FIELD EFFECT BASED NANOPORE DEVICE
    103.
    发明申请
    FIELD EFFECT BASED NANOPORE DEVICE 有权
    基于场效应的纳米器件

    公开(公告)号:US20160313278A1

    公开(公告)日:2016-10-27

    申请号:US14694316

    申请日:2015-04-23

    CPC classification number: G01N33/48721

    Abstract: A nanopore FET sensor device and method of making. The nanopore FET sensor device includes a FET device stack of material layers including a source, channel and drain layers, and a nanoscale hole through the FET device stack to penult flow of strands of molecular material, e.g., DNA, therethrough. The perimeter of the nanoscale hole forms a FET device gate surface. The source and drain layers are provided with respective contacts for connection with measuring instruments that measure a flow of current therebetween. The molecular strands having charged portions pass from one side of a wafer substrate to the other side through the (nanopore) gate and modulate the current flow sensed at the source or drain terminals. The sensor collects real-time measurements of the current flow modulations for use in identifying the type of molecule. Multiple measurements by the same nanopore FET sensor are collected and compared for enhanced detection.

    Abstract translation: 纳米孔FET传感器装置及其制造方法。 纳米孔FET传感器装置包括包括源极,沟道和漏极层的材料层的FET器件堆叠,以及穿过FET器件堆叠的纳米级孔,以通过其延伸分子材料(例如DNA)的线束。 纳米级孔的周长形成FET器件栅极表面。 源极和漏极层设置有用于与测量其间的电流的测量仪器连接的相应触点。 具有带电部分的分子束从晶片衬底的一侧通过(纳米孔)栅极的另一侧,并调制在源极或漏极端子处感测的电流。 传感器收集当前流量调节的实时测量,以用于识别分子的类型。 通过相同的纳米孔FET传感器的多次测量被收集和比较,以增强检测。

    Probe structure for physiological measurements using surface enhanced Raman spectroscopy

    公开(公告)号:US10694951B2

    公开(公告)日:2020-06-30

    申请号:US15293267

    申请日:2016-10-13

    Abstract: Surface enhanced Raman spectroscopy is employed to obtain chemical data with respect to body tissue and cells. The chemical environments of stimulation implants and drug-delivery catheters are spectroscopically monitored in real time using an implantable probe. The probe includes a surface enhancer that facilitates surface enhanced Raman spectroscopy in opposing relation to an array of optical fibers. Light emitted by the optical fibers can be employed for chemical detection and/or tissue stimulation. Wavelength and optical power are selected based on whether the probe is employed for such detection or stimulation. Fabrication of a probe assembly that enables surface enhanced Raman spectroscopy is further disclosed.

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