Substrates prepared by chemical amplification of self-assembled monolayers with spatially localized polymer brushes
    92.
    发明授权
    Substrates prepared by chemical amplification of self-assembled monolayers with spatially localized polymer brushes 有权
    通过化学扩增自组装单层与空间局部聚合物刷制备的底物

    公开(公告)号:US06780492B2

    公开(公告)日:2004-08-24

    申请号:US10074395

    申请日:2002-02-11

    IPC分类号: B32B500

    摘要: A method is disclosed for providing a patterned surface wherein predetermined regions of the surface are masked with a self-assembled monolayer (“SAM”) covalently bound to a brush polymer overlayer. The remainder of the substrate surface will generally be functionalized with a second self-assembled monolayer. Preferably, the method involves a microcontact printing technique, wherein a molecular moiety capable of spontaneously forming an SAM upon transfer to a surface is “stamped” onto a substrate surface, followed by growth (or covalent attachment) of a polymer on exposed functional groups within the SAM molecules. Coverage of surface regions with both an SAM and a polymer overlayer provides a number of advantages, particularly with regard to surface masking during etching and the like. The method is useful in the manufacture of microelectronic circuitry, biosensors, high-density assay plates, and the like.

    摘要翻译: 公开了一种用于提供图案化表面的方法,其中表面的预定区域被共价结合到刷式聚合物覆盖层上的自组装单层(“SAM”)掩蔽。 基底表面的其余部分通常将用第二自组装单层进行功能化。 优选地,该方法包括微接触印刷技术,其中能够在转移到表面时自发形成SAM的分子部分被“冲压”到基底表面上,随后在暴露的官能团上的聚合物的生长(或共价附着) SAM分子。 具有SAM和聚合物覆盖层的表面区域的覆盖提供了许多优点,特别是关于在蚀刻等期间的表面掩蔽。 该方法在制造微电子电路,生物传感器,高密度测定板等方面是有用的。

    Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom
    96.
    发明授权
    Antimicrobial hydrogels, methods of preparation thereof, and articles therefrom 有权
    抗微生物水凝胶,其制备方法及其制品

    公开(公告)号:US08496946B2

    公开(公告)日:2013-07-30

    申请号:US13213555

    申请日:2011-08-19

    IPC分类号: A61K9/00

    摘要: A covalently crosslinked hydrogel comprises a) three or more divalent poly(alkylene oxide) chains P′ covalently linked at respective first end units to a branched first core group C′, b) three or more divalent poly(alkylene oxide) chains P″ covalently linked at respective first end units to a branched second core group C″, the chains P″ comprising respective second end units which are covalently linked to between 0% and 100% of respective second end units of chains P′ by divalent linking groups L″, and c) at least one pendant cationic block copolymer chain A′-B′. A′-B′ comprises i) a divalent block A′ comprising a poly(alkylene oxide) backbone chain having an end unit covalently linked to a second end unit of one of the chains P′ by a divalent linking group L′, and ii) a monovalent block B′ comprising a first repeat unit, the first repeat unit comprising a backbone carbonate group and a cationic side chain group.

    摘要翻译: 共价交联的水凝胶包含a)三个或更多个在相应的第一末端单元共价连接至支化的第一核心基团C'的二价聚(烯化氧)链P',b)三个或更多个二价聚(烯化氧)链P“ 在各个第一末端单元共价连接至支链第二核心基团C“,链P”包含通过二价连接共价连接到链P'的相应第二末端单元的0%至100%之间的相应第二端单元 基团L“,和c)至少一个侧挂阳离子嵌段共聚物链A'-B'。 A'-B'包括:i)包含聚(环氧烷)主链的二价嵌段A',其具有通过二价连接基团L'与链P'之一共价连接的末端单元,ii )包含第一重复单元的单价嵌段B',所述​​第一重复单元包含骨架碳酸酯基团和阳离子侧链基团。