公开(公告)号：US20240252624A1

公开(公告)日：2024-08-01

申请号：US18000357

申请日：2021-06-16

申请人： Teshome MEBATSION ,  BOEHRINGER INGELHEIM ANIMAL HEALTH USA INC.

发明人： Teshome Mebatsion ,  Aemro Kassa

IPC分类号： A61K39/295 ,  A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  A61K39/17 ,  A61K39/255 ,  A61P31/14 ,  A61P31/16 ,  A61P31/22 ,  C07K14/005 ,  C12N15/86

CPC分类号： A61K39/295 ,  A61K39/12 ,  A61K39/145 ,  A61K39/17 ,  A61K39/255 ,  A61P31/14 ,  A61P31/16 ,  A61P31/22 ,  C07K14/005 ,  C12N15/86 ,  A61K2039/5256 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16334 ,  C12N2710/16343 ,  C12N2720/10022 ,  C12N2720/10034 ,  C12N2760/16122 ,  C12N2760/16134 ,  C12N2760/18122 ,  C12N2760/18134

摘要： Recombinant viral vectors and compositions that include them for use as vehicles to induce an immunological response. Multivalent viral vectors may be used in compositions or vaccines containing one or more recombinant viral vectors for protection against a variety of pathogens. Formation of these viral vectors may include insertion and expression of foreign genes to protect against a variety of pathogens. Further provided are methods of making and using the recombinant viral vectors, as well as immunogenic compositions that include the vectors and/or antigens. In particular, immunogenic compositions may include recombinant viral vectors such as vHVT509, vHVT522, and/or vHVT523.

公开(公告)号：US20240181477A1

公开(公告)日：2024-06-06

申请号：US18418467

申请日：2024-01-22

申请人： Boehringer Ingelheim Animal Health USA Inc.

发明人： Christopher Davis Leslie ,  Ludovic Porcher

IPC分类号： B05B3/10 ,  A01K45/00 ,  A61D1/02 ,  A61K9/00 ,  A61K9/06 ,  A61K35/00 ,  A61K35/741 ,  A61K39/00 ,  A61K39/17 ,  A61K39/215 ,  A61M11/00 ,  B01F23/213 ,  B01F35/32 ,  B01F101/00 ,  B05B1/28 ,  B05B7/24 ,  B05B9/08 ,  C12N7/00

CPC分类号： B05B3/1014 ,  A01K45/00 ,  A61D1/025 ,  A61K9/0073 ,  A61K9/06 ,  A61K35/741 ,  A61K39/17 ,  A61K39/215 ,  B01F23/21311 ,  B01F35/32025 ,  B05B1/28 ,  B05B3/105 ,  B05B3/1092 ,  B05B7/2416 ,  B05B7/2478 ,  B05B9/085 ,  B05B9/0894 ,  C12N7/00 ,  A61K2035/115 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/552 ,  A61M11/00 ,  B01F2101/2202 ,  C12N2760/18134 ,  C12N2760/18171 ,  C12N2770/20034 ,  C12N2770/20071

摘要： The disclosure relates to an extended-range spray applicator, and methods of making and use thereof, for dosing vaccines and/or probiotics to avian animals at a distance.

公开(公告)号：US11883481B2

公开(公告)日：2024-01-30

申请号：US17823566

申请日：2022-08-31

申请人： Zoetis Services LLC

发明人： Sing Rong ,  Yugang Luo ,  Tyler Brown

IPC分类号： A61K39/12 ,  A61P37/04 ,  A61P31/20 ,  A61P31/14 ,  A61K39/17 ,  C12N7/00 ,  C12N15/86 ,  A61K39/00

CPC分类号： A61K39/12 ,  A61K39/17 ,  A61P31/14 ,  A61P31/20 ,  A61P37/04 ,  C12N7/00 ,  C12N15/86 ,  A61K2039/53 ,  A61K2039/54 ,  A61K2039/552 ,  C12N2710/16021 ,  C12N2710/16034 ,  C12N2710/16043 ,  C12N2720/10021 ,  C12N2720/10034 ,  C12N2760/18121 ,  C12N2760/18134 ,  C12N2830/50

摘要： The invention relates to recombinant viral vectors for the insertion and expression of foreign genes for use in safe immunizations to protect against a variety of pathogens. The invention also relates to multivalent compositions or vaccine comprising one or more recombinant viral vectors for protection against a variety of pathogens. The present invention relates to methods of making an using said recombinant viral vectors.

公开(公告)号：US20230372467A1

公开(公告)日：2023-11-23

申请号：US18320558

申请日：2023-05-19

申请人： Phibro Animal Health Corporation ,  VTT Technical Research Centre of Finland Ltd. ,  Dyadic International (USA), Inc.

发明人： Andriy Kovalchuk ,  Avi Zrachya ,  Avner Finger ,  Noelia Valbuena ,  Ronen Tchelet ,  Markku Saloheimo

IPC分类号： A61K39/17 ,  C12N15/80 ,  C12N1/14

CPC分类号： A61K39/17 ,  C12N15/80 ,  C12N1/145 ,  C12N2800/108 ,  A61K2039/5252

摘要： The present disclosure concerns using transgenic fungus to express recombinant viral antigens. The composition, production, and administration of vaccines comprising those viral antigens also are disclosed. In some embodiments, these viral antigens can be used to formulate a vaccine against Newcastle Disease. These vaccines can be administered, for example, via intramuscular injection.

公开(公告)号：US20220396809A1

公开(公告)日：2022-12-15

申请号：US17831894

申请日：2022-06-03

申请人： University of Guelph

发明人： Sarah Wootton ,  Leonardo Susta ,  Byram Bridle ,  Pierre Major ,  Lisa Santry ,  Yanlong Pei

IPC分类号： C12N15/86 ,  C07K14/005 ,  A61K39/17 ,  A61K39/215 ,  A61P35/00 ,  A61P31/14

摘要： An engineered Newcastle Disease Virus (NDV) vector is provided. In particular, the present disclosure provides methods of treating or preventing a disease such as cancer, or an infectious disease, or methods for eliciting an immune response, with the engineered NDV vector. The engineered NDV vector provided herein is useful as an immunogenic composition, an oncolytic agent, or a vaccine.

公开(公告)号：US20220265811A1

公开(公告)日：2022-08-25

申请号：US17754280

申请日：2020-07-14

申请人： PULIKE BIOLOGICAL ENGINEERING, INC.

发明人： Kegong Tian ,  Mengyue Wang ,  Wujie Liu ,  Xuke Zhang

IPC分类号： A61K39/145 ,  A61K39/17 ,  A61K39/215 ,  A61K39/235 ,  A61K39/39 ,  A61P31/20

摘要： The present disclosure provides a tFiber protein fragment of avian egg drop syndrome virus, wherein the gene that encoded the tFiber protein fragment of avian egg drop syndrome virus has a nucleotide sequence shown in SEQ ID NO. 2 or a degenerate sequence thereof, and a vaccine composition prepared from the protein fragment. The fragment has good immunogenicity and is capable of preparing combined vaccine with various antigens, producing complete protection to the chickens and ducks.

公开(公告)号：US11285206B2

公开(公告)日：2022-03-29

申请号：US17234795

申请日：2021-04-20

申请人： INSTITUTE OF ANIMAL HUSBANDRY AND VETERINARY SCIENCES, HUBEI ACADEMY OF AGRICULTURAL SCIENCES

发明人： Guoyuan Wen ,  Li Li ,  Yu Shang ,  Huabin Shao ,  Qingping Luo ,  Honglin Wang ,  Ling Luo ,  Rongrong Zhang ,  Hongcai Wang ,  Tengfei Zhang ,  Wenting Zhang ,  Qin Lu

IPC分类号： C12N7/00 ,  A61K39/17 ,  A61K35/763

摘要： A heat-resistant recombinant Newcastle Disease Virus vaccine strain rLS-tFib2-C capable of expressing truncated Fiber 2 protein of fowl adenovirus serotype 4 has been preserved at the China Center for Type Culture Collection, Wuhan University, Wuhan, China with the preservation number of CCTCC No. V202042.

公开(公告)号：US20210386840A1

公开(公告)日：2021-12-16

申请号：US17141142

申请日：2021-01-04

申请人： City of Hope

发明人： Xiuli Wang ,  Stephen J. Forman ,  Don J. Diamond

IPC分类号： A61K39/00 ,  C07K14/705 ,  C12N5/0783 ,  C07K16/28 ,  A61K39/17 ,  A61K39/12 ,  A61K35/17 ,  C07K14/725 ,  A61P35/00 ,  A61K39/245 ,  C07K14/71

摘要： T cells expressing a chimeric antigen receptor and a T cell receptor specific for CMV (bi-specific T cells) are described as a methods for using such cells in immunotherapy. In the immunotherapy methods, the recipient can be exposed to a CMV vaccine in order to expand and/or stimulate the be-specific T cells.

公开(公告)号：US11103573B2

公开(公告)日：2021-08-31

申请号：US16309216

申请日：2017-05-31

申请人： Zoetis Services LLC

发明人： Carla Maria Batista de Freitas ,  Maria Carolina Ferreira dos Santos ,  Paul Joseph Dominowski ,  Harmen Jacob Geerligs

IPC分类号： A61K39/12 ,  A61K45/00 ,  A61K39/155 ,  A61K39/215 ,  A61K39/15 ,  A61K39/17 ,  A61K39/265 ,  A61K39/39 ,  A61K39/00

摘要： Poultry vaccines against infectious bronchitis and Turkey Rhinotracheitis are provided. The vaccines are adjuvanted with oil emulsion containing an immunostimulatory oligonucleotide. The methods of using the vaccines are also provided.

公开(公告)号：US20210196811A1

公开(公告)日：2021-07-01

申请号：US17017342

申请日：2020-09-10

申请人： Zoetis Services LLC

发明人： Sing RONG ,  Yugang LUO ,  Tyler BROWN

IPC分类号： A61K39/12 ,  C12N7/00 ,  C12N15/86 ,  A61K39/17 ,  A61P37/04 ,  A61P31/14 ,  A61P31/20

摘要： The invention relates to recombinant viral vectors for the insertion and expression of foreign genes for use in safe immunizations to protect against a variety of pathogens. The invention also relates to multivalent compositions or vaccine comprising one or more recombinant viral vectors for protection against a variety of pathogens. The present invention relates to methods of making an using said recombinant viral vectors.