其制造方法

    公开(公告)号：US08398866B2

    公开(公告)日：2013-03-19

    申请号：US13525639

    申请日：2012-06-18

    申请人： Yutaka Ozawa ,  Ryoichi Ohigashi ,  Koji Fujimoto ,  Shoji Takeuchi

    发明人： Yutaka Ozawa ,  Ryoichi Ohigashi ,  Koji Fujimoto ,  Shoji Takeuchi

    IPC分类号： B01F5/08

    CPC分类号： B01F3/0807 ,  B01F5/0646 ,  B01F5/0653 ,  B01F13/0062 ,  Y10T137/87652

    摘要： A microchip for forming an emulsion has a first glass substrate, a second glass substrate and a silicon substrate. The silicon substrate has formed therein a first fluid flow path through which a first fluid flows and a second fluid flow path through which a second fluid that is not mixed with the first fluid flows. The first fluid flow path has a plurality of branched flow paths that join at a joint portion. The second fluid flow path communicates with the joint portion. The silicon substrate has formed therein an emulsion formation flow path that faces an edge portion of the second fluid flow path at the joint portion. An emulsion composed of the first fluid and the second fluid that is surrounded by the first fluid is formed in the emulsion formation flow path.

    摘要翻译： 用于形成乳液的微芯片具有第一玻璃基板，第二玻璃基板和硅基板。 硅衬底在其中形成有第一流体流过的第一流体流动路径和不与第一流体混合的第二流体流过的第二流体流动路径。 第一流体流动路径具有连接在接合部分处的多个分支流路。 第二流体流路与接合部连通。 硅衬底中形成有乳液形成流动路径，其在接合部分处面向第二流体流路的边缘部分。 在乳液形成流动路径中形成由第一流体和第一流体包围的由第一流体包围的乳液。

    Method of producing ice-candy in an ice-candy molding container
    9.
    发明授权
    Method of producing ice-candy in an ice-candy molding container 有权
    在冰糖成型容器中制造冰糖的方法

    公开(公告)号：US08263152B2

    公开(公告)日：2012-09-11

    申请号：US13048215

    申请日：2011-03-15

    申请人： Shoji Takeuchi

    发明人： Shoji Takeuchi

    IPC分类号： A23G9/00

    CPC分类号： A23G9/04 ,  A23G1/22 ,  A23G3/0031 ,  A23G3/0268 ,  A23G9/22 ,  A23G9/50

    摘要： An ice-candy forming container is provided which produces ice-candies having a complicated shape copying the face of a cartoon character or the like with higher quality and without a loss in shape. A forming container includes a first mold having a pattern portion formed in one face thereof, and a second mold configured to slide over and along the one face of the first mold, in a close contact relation, in directions designated by arrows A1-A2, so as to contain the first mold therein. In such a containing position, the second mold contacts externally and closely substantially an entire surface of the outer periphery of the pattern portion.

    摘要翻译： 提供了一种冰糖成型容器，其产生具有复杂形状的冰糖，以更高质量复制卡通人物等的面部，并且没有形状损失。 成形容器包括：第一模具，其具有形成在其一个面上的图案部分;以及第二模具，其被构造成沿着箭头A1-A2所示的方向以紧密接触的方式在第一模具的一个面上滑动， 以便容纳其中的第一模具。 在这种容纳位置中，第二模具在图案部分的外周的外表面附近大致接近。

    MICROCHIP FOR FORMING EMULSION AND METHOD FOR MANUFACTURING THE SAME
    10.
    发明申请
    MICROCHIP FOR FORMING EMULSION AND METHOD FOR MANUFACTURING THE SAME 有权
    用于形成乳液的微型成型机及其制造方法

    公开(公告)号：US20100027372A1

    公开(公告)日：2010-02-04

    申请号：US12507369

    申请日：2009-07-22

    申请人： Yutaka OZAWA ,  Ryoichi Ohigashi ,  Koji Fujimoto ,  Shoji Takeuchi

    发明人： Yutaka OZAWA ,  Ryoichi Ohigashi ,  Koji Fujimoto ,  Shoji Takeuchi

    IPC分类号： B01F13/00 ,  B01F5/06 ,  B32B37/12

    CPC分类号： B01F3/0807 ,  B01F5/0646 ,  B01F5/0653 ,  B01F13/0062 ,  Y10T137/87652

    摘要： A microchip for forming an emulsion has a first glass substrate, a second glass substrate and a silicon substrate. The silicon substrate has formed therein a first fluid flow path through which a first fluid flows and a second fluid flow path through which a second fluid that is not mixed with the first fluid flows. The first fluid flow path has a plurality of branched flow paths that join at a joint portion. The second fluid flow path communicates with the joint portion. The silicon substrate has formed therein an emulsion formation flow path that faces an edge portion of the second fluid flow path at the joint portion. An emulsion composed of the first fluid and the second fluid that is surrounded by the first fluid is formed in the emulsion formation flow path.

    摘要翻译： 用于形成乳液的微芯片具有第一玻璃基板，第二玻璃基板和硅基板。 硅衬底在其中形成有第一流体流过的第一流体流动路径和不与第一流体混合的第二流体流过的第二流体流动路径。 第一流体流动路径具有连接在接合部分处的多个分支流路。 第二流体流路与接合部连通。 硅衬底中形成有乳液形成流动路径，其在接合部分处面向第二流体流路的边缘部分。 在乳液形成流动路径中形成由第一流体和第一流体包围的由第一流体包围的乳液。