公开(公告)号：US09829470B2

公开(公告)日：2017-11-28

申请号：US14898272

申请日：2014-06-17

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Martin Gilar ,  Bernard Bunner

IPC: G01N30/20 ,  G01N30/86 ,  G01N30/60 ,  G01N30/02

CPC classification number: G01N30/8668 ,  G01N30/6095 ,  G01N30/8665 ,  G01N2030/027

Abstract: Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.

公开(公告)号：US09764323B2

公开(公告)日：2017-09-19

申请号：US14489855

申请日：2014-09-18

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Martin Gilar ,  Robert A. Jencks ,  Charles T. Murphy

IPC: B01L3/00 ,  G01N30/60

CPC classification number: B01L3/502753 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N30/603 ,  G01N30/6095

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

公开(公告)号：US10583436B2

公开(公告)日：2020-03-10

申请号：US15702007

申请日：2017-09-12

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Martin Gilar ,  Robert A. Jencks ,  Charles T. Murphy

IPC: G01N30/60 ,  G01N30/50 ,  B01D15/08 ,  B01L3/00

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

公开(公告)号：US20170038350A1

公开(公告)日：2017-02-09

申请号：US15231302

申请日：2016-08-08

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Theodore A. Dourdeville

IPC: G01N30/72 ,  B23K20/02 ,  B23H9/12 ,  C23F1/14 ,  B23H9/14 ,  B23K26/382 ,  B23B35/00 ,  C23C16/44 ,  G01N30/60 ,  C23C26/00

CPC classification number: G01N30/7266 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B23B35/00 ,  B23H9/12 ,  B23H9/14 ,  B23K20/023 ,  B23K20/233 ,  B23K26/382 ,  B23K2101/18 ,  B23K2103/14 ,  C23C16/44 ,  C23C26/00 ,  C23F1/14 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167

Abstract: A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.

Abstract translation: 用于通过色谱分离样品的微流体装置包括连接在一起的扩散接合的金属片，以在每个相邻的金属片之间形成气密密封的界面，而不引入次级材料。 封隔在扩散接合片内的是可由入口或出口中的至少一个接近的分离通道。 分离通道用色谱分离中用作固定相的微米级颗粒填充。 分离通道的接液表面包括至少一层单层厚的有机材料的涂层。

公开(公告)号：US20160139095A1

公开(公告)日：2016-05-19

申请号：US14898272

申请日：2014-06-17

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： Geoff C. Gerhardt ,  Martin Gilar ,  Bernard Bunner

IPC: G01N30/86

CPC classification number: G01N30/8668 ,  G01N30/6095 ,  G01N30/8665 ,  G01N2030/027

Abstract: Provided are systems and methods for adapting to volume variations in microfluidic chromatography columns. A column is calibrated by comparing a parameter of the column with a same parameter of a reference column and generating, by a processor, an adjustment factor in response to the comparison between the parameter of the column with a same parameter of the reference column. Volume differences between the calibrated column and the reference column are compensated for by integrating the generated adjustment factor into a sample separation involving the calibrated column.

Abstract translation: 提供了适应微流体色谱柱体积变化的系统和方法。 通过将列的参数与参考列的相同参数进行比较来校准列，并且响应于列的参数与参考列的相同参数之间的比较，由处理器生成调整因子。 通过将生成的调整因子整合到涉及校准柱的样品分离中来补偿校准柱和参考柱之间的体积差异。

公开(公告)号：US20160082435A1

公开(公告)日：2016-03-24

申请号：US14489855

申请日：2014-09-18

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Martin Gilar ,  Robert A. Jencks ,  Charles T. Murphy

IPC: B01L3/00

CPC classification number: B01L3/502753 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/502746 ,  B01L2200/027 ,  B01L2300/0681 ,  B01L2400/0487 ,  B01L2400/086 ,  G01N30/603 ,  G01N30/6095

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

Abstract translation: 结合本公开的教导的系统可以包括例如包括获得包含具有第一形状和初始孔隙率分布的多孔材料的多孔介质的方法。 多孔介质与流体装置中的空腔接合，其中空腔与流体装置的通道流体连通。 可以将多孔材料的第一形状调节到第二形状，从而将初始孔隙率分布调整到目标孔隙率分布。 这种调节可以通过将多孔介质与空腔接合，通过在插入空腔之前预先调节多孔介质的形状，或通过其一些组合来实现。 公开了其他实施例。

公开(公告)号：US20190234915A1

公开(公告)日：2019-08-01

申请号：US16382083

申请日：2019-04-11

Applicant: Waters Technologies Corporation

Inventor： Geoff C. Gerhardt ,  Keith Fadgen ,  Joseph D. Michienzi ,  Bernard Bunner

IPC: G01N30/38 ,  B01L3/00 ,  F04D15/00 ,  F04D29/08 ,  G01N30/20 ,  F16K99/00

CPC classification number: G01N30/38 ,  B01L3/502715 ,  B01L3/502738 ,  B01L3/567 ,  B01L2200/0689 ,  B01L2400/0622 ,  B01L2400/0644 ,  F04D15/00 ,  F04D29/086 ,  F16K99/0013 ,  G01N30/20 ,  G01N2030/202

Abstract: A method may include reducing fluid flow between a rotor and a microfluidic device. The method may further include reducing a sealing force between the rotor and the microfluidic device. The method may also include rotating the rotor relative to the microfluidic device, at the reduced sealing force, to change a fluid pathway therebetween. The method may additionally include reestablishing the sealing force to produce a fluid tight seal between the rotor and the microfluidic device. Moreover, the method may include reestablishing the fluid flow between the rotor and the microfluidic device.

公开(公告)号：US20180021779A1

公开(公告)日：2018-01-25

申请号：US15702007

申请日：2017-09-12

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Martin Gilar ,  Robert A. Jencks ,  Charles T. Murphy

IPC: B01L3/00 ,  G01N30/60

Abstract: A system that incorporates teachings of the subject disclosure may include, for example, a process that includes obtaining a porous medium comprising a porous material having a first shape and an initial porosity profile. The porous medium is engaged with a cavity in a fluidic device, wherein the cavity is in fluid communication with a channel of the fluidic device. The first shape of the porous material can be adjusted to a second shape resulting in the initial porosity profile being adjusted to a target porosity profile. Such adjustment can be accomplished by the engaging of the porous medium with the cavity, by pre-adjusting a shape of the porous media before insertion into the cavity, or by some combination thereof. Other embodiments are disclosed.

公开(公告)号：US20160169843A1

公开(公告)日：2016-06-16

申请号：US15050929

申请日：2016-02-23

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Geoff C. Gerhardt ,  Theodore A. Dourdeville

IPC: G01N30/32 ,  G01L9/00 ,  B01L3/00 ,  G01N30/36

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/082 ,  B01L2400/086 ,  G01L9/0026 ,  G01L9/0042 ,  G01L9/0055 ,  G01L13/02 ,  G01L13/025 ,  G01L15/00 ,  G01L19/0023 ,  G01N30/00 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/326 ,  G05D7/0676 ,  Y10T137/7762 ,  B01D15/40

Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.

公开(公告)号：US09952186B2

公开(公告)日：2018-04-24

申请号：US15050929

申请日：2016-02-23

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Geoff C. Gerhardt ,  Theodore A. Dourdeville

IPC: G01L13/02 ,  G01N30/32 ,  B01L3/00 ,  G01N30/34 ,  G01N30/00 ,  G01L15/00 ,  G01L19/00 ,  G05D7/06 ,  G01N30/36 ,  G01L9/00 ,  B01D15/16

CPC classification number: G01N30/32 ,  B01D15/163 ,  B01L3/502746 ,  B01L2200/0605 ,  B01L2200/146 ,  B01L2300/0663 ,  B01L2300/0867 ,  B01L2300/0883 ,  B01L2300/14 ,  B01L2400/0487 ,  B01L2400/082 ,  B01L2400/086 ,  G01L9/0026 ,  G01L9/0042 ,  G01L9/0055 ,  G01L13/02 ,  G01L13/025 ,  G01L15/00 ,  G01L19/0023 ,  G01N30/00 ,  G01N30/34 ,  G01N30/36 ,  G01N2030/326 ,  G05D7/0676 ,  Y10T137/7762 ,  B01D15/40

Abstract: Flow through pressure sensors for use in fluid chromatography systems include a planar device formed from diffusion bonding of a plurality of metallic sheets and at least one sensing element. The planar device has a top surface, a bottom surface and a flow through channel. A diaphragm formed from a portion of one of the top or bottom surfaces is located adjacent to a sensing region of the flow through channel and is attached to the sensing element. The diaphragm is sized to deflect a distance in response to fluid pressure in the sensing region, which has an internal volume of less than about 25 microliters. The diaphragm and attached sensing element form a pressure sensor that measures strain or deflection of the diaphragm to calculate a pressure within the sensing region.