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公开(公告)号：WO2011044157A1
公开(公告)日：2011-04-14
申请号：PCT/US2010/051517
申请日：2010-10-05
Applicant: BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC. , ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
Inventor： ARNDT, Joseph , CHAN, Timothy , GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , LEE, Wen-Cherng , LIN, Edward, Yin-shiang , SCOTT, Daniel , SUN, Lihong , THOMAS, Jermaine , VAN VLOTEN, Kurt , WANG, Deping , ZHANG, Lei , ERLANSON, Daniel
IPC: A61K31/50
CPC classification number: C07D471/04 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/452 , A61K31/4725 , A61K31/496 , A61K31/497 , A61K31/498 , A61K31/4985 , A61K31/517 , A61K31/519 , A61K31/53 , A61K31/5377 , A61K31/5383 , C07D213/82 , C07D213/85 , C07D241/26 , C07D241/28 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/14 , C07D473/34 , C07D487/04 , C07D491/052 , C07D498/04 , C07D519/00
Abstract: The present invention provides compounds useful as inhibitors of PDK1. The present invention also provides compositions thereof, and methods of treating PDK1-mediated diseases.
Abstract translation: 本发明提供可用作PDK1抑制剂的化合物。 本发明还提供了其组合物，以及治疗PDK1介导的疾病的方法。
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2.发明申请BIARYL COMPOUNDS USEFUL FOR THE TREATMENT OF HUMAN DISEASES IN ONCOLOGY, NEUROLOGY AND IMMUNOLOGY 审中-公开用于治疗肿瘤，神经学和免疫学中的人类疾病的双芳基化合物
公开(公告)号：WO2015089337A1
公开(公告)日：2015-06-18
申请号：PCT/US2014/069853
申请日：2014-12-11
Applicant: BIOGEN IDEC MA INC. , SUNESIS PHARMACEUTICALS, INC.
Inventor： HOPKINS, Brian, T. , MA, Bin , CHAN, Timothy, Raymond , SUN, Lihong , ZHANG, Lei , KUMARAVEL, Gnanasambandam , LYSSIKATOS, Joseph, P. , KOCH, Kevin , MIAO, Hua
IPC: C07D403/12 , C07D401/14 , C07D413/14 , C07D409/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D513/04 , A61K31/44 , A61K31/505 , A61K31/506 , A61P25/02 , A61P35/00 , A61P37/00
CPC classification number: C07D403/12 , A61K31/506 , C07D239/30 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D495/04 , C07D513/04 , C07F5/027
Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.
Abstract translation: 本发明提供了化合物及其组合物，其可用作布鲁顿氏酪氨酸激酶的抑制剂，并表现出其所希望的特征。
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公开(公告)号：WO2014018881A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/052316
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , PENG, Hairuo , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , WANG, Deping , XIN, Zhili , ZHANG, Lei
IPC: A61K31/015 , A61K31/4375 , A61K31/44
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
Abstract translation: 公开了式（I）的双环芳基化合物，其可以调节自分泌素（ATX）酶的活性。 本发明还涉及作为ATX抑制剂的化合物，以及制备和使用这些化合物治疗由于损伤或疾病引起的脱髓鞘以及治疗增殖性疾病如癌症的方法。
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Patent Agency Ranking4.发明申请
公开(公告)号：WO2014025709A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/053669
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , SUN, Lihong , XIN, Zhili , ZHANG, Lei
IPC: A61K31/381 , C07C229/34 , A61K31/122 , A61K31/661
CPC classification number: C07D211/62 , A61K31/122 , A61K31/192 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/439 , A61K31/445 , A61K31/45 , A61K31/46 , A61K45/06 , C07C229/14 , C07C229/48 , C07C2601/14 , C07D211/34 , C07D211/60 , C07D451/02 , C07D451/14 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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公开(公告)号：WO2014018887A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/052325
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , WANG, Deping , XIN, Zhili , ZHANG, Lei
IPC: A61K31/683 , C07C47/575
CPC classification number: A61K31/662 , A61K31/196 , A61K31/397 , A61K31/435 , A61K31/445 , A61K31/454 , A61K31/47 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C229/46 , C07C229/48 , C07C233/47 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2602/26 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07D213/79 , C07D213/80 , C07D215/20 , C07D223/06 , C07D265/30 , C07D401/04 , C07D401/06 , C07F9/38 , C07F9/3808
Abstract: Compounds of formula (I) can modulate the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可调节自分泌素（ATX）的活性。
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公开(公告)号：WO2014152725A1
公开(公告)日：2014-09-25
申请号：PCT/US2014/027664
申请日：2014-03-14
Applicant: BIOGEN IDEC MA INC.
Inventor： PENG, Hairuo , XIN, Zhili , ZHANG, Lei , SUN, Lihong , KUMARAVEL, Gnanasambandam , TAVERAS, Art
IPC: C07D487/04 , C07D519/00 , A61K31/4985 , A61K31/551 , A61P25/00 , A61P29/00 , A61P35/00
CPC classification number: A61K31/198 , A61K36/9068 , C07D487/04 , C07D519/00
Abstract: Compounds of formula (I), and pharmaceutically acceptable salts thereof, can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX). Formula (1)
Abstract translation: 式（I）化合物及其药学上可接受的盐可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。 公式1）
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公开(公告)号：WO2014018891A1
公开(公告)日：2014-01-30
申请号：PCT/US2013/052329
申请日：2013-07-26
Applicant: BIOGEN IDEC MA INC.
Inventor： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , MI, Sha , PENG, Hairuo , SHAO, Zhaohui , SUN, Lihong , TAVERAS, Arthur , XIN, Zhili , ZHANG, Lei
IPC: A61K31/54
CPC classification number: C07F7/0818 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0809 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
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8.发明申请
公开(公告)号：WO2014025708A1
公开(公告)日：2014-02-13
申请号：PCT/US2013/053668
申请日：2013-08-05
Applicant: BIOGEN IDEC MA INC.
Inventor： GUCKIAN, Kevin , KUMARAVEL, Gnanasambandam , MA, Bin , SUN, Lihong , XIN, Zhili , ZHANG, Lei
IPC: A61K31/381 , C07C229/34 , A61K31/122 , A61K31/661
CPC classification number: C07D471/08 , A61K31/122 , A61K31/196 , A61K31/397 , A61K31/40 , A61K31/403 , A61K31/439 , A61K31/44 , A61K31/445 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C211/38 , C07C229/48 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D207/08 , C07D207/16 , C07D209/52 , C07D211/62 , C07D223/06 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）的化合物可以调节一种或多种SIP受体的活性和/或自体嗜酸性粒细胞趋化蛋白（ATX）的活性。
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