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公开(公告)号：US4292241A
公开(公告)日：1981-09-29
申请号：US115278
申请日：1980-01-25
申请人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
发明人： Kentaro Tanaka , Jun'ichi Shoji , Yoshimi Kawamura , Teruo Hattori , Eiji Kondo , Kouichi Matsumoto , Tadashi Yoshida , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C07D487/04 , C12P17/18 , C12R1/465
CPC分类号： C07D477/20 , C12P17/184 , C12R1/465
摘要： A new antibiotic having .beta.-lactamase inhibitory activity, PA-31088-IV, being useful as a medicament and a veterinary drug for inhibiting the growth of gram-positive and gram-negative phathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces tokunonensis sp. nov. in a suitable medium and recovering PA-31088-IV from the cultured broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新型抗生素PA-31088-IV可用作药物和用于抑制革兰氏阳性和革兰氏阴性致病微生物生长的兽药及其制备方法，其特征在于 培养链霉菌（Toreptomyces tokunonensis sp。） nov。 在合适的培养基中回收PA-31088-IV。
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公开(公告)号：US4256835A
公开(公告)日：1981-03-17
申请号：US15869
申请日：1979-02-27
IPC分类号： C12P1/06 , C07D501/57 , C12P35/08
CPC分类号： C12P35/08 , Y10S435/886
摘要： A novel process for preparing cephamycin C known antibiotic being useful as a medicament and veterinary drug, characterized by cultivating Streptomyces todorominensis sp. nov. in a suitable medium and recovering cephamycin C from the fermentation broth.
摘要翻译： 一种用于制备头孢霉素C的新型方法，已知的抗生素可用作药物和兽药，其特征在于培养链霉菌属（Streptomyces todorominensis sp。 nov。 在合适的培养基中并从发酵液中回收头霉素C。
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公开(公告)号：US5011952A
公开(公告)日：1991-04-30
申请号：US516982
申请日：1990-04-30
申请人： Tadashi Yoshida , Keizo Inoue , Hitoshi Arita , Shigeru Matsutani , Jun'ichi Shoji , Yoshimi Kawamura
发明人： Tadashi Yoshida , Keizo Inoue , Hitoshi Arita , Shigeru Matsutani , Jun'ichi Shoji , Yoshimi Kawamura
IPC分类号： C12P1/02 , A61K38/55 , A61P3/00 , A61P7/00 , A61P9/02 , A61P25/08 , C07D311/82 , C07K14/005 , C07K14/195 , C07K14/37 , C07K14/41 , C12N9/99 , C12P17/06 , C12R1/645
CPC分类号： C12R1/645 , C07D311/82 , C12P17/06
摘要： A compound of the formula: ##STR1## wherein the wave line means .alpha.-bond or .beta.-bond, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound, pharmaceutical composition containing the compound, and a cell culture of a microorganism Thielavia terricola RF-143 producing the compound are also provided.
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公开(公告)号：US4448723A
公开(公告)日：1984-05-15
申请号：US432102
申请日：1982-09-29
申请人： Kentaro Tanaka , Eiji Kondo , Mikao Mayama , Kouichi Matsumoto , Yoshimi Kawamura , Naoki Tsuji
发明人： Kentaro Tanaka , Eiji Kondo , Mikao Mayama , Kouichi Matsumoto , Yoshimi Kawamura , Naoki Tsuji
IPC分类号： C07D477/00 , A61K31/397 , A61K31/40 , A61P31/04 , C07D477/20 , C12P1/06 , C12P17/18 , C12R1/465 , C07D487/04
CPC分类号： C07D477/20 , C12P17/184
摘要： New antibiotics having .beta.-lactamase inhibitory activity, PA-41746-B and C of the formula ##STR1## wherein R is carboxymethylsulfinyl (PA-41746-B) or formylsulfinyl (PA-41746-C) and the pharmaceutically acceptable salts being useful as a medicament, a veterinary drug and a disinfectant for inhibiting the growth of gram-positive and gram-negative pathogenic microorganisms and a process for preparing the same, being characterized by cultivating Streptomyces pluracidomyceticus in a suitable medium and isolating PA-41746-B and/or PA-41746-C from the culture broth.
摘要翻译： 具有β-内酰胺酶抑制活性的新抗生素，式为IMA IMA的PA-41746-B和C，其中R为羧甲基亚磺酰基（PA-41746-B）或甲酰亚磺酰基（PA-41746-C），其药学上可接受的盐可用作 用于抑制革兰氏阳性和革兰氏阴性病原微生物生长的药物，兽药和消毒剂及其制备方法，其特征在于在合适的培养基中培养链霉菌（Streptomyces pluracidomyceticus）并分离PA-41746-B和/ 或来自培养液的PA-41746-C。
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公开(公告)号：US5456910A
公开(公告)日：1995-10-10
申请号：US243780
申请日：1994-05-17
申请人： Shigeru Matsutani , Tadashi Yoshida , Ryuji Sakazaki , Koichi Matsumoto , Shigeo Yagi , Bunji Kageyama , Yoshimi Kawamura , Toshiyuki Kamigauchi , Susumu Kamata
发明人： Shigeru Matsutani , Tadashi Yoshida , Ryuji Sakazaki , Koichi Matsumoto , Shigeo Yagi , Bunji Kageyama , Yoshimi Kawamura , Toshiyuki Kamigauchi , Susumu Kamata
摘要： Novel antibiotic stalobacins A to I having physico-chemical properties as shown in Tables 1 to 4 are provided, which are excellent antibiotics showing marked effects on Gram-positive bacteria.
摘要翻译： 提供了具有如表1至4所示的具有物理化学性质的新型抗生素stalobacins A至I，其是对革兰氏阳性细菌具有显着影响的优异的抗生素。
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公开(公告)号：US4946941A
公开(公告)日：1990-08-07
申请号：US3252
申请日：1987-01-14
申请人： Eiji Kondo , Naoki Tsuji , Koichi Matsumoto , Yoshimi Kawamura , Tadashi Yoshida , Shinzo Matsuura
发明人： Eiji Kondo , Naoki Tsuji , Koichi Matsumoto , Yoshimi Kawamura , Tadashi Yoshida , Shinzo Matsuura
摘要： The compounds of the formula: ##STR1## wherein R is ##STR2## or H, wherein X is NH.sub.2 and Y is CH.sub.3 ; or X is OH and Y is H, and their pharmaceutically acceptable salts. The compounds have a potent activity against gram-positive bacteria, especially, methicillin-resistant bacteria.
摘要翻译： 下式的化合物：其中R是H，其中X是NH 2，Y是CH 3; 或X为OH且Y为H及其药学上可接受的盐。 这些化合物对革兰氏阳性细菌，特别是耐甲氧西林细菌具有很强的活性。
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7.发明授权Aldose reductase inhibitor obtained from Crucibulum sp. RF-3817 失效从Crucibulum sp。获得的醛糖还原酶抑制剂 RF-3817
公开(公告)号：US5324742A
公开(公告)日：1994-06-28
申请号：US697009
申请日：1991-05-08
IPC分类号： A61K31/40 , A61P3/08 , A61P3/10 , A61P27/02 , A61P27/12 , A61P43/00 , C07D491/04 , C07D491/048 , C12N9/99 , C12P17/18 , C12Q1/26 , C12R1/645
CPC分类号： C07D491/04 , C12P17/18
摘要： The present invention relates to a novel aldose reductase inhibitor of the formula: ##STR1## wherein X is methylene or carbonyl;R is ##STR2## R.sup.1, R.sup.2, R.sup.3, and R.sup.4 each is hydrogen or lower alkyl, to a method for producing the inhibitor by culturing Crucibulum sp. RF-3817 or its variants, and to an agent for inhibiting an aldose reductase comprising the inhibitor.
摘要翻译： 本发明涉及下式的新型醛糖还原酶抑制剂：其中X是亚甲基或羰基; R是R 1，R 2，R 3和R 4各自为氢或低级烷基，通过培养Crucibulum sp来制备抑制剂的方法。 RF-3817或其变体，以及用于抑制包含抑制剂的醛糖还原酶的药剂。
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公开(公告)号：US5099034A
公开(公告)日：1992-03-24
申请号：US544673
申请日：1990-06-27
IPC分类号： C12P7/44 , A61K31/19 , A61K31/215 , A61K31/365 , A61P7/02 , A61P43/00 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D307/33 , C07D493/10 , C12N9/99 , C12P7/42 , C12P7/64 , C12P17/02 , C12P17/04 , C12P17/18 , C12R1/645
CPC分类号： C07D307/33 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D493/10 , C12P17/04 , C12P7/42 , C12R1/645
摘要： A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.
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公开(公告)号：US5120647A
公开(公告)日：1992-06-09
申请号：US617882
申请日：1990-11-26
IPC分类号： C12P7/44 , A61K31/19 , A61K31/215 , A61K31/365 , A61P7/02 , A61P43/00 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D307/33 , C07D493/10 , C12N9/99 , C12P7/42 , C12P7/64 , C12P17/02 , C12P17/04 , C12P17/18 , C12R1/645
CPC分类号： C07D307/33 , C07C59/245 , C07C59/42 , C07C69/675 , C07C69/732 , C07D493/10 , C12P17/04 , C12P7/42 , C12R1/645
摘要： A compound of the formula (I): ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are --COOR.sup.4, --COOR.sup.5, and --COOR.sup.6, respectively; R.sup.4, R.sup.5, and R.sup.6 each is hydrogen, lower alkyl, or alkali metal; W is hydroxyl; X, Y, and Z each is hydrogen or hydroxyl; a dotted line indicates the presence or absence of a single bond; or where W/R.sup.3, X/R.sup.1, and/or Z/R.sup.3 may be combined together, a lactone is formed, which compound is useful as a phospholipase A.sub.2 inhibitor. Process for the production of the compound (I) and a cell culture of a microorganism Circinotrichum falcatisporum RF-641 producing the same are also provided.
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公开(公告)号：US5112944A
公开(公告)日：1992-05-12
申请号：US536764
申请日：1990-06-12
CPC分类号： C07K5/126 , Y10S930/27
摘要： A cyclic tetrapeptide having the formula (I): ##STR1## wherein n is 4 or 3 and a process for preparing the above cyclic tetrapeptide. The cyclic tetrapeptide of the present invention inhibits transformation of cells caused by oncogenes and possesses activities for recovering to a normal cell and for inhibiting proliferation of carcinoma cells. Therefore, the cyclic tetrapeptide of the present invention is useful for an active ingredient of an antitumor agent.
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