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公开(公告)号：US08951999B2
公开(公告)日：2015-02-10
申请号：US12908172
申请日：2010-10-20
申请人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Robert Roenn , Benjamin Pelcman
发明人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Robert Roenn , Benjamin Pelcman
IPC分类号： A61K31/445 , C07D211/32 , C07C311/14 , C07D213/82 , C07C237/42 , C07C237/44 , C07C255/23 , C07C255/60 , C07D205/04 , C07D207/10 , C07D207/22 , C07D207/34 , C07D209/08 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/38 , C07D213/40 , C07D213/75 , C07D213/81 , C07D215/42 , C07D237/30 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D295/15 , C07D295/155 , C07D307/20 , C07D307/24 , C07D309/12 , C07D309/14 , C07D333/38 , C07D335/02 , C07D417/04
CPC分类号： C07D213/82 , C07C237/42 , C07C237/44 , C07C255/23 , C07C255/60 , C07C311/14 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/04 , C07D207/10 , C07D207/22 , C07D207/34 , C07D209/08 , C07D211/14 , C07D211/16 , C07D211/18 , C07D211/38 , C07D213/40 , C07D213/75 , C07D213/81 , C07D215/42 , C07D237/30 , C07D277/46 , C07D277/56 , C07D277/60 , C07D277/82 , C07D295/15 , C07D295/155 , C07D307/20 , C07D307/24 , C07D309/12 , C07D309/14 , C07D333/38 , C07D335/02 , C07D417/04
摘要： This invention relates to compounds of formula I, their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions such as inflammatory/nociceptive pain. A, M, R1, R2, R7, Ra, Rb, Q3, Q4, Q6, Z2, Z4, Z5, Z6 and W have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，它们作为微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂的用途，含有它们的药物组合物及其用作治疗和/或预防炎性疾病和相关病症的药物 如炎性/伤害性疼痛。 A，M，R 1，R 2，R 7，R a，R b，Q 3，Q 4，Q 6，Z 2，Z 4，Z 5，Z 6和W具有说明书中给出的含义。
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92.发明申请New beta-agonists, processes for preparing them and their use as pharmaceutical compositions 有权新的β-激动剂，其制备方法及其作为药物组合物的用途公开(公告)号：US20060173061A1
公开(公告)日：2006-08-03
申请号：US11276649
申请日：2006-03-09
IPC分类号： A61K31/4178 , A61K31/4172
CPC分类号： C07D233/64 , C07D233/84 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula 1: wherein the groups R1 to R12 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式1的新β-激动剂：其中R 1至R 12基团具有权利要求书和说明书中给出的含义，其异构体， 制备这些化合物的方法及其作为药物组合物的用途。
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公开(公告)号：US06934011B2
公开(公告)日：2005-08-23
申请号：US10697811
申请日：2003-10-30
申请人： Bernd Geh , Paul Gräupner , Thomas Stammler , Dirk Stenkamp , Jochen Stühler , Klaus Wurmbrand
发明人： Bernd Geh , Paul Gräupner , Thomas Stammler , Dirk Stenkamp , Jochen Stühler , Klaus Wurmbrand
IPC分类号： G02B7/02 , G01B11/00 , G02B13/00 , G02B27/00 , G03F7/20 , G03F7/207 , H01L21/027 , G03B27/32
CPC分类号： G03F7/706 , G01M11/0207 , G01M11/0242 , G01M11/0257 , G02B27/0012 , G03F7/70225 , G03F7/70258 , G03F7/70666
摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.
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公开(公告)号：US20120309755A1
公开(公告)日：2012-12-06
申请号：US13314574
申请日：2011-12-08
申请人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： C07D471/04 , A61K31/5377 , A61P29/00 , A61K31/437
CPC分类号： C07D471/04
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, Ra, Rb have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为用于治疗和/或预防炎性疾病及相关病症的药物的用途。 A，L，M，W，R 1，R 2，R 3，R 4，R 6，R 7，R a，R b具有说明书中给出的含义。
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95.发明申请Method for optimizing the image properties of at least two optical elements as well as methods for optimizing the image properties of at least three optical elements 失效用于优化至少两个光学元件的图像特性的方法以及用于优化至少三个光学元件的图像特性的方法公开(公告)号：US20050254042A1
公开(公告)日：2005-11-17
申请号：US11187730
申请日：2005-07-22
申请人： Bernd Geh , Paul Graupner , Thomas Stammler , Dirk Stenkamp , Jochen Stuhler , Klaus Wurmbrand
发明人： Bernd Geh , Paul Graupner , Thomas Stammler , Dirk Stenkamp , Jochen Stuhler , Klaus Wurmbrand
CPC分类号： G03F7/706 , G01M11/0207 , G01M11/0242 , G01M11/0257 , G02B27/0012 , G03F7/70225 , G03F7/70258 , G03F7/70666
摘要： In order to optimize the image properties of several optical elements of which at least one is moved relative to at least one stationary optical element, the overall image defect resulting from the interaction of all optical elements is first of all measured. This is represented as a linear combination of the base functions of an orthogonal function set. The movable element is then moved to a new measurement position and the overall image defect is measured once again. After the linear combination representation of the new overall image defect, the image defects of the movable element and of the stationary element are calculated from the data thereby obtained. With only one movable optical element a target position in which the overall image defect is minimized can be directly calculated and adjusted there from. If several movable optical elements are available, methods are given for the efficient determination of the respective target position.
摘要翻译： 为了优化其中至少一个相对于至少一个固定光学元件移动的多个光学元件的图像特性，首先测量由所有光学元件的相互作用产生的整体图像缺陷。 这被表示为正交函数集的基函数的线性组合。 然后将可移动元件移动到新的测量位置，并再次测量整个图像缺陷。 在新的整体图像缺陷的线性组合表示之后，根据获得的数据计算可移动元件和静止元件的图像缺陷。 只有一个可移动光学元件可以直接计算和调整整个图像缺陷最小化的目标位置。 如果有多个可移动的光学元件可用，则给出用于有效确定各个目标位置的方法。
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公开(公告)号：US08486968B2
公开(公告)日：2013-07-16
申请号：US13314574
申请日：2011-12-08
申请人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： A01N43/42 , A61K31/44 , A61K31/135 , A01N33/18 , A61K31/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, L, M, W, R1, R2, R3, R4, R6, R7, Ra, Rb have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为用于治疗和/或预防炎性疾病及相关病症的药物的用途。 A，L，M，W，R 1，R 2，R 3，R 4，R 6，R 7，R a，R b具有说明书中给出的含义。
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公开(公告)号：US08466186B2
公开(公告)日：2013-06-18
申请号：US13314565
申请日：2011-12-08
申请人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Raimund Kuelzer , Juergen Mack , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： A01N43/52 , A01N33/02 , A01N33/18 , A61K31/135 , A61K31/04
CPC分类号： C07D403/04 , C07D235/30 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D409/14 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), to pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R3, R4, R6, R2, R7, R8, R9, Ra, Rb have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合成酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为治疗和/或预防炎性疾病和相关病症的药物的用途 。 A，M，W，R 1，R 2，R 3，R 4，R 6，R 2，R 7，R 8，R 9，R a，R b具有在说明书中给出的含义。
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98.发明授权Beta-agonists, processes for preparing them and their use as pharmaceutical compositions 有权β-激动剂，制备它们的方法及其作为药物组合物的用途公开(公告)号：US07214698B2
公开(公告)日：2007-05-08
申请号：US11276649
申请日：2006-03-09
IPC分类号： A61K31/4164
CPC分类号： C07D233/64 , C07D233/84 , C07D249/08 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12
摘要： The present invention relates to new beta-agonists of general formula 1: wherein the groups R1 to R12 have the meanings given in the claims and specification, the isomers thereof, processes for preparing these compounds and their use as pharmaceutical compositions.
摘要翻译： 本发明涉及通式1的新β-激动剂：其中R 1至R 12基团具有权利要求书和说明书中给出的含义，其异构体， 制备这些化合物的方法及其作为药物组合物的用途。
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公开(公告)号：US08933079B2
公开(公告)日：2015-01-13
申请号：US13780343
申请日：2013-02-28
申请人： Thorsten Oost , Ralf Lotz , Dirk Stenkamp
发明人： Thorsten Oost , Ralf Lotz , Dirk Stenkamp
IPC分类号： A61K31/501 , A61K31/4412 , C07D213/69 , C07D237/16 , C07D401/12 , C07D401/14 , C07D401/10 , C07D413/10 , C07D413/12 , C07D403/10
CPC分类号： C07D401/12 , C07D213/69 , C07D237/16 , C07D401/10 , C07D401/14 , C07D403/10 , C07D413/10 , C07D413/12
摘要： Pyridone and pyridazinone derivatives that are active against the melanin-concentrating hormone (MCH) and useful as anti-obesity pharmaceuticals.
摘要翻译： 对黑色素浓缩激素（MCH）有活性的吡啶酮和哒嗪酮衍生物，可用作抗肥胖药物。
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公开(公告)号：US08586604B2
公开(公告)日：2013-11-19
申请号：US13211471
申请日：2011-08-17
申请人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
发明人： Henning Priepke , Henri Doods , Raimund Kuelzer , Roland Pfau , Dirk Stenkamp , Benjamin Pelcman , Robert Roenn , Dimitrijs Lubriks , Edgars Suna
IPC分类号： A61K31/437 , A61P29/00 , C07D471/04
CPC分类号： C07D471/04
摘要： This invention relates to compounds of formula I their use as inhibitors of the microsomal prostaglandin E2 synthase-1 (mPGES-1), pharmaceutical compositions containing them, and their use as medicaments for the treatment and/or prevention of inflammatory diseases and associated conditions. A, M, W, R1, R2, R6, R7 have meanings given in the description.
摘要翻译： 本发明涉及式I化合物，其用作微粒体前列腺素E2合酶-1（mPGES-1）的抑制剂，含有它们的药物组合物及其作为用于治疗和/或预防炎性疾病及相关病症的药物的用途。 A，M，W，R 1，R 2，R 6，R 7具有在说明书中给出的含义。
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