摘要:
This invention belongs to the field of biochemical engineering and relates to a method of cyclic utilization of water during separation of succinic acid made by fermentation. This invention uses water from separation process for aerobic growth of E. coli AFP111 and production of succinic acid by anaerobic fermentation, obtaining final succinic acid concentration of 55 g/L and yield of 91.6%. Compared with results of fermentation using culture medium prepared from tap water, succinic acid concentration and productivity increased by 8.5% and 8.46%, respectively. An outstanding advantage of this invention is recovery and utilization of evaporated water during separation of succinic acid, realizing cyclic use of water during industrial production of succinic acid, which is an environment-friendly process. Also, as evaporated water generated during separation of succinic acid contains small amount of organic acids such as acetic acid and formic acid, if this water is used for aerobic growth of thalli, the small amount of organic acids contained therein can be used as gluconeogenesis carbon source, improving activity of some key enzymes in cell and favoring succinic acid production by anaerobic fermentation of thalli.
摘要:
The present disclosure describes methods, systems, and computer program products for finding a best location scheme for a set of interactional objects in a constrained geographical area. A geographic region representing a wind farm is partitioned into a plurality of lattices. Initial chromosomes are generated, where a particular chromosome is a binary series used to represent the presence of a wind turbine in a layout of the plurality of lattices. A cost associated with each wind turbine associated with the initial chromosomes is evaluated. Parent chromosomes are selected for a genetic operation, and following the genetic operation, a cost associated with each wind turbine if evaluated. The parent chromosomes are updated using a fitness value.
摘要:
An array substrate comprises a first metal layer in which first signal lines are disposed; a second metal layer in which second signal lines are disposed; an insulation layer provided between the first and second metal layers. A repairing line is provided in edge regions of the second metal layer and insulated from the second signal lines, and the repairing line comprises a first longitudinal portion, a second longitudinal portion and a transverse portion, the first longitudinal portion is electrically connected to the second longitudinal portion by the transverse portion. A projection of the first longitudinal portion in a plane of the first metal layer intersects with one end of each of the first signal lines, and a projection of the second longitudinal portion in the plane of the first metal layer intersects with the other end of each of the first signal lines.
摘要:
Semiconductor devices and methods for manufacturing the same are disclosed. In one embodiment, the method comprises: sequentially forming a sacrificial layer and a semiconductor layer on a substrate; forming a first cover layer on the semiconductor layer; forming an opening extending into the substrate with the first cover layer as a mask; selectively removing at least a portion of the sacrificial layer through the opening, and filling an insulating material in a gap due to removal of the sacrificial layer; forming one of source and drain regions in the opening; forming a second cover layer on the substrate; forming the other of the source and drain regions with the second cover layer as a mask; removing a portion of the second cover layer; and forming a gate dielectric layer, and forming a gate conductor in the form of spacer on a sidewall of a remaining portion of the second cover layer.
摘要:
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.
摘要:
The present invention provides a method for locating a terminal by using a base station, and the method includes steps as follows: constructing a locating message by expanding a location report message or via an independent message; sending the locating message to a locating judgment center; and locating the terminal by using the locating message. The present invention is helpful to reduce the power consumption of the User Equipment (UE).
摘要:
The disclosure provides a method and system for sending a short message. The method includes: an SMS-SC sending a short message to an SMS-GMSC, and after the SMS-GMSC sends the short message to an MME, the MME sending a failure report to the SMS-GMSC when the MME detects that a terminal is unreachable (S202); the SMS-GMSC receiving the sent failure report and sending a short-message sending status message to an HSS, and the HSS setting waiting data according to the short-message sending status message (S204); upon detecting that the terminal switches from unreachable to reachable, the MME notifying the HSS that the terminal is reachable (S206); upon learning that the terminal is reachable, the HSS sending, according to the waiting data, a warning message to notify the SMS-SC that the terminal is reachable, and upon learning that the terminal is reachable again, the SMS-SC sending the short message again (S208). By means of the solution, a short message service can also be received in an area covered only by a packet switched network.
摘要:
The present invention provides Bruton's Tyrosine Kinase (Btk) inhibitor compounds according to Formula I or a pharmaceutically acceptable salt thereof or to pharmaceutical compositions comprising these compounds and to their use in therapy. In particular, the present invention relates to the use of Btk inhibitor compounds in the treatment of Btk mediated disorders.
摘要:
The present invention relates to novel Tetracyclic Xanthene Derivatives of Formula (I) and pharmaceutically acceptable salts thereof, wherein A, Y1, Y2, Z, Ra, Rb, R1a, R1b and R2 are as defined herein. The present invention also relates to compositions comprising at least one Tetracyclic Xanthene Derivative, and methods of using the Tetracyclic Xanthene Derivatives for treating or preventing HCV infection in a patient.
摘要:
The present invention relates to compounds of formula (I) that are useful as hepatitis C virus (HCV) NS5B polymerase inhibitors, the synthesis of such compounds, and the use of such compounds for inhibiting HCV NS5B polymerase activity, for treating or preventing HCV infections and for inhibiting HCV viral replication and/or viral production in a cell-based system.