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公开(公告)号：US20140242596A1
公开(公告)日：2014-08-28
申请号：US14348881
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald Danehy , Gary Lim , Jacob Freudenthal
IPC: C12Q1/68
CPC classification number: C12Q1/6806 , B01L3/50851 , B01L3/50855 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , B01L2300/161 , C12M23/12 , C12M23/38
Abstract: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
Abstract translation: 用于容纳多个生物样品的壳体包含基底，基底和盖。 底物附着到基底上，并且包括被配置成接收一个或多个生物样品的多个反应区域。 盖子包括内表面，并且被构造成附接到基座，使得基座和盖子一起提供容纳基底的空腔。 内表面包括中心区域和围绕中心区域设置的凹陷区域。 中心区域构造成覆盖反应区域，而凹陷区域在垂直于内表面的方向上偏离中心区域。
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公开(公告)号：US20230201839A1
公开(公告)日：2023-06-29
申请号：US18086416
申请日：2022-12-21
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686
CPC classification number: B01L3/50857 , B01L3/50 , C12Q1/6806 , G03F7/2002 , B01L3/50851 , C12Q1/686 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , B01L2300/0654 , B01L2300/0829 , B01L2200/142 , B01L2300/046 , B01L2200/0642 , B01L7/52
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：US11590506B2
公开(公告)日：2023-02-28
申请号：US16426631
申请日：2019-05-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686 , B01L7/00
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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公开(公告)号：US20160271604A1
公开(公告)日：2016-09-22
申请号：US15037471
申请日：2014-11-18
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Gary Lim , Theodore Straub
CPC classification number: B01L3/0293 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2300/0829 , B01L2300/0893 , B01L2300/12 , B01L2400/0406 , C12Q1/686
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action. The first and second blade may dispense the liquid by laterally moving over the plurality of reaction sites, where a motor laterally moves the first and second blade.
Abstract translation: 提供了一种用于将液体样品加载到基底内的多个反应位点的样品装载器。 样品装载器包括第一叶片和联接到第一叶片的第二叶片。 样品装载器还包括在第一叶片和第二叶片之间的流动路径，其构造成将液体样品分配到包括多个反应位点的基底。 此外，在各种实施例中，液体样品与第一和第二叶片具有85 +/- 15度的前进接触角。 此外，从流动路径分配到多个反应位点的液体样品的装载可以基于毛细作用。 第一和第二叶片可以通过横向移动多个反应部位来分配液体，其中马达横向移动第一和第二叶片。
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公开(公告)号：US09267170B2
公开(公告)日：2016-02-23
申请号：US14348881
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Ronald Danehy , Gary Lim , Jacob Freudenthal
CPC classification number: C12Q1/6806 , B01L3/50851 , B01L3/50855 , B01L3/50857 , B01L2200/026 , B01L2200/0642 , B01L2200/0684 , B01L2200/142 , B01L2300/0819 , B01L2300/0829 , B01L2300/0858 , B01L2300/0893 , B01L2300/161 , C12M23/12 , C12M23/38
Abstract: A case for containing a plurality of biological samples contains a base, a substrate and a cover. The substrate is attached to the base and comprises a plurality of reaction regions configured to receive one or more biological samples. The cover comprises an inner surface and is configured to be attached to the base such that the base and cover together provide a cavity containing the substrate. The inner surface includes a central area and a recessed area disposed about the central area. The central area is configured to cover the reaction regions, while the recessed area is offset from the central area in a direction normal to the inner surface.
Abstract translation: 用于容纳多个生物样品的壳体包含基底，基底和盖。 底物附着到基底上，并且包括被配置成接收一个或多个生物样品的多个反应区域。 盖子包括内表面，并且被构造成附接到基座，使得基座和盖子一起提供容纳基底的空腔。 内表面包括中心区域和围绕中心区域设置的凹陷区域。 中心区域构造成覆盖反应区域，而凹陷区域在垂直于内表面的方向上偏离中心区域。
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Patent Agency Ranking
公开(公告)号：US11339425B2
公开(公告)日：2022-05-24
申请号：US16382294
申请日：2019-04-12
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Ted Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lends can be a bi-convex lens.
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公开(公告)号：US20150080247A1
公开(公告)日：2015-03-19
申请号：US14385730
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan W. Foster , Jorge Fonseca , Kevin Maher
CPC classification number: B01L3/50857 , B01L3/50 , B01L3/50851 , B01L7/52 , B01L2200/0642 , B01L2200/142 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , C12Q1/6806 , C12Q1/686 , G03F7/2002
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
Abstract translation: 提供了用于进行生物反应的系统。 该系统包括包括基底和多个反应位点的芯片。 多个反应位点各自被配置为包括至多一个纳升级的液体样品。 此外，该系统包括被配置为启动液体样品内的生物反应的控制系统。 该系统还包括被配置为检测芯片上的生物反应的检测系统。 根据各种实施方案，芯片包括至少20000个反应位点。 在其它实施方案中，芯片包括至少30000个反应位点。
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公开(公告)号：US20150072897A1
公开(公告)日：2015-03-12
申请号：US14385735
申请日：2013-03-15
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Evan W. Foster
CPC classification number: G01N35/1002 , B01J19/0046 , B01J2219/00286 , B01J2219/00317 , B01J2219/00351 , B01J2219/0038 , B01J2219/00599 , B01J2219/00619 , B01J2219/00637 , B01L3/5088 , B01L2200/0642 , B01L2200/12 , B01L2300/0893 , B01L2300/0896 , B01L2300/161 , B01L2300/165 , B01L2400/0406 , C40B60/14
Abstract: A sample loader for loading a liquid sample into a plurality of reaction sites within a substrate is provided. The sample loader includes a first blade, and a second blade coupled to the first blade. The sample loader further comprises a flow path between the first blade and second blade configured to dispense a liquid sample to a substrate including a plurality of reaction sites. Further, in various embodiments the liquid sample has an advancing contact angle of 85+/−15 degrees with the first and second blade. Furthermore, loading of the liquid sample dispensed from the flow path to the plurality of reaction sites may be based on capillary action.
Abstract translation: 提供了一种用于将液体样品加载到基底内的多个反应位点的样品装载器。 样品装载器包括第一叶片和联接到第一叶片的第二叶片。 样品装载器还包括在第一叶片和第二叶片之间的流动路径，其构造成将液体样品分配到包括多个反应位点的基底。 此外，在各种实施例中，液体样品与第一和第二叶片具有85 +/- 15度的前进接触角。 此外，从流动路径分配到多个反应位点的液体样品的装载可以基于毛细作用。
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公开(公告)号：US20140213487A1
公开(公告)日：2014-07-31
申请号：US14348504
申请日：2012-09-28
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Jacob K. Freudenthal , Geoffrey Dahlhoff , Kevin Maher , Ming Song Chen , Gary Lim , Ronald Danehy , David Fortescue , Ming Shen , Woon Liang Soh , Francis T. Cheng , Ruoyun Wu , Thiam Chye Lee , Gary A. Chappell , Chee Kiong Lim , Jeff Dere , Theodore E. Straub , Jorge Fonseca , Kuan Moon Boo , Soo Yong Lau
CPC classification number: C12Q1/686 , B01L3/50855 , B01L3/50857 , B01L7/52 , B01L2200/023 , B01L2200/025 , B01L2200/028 , B01L2200/143 , B01L2300/021 , B01L2300/046 , B01L2300/0654 , B01L2300/0829 , B01L2300/1827 , B01L2300/1844
Abstract: A biological analysis system is provided. The system comprises an interchangeable assembly configured to accommodate any one of a plurality of sample holders, each respective sample holder configured to receive a plurality of samples. The system also includes a control system configured to cycle the plurality of samples through a series of temperatures. The system further includes an optical system configured to detect fluorescent signals emitted from the plurality of samples. The optical system, in particular, can comprise a single field lens, an excitation source, an optical sensor, and a plurality of filter components. The excitation source can be one or more light emitting diodes. The field lens can be a bi-convex lens.
Abstract translation: 提供生物分析系统。 该系统包括被配置为容纳多个样品保持器中的任何一个的可互换组件，每个样品保持器被配置为接收多个样品。 该系统还包括被配置为使多个样品循环通过一系列温度的控制系统。 该系统还包括被配置为检测从多个样本发射的荧光信号的光学系统。 特别地，光学系统可以包括单个场透镜，激发源，光学传感器和多个滤光器组件。 激发源可以是一个或多个发光二极管。 场透镜可以是双凸透镜。
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公开(公告)号：US20190381502A1
公开(公告)日：2019-12-19
申请号：US16426631
申请日：2019-05-30
Applicant: LIFE TECHNOLOGIES CORPORATION
Inventor： Michael C. Pallas , James C. Nurse , Gary Lim , Theodore E. Straub , Eliodor Ghenciu , Evan Foster , Jorge Fonseca , Kevin Maher
IPC: B01L3/00 , C12Q1/6806 , G03F7/20 , C12Q1/686
Abstract: A system for performing biological reactions is provided. The system includes a chip including a substrate and a plurality of reaction sites. The plurality of reaction sites are each configured to include a liquid sample of at most one nanoliter. Further, the system includes a control system configured to initiate biological reactions within the liquid samples. The system further includes a detection system configured to detect biological reactions on the chip. According to various embodiments, the chip includes at least 20000 reaction sites. In other embodiments, the chip includes at least 30000 reaction sites.
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