摘要:
The invention concerns LTA4 hydrolase inhibiting compositions of formula (1) as set forth below. It also concerns their therapeutic, in particular anti-inflammatory, applications.
摘要:
The present invention relates to compositions and methods for inhibiting fungal growth. In particular, the present invention relates to methods for use as anti-fungal agents of inhibitors, and compositions thereof, of fungal GGPTase. The inhibitors of fungal GGPTase may be peptides, peptidomimetics, or non-peptides.
摘要:
Substituted aryloxyalkylamines of formula (I), compositions containing them, and methods of making and using them to treat histamine-mediated conditions.
摘要:
Substituted non-imidazole aryloxypiperidine compounds, compositions containing them, and methods of making and using them to treat or prevent histamine-mediated conditions.
摘要:
This invention relates to covulcanizable anti-aging agents which can be produced by the reaction of p-phenylenediamines, which are optionally substituted, and/or of sterically hindered phenols, with bifunctional alkyl, aryl and/or aralkyl compounds and by subsequent reaction of the products thus obtained with sulfur and/or sulfur donor compounds. The anti-aging agents according to the present invention maintain their efficacy over a long period of time and are distinguished in particular by the fact that in practice, they are hardly extracted from the vulcanized products by water, by oil and/or petrol, or by hydraulic fluids.
摘要:
A process for preparing S-(&ohgr;-aminoalkylamino) alkyl aryl sulfide dihydrochlorides includes the steps of (a) reacting aryl mercaptan and (&ohgr;-aminoalkylamino) alkylbromide dihydrobromide to cause condensation thereof in the presence of an organic base in an organic solvent and provide a condensation product; (b) converting the condensation product to a dihydrochloride salt; and (c) precipitating the dihydrochloride salt. Preferably the precipitated dihydrochloride salt is recrystallized. These dihydrochlorides are new and effective antidotes for sulfur mustard toxicity.
摘要:
A method for producing an amide derivative of the formula [XV] wherein each-symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound [XV] at high yields, which includes compound [XVI] having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound [XVI] but also compounds useful as X-ray contrast media.
摘要:
A novel polyisocyanate compound, which compound is useful as a starting material for an optical material having excellent optical characteristics such as a high refractive index and a low dispersion, and a process for producing this compound at good efficiency. Specifically, a polyisocyanate compound represented by general formula (I): wherein Z represents a direct bond, or —CH2—. The invention also relates to processes for producing the desired polyisocyanate compound through a tricarboxylic acid ester and a tricarbonyl hydrazide using a dihalogeno-aliphatic carboxylic acid lower alkyl ester and a thioglycolic acid lower alkyl ester. In addition, the invention relates to optical materials, such as lenses, etc., made by a polyaddition reaction of compounds of formula (I) and other monomers.
摘要:
Tertiary amines of the formula ##STR1## wherein A.sup.1, A.sup.2, A.sup.3, A.sup.4, L, M, p, T, and Q are as defined herein, have antimycotic and cholesterol-lowering activity.