公开(公告)号：US20180177919A1

公开(公告)日：2018-06-28

申请号：US15847158

申请日：2017-12-19

申请人： LifeCell Corporation

发明人： Israel James Jessop

IPC分类号： A61L27/36 ,  A61L27/50 ,  B26D3/24 ,  F25D31/00

CPC分类号： A61L27/3691 ,  A61B17/322 ,  A61B2017/3225 ,  A61L27/3604 ,  A61L27/3683 ,  A61L27/3695 ,  A61L27/50 ,  A61L2400/08 ,  A61L2400/18 ,  A61L2430/34 ,  B26D3/24 ,  B26D7/018 ,  B26D7/10 ,  F25D31/00

摘要： The present application relates to a method and device for processing tissue. The method and device allow for machining of soft tissue samples to produce uniform shapes (e.g., uniform thicknesses) or reliably produce alterations such as openings or holes in soft tissue products. The method and device can alternatively or additionally be used to process tissue to produce particulates with desired properties.

公开(公告)号：US09974886B2

公开(公告)日：2018-05-22

申请号：US14420278

申请日：2013-07-26

申请人： Nanyang Technological University

发明人： Dongan Wang ,  Ting Ting Lau ,  Wenyan Leong

IPC分类号： A61L27/52 ,  A61L27/38 ,  A61L27/14 ,  A61L27/22 ,  A61L27/56

CPC分类号： A61L27/52 ,  A61L27/14 ,  A61L27/222 ,  A61L27/38 ,  A61L27/3817 ,  A61L27/56 ,  A61L2400/06 ,  A61L2400/08 ,  A61L2430/00 ,  A61L2430/06

摘要： Method of manufacturing hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein is provided. The method includes dissolving a hydrogel-forming agent in an aqueous medium to form a solution; suspending one or more species of living cells in the solution to form a cell suspension; dispersing the cell suspension into an organic oil to form a microemulsion; and subjecting the microemulsion to conditions that allow the hydrogel-forming agent to form hydrogel microparticles comprising one or more species of living cells attached thereon and/or encapsulated therein. Composition comprising a mixture of a degradable hydrogel and at least one hydrogel microparticle having one or more species of living cells, and method of manufacturing a scaffold for tissue engineering are also provided.

公开(公告)号：US20180055643A1

公开(公告)日：2018-03-01

申请号：US15671048

申请日：2017-08-07

申请人： Nanochon, LLC

发明人： Nathan Jonathan Castro ,  Benjamin Blair Holmes

IPC分类号： A61F2/30 ,  A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08J9/00 ,  A61L27/12 ,  B29C64/30 ,  B33Y10/00 ,  B33Y80/00

CPC分类号： A61F2/30942 ,  A61F2/28 ,  A61F2/30756 ,  A61F2/30771 ,  A61F2002/2835 ,  A61F2002/30766 ,  A61F2002/30784 ,  A61F2002/30838 ,  A61F2002/3084 ,  A61F2002/3092 ,  A61F2002/3093 ,  A61F2002/30948 ,  A61F2002/30962 ,  A61F2002/30968 ,  A61F2002/3097 ,  A61F2002/30971 ,  A61F2002/30985 ,  A61L27/12 ,  A61L27/18 ,  A61L27/48 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2400/08 ,  A61L2400/12 ,  A61L2430/02 ,  A61L2430/06 ,  B29C64/118 ,  B29C64/30 ,  B29K2071/02 ,  B29K2075/00 ,  B29K2995/0056 ,  B29L2031/7532 ,  B33Y10/00 ,  B33Y80/00 ,  C08J9/0061 ,  C08J9/0071 ,  C08J9/26 ,  C08J2201/0464 ,  C08J2205/04 ,  C08J2205/042 ,  C08J2205/044 ,  C08J2205/06 ,  C08J2207/10 ,  C08J2325/06 ,  C08J2367/04 ,  C08J2375/04 ,  C08J2405/04 ,  C08J2429/04 ,  C08J2471/02 ,  C08J2489/00 ,  C08L75/04 ,  C08L67/04

摘要： The present disclosure relates to a three-dimensionally (3D) printed tissue engineering scaffold for tissue regeneration and a method for manufacturing the 3D printed tissue engineering scaffold. The 3D printed tissue engineering scaffold may be fabricated at least in part from a composite material having an insoluble component and soluble component. The three-dimensional tissue scaffolds of the disclosure may be fabricated via a rapid prototyping machine. In some instances, the three-dimensional shape of the fabricated tissue engineering scaffold may correspond to a three-dimensional shape of a tissue defect of a patient.

公开(公告)号：US09676914B2

公开(公告)日：2017-06-13

申请号：US14651764

申请日：2013-12-23

申请人： Fondazione Istituto Italiano de Tecnologia

发明人： Despina Fragouli ,  Elisa Mele ,  Athanasia Athanasiou

IPC分类号： C08J9/26 ,  C08J9/36 ,  C08J9/00 ,  A61L27/48 ,  A61L27/56

CPC分类号： C08J9/26 ,  A61L27/48 ,  A61L27/56 ,  A61L2400/08 ,  C08J9/0061 ,  C08J9/36 ,  C08J2201/046 ,  C08J2201/0464 ,  C08J2205/022 ,  C08J2205/05 ,  C08J2333/06 ,  C08J2375/04 ,  C08J2383/04 ,  C08J2389/00 ,  C08J2400/14 ,  C08J2401/02 ,  C08J2405/04 ,  C08J2405/08 ,  C08J2431/04 ,  C08J2433/26 ,  C08J2477/06

摘要： Process for the production of a polymer foam with use of hydrogel pearls as porosity generating template, comprising the steps of:—providing a matrix of polymer or prepolymer in viscous state including, as a dispersed phase, hydrogel pearls, where said pearls are dispersed in said matrix so as to generate intercommunicating cells,—causing the solidification of the matrix of polymer or prepolymer to obtain said polymer foam including said hydrogel pearls, characterised in that it comprises the operation of subjecting the thus obtained foam to conditions which cause the dehydration of said hydrogel pearls so as to obtain a reduction of volume of said pearls and—removing the dehydrated pearls by immersion in water of the polymer foam or by exposure of the foam to a flow of pressurized gas or water.

公开(公告)号：US20170100775A1

公开(公告)日：2017-04-13

申请号：US15128887

申请日：2015-03-24

申请人： ALEACIONES DE METALES SINTERIZADOS, S.A.

发明人： JOSE ANTONIO CALERO MARTINEZ ,  FRANCISCO JAVIER GIL MUR

IPC分类号： B22F3/11 ,  A61L27/56 ,  B22F3/04 ,  B22F3/16 ,  B22F3/10 ,  B22F3/24 ,  A61L27/06 ,  B22F1/00

CPC分类号： B22F3/11 ,  A61F2/4455 ,  A61F2310/00023 ,  A61F2310/00598 ,  A61F2310/00616 ,  A61L27/06 ,  A61L27/56 ,  A61L2400/08 ,  A61L2430/38 ,  B22F1/0062 ,  B22F1/007 ,  B22F3/04 ,  B22F3/1021 ,  B22F3/1125 ,  B22F3/1146 ,  B22F3/16 ,  B22F3/24 ,  B22F2003/241 ,  B22F2003/247 ,  B22F2301/205 ,  B22F2302/45 ,  B22F2303/01 ,  B22F2998/10 ,  B22F1/0003 ,  B22F1/0059 ,  B22F3/02

摘要： Disclosed is a method for obtaining a porous titanium part in a metal material, wherein a starting titanium powder is pure, which has a mean particle size of 200 micrometers, a flow rate of 93 s calculated according to ISO 4490 standard, an apparent density of 1.0 g/cm3 calculated according to ISO 3923/1, and the starting titanium powder is mixed at a proportion of 34% of titanium by weight with at least 50% by weight of sodium chloride (NaCl) having a particle size between 300 and 600 micrometers.

公开(公告)号：US09533075B2

公开(公告)日：2017-01-03

申请号：US12865633

申请日：2009-02-02

申请人： Thomas Buckland ,  Charles Campion

发明人： Thomas Buckland ,  Charles Campion

IPC分类号： A61F2/00 ,  A61K33/42 ,  C01B15/16 ,  A61L27/56 ,  A61L27/12 ,  A61F2/28

CPC分类号： A61L27/56 ,  A61F2/28 ,  A61L27/025 ,  A61L27/12 ,  A61L2400/08 ,  A61L2430/02 ,  Y10T428/2982

摘要： A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.

摘要翻译： 提供了一种合成的骨诱导性多孔生物材料，包括：相互连接的微孔网，其中微孔率为23体积％以上; 其中所述生物材料的表面自由能为19mJ / m以上; 选择平均互连直径和平均互连直径和表面自由能，以提供由0.206nm 2或更大的微孔产生的渗透性和3.7kPa以上的毛细管压力差。 生物材料含有羟基磷灰石和硅。

公开(公告)号：US20160346434A1

公开(公告)日：2016-12-01

申请号：US15236093

申请日：2016-08-12

申请人： ApaTech Limited

发明人： Thomas Buckland ,  Charles Campion

IPC分类号： A61L27/56 ,  A61L27/02 ,  A61L27/12

CPC分类号： A61L27/56 ,  A61F2/28 ,  A61L27/025 ,  A61L27/12 ,  A61L2400/08 ,  A61L2430/02 ,  Y10T428/2982

摘要： A synthetic osteoinductive porous biomaterial is provided comprising: a network of interconnected micropores, wherein the microporosity is 23% by volume or more; wherein the surface free energy of the biomaterial is 19 mJ/m or more; and the mean interconnection diameter and the mean interconnection diameter and the surface free energy are chosen to provide a permeability resulting from the micropores of 0.206 nm2 or greater and a capillary pressure difference in water of 3.7 kPa or more. The biomaterial contains hydroxyapatite and silicon.

公开(公告)号：US20160339145A1

公开(公告)日：2016-11-24

申请号：US15106468

申请日：2014-12-19

申请人： KENT STATE UNIVERSITY

发明人： Elda Hegmann ,  Torsten Hegmann ,  Yunxiang Gao

IPC分类号： A61L27/18 ,  A61L27/56 ,  C08J9/26 ,  C08G63/682 ,  C09K19/38 ,  C12N5/00 ,  A61L27/58

CPC分类号： A61L27/18 ,  A61L27/3834 ,  A61L27/54 ,  A61L27/56 ,  A61L27/58 ,  A61L2300/63 ,  A61L2400/00 ,  A61L2400/08 ,  C08G63/6822 ,  C08J9/26 ,  C08J2201/0442 ,  C08J2207/10 ,  C08J2367/04 ,  C09K19/3833 ,  C09K19/3838 ,  C09K2219/00 ,  C12N5/0062 ,  C12N2533/30 ,  C12N2537/10 ,  C08L67/04 ,  C08L101/12

摘要： A polymeric scaffold contains pendant liquid crystal side chains and has fully interconnected pores. Such a polymeric scaffold will preferably be 3D in nature and elastomeric, biocompatible and biodegradable. Such 3D liquid crystal elastomer (LCE) scaffolds can be used for various biomedical applications, including cell culture applications. A method for the production of such a polymeric scaffold containing liquid crystals and having interconnected pores is also disclosed that uses a metal foam sacrificial template as a scaffold to produce the polymeric smart response scaffold of the present invention. Consistent and controlled pore sizes result from etching the sacrificial metal foam template away from the polymeric scaffold, permitting the incorporation of growth factors, when needed, for enhancing cell viability and proliferation.

摘要翻译： 聚合物支架包含侧链液晶侧链并且具有完全互连的孔。 这种聚合物支架本质上优选为3D，弹性体，生物相容性和生物降解性。 这种3D液晶弹性体（LCE）支架可用于各种生物医学应用，包括细胞培养应用。 还公开了一种用于生产含有液晶并具有互连孔的聚合物支架的方法，其使用金属泡沫牺牲模板作为支架来生产本发明的聚合智能反应支架。 通过将牺牲金属泡沫模板蚀刻离开聚合物支架，导致一致和受控的孔径，允许在需要时引入生长因子以增强细胞活力和增殖。

公开(公告)号：US20160310634A1

公开(公告)日：2016-10-27

申请号：US14903133

申请日：2015-01-06

申请人： COUNCIL OF SCIENCETIFIC & INDUSTRIAL RESEARCH

发明人： Gaurav Kumar GUPTA ,  Mohit SHARMA ,  Om Prakash MODI ,  Braj Kishore PRASAD

IPC分类号： A61L27/06 ,  B22F3/11 ,  C22C1/08 ,  A61L27/56

CPC分类号： A61L27/06 ,  A61L27/56 ,  A61L2400/02 ,  A61L2400/08 ,  A61L2430/02 ,  B22F3/1125 ,  B22F2998/10 ,  B22F2999/00 ,  C22C1/08 ,  B22F2301/25 ,  B22F1/0059 ,  B22F3/02 ,  B22F3/10

摘要： The disclosure relates to a process for the preparation of a titanium foam through a powder metallurgy route using Acrawax particles as a space holder material. An open cellular titanium foam is provided, having desirable porosity and good mechanical properties. The titanium foam is useful as a bone implant material.

摘要翻译： 本公开内容涉及通过使用Acrawax颗粒作为空间保持材料的粉末冶金路线制备钛泡沫的方法。 提供开孔的细胞钛泡沫，其具有所需的孔隙率和良好的机械性能。 钛泡沫可用作骨植入材料。

公开(公告)号：US20160289399A1

公开(公告)日：2016-10-06

申请号：US15036108

申请日：2014-11-19

申请人： ESP TECHNOLOGY LIMITED

发明人： Christopher John Underwood ,  Robert Stevens

IPC分类号： C08J3/24 ,  A61L27/34 ,  H01M8/0239 ,  A61L27/56 ,  A61L31/14 ,  B05D3/00 ,  C08J9/28 ,  A61L31/04

CPC分类号： C08J3/24 ,  A61L27/16 ,  A61L27/34 ,  A61L27/56 ,  A61L31/048 ,  A61L31/146 ,  A61L2400/08 ,  A61L2420/02 ,  B05D3/007 ,  C08J9/26 ,  C08J9/283 ,  C08J2201/026 ,  C08J2201/04 ,  C08J2201/042 ,  C08J2201/044 ,  C08J2201/046 ,  C08J2205/05 ,  C08J2327/12 ,  H01M8/0239 ,  C08L27/18

摘要： The present invention relates to a process for the processing of perfluoropolymer materials, and to the use of the resultant products in different potential applications, such as in the medical device field.

摘要翻译： 本发明涉及一种用于处理全氟聚合物材料的方法，以及在不同的潜在应用中，例如在医疗器械领域中使用所得产品。