-
公开(公告)号：US09916968B1
公开(公告)日：2018-03-13
申请号：US15365935
申请日：2016-11-30
CPC分类号： H01J49/005 , H01J49/10
摘要： An electrode assembly is provided in a high sub-atmospheric pressure region of an ion source, between an ionization chamber and a vacuum region of a spectrometer, such as a mass spectrometer, an ion mobility spectrometer, or an ion mobility-mass spectrometer. The electrode assembly is spaced at a distance from an outlet of an ion transfer device. A voltage source imparts a potential difference between the ion transfer device and the electrode assembly to accelerate ions emitted from the outlet to a collision energy. The collision energy is effective to cause collisional heating of ions in the high sub-atmospheric pressure region without voltage breakdown. The collision energy may be set to cause unfolding of folded biomolecular ions and/or dissociation of ions.
-
公开(公告)号：US09890882B2
公开(公告)日：2018-02-13
申请号：US14771392
申请日：2013-02-28
发明人： Darijo Zeko , Manfred Berndt
IPC分类号： B01L3/00 , F16L21/02 , G01N30/60 , B01D15/10 , B01D15/14 , C12M1/12 , C12M3/00 , F16L13/02 , F16L13/08 , F16L13/10 , F16L15/04 , F16L47/02 , F16L47/16 , G01N30/16 , G01N30/02
CPC分类号： F16L21/02 , B01D15/10 , B01D15/14 , B01L3/502715 , B01L3/565 , B01L2200/027 , B01L2200/0689 , C12M23/04 , C12M23/46 , F16L13/0209 , F16L13/08 , F16L13/103 , F16L15/04 , F16L47/02 , F16L47/16 , G01N30/16 , G01N30/60 , G01N30/6026 , G01N30/6095 , G01N2030/027
摘要： A fluidic device includes a planar structure constituted by a plurality of laminated layers and accommodating a fluid channel extending up to a surface of the planar structure, and a female adapter piece configured for a fluid-tight accommodation of a male adapter piece having a fluid conduit. The the female adapter piece is connected or connectable with the planar structure so that, when the male adapter piece is accommodated in the female adapter piece, the fluid conduit is brought in fluid-tight fluid communication with the fluid channel. The fluid channel is exposed to the female adapter piece at a lateral surface of the planar structure at which the laminated layers are exposed.
-
公开(公告)号：US09876330B1
公开(公告)日：2018-01-23
申请号：US15419859
申请日：2017-01-30
发明人： Guthrie Partridge
CPC分类号： H01S5/141 , H01S3/08059 , H01S3/1003 , H01S3/1055 , H01S3/125 , H01S5/1025 , H01S5/1092 , H01S5/14 , H01S5/3401
摘要： A light source having a gain chip, a retro reflecting prism and a first actuator is disclosed. The gain chip amplifies light passing therethrough. The retro reflecting prism is characterized by a pivot axis within the retro reflecting prism, an input light direction, an output light direction, and a diffraction grating that receives light emitted by the gain chip traveling in the input direction, returns a diffracted light beam to the gain chip along the input light direction and generates an output light beam. The first actuator causes the retro reflecting prism to rotate about the pivot axis in response to a control signal being coupled to the first actuator.
-
公开(公告)号：US09875884B2
公开(公告)日：2018-01-23
申请号：US14634745
申请日：2015-02-28
IPC分类号： H01J49/10 , H01J49/04 , H01J49/00 , H01J49/16 , H05H1/46 , G01N21/71 , G01N30/95 , H01J27/16
CPC分类号： H01J49/102 , G01N21/714 , G01N30/95 , H01J27/16 , H01J49/0031 , H01J49/0409 , H01J49/049 , H01J49/105 , H01J49/161 , H05H1/46
摘要： An ion source includes a plasma generator for supplying plasma at an ionization region proximate to a sample surface. The plasma generator applies energy that may be utilized for desorbing analytes from the sample surface as well as for generating plasma by which analytes are excited or ionized. Desorption and ionization/excitation may be controlled as individual modes. The ion source may be interfaced with an ion-based or optical-based spectrometer. A sample support may be provided, which may be capable of performing analytical separation.
-
公开(公告)号：US09863921B2
公开(公告)日：2018-01-09
申请号：US13974549
申请日：2013-08-23
发明人： Holger Rapp
CPC分类号： G01N30/38 , B01L3/502715 , B01L3/502746 , B01L2300/0864 , B01L2400/0487 , G01L1/125 , G01N30/6017 , G01N30/62 , G01N2030/6013 , Y10T137/0318 , Y10T137/85938
摘要： A fluid transfer device transfers a fluid from a first fluid channel with a first cross-sectional area into a second fluid channel with a second cross-sectional area, larger than the first cross-sectional area. The fluid transfer device includes a fluid inlet interface at which the fluid is transferable from the first fluid channel into the fluid transfer device; an inlet branch configured to split the fluid from the first fluid channel into multiple inlet branch channels; multiple outlet branches, each of which is configured to split the fluid from the inlet branch channels into respective outlet branch channels; and a fluid outlet interface configured to transfer the fluid in the outlet branch channels into the second fluid channel. The inlet and output branches and branch channels are disposed such that the fluid exits from the fluid outlet interface, distributed in a two-dimensional manner across the second cross-sectional area.
-
公开(公告)号：USD805164S1
公开(公告)日：2017-12-12
申请号：US29531557
申请日：2015-06-26
设计人： Wesley M. Norman , Wei J. Song
-
公开(公告)号：US09833754B2
公开(公告)日：2017-12-05
申请号：US14443126
申请日：2012-11-15
发明人： Herbert Anderer
CPC分类号： B01F3/0865 , B01F3/088 , B01F15/00188 , B01F15/00253 , B01F15/00422 , B01F15/026 , B01F2003/0896 , B01F2215/0037 , G01N1/38 , G01N30/06 , G01N35/1097 , G01N2001/383
摘要： A dilution apparatus (100) for diluting a fluidic sample in accordance with a specifiable dilution ratio, wherein the dilution apparatus (100) comprises a dilution fluid supply device (102) configured for supplying a dilution fluid at a first quantity per time, a transport fluid supply device (104) configured for supplying a transport fluid at a second quantity per time, a first fluid accommodation unit (106) configured for accommodating a first fluid volume, a second fluid accommodation unit (108) configured for accommodating a second fluid volume, and a control device (110, 112) configured for controlling the flow of the dilution fluid, the transport fluid and the fluidic sample so that in a first operation mode, the fluidic sample, being accommodated in the first fluid accommodation unit (106), is forced to flow to the second fluid accommodation unit (108) while being diluted by being mixed with dilution fluid, and in a second operation mode, the mixture of dilution fluid and fluidic sample, being accommodated in the second fluid accommodation unit (108), is forced to flow from the second fluid accommodation unit (108) to the first fluid accommodation unit (106) while being further diluted by being mixed with further dilution fluid.
-
118.发明授权公开(公告)号：US09823226B2
公开(公告)日：2017-11-21
申请号：US14898392
申请日：2013-06-14
发明人： Klaus Witt , Konstantin Shoykhet , Manfred Berndt
CPC分类号： G01N30/20 , G01N30/465 , G01N2030/027 , G01N2030/202 , G01N2030/208
摘要： Disclosed is a sample dispatcher configured for individually introducing a plurality of portions of one or more sample fluids into a flow of a mobile phase of a separation system configured for separating compounds of the sample fluids. The separation system comprises a mobile phase drive configured for driving the mobile phase through a separation unit configured for separating compounds of the sample fluids in the mobile phase. The sample dispatcher comprises a plurality of sample reservoirs, each configured for receiving and temporarily storing a respective sample fluid portion or at least a part thereof. The sample dispatcher is configured for selectively coupling one of the plurality of sample reservoirs between the mobile phase drive and the separation unit, and further for coupling at least two of the plurality of sample reservoirs in parallel between the mobile phase drive and the separation unit.
-
公开(公告)号：US09803782B2
公开(公告)日：2017-10-31
申请号：US13695878
申请日：2010-05-03
申请人： Bernhard Dehmer
发明人： Bernhard Dehmer
CPC分类号： F16L17/10 , B01D15/14 , F16L19/041 , F16L19/046 , F16L19/06 , F16L19/07 , G01N30/6039
摘要： A fitting element, in particular for an HPLC application, is configured for providing a fluidic coupling of a tubing to a fluidic device. The fitting element comprises a gripping piece to exert—upon coupling of the tubing to the fluidic device—a grip force (G) between the fitting element and the tubing. The gripping piece comprises a hydraulic element configured to transform an axial force (S) into a hydraulic pressure (P) within the hydraulic element. The hydraulic pressure (P) in the hydraulic element causes the grip force (G).
-
公开(公告)号：US09802975B2
公开(公告)日：2017-10-31
申请号：US14724613
申请日：2015-05-28
IPC分类号： C07H5/06 , C07H7/06 , C07H23/00 , C07H21/00 , C07D211/00
CPC分类号： C07H23/00 , C07D211/00 , C07H7/06 , C07H21/00 , Y02P20/55
摘要： The present disclosure provides nucleoside compounds and oligonucleotides including an unnatural 6-amino-2-pyridone heterocyclic base where the 6-amino and 2-positions are protected. The 2-position of the heterocyclic base can be protected with an acyl-oxy-methyl protecting group. In some embodiments, the protected heterocyclic base has the following structure where AcOM is an acetyl-oxy-methyl group and R is a ribose or deoxyribose sugar: Methods for synthesizing an oligonucleotide are provided in which the subject compounds find use. The method can include protecting an unnatural (e.g., Z) nucleotide with an acetyl-oxy-methyl group; incorporating the protected unnatural nucleotide into a nucleotide sequence on a solid support; and removing the acetyl-oxy-methyl group from the unnatural nucleotide incorporated into the nucleotide sequence. The compounds and methods find use in the synthesis of long oligonucleotides including Z nucleotides.
-
-
-
-
-
-
-
-
-
搜索结果
4029 条记录 (耗时 0.046 秒)
