公开(公告)号：US20240358825A1

公开(公告)日：2024-10-31

申请号：US18406869

申请日：2024-01-08

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Ramasamy Mannar Mannan ,  Richard Lee Krebs ,  James Richard Thompson ,  Tedd Alan Childers ,  Mary Kathryn Olsen ,  Robert John Yancey, Jr. ,  Risini Dhammika Weeratna ,  Shucheng Zhang ,  Cedo Martin Bagi

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/02 ,  A61K39/108 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02

CPC分类号： A61K39/39 ,  A61K39/0011 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0208 ,  A61K39/0241 ,  A61K39/0258 ,  A61K39/12 ,  A61K39/145 ,  A61K39/15 ,  A61K39/21 ,  A61K39/215 ,  A61P37/02 ,  A61K2039/521 ,  A61K2039/5252 ,  A61K2039/5254 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/13034 ,  C12N2740/13051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2770/20034 ,  C12N2770/20051 ,  C12N2770/24334 ,  C12N2770/24351 ,  Y02A50/30

摘要： This invention relates to adjuvant formulations comprising various combinations of triterpenoids, sterols, immunomodulators, polymers, and Th2 stimulators; methods for making the adjuvant compositions; and the use of the adjuvant formulations in immunogenic and vaccine compositions with different antigens. This invention further relates to the use of the formulations in the treatment of animals.

公开(公告)号：US12121576B2

公开(公告)日：2024-10-22

申请号：US18318093

申请日：2023-05-16

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Dennis L. Foss ,  Guillermo Gallo ,  John Morgan Hardham ,  Richard Lee Krebs ,  Sandra Ann Marie Lightle ,  Suman Mahan ,  Sangita Mediratta ,  Kaori Mohr ,  Duncan Mwangi ,  Sharath K. Rai ,  Sarah A. Salmon ,  Shaunak Vora ,  Lauren Wilmes

IPC分类号： A61K39/00 ,  A61K39/002 ,  A61K39/012 ,  A61K39/05 ,  A61K39/08 ,  A61K39/085 ,  A61K39/09 ,  A61K39/108 ,  A61K39/118 ,  A61K39/12 ,  A61K39/39 ,  C12N7/00 ,  G01N33/569

CPC分类号： A61K39/092 ,  A61K39/0002 ,  A61K39/0003 ,  A61K39/0005 ,  A61K39/002 ,  A61K39/012 ,  A61K39/0258 ,  A61K39/05 ,  A61K39/08 ,  A61K39/085 ,  A61K39/118 ,  A61K39/12 ,  A61K39/39 ,  G01N33/56944 ,  A61K2039/552 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/55583 ,  G01N2333/315 ,  G01N2469/10 ,  Y02A50/30

摘要： The instant invention provides various formulations comprising combinations of immunostimulating oligonucleotides, polycationic carriers, sterols, saponins, quaternary amines, TLR-3 agonists, glycolipids, and MPL-A or analogs thereof in oil emulsions, use thereof in preparations of immunogenic compositions and vaccines, and use thereof in the treatment of animals.

公开(公告)号：US20240293524A1

公开(公告)日：2024-09-05

申请号：US18620109

申请日：2024-03-28

申请人： GLAXOSMITHKLINE BIOLOGICALS SA

发明人： Renzo ALFINI ,  Roberta Di Benedetto ,  Francesca Micoli ,  Allan James Saul

IPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/00 ,  A61K39/108 ,  A61K47/69

CPC分类号： A61K39/095 ,  A61K35/74 ,  A61K39/0258 ,  A61K47/6911 ,  A61K2039/6018 ,  A61K2039/6087 ,  A61K2039/627

摘要： The present invention is in the field of conjugating native, non-detergent extracted, outer membrane vesicles (nOMV) to multiple antigens to form multi functionalized nOMV-antigen conjugated derivatives, which are particularly useful for immunogenic compositions and immunisation; processes for the preparation and use of such conjugates are also provided.

公开(公告)号：US20240197868A1

公开(公告)日：2024-06-20

申请号：US18285287

申请日：2022-04-01

申请人： UNIVERSITE DE VERSAILLES-SAINT-QUENTIN-EN-YVELINES ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  BUREAU D’ÉTUDES BIOLOGIQUES SCIENTIFIQUES ET MÉDICALES

发明人： Jacques Henri Max COHEN ,  Clémence SICARD ,  Effrosyni GKANIATSOU

IPC分类号： A61K39/39 ,  A61K39/00 ,  A61K39/08 ,  A61K39/09 ,  A61K39/108 ,  A61K39/13 ,  A61K47/69 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04

CPC分类号： A61K39/39 ,  A61K39/0258 ,  A61K39/08 ,  A61K39/092 ,  A61K39/13 ,  A61K47/6949 ,  A61P31/04 ,  A61P31/12 ,  A61P37/04 ,  A61K2039/521 ,  A61K2039/55505 ,  A61K2039/55511 ,  A61K2039/55544 ,  A61K2039/55561

摘要： An immunogenic composition containing at least one antigen and at least one adjuvant including at least one Metal-Organic Framework including an inorganic part based on aluminum and an organic part based on polydentate ligand chosen from fumarate, muconate, mesaconate, oxalate, oxaloacetate, succinate, malate, citrate, aconitate, isophthalate, substituted isophthalate, 2,5-thiophenedicarboxylate, 2,5-furandicarboxylate, trimesate, trimellitate and pyromellitate, the antigen being immobilized at least within the Metal-Organic Framework.

公开(公告)号：US12012435B2

公开(公告)日：2024-06-18

申请号：US17814966

申请日：2022-07-26

申请人： Janssen Pharmaceuticals, Inc.

发明人： Jan Grijpstra ,  Marleen Eveline Weerdenburg ,  Jeroen Geurtsen ,  Cristhina Kellen Fae ,  Jakob Louris Feitsma

IPC分类号： A61K39/02 ,  A61K39/108 ,  C07K14/195 ,  C07K14/245 ,  C07K16/12

CPC分类号： C07K14/195 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/0266 ,  C07K14/245 ,  C07K16/1232

摘要： Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：US20240131135A1

公开(公告)日：2024-04-25

申请号：US18277150

申请日：2022-02-16

申请人： Duke University

发明人： Soman Abraham ,  Jianxuan Wu

IPC分类号： A61K39/108 ,  A61K39/02 ,  A61K39/39 ,  A61P31/04

CPC分类号： A61K39/0266 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/39 ,  A61P31/04 ,  A61K2039/55561

摘要： Disclosed herein are vaccine compositions for the treatment and prevention of urinary tract infections (UT!s) and methods for delivery of the vaccine compositions. Moreover, the disclosure provides adjuvant compositions for vaccines to modulate cellular responses. such as an immune response.

公开(公告)号：US20240115686A1

公开(公告)日：2024-04-11

申请号：US17768766

申请日：2020-10-14

申请人： THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS

发明人： Weiping Zhang

IPC分类号： A61K39/112 ,  A61K39/108 ,  A61P31/04 ,  C07K14/245 ,  C07K14/25

CPC分类号： A61K39/0283 ,  A61K39/0258 ,  A61P31/04 ,  C07K14/245 ,  C07K14/25 ,  A61K2039/55544

摘要： Compositions and methods for eliciting an immune response in a subject (such as against Shigella) are provided. In examples, the compositions can include fusion proteins including one or more epitopes from Shigella or E. coli. In examples, the methods can include administering a disclosed fusion protein to a subject.

公开(公告)号：US11883477B2

公开(公告)日：2024-01-30

申请号：US17532217

申请日：2021-11-22

申请人： Qingdao Bolin Biological Technology Co., Ltd.

发明人： Yongda Zhao ,  Lili Guo ,  Lihua Ma

IPC分类号： A61K39/112 ,  A61P31/04 ,  A61K39/02 ,  A61K39/108 ,  A61K39/00

CPC分类号： A61K39/0275 ,  A61K39/0208 ,  A61K39/0258 ,  A61P31/04 ,  A61K2039/521 ,  A61K2039/70

摘要： The present disclosure belongs to the technical field of veterinary biological products, and specifically relates to a triple vaccine for diseases caused by Salmonella typhimurium, Riemerella anatipestifer and Escherichia coli. In the triple vaccine, antigens are an inactivated Salmonella typhimurium S01 strain, an inactivated Riemerella anatipestifer R01 strain and an inactivated Escherichia coli E01 strain. The three strains used in the vaccine have high virulence, disable immunogenicity and disable cross-protection. The prepared vaccine has a desirable safety, causing no local or systemic adverse reactions. In a shelf life test, all indicators of the vaccine are stable and effective after a data analysis of traits, a safety test and an efficacy test; in addition, efficacy test results prove that the inactivated triple vaccine can produce desirable antibodies and relatively desirable attacking protection.

公开(公告)号：US11865144B2

公开(公告)日：2024-01-09

申请号：US16052285

申请日：2018-08-01

申请人： Northwestern University

发明人： Jonathan F. Anker ,  Praveen Thumbikat ,  Sarki A. Abdulkadir ,  Anthony J. Schaeffer

IPC分类号： A61K35/74 ,  A61P35/00 ,  A61K45/06 ,  A61K39/00 ,  C07K16/28 ,  A61K39/108 ,  A61K39/395

CPC分类号： A61K35/74 ,  A61K39/001193 ,  A61K39/001194 ,  A61K39/0258 ,  A61K39/3955 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2818 ,  A61K2039/505 ,  A61K2039/523 ,  A61K2039/585 ,  A61K2039/884 ,  C12N2740/16043 ,  A61K39/3955 ,  A61K2300/00 ,  A61K39/0258 ,  A61K2300/00

摘要： Provided herein are composition and methods for the treatment of cancer by the administration of uropathogenic bacteria. In particular, CP1 E. coli is administered for the treatment of prostate cancer.

公开(公告)号：US20230414740A1

公开(公告)日：2023-12-28

申请号：US18105791

申请日：2023-02-03

申请人： University of Maryland, Baltimore ,  Affinivax, Inc.

发明人： Donna Ambrosino ,  Teresa J. Broering ,  Alan Cross ,  Richard Malley ,  Francis Michon ,  George Rainer Siber ,  Raphael Simon ,  Sharon Tennant

IPC分类号： A61K39/104 ,  A61P31/04 ,  A61K39/108 ,  A61K39/40 ,  C07K14/21 ,  C07K14/26 ,  C08B37/00

CPC分类号： A61K39/104 ,  A61P31/04 ,  A61K39/0258 ,  A61K39/0266 ,  A61K2039/6031 ,  C07K14/21 ,  C07K14/26 ,  C08B37/0003 ,  A61K39/40

摘要： Technologies for the prevention and/or treatment of nosocomial infections.