公开(公告)号：US20240327886A1

公开(公告)日：2024-10-03

申请号：US18561233

申请日：2022-05-17

申请人： DSM IP Assets B.V.

发明人： Manos PAPADAKIS ,  Ted JOHANSON ,  Peter BECKER

IPC分类号： C12P19/04 ,  C07K14/245 ,  C12N1/20 ,  C12N9/10 ,  C12N15/52 ,  C12P19/18 ,  C12R1/19

CPC分类号： C12P19/04 ,  C07K14/245 ,  C12N1/20 ,  C12N9/1051 ,  C12N15/52 ,  C12P19/18 ,  C12R2001/19 ,  C12Y204/01062 ,  C12Y204/01069 ,  C12Y204/01222

摘要： This invention relates to a method of producing mixtures of various human milk oligosaccharides (HMOs) with unique HMO blend profiles, consisting predominantly of LNFP-I and LNT and of other HMOs in less significant amounts. The less abundant HMOs might be 2′-FL, LNT-II or DFL. The strategies for achieving specific HMO blends include strain engineering and fermentation methods.

公开(公告)号：US12049484B2

公开(公告)日：2024-07-30

申请号：US18186724

申请日：2023-03-20

申请人： Stichting Amsterdam UMC

发明人： Arjan Willem Griffioen ,  Elisabeth Johanna Maria Huijbers ,  Patrycja Nowak-Sliwinska

IPC分类号： A61K39/00 ,  A61P35/00 ,  C07K14/245 ,  C07K14/47 ,  C07K14/78 ,  C07K16/18 ,  C12N15/62 ,  C12Q1/6886

CPC分类号： C07K14/4748 ,  A61K39/0011 ,  A61P35/00 ,  C07K14/245 ,  C07K14/78 ,  C07K16/18 ,  C12N15/62 ,  C12Q1/6886 ,  A61K2039/55566 ,  A61K2039/585 ,  A61K2039/6068 ,  C07K2319/21 ,  C07K2319/35 ,  C12Q2600/106 ,  C12Q2600/112

摘要： The invention is in the field of medicine. More specifically, it is in the field of diagnosing tumor angiogenesis status and in the field of medical treatment of a subject who is suffering, suspected to suffer, or might suffer from a tumor in the future. In particular, the invention relates to a fusion polypeptide comprising a foreign antigen and a self antigen, wherein said foreign antigen consists of a polypeptide comprising an amino acid sequence of at least 12-15 amino acid residues, 12-24% of which residues are hydrophilic, bulky amino acid residues selected from the group consisting of histidine, glutamate, arginine, glutamine, aspartic acid and/or lysine.

公开(公告)号：US20240247207A1

公开(公告)日：2024-07-25

申请号：US18288397

申请日：2022-04-29

申请人： AVIGNON UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE MONTPELLIER ,  ECOLE NATIONALE SUPERIEURE DE CHIMIE DE MONTPELLIER

发明人： GRÉGORY DURAND ,  MOHEDDINE WEHBIE

IPC分类号： C11D1/00 ,  C07C317/28 ,  C07H15/06 ,  C07H15/18 ,  C07K14/245

CPC分类号： C11D1/004 ,  C07C317/28 ,  C07H15/06 ,  C07H15/18 ,  C07K14/245 ,  C07C2601/14

摘要： The present invention relates to new amphiphilic perfluorinated compounds and their use as a detergent for extracting membrane-proteins or synthesizing membrane-proteins in acellular system. It also relates to a method for extracting a membrane-protein from a biological sample using such compounds.

公开(公告)号：US12037621B2

公开(公告)日：2024-07-16

申请号：US17476162

申请日：2021-09-15

申请人： Archer Daniels Midland Company

发明人： Benjamin Mason ,  Jason Helvey

IPC分类号： C12P13/08 ,  C07K14/245 ,  C12N1/20 ,  C12N9/00 ,  C12N9/80 ,  C12N9/88 ,  C12R1/19

CPC分类号： C12P13/08 ,  C07K14/245 ,  C12N1/205 ,  C12N9/80 ,  C12N9/88 ,  C12N9/93 ,  C12R2001/19 ,  C12Y305/01003 ,  C12Y403/01019 ,  C12Y604/01001

摘要： Improved production of threonine from E. coli by fermentation is accomplished by attenuation but not elimination of the expression of either or both of the yajV gene encoding omega-amidase (a.k.a. 2-oxoglutaramate amidase) and the ilvA gene encoding threonine dehydratase (a.k.a threonine deaminase). In cases where there is attenuated expression of the ilvA gene, there is no need to express an exogenous cimA gene. In examples of both cases, attenuation is accomplished by engineering these genes to contain a weaker ribosome site. Further improvements in threonine production are made by expression of a heterologous pyruvate carboxylase gene exemplified by expression of the Corynebacterium glutamicum pyc gene under control of an E. coli promoter, to provide expression of pyruvate carboxylase that is not naturally expressed in E. coli.

公开(公告)号：US20240228552A9

公开(公告)日：2024-07-11

申请号：US18482052

申请日：2023-10-06

申请人： UNIVERSITY OF MASSACHUSETTS

发明人： Min Chen ,  Fanjun Li

IPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/48

CPC分类号： C07K14/245 ,  B82Y5/00 ,  C12N9/12 ,  C12Q1/485 ,  C12Y207/10001

摘要： Disclosed herein are nanopore tweezer systems that can be used to screen for allosteric inhibitors of protein kinases. In some embodiments, the protein kinase is a mutant kinase that confers resistance to chemotherapeutic drugs during cancer treatment. Therefore, the disclosed systems and methods can be used to identify drugs for treating drug resistant cancers.

公开(公告)号：US12030913B2

公开(公告)日：2024-07-09

申请号：US16938377

申请日：2020-07-24

申请人： THE UAB RESEARCH FOUNDATION

发明人： Dmitry Vassylyev ,  Norman Patrick Higgins ,  Marina Vassylyeva ,  Alexey Vasiliev

IPC分类号： C07K1/22 ,  C07K14/245 ,  C12N9/22 ,  C12N15/62 ,  C12P21/02 ,  C12P21/06

CPC分类号： C07K1/22 ,  C07K14/245 ,  C12N9/22 ,  C12N15/62 ,  C12P21/02 ,  C12P21/06 ,  C07K2319/00 ,  C07K2319/21 ,  C07K2319/23 ,  C07K2319/24 ,  C07K2319/50 ,  C12N2310/20

摘要： Compositions comprising colicin immunity proteins and methods of using same for protein purification are described.

公开(公告)号：US20240209037A1

公开(公告)日：2024-06-27

申请号：US18557282

申请日：2022-04-28

申请人： CJ CHEILJEDANG CORPORATION

发明人： Heejung KIM ,  Moo Young JUNG ,  Hye Mi KIM ,  Hyun Ah KIM

IPC分类号： C07K14/245 ,  C12N15/70 ,  C12P13/22 ,  C12R1/19

CPC分类号： C07K14/245 ,  C12N15/70 ,  C12P13/227 ,  C12R2001/19

摘要： Provided are a variant SpoT protein and a method of producing an L-amino acid using the same.

公开(公告)号：US12018326B2

公开(公告)日：2024-06-25

申请号：US17511391

申请日：2021-10-26

申请人： Oxford Nanopore Technologies PLC

发明人： Lakmal Jayasinghe ,  Elizabeth Jayne Wallace

IPC分类号： C07K14/00 ,  C07K14/245 ,  C12Q1/6869 ,  G01N33/487

CPC分类号： C12Q1/6869 ,  C07K14/245 ,  G01N33/48721 ,  C12Q2565/631 ,  C12Q1/6869 ,  C12Q2565/631

摘要： The invention relates to mutant forms of CsgG. The invention also relates to analyte detection and characterization using CsgG.

公开(公告)号：US11999768B2

公开(公告)日：2024-06-04

申请号：US17264509

申请日：2020-10-22

申请人： ENZYNOMICS CO. LTD. ,  DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY

发明人： Yong Keol Shin ,  Jeongyeon Yoon ,  Ki Hoon Nam ,  Seulki Lim ,  Wookyung Yu ,  Seongjun Park ,  Juhwan Lee ,  Sangyeol Kim ,  Moo Seok Kang ,  Minjae Seo

IPC分类号： C07K14/245 ,  C12N15/63 ,  C12Q1/6848 ,  C12Q1/686

CPC分类号： C07K14/245 ,  C12N15/63 ,  C12Q1/6848 ,  C12Q1/686

摘要： Provided is a mutant UDG having improved thermal sensitivity compared to a wild-type UDG. The mutant UDG of the presently claimed subject matter having a high thermal sensitivity has no inhibitory effect on the PCR reaction and thus can be advantageously used for the development of PCR/qPCR Premix and particularly PCR diagnostic kits employing UDG which requires the use of relatively low temperature in melting and amplification steps.

公开(公告)号：US20240150745A1

公开(公告)日：2024-05-09

申请号：US18481673

申请日：2023-10-05

申请人： 10x Genomics, Inc.

发明人： Shankar SHASTRY ,  Javelin C. CHI ,  Paul Eugene LUND

IPC分类号： C12N9/00 ,  C07K14/245 ,  C12Q1/6827

CPC分类号： C12N9/93 ,  C07K14/245 ,  C12Q1/6827 ,  C07K2319/21 ,  C07K2319/60 ,  C07K2319/80

摘要： A recombinant ligase composition including a recombinantly-produced ligase isolated from Acanthocystis turfacea chlorella virus 1 (ATCV-1) fused to at least one polynucleotide-binding polypeptide is provided. Compositions containing the recombinant ligase composition, vectors encoding the recombinant ligase composition, and methods of making and using the recombinant ligase composition are also provided.