公开(公告)号：US20240302266A1

公开(公告)日：2024-09-12

申请号：US18548283

申请日：2022-03-04

申请人： Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e. V.

发明人： Thorsten GRAUNKE ,  Wladimir TSCHEKALINSKIJ ,  Stephan JUNGER ,  Jens-Uwe GARBAS

IPC分类号： G01N21/25 ,  G01N21/17 ,  G01N21/31 ,  G01N21/3504 ,  G01N21/3577

CPC分类号： G01N21/255 ,  G01N21/1702 ,  G01N21/3504 ,  G01N2021/1704 ,  G01N2021/3133 ,  G01N21/3577 ,  G01N2201/0675

摘要： The invention relates to an assembly for a multispectral light emission, comprising at least one wide-band light source (1), a filter array (4) of multiple spectral filters, and an optical switch device (2) for controlling the passage of the light emitted from the light source (1) through the filter array (4). In one embodiment, the optical switch device (2) is made of an array of micromirrors (16) or micro-diaphragms and is designed and arranged such that the optical switch can guide light emitted from the light source (1) only through one or more arbitrarily specifiable spectral filters of the filter array (4) in a controlled manner. The invention also relates to a multispectral sensor comprising such an assembly for a multispectral light emission. The assembly allows a multispectral sensor to be provided inexpensively in a miniaturized design with a plurality of spectral channels.

公开(公告)号：US12085505B2

公开(公告)日：2024-09-10

申请号：US17403455

申请日：2021-08-16

申请人： Brewmetrix LLC

发明人： Sydney Sukuta

IPC分类号： G01N21/3577 ,  G01N21/33 ,  G01N21/359 ,  G01N33/14

CPC分类号： G01N21/3577 ,  G01N21/33 ,  G01N21/359 ,  G01N33/146 ,  G01N2201/0646

摘要： Parameters of an alcoholic or non-alcoholic beverage can be determined through spectroscopic methods. In one example, the method includes obtaining a beverage sample and obtaining spectrographic data from the beverage. The spectroscopic data may be processed by a remote lab to determine a value range of the one or more beverage parameters, and a value of the one or more beverage parameters. The one or more beverage parameters may include one or more of beverage color, bitterness, Free Amino Nitrogen (FAN), yeast count and yeast viability.

公开(公告)号：US12073924B2

公开(公告)日：2024-08-27

申请号：US17643128

申请日：2021-12-07

申请人： Genzyme Corporation

发明人： Dhanuka Pulasthi Wasalathanthri ,  Jagdish C. Tewari ,  Xuezhen Kang ,  Marina Hincapie ,  Shawn L. Barrett ,  Julie Susanne Pollock

IPC分类号： C12M3/00 ,  B01L3/00 ,  C07K1/16 ,  C12M1/00 ,  C12M1/12 ,  C12M1/36 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  G16C20/10 ,  B01D15/18 ,  G01N21/35 ,  G01N21/84 ,  G01N30/88

CPC分类号： G16C20/10 ,  C07K1/16 ,  C12M21/14 ,  C12M37/00 ,  C12M41/48 ,  C12M47/12 ,  G01N21/3577 ,  G01N21/552 ,  G01N30/46 ,  G01N30/78 ,  G01N30/86 ,  B01D15/1814 ,  B01D15/1871 ,  G01N2021/3595 ,  G01N2021/8416 ,  G01N2030/8813 ,  G01N2030/8886 ,  G01N2201/129

摘要： The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.

公开(公告)号：US12066440B2

公开(公告)日：2024-08-20

申请号：US17082979

申请日：2020-10-28

申请人： Labrador Diagnostics LLC

发明人： Chinmay Pangarkar ,  Karan Mohan ,  James R. Wasson

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C08L5/08 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  G01N1/30 ,  G01N15/10 ,  G01N21/03 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/487 ,  G01N33/49 ,  G01N33/50 ,  G01N33/53 ,  G01N33/564 ,  G01N33/569 ,  G01N33/58 ,  G01N33/68 ,  G02B7/09 ,  G02B21/00 ,  G02B21/08 ,  G02B21/12 ,  G02B21/16 ,  G02B21/24 ,  G02B21/36

CPC分类号： G01N33/56972 ,  B01L3/502715 ,  G01N1/30 ,  G01N15/1012 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/17 ,  G01N21/27 ,  G01N21/6428 ,  G01N21/645 ,  G01N21/6458 ,  G01N21/6486 ,  G01N33/487 ,  G01N33/49 ,  G01N33/5005 ,  G01N33/53 ,  G01N33/5308 ,  G01N33/56966 ,  G01N33/582 ,  G02B7/09 ,  G02B21/0076 ,  G02B21/088 ,  G02B21/125 ,  G02B21/16 ,  G02B21/244 ,  G02B21/365 ,  G01N2015/1014 ,  G01N2021/1738 ,  G01N2021/6439 ,  G01N2201/061 ,  G01N2201/12 ,  G01N2333/70589 ,  G01N2333/70596

摘要： Methods, devices, systems, and apparatuses are provided for the image analysis of measurement of biological samples.

公开(公告)号：US12061150B2

公开(公告)日：2024-08-13

申请号：US17059690

申请日：2019-05-31

申请人： ORB XYZ, INC.

发明人： Lorenzo Falzarano ,  Andreia Michelle Smith-Moritz

IPC分类号： B01L3/00 ,  B01F23/00 ,  B01F23/41 ,  B01F101/23 ,  B23Q17/24 ,  C12M1/34 ,  C12Q1/04 ,  C12Q1/18 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/39 ,  G01N21/45 ,  G01N21/64 ,  G01N30/12 ,  G01N30/68 ,  G01N30/70 ,  G01N30/72 ,  G01N30/88 ,  G01N33/00 ,  G01N33/18 ,  G01N33/50 ,  G01N33/68

CPC分类号： G01N21/6486 ,  C12Q1/04 ,  G01N33/1826

摘要： The invention generally relates to detecting biological substances. In certain aspects, the invention is directed to a method directing one or more wavelengths of light within a deep ultraviolet (UV) spectrum into a medium to excite a biological substance in the medium, detect emission from the excited biological substance via a plurality of semiconductor photodetectors, and analyze the deep UV emission data for presence of a deep UV spectral signature indicative of the biological substance, wherein presence of the deep UV spectral signature indicates that the medium comprises a biological substance. The invention is also directed to identifying a pathogen in a medium comprising a pathogen and a non-pathogen biological substance.

公开(公告)号：US12031907B2

公开(公告)日：2024-07-09

申请号：US16847236

申请日：2020-04-13

申请人： betaSENSE GmbH

发明人： Klaus Gerwert ,  Jens Wiltfang ,  Julian Ollesch ,  Andreas Nabers ,  Jonas Schartner ,  Carsten Kötting

IPC分类号： G01N21/3577 ,  G01N21/552 ,  G01N21/64 ,  G01N33/68 ,  G01N21/05

CPC分类号： G01N21/3577 ,  G01N21/552 ,  G01N21/6428 ,  G01N21/6458 ,  G01N33/6896 ,  G01N21/05 ,  G01N2021/6421 ,  G01N2800/2821 ,  G01N2800/2835

摘要： Provided herein is a biosensor for conformation and secondary structure analysis, notably for the direct non-invasive qualitative secondary structure analysis of a single selected protein within a complex mixture, as e.g. a body fluid, by vibrational spectroscopic methods. For the analysis it is not required that the selected substance be isolated, concentrated, or pretreated by a special preparative procedure.

公开(公告)号：US20240210323A1

公开(公告)日：2024-06-27

申请号：US18682657

申请日：2021-07-09

申请人： Ayna Analytics GmbH

发明人： Laura RODRÍGUEZ GARCÍA ,  David MAINKA

IPC分类号： G01N21/65 ,  G01N21/3577 ,  G01N21/359

CPC分类号： G01N21/65 ,  G01N21/3577 ,  G01N21/359 ,  G01N2201/0636 ,  G01N2201/08

摘要： A measurement chamber extension for a spectrophotometric characterization with a NIR-spectrophotometer of a Raman-spectrophotometer of a liquid in a polymer container, wherein a measurement chamber extension comprises: an adapter plate having an adapter opening; a container holder, and an optical element, selected from a mirror and a waveguide. The adapter is configured to cover in a light-tight manner the measurement chamber of the NIR-spectrophotometer or of the Raman-spectrophotometer. The container holder is configured to allow a close placement of the optical element adjacent to the polymer container containing the liquid providing a loss-free transmission or transflection of the measurement light beam from the optical element to a detector of the NIR-spectrophotometer or Raman-spectrophotometer.

公开(公告)号：US12007324B2

公开(公告)日：2024-06-11

申请号：US17860428

申请日：2022-07-08

申请人： University of Maryland, College Park

发明人： Yang Tao ,  Anjana Hevaganinge ,  Chiao-Yi Wang ,  Dongyi Wang ,  Mohamed Amr Ali

IPC分类号： G01N21/3577 ,  G01J3/10 ,  G01J3/28 ,  G01N21/359

CPC分类号： G01N21/3577 ,  G01J3/108 ,  G01J3/2823 ,  G01N21/359 ,  G01J2003/2843 ,  G01N2201/126

摘要： A non-contact system for the sensing of pH includes a hyperspectral imaging device configured to capture a hyperspectral image of a fluid, a flow cell configured to enable the capturing of a hyperspectral image of a fluid, a process, and a memory. The memory includes instructions stored thereon, which, when executed by the processor, cause the system to generate a hyperspectral image of the fluid in the flow cell, generate several spectral signals based on the hyperspectral image, provide the spectral signal as an input to a machine learning network, and predict by the machine learning network a pH of a fluid.

公开(公告)号：US20240170093A1

公开(公告)日：2024-05-23

申请号：US18283996

申请日：2022-03-31

申请人： UNIVERSITY OF LANCASTER

发明人： Carlos Alejandro Meza Ramirez ,  Craig Williams ,  Ihtesham ur Rehman

IPC分类号： G16B15/00 ,  G01N21/3577 ,  G01N21/65 ,  G06N20/00 ,  G16B40/20

CPC分类号： G16B15/00 ,  G01N21/3577 ,  G01N21/65 ,  G06N20/00 ,  G16B40/20

摘要： Methods, apparatus, a system, a computer program and a computer-readable data carrier are disclosed. A method comprises providing spectroscopic data associated with at least one microorganism, and obtained via a Raman or Infrared spectroscopy technique, as an input into at least one machine learning module, and responsive to providing the spectroscopic data, providing at least one trained machine learning model, wherein the trained machine learning model is configured to identify at least one microorganism in a biological sample.

公开(公告)号：US20240159667A1

公开(公告)日：2024-05-16

申请号：US18511574

申请日：2023-11-16

申请人： Purdue Research Foundation

发明人： Ji-Xin CHENG ,  Yeran BAI ,  Delong ZHANG ,  Ali SHAKOURI ,  D. Kerry MAIZE

IPC分类号： G01N21/3577

CPC分类号： G01N21/3577 ,  G01N2201/06113

摘要： Systems and methods for detecting photothermal effect in a sample are described herein. In these systems and methods, a pump source is configured to generate a pump pulse train, a probe source is configured to generate a probe pulse train and is synchronized with the pump pulse train, and a camera collects the resulting data. The camera is configured to collect a first signal corresponding to a hot frame, wherein the hot frame includes visible probe beam as modified by a pump beam and a second signal corresponding to a cold frame, wherein the cold frame includes visible probe beam that has not been modified by a pump beam. A processor can subtract the second signal from the first signal to detect the photothermal effect.