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公开(公告)号：US20210170411A1
公开(公告)日：2021-06-10
申请号：US17075116
申请日：2020-10-20
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , C12Q1/04 , C12N5/09 , G01N15/14 , G01N33/574 , C12N5/078 , B82Y30/00 , G01N15/10 , G01N15/00 , G01N1/30
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
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公开(公告)号：US20240084286A1
公开(公告)日：2024-03-14
申请号：US18273922
申请日：2022-01-25
Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
Inventor： Viktor A. Adalsteinsson , Shervin Tabrizi , Sangeeta N. Bhatia , J. Christopher Love , Maria Carmen Martin Alonso , Kan Xiong
CPC classification number: C12N15/1006 , A61K9/5123 , A61K38/005
Abstract: This disclosure provides a method for substantially increasing the concentration of cfDNA in a patient. By injecting a patient with lipid and/or polymer nanoparticles, agents that bind cfDNA, or inhibit deoxyribonucleases prior to collection of a sample of cfDNA, e.g., by way of a liquid biopsy, major pathways for the degradation of cfDNA are temporarily blocked, permitting transient accumulation of cfDNA. This strategy has the potential to dramatically enhance the quality of detection achieved by downstream cfDNA e analytical applications, such as sequencing applications.
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公开(公告)号：US20190030536A1
公开(公告)日：2019-01-31
申请号：US16145865
申请日：2018-09-28
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , G01N33/574 , G01N15/14 , C12N5/078 , C12N5/09 , C12Q1/04 , B82Y30/00 , G01N15/00 , G01N15/10 , G01N1/30
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
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公开(公告)号：US10078778B2
公开(公告)日：2018-09-18
申请号：US14997439
申请日：2016-01-15
Applicant: Massachusetts Institute of Technology
Inventor： Viktor A. Adalsteinsson , Denis Loginov , J. Christopher Love , Alan Stockdale , Todd Gierahn
IPC: G01N15/14 , G01N35/00 , G02B21/16 , H04N5/225 , G02B21/26 , B01L3/00 , G06K9/00 , G01N33/483 , G06K9/03 , G06K9/46 , G01N15/00 , G01N15/10
CPC classification number: G06K9/00147 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/0896 , B01L2300/12 , G01N15/1425 , G01N15/1463 , G01N33/4833 , G01N35/00029 , G01N35/00871 , G01N2015/0065 , G01N2015/1006 , G01N2035/00148 , G02B21/16 , G02B21/26 , G06K9/0014 , G06K9/036 , G06K9/4647 , G06K9/4652 , G06K9/4661 , H04N5/2256
Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
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公开(公告)号：US20240182948A1
公开(公告)日：2024-06-06
申请号：US18285103
申请日：2022-03-30
Applicant: The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
Inventor： Viktor A. Adalsteinsson , Nir Hacohen , Sangeeta N. Bhatia , Sahil Patel , Zhenyi An
IPC: C12Q1/6806 , A61K31/4706 , A61K31/713 , C12Q1/6886
CPC classification number: C12Q1/6806 , A61K31/4706 , A61K31/713 , C12Q1/6886
Abstract: This disclosure provides a method and compositions for substantially increasing the concentration of DNA in macrophages of a patient. By administering to a patient one or more agents which prevent the activity of deoxyribonucleases within lysosomes of macrophages, degradation of DNA phagocytosed by macrophages is temporarily blocked, permitting its accumulation. This strategy has the potential to enhance the detection of genetic biomarkers from cells typically phagocytosed by macrophages, such as tumor cells, and thus has applications for early or residual detection of cancer.
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Patent Agency Ranking
公开(公告)号：US20190005304A1
公开(公告)日：2019-01-03
申请号：US16102118
申请日：2018-08-13
Applicant: Massachusetts Institute of Technology
Inventor： Viktor A. Adalsteinsson , Denis Loginov , J. Christopher Love , Alan Stockdale , Todd Gierahn
IPC: G06K9/00 , G01N33/483 , G01N15/14 , G01N35/00
CPC classification number: G06K9/00147 , B01L3/5085 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/0896 , B01L2300/12 , G01N15/1425 , G01N15/1463 , G01N33/4833 , G01N35/00029 , G01N35/00871 , G01N2015/0065 , G01N2015/1006 , G01N2035/00148 , G02B21/16 , G02B21/26 , G06K9/0014 , G06K9/036 , G06K9/4647 , G06K9/4652 , G06K9/4661 , H04N5/2256
Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
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公开(公告)号：US12172166B2
公开(公告)日：2024-12-24
申请号：US16990390
申请日：2020-08-11
Applicant: Massachusetts Institute of Technology
Inventor： Viktor A. Adalsteinsson , Denis Loginov , J. Christopher Love , Alan Stockdale , Todd Gierahn
IPC: G01N15/01 , B01L3/00 , G01B21/08 , G01N15/14 , G01N15/1433 , G01N33/483 , G01N35/00 , G02B21/00 , G02B21/06 , G02B21/16 , G02B21/26 , G06V20/69 , H04N23/56 , G01N15/10
Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
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公开(公告)号：US20200372241A1
公开(公告)日：2020-11-26
申请号：US16990390
申请日：2020-08-11
Applicant: Massachusetts Institute of Technology
Inventor： Viktor A. Adalsteinsson , Denis Loginov , J. Christopher Love , Alan Stockdale , Todd Gierahn
IPC: G06K9/00 , B01L3/00 , G01N15/14 , G01N35/00 , G02B21/16 , G02B21/26 , H04N5/225 , G01N33/483 , G06K9/03 , G06K9/46
Abstract: Described herein are systems, methods, and apparatus for automatically identifying and recovering individual cells of interest from a sample of biological matter, e.g., a biological fluid. Also described are methods of enriching a cell type of interest. These systems, methods, and apparatus allow for coordinated performance of two or more of the following, e.g., all with the same device, thereby enabling high throughput: cell enrichment, cell identification, and individual cell recovery for further analysis (e.g., sequencing) of individual recovered cells.
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公开(公告)号：US10124336B2
公开(公告)日：2018-11-13
申请号：US14912001
申请日：2014-08-15
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , C12N5/09 , C12N5/078 , G01N15/14 , C12Q1/04 , G01N33/574 , G01N15/00 , B82Y30/00 , G01N1/30 , G01N15/10
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
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公开(公告)号：US20160193605A1
公开(公告)日：2016-07-07
申请号：US14912001
申请日：2014-08-15
Applicant: Massachusetts Institute of Technology
Inventor： Armon R. Sharei , Viktor A. Adalsteinsson , Nahyun Cho , Robert S. Langer , J. Christopher Love , Klavs F. Jensen
IPC: B01L3/00 , G01N15/14 , G01N33/574 , C12Q1/04
CPC classification number: B01L3/502761 , B01L2200/0652 , B01L2300/08 , B01L2400/0487 , B82Y30/00 , C12N5/0634 , C12N5/0693 , C12Q1/04 , G01N1/30 , G01N15/1459 , G01N15/1484 , G01N33/574 , G01N2015/0065 , G01N2015/1006 , G01N2015/1081
Abstract: Isolating or identifying a cell based on a physical property of said cell can include providing a cell suspension; passing said suspension through a microfluidic channel that includes a constriction; passing the cell suspension through the constriction; and, contacting said cell suspension solution with a compound. The constriction can be sized to preferentially deform a relatively larger cell compared to a relatively smaller cell.
Abstract translation: 基于所述细胞的物理性质分离或鉴定细胞可以包括提供细胞悬浮液; 将所述悬浮液通过包括收缩的微流体通道; 使细胞悬液通过狭窄; 并使所述细胞悬浮液与化合物接触。 与相对较小的细胞相比，收缩部的大小可优先变形相对较大的细胞。
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