Covulcanizable anti-aging agents
    95.
    发明申请
    Covulcanizable anti-aging agents 失效
    可共聚抗老化剂

    公开(公告)号:US20020006994A1

    公开(公告)日:2002-01-17

    申请号:US09850511

    申请日:2001-05-07

    摘要: This invention relates to covulcanizable anti-aging agents which can be produced by the reaction of p-phenylenediamines, which are optionally substituted, and/or of sterically hindered phenols, with bifunctional alkyl, aryl and/or aralkyl compounds and by subsequent reaction of the products thus obtained with sulfur and/or sulfur donor compounds. The anti-aging agents according to the present invention maintain their efficacy over a long period of time and are distinguished in particular by the fact that in practice, they are hardly extracted from the vulcanized products by water, by oil and/or petrol, or by hydraulic fluids.

    摘要翻译: 本发明涉及可通过任选取代的对苯二胺和/或空间位阻酚与双官能烷基,芳基和/或芳烷基化合物的反应产生的共可硫化抗老化剂, 用硫和/或硫供体化合物得到的产物。 根据本发明的抗老化剂在长时间内保持它们的功效,并且特别区别在于,实际上它们几乎不被水,油和/或汽油从硫化产物中提取,或 通过液压油。

    Process for the preparation of S(&ohgr;-aminoalkylamino) alkyl aryl sulfide dihydrochlorides
    96.
    发明授权
    Process for the preparation of S(&ohgr;-aminoalkylamino) alkyl aryl sulfide dihydrochlorides 失效
    制备S(ω-氨基烷基氨基)烷基芳基硫醚二氢氯化物的方法

    公开(公告)号:US06320079B1

    公开(公告)日:2001-11-20

    申请号:US09533728

    申请日:2000-03-23

    IPC分类号: C07C32116

    CPC分类号: C07C323/25 C07C319/14

    摘要: A process for preparing S-(&ohgr;-aminoalkylamino) alkyl aryl sulfide dihydrochlorides includes the steps of (a) reacting aryl mercaptan and (&ohgr;-aminoalkylamino) alkylbromide dihydrobromide to cause condensation thereof in the presence of an organic base in an organic solvent and provide a condensation product; (b) converting the condensation product to a dihydrochloride salt; and (c) precipitating the dihydrochloride salt. Preferably the precipitated dihydrochloride salt is recrystallized. These dihydrochlorides are new and effective antidotes for sulfur mustard toxicity.

    摘要翻译: 制备S-(ω-氨基烷基氨基)烷基芳基硫醚二氢氯化物的方法包括以下步骤:(a)使芳基硫醇和(ω-氨基烷基氨基)烷基溴二氢溴酸盐反应,使其在有机溶剂存在下在有机碱存在下缩合,并提供 缩合产物; (b)将缩合产物转化成二盐酸盐; 和(c)沉淀二盐酸盐。 优选将沉淀的二盐酸盐重结晶。 这些二氢氯化物是硫芥子毒性的新型和有效的解毒剂。

    Production of amide derivatives and intermediates therefor
    97.
    发明授权
    Production of amide derivatives and intermediates therefor 失效
    酰胺衍生物及其中间体的生产

    公开(公告)号:US06252085B1

    公开(公告)日:2001-06-26

    申请号:US09580831

    申请日:2000-05-30

    IPC分类号: C07D26308

    摘要: A method for producing an amide derivative of the formula [XV] wherein each-symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.

    摘要翻译: 一种制备式[XV]的酰胺衍生物的方法,其中每个符号如说明书中所定义,及其对映异构体,可用于制备所述化合物的新型中间体及其制备方法。本发明的制备方法 与常规方法相比非常容易和简单,并且能够以高产率有效生产化合物[XV],其包括具有HIV蛋白酶抑制作用的化合物[XVI]。 此外,本发明的新型中间体作为用于生产上述化合物[XVI]的中间体以及用作X射线造影剂的化合物是非常有用的。

    Polyisocyanate compound, process for producing the same and optical materials using the same
    98.
    发明授权
    Polyisocyanate compound, process for producing the same and optical materials using the same 有权
    多异氰酸酯化合物,其制造方法和使用其的光学材料

    公开(公告)号:US06194603B1

    公开(公告)日:2001-02-27

    申请号:US09362094

    申请日:1999-07-28

    IPC分类号: C07C24900

    摘要: A novel polyisocyanate compound, which compound is useful as a starting material for an optical material having excellent optical characteristics such as a high refractive index and a low dispersion, and a process for producing this compound at good efficiency. Specifically, a polyisocyanate compound represented by general formula (I): wherein Z represents a direct bond, or —CH2—. The invention also relates to processes for producing the desired polyisocyanate compound through a tricarboxylic acid ester and a tricarbonyl hydrazide using a dihalogeno-aliphatic carboxylic acid lower alkyl ester and a thioglycolic acid lower alkyl ester. In addition, the invention relates to optical materials, such as lenses, etc., made by a polyaddition reaction of compounds of formula (I) and other monomers.

    摘要翻译: 一种新颖的多异氰酸酯化合物,该化合物可用作具有优异的光学特性如高折射率和低分散性的光学材料的起始材料,以及以高效率生产该化合物的方法。 具体地,由通式(I)表示的多异氰酸酯化合物:其中Z表示直接键或-CH 2 - 。 本发明还涉及使用二卤代脂族羧酸低级烷基酯和巯基乙酸低级烷基酯通过三羧酸酯和三羰基酰肼生产所需多异氰酸酯化合物的方法。 此外,本发明涉及通过式(I)化合物与其它单体的加成反应制备的光学材料,例如透镜等。