摘要:
The present disclosure provides tetra-substituted cyclobutane inhibitors of Androgen Receptor Action, and methods of using such inhibitors, for the treatment of hormone-refractory cancers.
摘要:
The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.
摘要:
Method for producing carboxylic anhydride, the method includes heating raw material compound represented by the following general formula (1): [in the formula (1), R1 is tetravalent organic group having at least two carbon atoms adjacent to each other, and groups represented by the formulae: —COOR2 and —COOR3 are bonded to one and the other of the two adjacent carbon atoms, respectively, R2 and R3 each represent hydrogen atom or the like, X represents hydrogen atom or the like, and Y represents hydrogen atom or the like] in carboxylic acid having 1 to 5 carbon atoms with catalyst being used, to thereby obtain the carboxylic anhydride, wherein the catalyst is homogeneous acid catalyst having acid dissociation constant (pKa) of −6.5 or lower and boiling point of 100° C. or higher, the acid dissociation constant (pKa) being determined by quantum chemistry calculation based on density functional method.
摘要:
To provide a liquid crystal compound satisfying at least one of physical properties such as high stability to ultraviolet light and heat, a high clearing point, low minimum temperature of a liquid crystal phase, small viscosity, suitable optical anisotropy, large dielectric anisotropy and excellent compatibility with other liquid crystal compounds, and a liquid crystal composition containing the compound, and a liquid crystal display device including the composition.The compound includes a compound represented by formula (1): wherein, Ra and Rb are alkyl or the like; A1, A2 and A3 are 1,4-cyclohexylene, 1,4-phenylene or the like; G is a divalent group represented by formula (pr-1) or (pr-2); wherein, Z1, Z2 and Z3 are a single bond, alkylene or the like; and a and b are 0, 1, 2 or 3, and a sum of a and b is 4 or less.
摘要:
The present invention relates to novel cycloalkyl-hydroxyl compounds, compositions comprising hydroxyl compounds, and methods useful for treating and preventing a variety of diseases and conditions such as, but not limited to aging, Alzheimer's Disease, cancer, cardiovascular disease, diabetic nephropathy, diabetic retinopathy, a disorder of glucose metabolism, dyslipidemia, dyslipoproteinemia, hypertension, impotence, inflammation, insulin resistance, lipid elimination in bile, obesity, oxysterol elimination in bile, pancreatitis, Parkinson's disease, a peroxisome proliferator activated receptor-associated disorder, phospholipid elimination in bile, renal disease, septicemia, Syndrome X, thrombotic disorder. Compounds and methods of the invention can also be used to modulate C reactive protein or enhance bile production in a patient. In certain embodiments, the compounds, compositions, and methods of the invention are useful in combination therapy with other therapeutics, such as hypocholesterolemic and hypoglycemic agents.
摘要:
A selected morphology for a deposited bioactive agent can be obtained by selecting solvent composition, preparing a solution of the bioactive agent in the solvent composition, and applying the bioactive agent to a substrate as a plurality of droplets so that evaporation of the applied solution produces particles having the target particle morphology.
摘要:
Compounds of the formula ##STR1## are described wherein X is a C.sup.2-11 -alkyl group, optionally substituted by a protected hydroxy, protected oxo or protected carboxy group.
摘要:
Prostanoic acid derivatives represented by the general formula: ##STR1## in which X represents hydrogen or hydroxy, X.sub.1 represents hydrogen or X and X.sub.1, when they are taken together with the carbon atom to which they are attached, represent a carbonyl group and Z represents hydrogen or hydroxy and pharmaceutically acceptable alkali metal salts thereof.They can be used as bronchodilators and/or inhibitors of blood-platelet aggregation.
摘要:
Methylenecyclopentane derivatives, for example ##STR1## wherein R.sub.2 is a blocking group such as tetrahydropyranyl, and a process for preparing them; said derivatives having utility as prostaglandin intermediates.