公开(公告)号：US06230992B1

公开(公告)日：2001-05-15

申请号：US09308484

申请日：1999-07-19

申请人： Stefan Arndt ,  Martin Maier ,  Jörg Heyse

发明人： Stefan Arndt ,  Martin Maier ,  Jörg Heyse

IPC分类号： B05B130

CPC分类号： F02M61/184 ,  B05B7/0815 ,  B05B7/0853 ,  B05B7/0892 ,  F02M61/186 ,  F02M69/047 ,  F02M2051/08

摘要： A perforated disk has a complete passage for a fluid and composed of an inlet opening, outlet openings, and at least one cavity positioned between them. The at least three functional plates of the perforated disk, each of which has a characteristic opening structure, are applied onto one another by electrodeposition (multilayer electroplating) so that the perforated disk is composed of a single piece. Gas supply openings through which a gas can be supplied in the direction of the fluid to be sprayed are located in the lower functional plate, thus providing very fine atomization of the fluid. The outlet openings are part of the gas supply openings. The perforated disk is especially suitable for use in injection valves for mixture-compressing internal combustion engines with externally supplied ignition.

摘要翻译： 多孔盘具有用于流体的完整通道并由入口开口，出口开口和位于它们之间的至少一个空腔组成。 通过电沉积（多层电镀）将具有特征开口结构的多孔板的至少三个功能板相互施加，使得多孔板由单件组成。 可以在待喷射流体的方向上供应气体的气体供应开口位于下部功能板中，从而提供非常细小的流体雾化。 出口是供气口的一部分。 多孔盘特别适合用于喷射阀，用于混合压缩内燃机与外部提供的点火。

公开(公告)号：US06736104B2

公开(公告)日：2004-05-18

申请号：US10312377

申请日：2003-03-21

申请人： Martin Maier ,  Günter Dantes ,  Detlef Nowak ,  Jörg Heyse

发明人： Martin Maier ,  Günter Dantes ,  Detlef Nowak ,  Jörg Heyse

IPC分类号： F02M6118

CPC分类号： F02M61/184 ,  F02B1/04 ,  F02B2075/125 ,  F02M51/0671 ,  F02M61/047 ,  F02M61/168 ,  F02M2200/06 ,  Y02T10/123

摘要： A fuel injector, for example, a high-pressure injection valve for the direct injection of fuel into a combustion chamber of an internal combustion engine having external ignition, which is distinguished in that an outlet orifice is provided downstream from the valve seat which, at its downstream end, has a slot-forming element that largely closes off the outlet orifice. Between the outlet orifice and a front face of the valve-seat member, the slot-forming element leaves open a slot-shaped flow outlet, through which a fuel spray may be spray-discharged in a fan-jet pattern.

摘要翻译： 燃料喷射器，例如用于将燃料直接喷射到具有外部点火的内燃机的燃烧室中的高压喷射阀，其特征在于，在阀座的下游设置有出口孔， 其下游端具有大致封闭出口孔的槽形元件。 在出口孔和阀座构件的前表面之间，槽形成元件离开开口的槽形流出口，燃料喷雾可以通过该出口形式以扇形喷射图案喷出。

公开(公告)号：US20080035130A1

公开(公告)日：2008-02-14

申请号：US10577801

申请日：2004-10-21

申请人： Stefan Arndt ,  Martin Maier ,  Joerg Heyse

发明人： Stefan Arndt ,  Martin Maier ,  Joerg Heyse

IPC分类号： F02M29/04

CPC分类号： F02M61/188 ,  F02M61/162 ,  F02M61/168 ,  F02M61/18

摘要： Known fuel injectors have a valve-closure member, which cooperates with a sealing seat of a valve seat, and a flow exit region situated downstream from the sealing seat, the fuel spray generated by the fuel injectors having an average droplet diameter that is not small enough for future regulations governing exhaust emission. In the fuel injector according to the present invention the atomization is improved in a simple manner and the average droplet diameter is reduced without additional auxiliary power. The projections which influence the fuel flow are situated in the flow exit region.

摘要翻译： 已知的燃料喷射器具有与阀座的密封座配合的阀关闭构件和位于密封座下游的流出口区域，由燃料喷射器产生的燃料喷雾具有不小的平均液滴直径 足够用于今后的废气排放法规。 在根据本发明的燃料喷射器中，以简单的方式改进了雾化，并且在没有额外的辅助动力的情况下平均液滴直径减小。 影响燃料流量的突起位于流出口区域。

公开(公告)号：US06902124B2

公开(公告)日：2005-06-07

申请号：US10088278

申请日：2001-07-13

申请人： Stefan Arndt ,  Werner Herden ,  Martin Maier ,  Guenther Hohl

发明人： Stefan Arndt ,  Werner Herden ,  Martin Maier ,  Guenther Hohl

IPC分类号： F02B75/12 ,  F02M45/08 ,  F02M51/06 ,  F02M61/16 ,  F02M61/18 ,  F02M61/20 ,  F02M59/00 ,  B05B1/30 ,  F02M39/00

CPC分类号： F02M61/182 ,  F02B2075/125 ,  F02M45/083 ,  F02M45/086 ,  F02M51/0671 ,  Y02T10/123

摘要： A fuel injector, in particular, an injector for fuel injection systems of internal combustion engines, having an actuator, which cooperates with a valve needle, has a first valve closure member that is arranged on the valve needle, the valve closure member cooperating with a first valve seat surface on a valve body forming a first sealing seat. A second valve closure member cooperates with a second valve seat surface in the valve seat body forming a second sealing seat. The valve needle, or the first valve closure member, has a limit stop, against which, after a partial stroke of the valve needle, a counter limit stop of the second valve closure member strikes, lifting the second valve closure member from the second sealing seat in response to a further stroke of the valve needle.

摘要翻译： 燃料喷射器，特别是用于内燃机的燃料喷射系统的喷射器，其具有与阀针配合的致动器，其具有布置在阀针上的第一阀关闭件，阀闭合件与 形成第一密封座的阀体上的第一阀座表面。 第二阀关闭构件与阀座主体中的第二阀座表面协作，形成第二密封座。 阀针或第一阀关闭构件具有限位挡块，在阀针的部分行程之后，第二阀关闭构件的反限位挡块撞击，极限止挡件将第二阀闭合构件从第二密封件 响应于阀针的进一步行程。

公开(公告)号：US09999673B2

公开(公告)日：2018-06-19

申请号：US13979336

申请日：2012-01-11

申请人： Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

发明人： Kallanthottathil G. Rajeev ,  Muthiah Manoharan ,  Muthusamy Jayaraman ,  Martin Maier ,  Jayaprakash K. Nair ,  David Butler

IPC分类号： A61K47/18 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D307/20 ,  C07D207/14 ,  C07D307/12 ,  C08G65/329 ,  A61K47/48

CPC分类号： A61K47/18 ,  A61K47/6911 ,  C07C235/06 ,  C07C271/16 ,  C07D207/12 ,  C07D207/14 ,  C07D307/12 ,  C07D307/20 ,  C08G65/329 ,  C08L2203/02

摘要： The invention provides poly(ethylene glycol)-lipid conjugates for use in drug delivery.

公开(公告)号：US09810189B2

公开(公告)日：2017-11-07

申请号：US13609694

申请日：2012-09-11

申请人： Martin Maier ,  Martin Goehner ,  Markus Feigl ,  Helmut Schneider ,  Nikolaus Hautmann ,  Dietmar Uhlenbrock ,  Holger Uhrig

发明人： Martin Maier ,  Martin Goehner ,  Markus Feigl ,  Helmut Schneider ,  Nikolaus Hautmann ,  Dietmar Uhlenbrock ,  Holger Uhrig

IPC分类号： F02M69/50 ,  F02M55/02

CPC分类号： F02M69/50 ,  F02M55/025 ,  F02M2200/25 ,  F02M2200/26 ,  F02M2200/315 ,  F02M2200/857

摘要： A fuel distributor, which is used, in particular, for fuel injection systems of mixture-compressing, internal combustion engines having externally supplied ignition, includes a distributor pipe, a first holder and at least one second holder. The distributor pipe has a longitudinal axis. In this connection, the first holder and the second holder are situated at the distributor pipe so as to be axially set apart from one another with respect to the longitudinal axis. The distributor pipe is designed to allow axial length compensation. It is also possible for at least one holder to be designed to allow axial length compensation.

公开(公告)号：US09325165B2

公开(公告)日：2016-04-26

申请号：US14344985

申请日：2011-09-16

申请人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

发明人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

IPC分类号： H02H5/04 ,  H02P29/00 ,  H02P29/02 ,  G01K7/01 ,  G01R19/165 ,  H02H7/085 ,  H02H3/08

CPC分类号： H02H5/047 ,  G01K7/01 ,  G01R19/16571 ,  H02H3/085 ,  H02H7/0852 ,  H02P29/027 ,  H02P29/68

摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.

摘要翻译： 公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。 为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接 当前路径。 第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。 第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

公开(公告)号：US08999351B2

公开(公告)日：2015-04-07

申请号：US13128287

申请日：2009-11-10

申请人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

发明人： Muthiah Manoharan ,  Kallanthottathil G. Rajeev ,  Muthusamy Jayaraman ,  David Butler ,  Jayaprakash K. Narayanannair ,  Martin Maier ,  Laxman Eltepu

IPC分类号： A61K39/12 ,  A61K9/127 ,  A61K39/00 ,  C12N15/11

CPC分类号： A61K47/44 ,  A61K9/1272 ,  A61K31/7088 ,  A61K31/713 ,  A61K39/00 ,  A61K39/39 ,  A61K47/10 ,  A61K47/18 ,  A61K47/20 ,  A61K47/28 ,  A61K2039/55555 ,  A61K2039/55561 ,  C07C229/08 ,  C07C229/30 ,  C07C237/16 ,  C07C251/38 ,  C07C251/78 ,  C07C271/12 ,  C07C271/20 ,  C07C323/25 ,  C07D203/10 ,  C07D317/28 ,  C07D317/44 ,  C07D317/46 ,  C07D317/72 ,  C07D319/06 ,  C07D405/12 ,  C07D491/056 ,  C07D491/113 ,  C12N15/111 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/3515 ,  C12N2320/32 ,  Y02A50/464

摘要： The present invention provides lipids that are advantageously used in lipid particles for the in vivo delivery of therapeutic agents to cells. In particular, the invention provides lipids having the following structure (I) wherein R1 and R2 are each independently for each occurrence optionally substituted C10-C30 alkyl, optionally substituted C10-C30 alkenyl, optionally substituted C10-C30 alkynyl, optionally substituted C10-C30 acyl, or -linker-ligand; R3 is H, optionally substituted C1-C10 alkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, alkylhetrocycle, alkylphosphate, alkylphosphorothioate, alkylphosphorodithioate, alkylphosphonates, alkylamines, hydroxyalkyls, ω-aminoalkyls, ω-(substituted)aminoalkyls, ω-phosphoalkyls, ω-thiophosphoalkyls, optionally substituted polyethylene glycol (PEG, mw 100-40K), optionally substituted mPEG (mw 120-40K), heteroaryl, heterocycle, or linker-ligand; E is O, S, N(Q), C(O), N(Q)C(O), C(O)N(Q), (Q)N(CO)O, O(CO)N(Q), S(O), NS(O)2N(Q), S(O)2, N(Q)S(O)2, SS, O═N, aryl, heteroaryl, cyclic or heterocycle; and, Q is H, alkyl, ω-aminoalkyl, ω-(substituted)aminoalky, ω-phosphoalkyl or ω-thiophosphoalkyl.

摘要翻译： 本发明提供有利地用于脂质颗粒以用于体内递送治疗剂至细胞的脂质。 特别地，本发明提供具有以下结构（I）的脂质，其中R1和R2各自独立地为任何取代的C 10 -C 30烷基，任选取代的C 10 -C 30烯基，任选取代的C 10 -C 30炔基，任选取代的C 10 -C 30 酰基或 - 连接子 - 配体; R 3为H，任选取代的C 1 -C 10烷基，任选取代的C 2 -C 10烯基，任选取代的C 2 -C 10炔基，烷基硫代烷基磷酸酯，烷基硫代磷酸酯，烷基二硫代磷酸酯，烷基膦酸酯，烷基胺，羟基烷基，ω-氨基烷基，ω-（取代的）氨基烷基， ω-磷酸烷基酯，ω-硫代磷酰基烷基酯，任选取代的聚乙二醇（PEG，mw 100-40K），任选取代的mPEG（mw 120-40K），杂芳基，杂环或连接基 - 配体; E是O，S，N（Q），C（O），N（Q）C（O），C（O）N（Q），（Q） ），S（O），NS（O）2N（Q），S（O）2，N（Q）S（O）2，SS，O = N，芳基，杂芳基，环状或杂环; Q为H，烷基，ω-氨基烷基，ω-（取代）氨基烷基，ω-磷酸烷基或ω-硫代磷酰基烷基。

公开(公告)号：US20140375301A1

公开(公告)日：2014-12-25

申请号：US14344985

申请日：2011-09-16

申请人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

发明人： Klaus Behringer ,  Martin Maier ,  Klaus Pfitzner ,  Bernhard Rösch

IPC分类号： H02H5/04 ,  G01K7/01 ,  G01R19/165

CPC分类号： H02H5/047 ,  G01K7/01 ,  G01R19/16571 ,  H02H3/085 ,  H02H7/0852 ,  H02P29/027 ,  H02P29/68

摘要： A device is disclosed for protecting a consumer, with a first current path having two lines, and a monitoring arrangement for detecting an imminent overload of the electrical consumer. In order to enable the detection of an imminent overload of a consumer, it is proposed that the monitoring arrangement includes a first temperature measuring unit, an evaluation unit and a first measuring element, which establishes an electrically conductive connection between the two lines of the first current path. The first temperature measuring unit is electrically isolated from the first measuring element and includes a first and a second temperature sensor. The first and second temperature sensor of the first temperature measuring unit are configured to simultaneously record a temperature of the first measuring element and the evaluation unit is configured to detect an imminent overload of the consumer based upon the recorded temperatures of the first temperature measuring unit.

摘要翻译： 公开了一种用于保护消费者的装置，其中具有两条线路的第一电流路径以及用于检测电消费者即将发生的过载的监视装置。 为了能够检测到消费者即将发生的过载，建议监视装置包括第一温度测量单元，评估单元和第一测量元件，该第一测量单元，第一测量单元在第一和第二测量单元的两条线之间建立导电连接 当前路径。 第一温度测量单元与第一测量元件电隔离并且包括第一和第二温度传感器。 第一温度测量单元的第一温度传感器和第二温度传感器被配置为同时记录第一测量元件的温度，并且评估单元被配置为基于第一温度测量单元的记录温度来检测消费者即将发生的过载。

公开(公告)号：US20130017223A1

公开(公告)日：2013-01-17

申请号：US13516335

申请日：2010-12-17

申请人： Michael J Hope ,  Thomas D. Madden ,  Pieter R. Cullis ,  Martin Maier ,  Muthusamy Jayaraman ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Muthiah Manoharan

发明人： Michael J Hope ,  Thomas D. Madden ,  Pieter R. Cullis ,  Martin Maier ,  Muthusamy Jayaraman ,  Kallanthottathil G. Rajeev ,  Akin Akinc ,  Muthiah Manoharan

IPC分类号： A61K47/24 ,  A61K47/28 ,  A61P37/04 ,  A61K31/713 ,  C12N5/071 ,  C12N15/85 ,  A61K31/7088 ,  A61K31/7105

CPC分类号： A61K47/543 ,  A61K9/1272 ,  A61K47/6911 ,  C12N15/88

摘要： A lipid particle can include a plurality of cationic lipids, such as a first cationic lipid and a second cationic lipid. The first cationic lipid can be selected on the basis of a first property and the second cationic can be selected on the basis of a second property. The first and second properties are complementary. The attributes of the lipid particle can reflect the selected properties of the cationic lipids, and the complementary nature of those properties.

摘要翻译： 脂质颗粒可以包括多个阳离子脂质，例如第一阳离子脂质和第二阳离子脂质。 可以基于第一性质选择第一阳离子脂质，并且可以基于第二性质选择第二阳离子脂质。 第一和第二属性是互补的。 脂质颗粒的属性可以反映阳离子脂质的选择性质，以及这些性质的互补性质。