公开(公告)号：US09025152B2

公开(公告)日：2015-05-05

申请号：US13805806

申请日：2011-02-04

Applicant: Cedric Florian Aymeric Floquet ,  Hywel Morgan ,  Vincent Joseph Sieben ,  Iain Rodney George Ogilvie ,  Matthew Charles Mowlem

Inventor： Cedric Florian Aymeric Floquet ,  Hywel Morgan ,  Vincent Joseph Sieben ,  Iain Rodney George Ogilvie ,  Matthew Charles Mowlem

IPC: G01N21/17 ,  B01L3/00 ,  G01N21/03 ,  G01N21/05

CPC classification number: G01N21/17 ,  B01L3/502715 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/12 ,  G01N21/0303 ,  G01N21/05 ,  G01N2021/0346 ,  G01N2021/0389 ,  G01N2201/064

Abstract: An absorption cell for microfluidic chemical analysis made from tinted or colored polymers, for example polymethylmethacrylate (PMMA), in which microfluidic channels are cut. Light is coupled into the absorption cell via two windows (typically 200 um thick) that are retained at either end of the channel. Absorption is measured using a light source, such as a light emitting diode (LED) and a photodiode butted against the windows. Spurious scattered and/or reflected light is absorbed by the colored polymer over the length of the measurement cell, while very little light loss occurs at the coupling windows.

Abstract translation: 用于由有色或有色聚合物（例如聚甲基丙烯酸甲酯（PMMA））制成的微流控化学分析的吸收单元，其中切割微流体通道。 光通过保留在通道任一端的两个窗口（通常为200μm厚）耦合到吸收单元中。 使用光源测量吸收，例如发光二极管（LED）和光电二极管对着窗户。 杂散散射和/或反射光在测量单元的长度上被有色聚合物吸收，而在耦合窗处发生很少的光损失。

公开(公告)号：US20150045639A1

公开(公告)日：2015-02-12

申请号：US14520896

申请日：2014-10-22

Applicant: SEIKO EPSON CORPORATION

Inventor： Hideto YAMASHITA ,  Yoshitaka IIJIMA

IPC: A61B5/024 ,  A61B5/00 ,  A61B5/1455

CPC classification number: A61B5/0059 ,  A61B5/02055 ,  A61B5/02427 ,  A61B5/02438 ,  A61B5/02444 ,  A61B5/14552 ,  A61B5/681 ,  A61B5/7278 ,  A61B2562/0219 ,  A61B2562/0238 ,  G01N21/474 ,  G01N21/49 ,  G01N2201/064

Abstract: A biological information detector includes a wristband, a light-emitting part, a reflecting part, a light-receiving part, a protecting part, an acceleration sensor and a processing part. The wristband is adapted to be attached to a body of a user. The light-emitting part is configured to emit green light. The reflecting part is configured to reflect the light emitted by the light-emitting part. The light-receiving part is configured to receive reflected light reflected at a detection site of the body of the user. The protecting part is configured to protect the light-emitting part, the protecting part having a contact surface configured to contact with the detection site. The acceleration sensor is configured to detect acceleration generated by the user. The processing part is configured to process a light reception signal outputted from the light-receiving part.

Abstract translation: 生物信息检测器包括腕带，发光部，反射部，受光部，保护部，加速度传感器和处理部。 腕带适于附接到使用者的身体。 发光部被配置为发出绿光。 反射部被配置为反射由发光部发射的光。 光接收部被配置为接收在用户的身体的检测部位处反射的反射光。 保护部被配置为保护发光部，保护部具有被配置为与检测部位接触的接触面。 加速度传感器被配置为检测用户生成的加速度。 处理部被配置为处理从光接收部输出的光接收信号。

公开(公告)号：US08760652B2

公开(公告)日：2014-06-24

申请号：US13654747

申请日：2012-10-18

Applicant: Postnova Analytics GmbH

Inventor： Dietheim Fröse ,  Roland Welz

IPC: G01N21/00

CPC classification number: G01N21/51 ,  G01N21/53 ,  G01N30/74 ,  G01N2021/4711 ,  G01N2201/064

Abstract: An apparatus for measuring the light scattering properties of a sample in a liquid medium, wherein the liquid medium with the sample is illuminated by a laser beam in a measuring cell transversely to the direction of filling the liquid medium in the measuring cell or transversely to the flow direction of the liquid medium within the measuring cell, comprising a laser, a cylindrical measuring cell, a first inner aperture system, a second outer aperture system and at least two detectors, wherein the detectors are arranged outside of the second outer aperture system so that they collect the light scattered on the sample within set, different angle ranges, wherein the first inner aperture system and the second outer aperture system are formed and arranged circularly and concentrically around the axis of the measuring cell. Use of the apparatus and a method that makes use of the apparatus are also disclosed.

Abstract translation: 一种用于测量液体介质中的样品的光散射性质的装置，其中具有样品的液体介质通过横向于在测量池中填充液体介质的方向的横向于横向于测量单元的测量单元中的激光束照射 测量单元内的液体介质的流动方向，包括激光器，圆柱形测量单元，第一内孔系统，第二外孔系统和至少两个检测器，其中检测器布置在第二外孔系统的外侧，因此 它们收集在集合的不同角度范围内散射在样品上的光，其中第一内孔系统和第二外孔系统被形成并围绕测量池的轴线圆周且同心地布置。 还公开了使用该装置和使用该装置的方法。

公开(公告)号：US20140099659A1

公开(公告)日：2014-04-10

申请号：US14049470

申请日：2013-10-09

Applicant: Howard Hughes Medical Institute

Inventor： Philipp Johannes Keller

IPC: G01N21/64

CPC classification number: G01N21/6486 ,  A61B5/0071 ,  A61B2503/42 ,  G01N21/64 ,  G01N33/4833 ,  G01N2021/1736 ,  G01N2201/06193 ,  G01N2201/064 ,  G02B21/0004 ,  G02B21/0048 ,  G02B21/06 ,  G02B21/16 ,  G02B21/361 ,  G02B21/362 ,  G02B21/367 ,  G02B27/1013

Abstract: A live biological specimen is imaged by generating a plurality of light sheets; directing the plurality of light sheets along an illumination axis through the biological specimen such that the light sheets spatially and temporally overlap within the biological specimen along an image plane, and optically interact with the biological specimen within the image plane; and recording, at each of a plurality of views, images of the fluorescence emitted along a detection axis from the biological specimen due to the optical interaction between the light sheets and the biological specimen. The temporal overlap is within a time shift that is less than a resolution time that corresponds to a spatial resolution limit of the microscope.

Abstract translation: 通过生成多个光片对活体生物样本进行成像; 沿着照明轴线引导多个光片通过生物样本，使得光片沿着图像平面在空间和时间上在生物样本内重叠，并与图像平面内的生物样本光学相互作用; 并且在多个视图的每一个处，由于光片和生物样本之间的光学相互作用，沿着检测轴从生物样本记录荧光的图像。 时间重叠在时间偏移之内，其小于对应于显微镜的空间分辨率极限的分辨率时间。

公开(公告)号：US20130313417A1

公开(公告)日：2013-11-28

申请号：US13983754

申请日：2012-01-25

Applicant: Makoto Ogusu

Inventor： Makoto Ogusu

IPC: G01J1/42 ,  B29D11/00

CPC classification number: G01J1/42 ,  B01L3/502707 ,  B01L2200/0689 ,  B01L2300/0654 ,  B01L2300/0816 ,  B01L2300/0877 ,  B01L2300/1827 ,  B29D11/00 ,  G01N21/0332 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0346 ,  G01N2201/064

Abstract: A light emission detection device having a flow path from which light to be detected is emitted is provided. The device includes a detection-side substrate having a joining surface and a detection surface provided opposite the joining surface, the joining surface having a depression and a light-shielding film provided over an area excluding the depression, the depression forming the flow path, the detection surface transmitting the light emitted from the flow path; and a wiring-side substrate having a joining surface and a conductive pattern provided with a varying thickness on the joining surface, the joining surface of the wiring-side substrate joining the joining surface of the detection-side substrate. In the area over which the light-shielding film is provided, adhesive is provided with a thickness corresponding to the varying thickness of the conductive pattern and the detection-side substrate and the wiring-side substrate are closely joined to each other with the adhesive.

Abstract translation: 提供一种发光检测装置，其具有从其被发射的光的流路。 该装置包括检测侧基板，其具有接合面和与接合面相对设置的检测面，所述接合面具有设置在不包括凹部的区域上的凹部和遮光膜，形成流路的凹部， 检测表面透射从所述流路发射的光; 以及布线侧基板，其具有接合面和在接合面上具有变化厚度的导电图案，所述布线侧基板的接合面与检测侧基板的接合面接合。 在设置有遮光膜的区域中，粘合剂具有与导电图案的变化厚度对应的厚度，并且检测侧基板和布线侧基板用粘合剂彼此紧密接合。

公开(公告)号：US08575569B2

公开(公告)日：2013-11-05

申请号：US13119418

申请日：2008-09-18

Applicant: Atsushi Yajima ,  Ichiro Oda ,  Kentaro Hizume ,  Yoshio Tsunazawa

Inventor： Atsushi Yajima ,  Ichiro Oda ,  Kentaro Hizume ,  Yoshio Tsunazawa

IPC: G01J1/58 ,  H01J40/14

CPC classification number: G01N21/6458 ,  A61B5/0059 ,  G01J3/4406 ,  G01J2003/1226 ,  G01N21/6428 ,  G01N2021/6471 ,  G01N2201/0612 ,  G01N2201/064 ,  G02B5/285 ,  G02B21/0032 ,  G02B21/0076

Abstract: In order to reduce light leak influencing the detection capability of a fluorescence imaging apparatus, an interference filter and an absorption filter on an emission-side filter section are arranged serially in the traveling direction of the fluorescence. The interference filter and the absorption filter that are in use for such an arrangement block the waveband light equivalent to the excitation light irradiated onto a sample while fully transmitting the waveband light equivalent to the fluorescence.

Abstract translation: 为了减少影响荧光成像装置的检测能力的光泄漏，发射侧滤波器部分上的干涉滤光器和吸收滤光器在荧光的行进方向上串联布置。 用于这种布置的干涉滤光器和吸收滤光器在完全透射等效于荧光的波段光的同时，阻挡与照射到样品上的激发光相当的波段光。

公开(公告)号：US20130286398A1

公开(公告)日：2013-10-31

申请号：US13456493

申请日：2012-04-26

Applicant: Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

Inventor： Robert Freese ,  Christopher Michael Jones ,  David Perkins ,  Michael Simcock ,  William Soltmann

IPC: G01N21/59 ,  G06E3/00

CPC classification number: G01N21/59 ,  G01N21/31 ,  G01N21/85 ,  G01N2201/064 ,  G06E3/00 ,  G06E3/001

Abstract: Optical computing devices are disclosed. One optical computing device includes an electromagnetic radiation source that emits electromagnetic radiation into an optical train to optically interact with a sample and at least one integrated computational element, the sample being configured to generate optically interacted radiation. A sampling window is arranged adjacent the sample and configured to allow transmission of the electromagnetic radiation therethrough and has one or more surfaces that generate one or more stray signals. A first focal lens is arranged to receive the optically interacted radiation and the one or more stray signals and generate a primary focal point from the optically interacted radiation. A structural element defines a spatial aperture aligned with the primary focal point such that the optically interacted radiation is able to pass therethrough while transmission of the one or more stray signals is substantially blocked by the structural element.

Abstract translation: 公开了光学计算设备。 一个光学计算设备包括电磁辐射源，其将电磁辐射发射到光学系列中以与样品和至少一个集成的计算元件光学相互作用，所述样品被配置为产生光学相互作用的辐射。 采样窗口布置在样本附近并且被配置为允许电磁辐射通过其中并且具有产生一个或多个杂散信号的一个或多个表面。 布置第一焦点透镜以接收光学相互作用的辐射和一个或多个杂散信号，并从光学相互作用的辐射产生主要焦点。 结构元件限定与主焦点对准的空间孔，使得光学相互作用的辐射能够通过，其中一个或多个杂散信号的传输被结构元件基本上阻挡。

公开(公告)号：US20130135613A1

公开(公告)日：2013-05-30

申请号：US13814669

申请日：2011-08-01

Applicant: Perry A. Palumbo

Inventor： Perry A. Palumbo

IPC: G01N21/01

CPC classification number: G02B19/0076 ,  G01N15/06 ,  G01N21/01 ,  G01N21/53 ,  G01N33/18 ,  G01N2015/0693 ,  G01N2201/064 ,  G02B3/04 ,  G02B5/001 ,  G02B13/18 ,  G02B19/0028 ,  G02B19/008 ,  G02B26/0808 ,  G02B2003/0093 ,  Y10T29/49826

Abstract: An annular optical device (100) includes an annular meso-optic (1) including an annulus (11) centered about an axis of revolution (A) and a secondary optical structure (2) substantially coaxial within the annulus (11). The secondary optical structure (2) and the annular meso-optic (1) are separated by a media (12) including a media refractive index that is lower than the refractive index of the secondary optical structure. The secondary optical structure (2) holds a specimen to be radiated by impinging electromagnetic radiation. Scattered radiation from the secondary optical structure (2) and within the annulus (11) of the annular meso-optic (1) is allowed into the annular meso-optic (1) if an angle of incidence of the scattered radiation exceeds a predetermined incidence threshold. The annular meso-optic (1) re-directs the scattered radiation to comprise re-directed radiation that is substantially parallel to the axis of revolution (A).

Abstract translation: 环形光学装置（100）包括环形介质光学器件（1），其包括以旋转轴线（A）为中心的环形空间（11）和在环形空间（11）内基本同轴的次级光学结构（2）。 二次光学结构（2）和环形中视镜（1）由介质折射率低于第二光学结构的折射率的介质（12）分开。 二次光学结构（2）通过撞击电磁辐射而保持待辐射的样本。 如果散射辐射的入射角超过预定的入射角，则允许来自环形介质光学器件（1）的二次光学结构（2）和环形空间（11）内的散射辐射进入环形中视镜（1） 阈。 环形介质光学器件（1）重新引导散射的辐射，以包括基本上平行于旋转轴线（A）的重新定向的辐射。

公开(公告)号：US08436321B2

公开(公告)日：2013-05-07

申请号：US12785308

申请日：2010-05-21

Applicant: Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

Inventor： Sean B. Pieper ,  Ahmed Bouzid ,  Donald T. Lamb ,  Andrew G. Ragatz

IPC: G01N21/64

CPC classification number: G01N21/6456 ,  G01N2201/064 ,  G01N2201/0642

Abstract: A fluorescence imaging system having an enclosure having an optical excitation and detection system and features designed to suppress or reduce background fluorescence. In certain aspects, all or a portion of the interior walls has a material finish and texture that provides a surface that absorbs at least a portion of any impinging excitation light and which has low auto-fluorescing properties. In certain aspects, a baffle structure is provided on the interior of the structure and is configured to mask portions of the interior and reduce the opening through which light impinges on the detector. In certain aspects, a platform having an optically transparent window is located in the interior of the housing structure for holding a sample for excitation by excitation light from an excitation source, wherein a light-trap structure is positioned or located on an opposite side of the platform relative to the excitation source and configured to receive and contain a substantial portion of any scattered or transmitted excitation light.

Abstract translation: 一种荧光成像系统，其具有具有光学激发和检测系统的外壳和被设计为抑制或减少背景荧光的特征。 在某些方面，内壁的全部或一部分具有提供吸收至少一部分任何入射激发光并且具有低自发荧光特性的表面的材料表面和纹理。 在某些方面，挡板结构设置在结构的内部，并且构造成掩盖内部的一部分并且减小光照射在检测器上的开口。 在某些方面，具有光学透明窗口的平台位于壳体结构的内部，用于通过来自激发源的激发光来保持用于激发的样品，其中光阱结构被定位或位于 平台相对于激发源并且被配置为接收和容纳任何散射或透射的激发光的实质部分。

公开(公告)号：US20130034857A1

公开(公告)日：2013-02-07

申请号：US13546733

申请日：2012-07-11

Applicant: Junji Kajihara ,  Shinichi Kai ,  Isao Ichimura ,  Yuji Segawa

Inventor： Junji Kajihara ,  Shinichi Kai ,  Isao Ichimura ,  Yuji Segawa

IPC: G01N21/75 ,  C12M1/40

CPC classification number: G01N21/6452 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6482 ,  G01N2201/062 ,  G01N2201/0633 ,  G01N2201/064

Abstract: Disclosed herein is an optical analysis apparatus including: a light source; a light guiding plate configured to guide incident light from the light source to each of reaction areas; a light shielding structure configured to restrict emission directions of light beams emitted from the inside of the reaction areas; and a detection system configured to detect the light beams emitted from the inside of the reaction areas by radiation of the light.

Abstract translation: 本发明公开了一种光学分析装置，包括：光源; 导光板，其构造成将来自所述光源的入射光引导到各反射区域; 遮光结构，被配置为限制从所述反应区域的内部发射的光束的发射方向; 以及检测系统，被配置为通过所述光的辐射来检测从所述反应区域的内部发射的光束。