公开(公告)号：US20020031783A1

公开(公告)日：2002-03-14

申请号：US09827076

申请日：2001-04-05

Inventor： Stephen A. Empedocles ,  Andrew R. Watson

IPC: G01N033/53 ,  G06K009/00 ,  G01N033/551 ,  C12M001/34

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Improved devices, systems, and methods for sensing and/or identifying signals from within a signal detection region are well-suited for identification of spectral codes. Large numbers of independently identifiable spectral codes can be generated by quite small bodies, and a plurality of such bodies or probes may be present within a detection region. Simultaneously imaging of identifiable spectra from throughout the detection region allows the probes to be identified. As the identifiable spectra can be treated as being generated from a point source within a much larger detection field, a prism, diffractive grading, holographic transmissive grading, or the like can spectrally disperse the images of the labels across a sensor surface. A CCD can identify the relative wavelengths of signals making up the spectra. Absolute signal wavelengths may be identified by determining positions of the labels, by an internal wavelength reference within the spectra, or the like.

公开(公告)号：US20020022273A1

公开(公告)日：2002-02-21

申请号：US09827013

申请日：2001-04-05

Inventor： Stephen A. Empedocles ,  Joseph A. Treadway ,  Andrew R. Watson

IPC: G01N021/29

CPC classification number: G01N21/272 ,  B01J2219/00317 ,  B01J2219/00432 ,  B01J2219/005 ,  B01J2219/00574 ,  B01J2219/00576 ,  B01J2219/00578 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00648 ,  B01J2219/00657 ,  B01J2219/00659 ,  B01J2219/00677 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00743 ,  B01L3/5025 ,  B01L3/502715 ,  B01L3/502761 ,  B01L3/5085 ,  B01L3/545 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0819 ,  B01L2300/0829 ,  B01L2400/0454 ,  B01L2400/0457 ,  B82Y30/00 ,  C40B40/06 ,  C40B60/14 ,  G01N21/25 ,  G01N21/253 ,  G01N21/274 ,  G01N21/278 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N21/6486 ,  G01N21/6489 ,  G01N33/54373 ,  G01N2015/0092 ,  G01N2015/1472 ,  G01N2015/1497 ,  G01N2021/6441 ,  G01N2021/6482 ,  G01N2035/00158 ,  G01N2035/00742 ,  G01N2035/00752 ,  G01N2201/04 ,  G01N2201/06113 ,  G01N2201/12

Abstract: Devices, systems, methods, and compositions of matter can track and/or identify a library of elements, particularly for use with fluids, particulates, cells, and the like. Signals from one or more semiconductor nanocrystals may be combined to define spectral codes. Separation of signal wavelengths within dedicated wavelength ranges or windows facilitates differentiation of spectral codes, while calibration signals within the spectral codes can avoid ambiguity. Modeling based on prior testing can help derive libraries of acceptable codes.

Abstract translation: 物质的装置，系统，方法和组合物可以跟踪和/或识别元件库，特别是用于流体，微粒，细胞等。 来自一个或多个半导体纳米晶体的信号可以被组合以限定光谱代码。 信号波长在专用波长范围或窗口内的分离有助于光谱代码的分化，而光谱码内的校准信号可以避免歧义。 基于先前测试的建模可以帮助导出可接受代码的库。

公开(公告)号：US5460968A

公开(公告)日：1995-10-24

申请号：US348210

申请日：1994-11-28

Applicant: Kasumi Yoshida ,  Isao Shindo ,  Susumu Kai ,  Yutaka Kimura

Inventor： Kasumi Yoshida ,  Isao Shindo ,  Susumu Kai ,  Yutaka Kimura

IPC: G01N1/10 ,  G01N21/78 ,  G01N33/52 ,  G01N35/00 ,  G01N35/02 ,  G01N35/04 ,  G01N35/10

CPC classification number: G01N35/00029 ,  G01N2035/00108 ,  G01N2035/0441 ,  G01N2035/1025 ,  G01N2201/04 ,  Y10T436/112499 ,  Y10T436/113332 ,  Y10T436/114165

Abstract: A sample container containing a urine sample is transferred by a sample positioning device to a liquid level sensing position. At this sensing position, the liquid level in the sample container is detected by a level sensor, followed by transfer of the sample container to a dipping position. A liquid level rising member is then inserted into the sample container. While being held by a handling device, a test strip is dipped into the sample in the sample container with the liquid level raised. Thereafter, the test strip is lifted out of the sample container and transferred to a measuring device. Color development in reagent sections on the test strip is measured by a photometer in terms of the reflected light strength. With the present invention, analysis using test strips can be implemented even when the sample volume into the sample container is small.

Abstract translation: 容纳尿样的样品容器通过样品定位装置转移到液位检测位置。 在该检测位置，通过液位传感器检测样品容器中的液位，随后将样品容器转移到浸渍位置。 然后将液位升高构件插入样品容器中。 在被处理装置保持的同时，将测试条浸入样品容器中，液面升高。 此后，将测试条从样品容器中提出并转移到测量装置。 根据反射光强度，通过光度计测定试片上试剂部分的显色性。 通过本发明，即使在样品容器中的样品体积小的情况下也可以实施使用测试条的分析。

公开(公告)号：US5200321A

公开(公告)日：1993-04-06

申请号：US578390

申请日：1990-09-07

Applicant: David A. Kidwell

Inventor： David A. Kidwell

IPC: G01N33/53 ,  B01L3/00 ,  G01N21/03 ,  G01N21/29 ,  G01N21/76 ,  G01N21/78 ,  G01N31/20 ,  G01N33/52 ,  G01N33/543 ,  G01N33/545 ,  G01N33/552 ,  G01N33/94

CPC classification number: G01N33/54386 ,  B01L3/5023 ,  G01N21/78 ,  G01N33/525 ,  B01L2200/0621 ,  B01L2300/0681 ,  B01L2300/069 ,  B01L2300/0819 ,  B01L2300/0822 ,  B01L2300/087 ,  B01L2300/0887 ,  B01L2400/0406 ,  G01N21/29 ,  G01N21/76 ,  G01N2201/04 ,  Y10S435/805 ,  Y10S435/81 ,  Y10S435/967 ,  Y10S435/969 ,  Y10S435/97 ,  Y10S436/805 ,  Y10S436/808 ,  Y10S436/81

Abstract: A microassay card for a includes an upper layer containing wells for receiving a liquid sample. A second layer of the card, beneath the first layer, includes a supporting surface bound to a reactive species. A third layer includes a superabsorbent support impregnated with an indicator. Typically, the indicator is a substrate for an enzyme, such as a reduced dye precursor and a source of hydrogen peroxide necessary for the action of the enzyme upon the substrate to cause a spectral change in the absorbent layer. By selecting the structure of the first and second layers, the card can be formatted for a displacement assay or a competitive assay. The microassay card of the present invention is particularly useful for drug testing.

Abstract translation: 用于a的微型卡片包括含有用于接收液体样品的孔的上层。 在第一层下方的卡的第二层包括与活性物质结合的支撑表面。 第三层包括浸渍有指示剂的超吸收剂载体。 通常，指示剂是用于酶的底物，例如还原的染料前体和过氧化氢源，用于酶在底物上起作用以引起吸收层中的光谱变化。 通过选择第一层和第二层的结构，可以将卡格式化为位移测定或竞争性测定。 本发明的微量测定卡对于药物测试特别有用。

公开(公告)号：US4963027A

公开(公告)日：1990-10-16

申请号：US363826

申请日：1989-06-09

Applicant: Takashi Koizumi ,  Tadashi Uekusa

Inventor： Takashi Koizumi ,  Tadashi Uekusa

IPC: G01N21/78 ,  G01N21/25 ,  G01N21/27 ,  G01N21/59 ,  G01N21/86 ,  G01N35/00 ,  G02B6/00 ,  G02B6/32 ,  G02B6/34 ,  G02B6/38

CPC classification number: G02B6/32 ,  G01N21/255 ,  G01N35/00009 ,  G01N2035/00445 ,  G01N2035/00455 ,  G01N21/5907 ,  G01N21/8483 ,  G01N2201/04 ,  G01N2201/0484 ,  G01N2201/0826 ,  G02B6/2937

Abstract: An optical density measuring system has a light projecting system which includes a light source and an optical fiber bundle which transmits light emitted from the light source to the specimen. The optical fiber bundle consists of first and second portions which are connected by an optical fiber connector. The connector includes a first optical fiber plug which holds the light emanating end face of the first portion of the bundle, a second optical fiber plug which holds the light incident end face of the second portion of the bundle, a plug holder which can be mated with both the first and second optical fiber plugs in such a manner that the light emanating end face of the first portion and the light incident end face of the second portion are closely opposed to each other, and an optical filter which transmits only light having a selected wavelength and is mounted on the plug holder in a position in which the optical filter is interposed between the light emanating end face of the first portion and the light incident end face of the second portion.

Abstract translation: 光密度测量系统具有光投射系统，其包括光源和将从光源发射的光透射到样本的光纤束。 光纤束由通过光纤连接器连接的第一和第二部分组成。 连接器包括保持束的第一部分的发光端面的第一光纤插头，保持束的第二部分的光入射端面的第二光纤插头，可配合的插头保持器 同时第一和第二光纤插头都以这样的方式使得第一部分的光发射端面和第二部分的光入射端面彼此紧密相对;以及滤光器，其仅透射具有 并且安装在插头保持器上，其中滤光器插入在第一部分的光发射端面和第二部分的光入射端面之间。

公开(公告)号：US4879097A

公开(公告)日：1989-11-07

申请号：US848134

申请日：1986-04-04

Applicant: Thomas P. Whitehead ,  Gary H. G. H. Thorpe ,  Larry J. Kricka ,  John E. C. Gibbons ,  Roger A. Bunce

Inventor： Thomas P. Whitehead ,  Gary H. G. H. Thorpe ,  Larry J. Kricka ,  John E. C. Gibbons ,  Roger A. Bunce

IPC: G01N35/00 ,  B01L3/02 ,  G01N21/76

CPC classification number: G01N21/76 ,  B01L3/021 ,  G01N2201/04

Abstract: A recording apparatus has a holder for a plurality of reaction vessels including a support plate (11) having an array of holes (15) therein for receiving an array of reaction vessels (16), a housing (10) for receiving the holder and being sealed to prevent entry of stray light, an openable cover (24, 249) for the housing, a film back (12) for holding a photographic film adjacent the underside of the plate (11), and a removable shutter (13) for interposition between the film and the support plate.

公开(公告)号：US4801187A

公开(公告)日：1989-01-31

申请号：US858218

申请日：1986-04-30

Applicant: Lawrence E. Elbert ,  John C. Mazza ,  Raymond L. Hecker

Inventor： Lawrence E. Elbert ,  John C. Mazza ,  Raymond L. Hecker

IPC: G01N21/01 ,  G01N21/03 ,  G01N21/25 ,  G01N35/02 ,  G02B6/00 ,  G02B6/032 ,  G02B6/26

CPC classification number: G02B6/032 ,  G01N21/255 ,  G01N2201/04 ,  G01N2201/08

Abstract: An improved and unique liquid light tube (guide) end cap assembly particularly useful in a system for the clinical analysis of liquid biological samples for directing wavelengths of light is described. The assembly comprises a light guide having projecting at one end portion thereof a quartz member and a housing for containing the end portion of the light guide and the quartz member, thereby forming an aperture between the quartz member and the housing, the aperture having a depth of between about 0.002 and 0.007 inches.

Abstract translation: 描述了一种改进和独特的液体光管（引导）端盖组件，其特别可用于用于引导光波长的液体生物样品的临床分析系统。 该组件包括一个导光体，该导光体在其一个端部具有一个石英构件和用于容纳导光体和石英构件的端部的壳体，从而在石英构件和壳体之间形成孔， 在0.002和0.007英寸之间。