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    SYSTEM AND METHOD FOR RANKING BACTERIAL ACTIVITY LEADING TO TOOTH AND GUM DISEASE
    4.
    发明申请
    SYSTEM AND METHOD FOR RANKING BACTERIAL ACTIVITY LEADING TO TOOTH AND GUM DISEASE 审中-公开

    公开(公告)号：US20190328234A1

    公开(公告)日：2019-10-31

    申请号：US16344728

    申请日：2017-10-27

    申请人： University of Washington

    发明人： Eric J. Seibel ,  Yuanzheng Gong ,  Zheng Xu ,  Jeffrey S. McLean ,  Yaxuan Zhou

    IPC分类号： A61B5/00 ,  A61B5/145 ,  A61C19/06

    摘要： A system for the optical measurement of pH includes a light emitter to emit an excitation light, and a detector coupled to receive florescence light produced by a compound in a mouth of a patient in response to the excitation light. A controller is coupled to the detector, and the controller includes logic that when executed by the controller, causes the system to perform operations. The operations may include emitting the excitation light from the light emitter; measuring an intensity of the florescence light emitted from a surface of individual teeth in a plurality of teeth in the mouth; and determining, based on the intensity of the florescence light, one or more locations on the individual teeth likely to develop demineralization.

    Extended depth of focus for high-resolution optical image scanning
    7.
    发明授权
    Extended depth of focus for high-resolution optical image scanning 有权

    公开(公告)号：US11330170B2

    公开(公告)日：2022-05-10

    申请号：US16708728

    申请日：2019-12-10

    申请人： University of Washington through its Center for Commercialization

    发明人： Eric J. Seibel ,  Brian T. Schowengerdt

    IPC分类号： H04N5/232 ,  G02B23/24 ,  G02B23/26 ,  G02B27/40 ,  A61B1/06 ,  A61B1/07 ,  G02B26/10 ,  A61B1/00 ,  G03B21/14

    摘要： Methods and systems for acquiring and/or projecting images from and/or to a target area are provided. Such a method or system can include an optical fiber assembly which may be driven to scan the target area in a scan pattern. The optical fiber assembly may provide multiple effective light sources (e.g., via a plurality of optical fibers) that are axially staggered with respect to an optical system located between the optical fiber and the target area. The optical system may be operable to focus and/or redirect the light from the multiple light sources onto separate focal planes. A composite image may be generated based on light reflected from and/or projected onto the separate focal planes. The composite image may have an extended depth of focus or field spanning over a distance between the separate focal planes while maintaining or improving image resolution.

    Dental demineralization detection, methods and systems
    8.
    发明授权
    Dental demineralization detection, methods and systems 有权

    公开(公告)号：US10888230B2

    公开(公告)日：2021-01-12

    申请号：US15868623

    申请日：2018-01-11

    申请人： University of Washington through its Center for Commercialization

    发明人： Eric J. Seibel ,  Leonard Y. Nelson

    IPC分类号： A61B5/00 ,  G01J3/02 ,  G01J3/06 ,  G01J3/44 ,  G01J3/10 ,  G01N21/64 ,  A61B1/00 ,  A61B1/015 ,  A61B1/07 ,  A61B1/247 ,  A61C19/04

    摘要： Methods and systems for detecting early stage dental caries and decays are provided. In particular, in an embodiment, laser-induced autofluorescence (AF) from multiple excitation wavelengths is obtained and analyzed. Endogenous fluorophores residing in the enamel naturally fluoresce when illuminated by wavelengths ranging from ultraviolet into the visible spectrum. The relative intensities of the AF emission changes between different excitation wavelengths when the enamel changes from healthy to demineralized. By taking a ratio of AF emission spectra integrals between different excitation wavelengths, a standard is created wherein changes in AF ratios within a tooth are quantified and serve as indicators of early stage enamel demineralization. The techniques described herein may be used in conjunction with a scanning fiber endoscope (SFE) to provide a reliable, safe and low-cost means for identifying dental caries or decays.

    Catheterscope 3D guidance and interface system
    10.
    发明授权
    Catheterscope 3D guidance and interface system 有权
    导管3D引导和界面系统

    公开(公告)号：US09554729B2

    公开(公告)日：2017-01-31

    申请号：US14951279

    申请日：2015-11-24

    申请人： University of Washington

    发明人： Timothy D. Soper ,  Robb W. Glenny ,  Eric J. Seibel

    IPC分类号： A61B1/04 ,  A61B1/00 ,  A61B5/06 ,  A61B1/267 ,  A61B1/005 ,  A61B1/07 ,  A61B5/08 ,  A61B5/00 ,  A61B6/00 ,  A61B19/00

    CPC分类号： A61B5/066 ,  A61B1/00009 ,  A61B1/00016 ,  A61B1/00045 ,  A61B1/0008 ,  A61B1/00172 ,  A61B1/005 ,  A61B1/04 ,  A61B1/07 ,  A61B1/2676 ,  A61B5/06 ,  A61B5/062 ,  A61B5/065 ,  A61B5/08 ,  A61B5/0816 ,  A61B5/7285 ,  A61B6/541 ,  A61B34/20 ,  A61B2034/2051 ,  A61B2090/3762

    摘要： Visual-assisted guidance of an ultra-thin flexible endoscope to a predetermined region of interest within a lung during a bronchoscopy procedure. The region may be an opacity-identified by non-invasive imaging methods, such as high-resolution computed tomography (HRCT) or as a malignant lung mass that was diagnosed in a previous examination. An embedded position sensor on the flexible endoscope indicates the position of the distal tip of the probe in a Cartesian coordinate system during the procedure. A visual display is continually updated, showing the present position and orientation of the marker in a 3-D graphical airway model generated from image reconstruction. The visual display also includes windows depicting a virtual fly-through perspective and real-time video images acquired at the head of the endoscope, which can be stored as data, with an audio or textual account.

    摘要翻译： 在支气管镜检查过程期间，将超薄柔性内窥镜视觉辅助引导到肺内的预定感兴趣区域。 该区域可以是通过非侵入性成像方法识别的不透明度，例如高分辨率计算机断层摄影（HRCT）或作为在以前检查中诊断的恶性肺肿块。 柔性内窥镜上的嵌入式位置传感器在手术过程中指示探针的远端在笛卡尔坐标系中的位置。 视觉显示不断更新，显示了从图像重建产生的3-D图形气道模型中的标记的当前位置和方向。 视觉显示还包括描绘虚拟透视透视图和在内窥镜头部处获取的实时视频图像的窗口，其可以作为数据存储，具有音频或文本帐户。