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    Whole proteome tiling microarrays
    1.
    发明授权
    Whole proteome tiling microarrays 有权
    全蛋白质组织微阵列

    公开(公告)号：US08658572B2

    公开(公告)日：2014-02-25

    申请号：US13419197

    申请日：2012-03-13

    申请人： Tom Albert ,  Todd Richmond ,  Matthew Rodesch ,  Klaus-Peter Stengele ,  Jochen Bühler

    发明人： Tom Albert ,  Todd Richmond ,  Matthew Rodesch ,  Klaus-Peter Stengele ,  Jochen Bühler

    IPC分类号： C40B40/10

    CPC分类号： G01N33/6842 ,  C07K1/047 ,  G01N33/6845 ,  G01N2570/00

    摘要： The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.

    摘要翻译： 本发明涉及包含至少50,000个寡肽特征/ cm 2的微阵列，其中寡肽特征表示至少50％，60％，70％，80％，90％，95％，99％或100％的蛋白质组 病毒或有机体。 本发明还涉及用于合成这种微阵列的方法和使用每cm 2包含至少50,000个寡肽特征的微阵列的方法。 在本发明的一个实施方案中，寡肽特征表示在相同物种中表达的蛋白质，其中寡肽特征呈现代表在物种中表达的至少约5,000至至少约25,000个蛋白质的平铺图案。 在一些实施方案中，寡肽微阵列特征表示在相同物种中表达的蛋白质，其中微阵列特征以表示至少约5,000至至少约50,000个表达的蛋白质的平铺图案存在。

    WHOLE PROTEOME TILING MICROARRAYS
    2.
    发明申请
    WHOLE PROTEOME TILING MICROARRAYS 有权
    全面保护倾斜微波

    公开(公告)号：US20120245057A1

    公开(公告)日：2012-09-27

    申请号：US13419197

    申请日：2012-03-13

    申请人： Tom Albert ,  Todd Richmond ,  Matthew Rodesch ,  Klaus-Peter Stengele ,  Jochen Buhler

    发明人： Tom Albert ,  Todd Richmond ,  Matthew Rodesch ,  Klaus-Peter Stengele ,  Jochen Buhler

    IPC分类号： C40B40/10 ,  C40B50/18

    CPC分类号： G01N33/6842 ,  C07K1/047 ,  G01N33/6845 ,  G01N2570/00

    摘要： The present invention relates to a microarray comprising at least 50,000 oligopeptide features per cm2 where the oligopeptide features represent at least 50%, 60%, 70%, 80%, 90%, 95%, 99%, or 100% of the proteome of a virus or an organism. The present invention further relates to methods for the synthesis of such microarrays and methods of using microarrays comprising at least 50,000 oligopeptide features per cm2. In an embodiment of the invention, the oligopeptide features represent proteins expressed in the same species, wherein the oligopeptide features are presented in a tiling pattern representing at least about 5,000 to-at least about 25,000 proteins expressed in a species. In some embodiments, the oligopeptide microarray features represent proteins expressed in the same species, wherein the microarray features are present in a tiling pattern that represents at least about 5,000 to at least about 50,000 expressed proteins.

    摘要翻译： 本发明涉及包含至少50,000个寡肽特征/ cm 2的微阵列，其中寡肽特征表示至少50％，60％，70％，80％，90％，95％，99％或100％的蛋白质组 病毒或有机体。 本发明还涉及用于合成这种微阵列的方法和使用每cm 2包含至少50,000个寡肽特征的微阵列的方法。 在本发明的一个实施方案中，寡肽特征表示在相同物种中表达的蛋白质，其中寡肽特征呈现代表在物种中表达的至少约5,000至至少约25,000个蛋白质的平铺图案。 在一些实施方案中，寡肽微阵列特征表示在相同物种中表达的蛋白质，其中微阵列特征以表示至少约5,000至至少约50,000个表达的蛋白质的平铺图案存在。