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    Mechanical zoom imaging apparatus
    181.
    发明授权
    Mechanical zoom imaging apparatus 有权

    公开(公告)号：US09618733B2

    公开(公告)日：2017-04-11

    申请号：US14444709

    申请日：2014-07-28

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Steve Swihart ,  Evan Thrush ,  Evelio Perez ,  Kevin McDonald

    IPC: G02B15/14

    CPC classification number: G02B15/14

    Abstract: An imaging assembly for the viewing, imaging, and analysis of chemiluminescent or bioluminescent samples in gels or other substrates, in which an adjustable camera and lens module having a prime or fixed lens or a focusing lens is moved to change the field of view by shifting the focal plane of the camera and lens module. The imaging assembly can also include a mirror to bend or fold the optical path between the camera and lens module and the target area having a sample, in which the mirror can move in the same vertical direction as the camera and lens module. Further, the camera and lens module can be configured to more move in a diagonal direction relative to the location of the imaging target area. The imaging assembly can further have a duct system adaptable to adjust with the movement of the camera and lens module.

    Targeted delivery of reagents to spots on a planar support through patterned transfer sheets
    182.
    发明授权
    Targeted delivery of reagents to spots on a planar support through patterned transfer sheets 有权
    通过图案化转印片将试剂靶向递送到平面支架上的斑点

    公开(公告)号：US09594054B2

    公开(公告)日：2017-03-14

    申请号：US13950590

    申请日：2013-07-25

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Clayton T. McKee ,  William Strong

    IPC: G01N27/447

    CPC classification number: G01N27/44739 ,  G01N27/44747 ,  G01N33/54306 ,  G01N33/54393

    Abstract: Molecular species that are immobilized in discrete locations on a planar support such as protein bands on a gel or a blotting membrane or species applied in dots or spots on a membrane are reacted with binding reagents that are applied through a porous hydrophilic transfer sheet placed over the planar support, the sheet having at least one region that is laterally bordered by a barrier with the binding reagent retained within the bordered region. The bordered region is placed directly over an area on the planar support where the molecular species are expected to reside if they are present on the support. The binding reagent is then delivered into the support to contact the species. Targeted delivery of the binding reagent is thus achieved with improved efficiency.

    Abstract translation: 固定在平面载体上的离散位置上的分子物质如凝胶或印迹膜上的蛋白质条带或涂在膜上的点或点上的物质与通过多孔亲水转移片施加的结合试剂反应， 所述片材具有至少一个区域，所述至少一个区域被阻挡物侧向界定，所述粘合剂保留在所述边界区域内。 如果分子种类存在于支持体上，则边界区域直接放置在平面支撑体上的分子种类预期驻留的区域上。 然后将结合试剂输送到载体中以接触物种。 因此，以提高的效率实现了结合试剂的靶向递送。

    Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry
    184.
    发明授权
    Flow rate balanced, dynamically adjustable sheath delivery system for flow cytometry 有权
    流量平衡，动态可调护套输送系统，用于流式细胞术

    公开(公告)号：US09551637B2

    公开(公告)日：2017-01-24

    申请号：US13918156

    申请日：2013-06-14

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Daniel N. Fox ,  Nathan Michael Gaskill-Fox

    IPC: G01N1/28 ,  G01N15/14

    CPC classification number: G01N15/1404 ,  G01N1/28 ,  G01N1/286 ,  G01N2015/0065 ,  G01N2015/1006 ,  G01N2015/1406 ,  G01N2015/1409 ,  Y10T137/0324 ,  Y10T137/7287 ,  Y10T137/7303 ,  Y10T137/85978

    Abstract: Disclosed is a sheath delivery system that uses a continuous flow of sheath fluid into a pressurized internal reservoir that substantially matches the outflow of sheath fluid through the nozzle of a flow cytometer. A substantially constant level of the sheath fluid is maintained. If the sheath fluid level falls below a desired level, or goes above a desired level, a dampened control system is used to reach the desired level. In addition, air pressure in the pressurized internal container is controlled so that an external sheath container can be removed and refilled with additional sheath fluid without stopping the sheath delivery system 100. Differences in pressure are detected by a droplet camera, which measures the droplet breakoff point to determine the pressure of the sheath fluid in the nozzle.

    Abstract translation: 公开了一种护套递送系统，其使用鞘流体连续流入加压的内部储存器，其基本上匹配鞘液通过流式细胞仪的喷嘴的流出。 保持基本恒定水平的鞘液。 如果护套液体液位低于期望水平或高于所需水平，则使用阻尼控制系统达到所需水平。 此外，加压的内部容器中的空气压力被控制，使得可以移除外部护套容器并且用另外的护套流体重新填充，而不停止护套输送系统100.压力的差异通过液滴照相机来检测，其测量液滴断裂 以确定喷嘴中鞘液的压力。

    USING PATIENT RISK IN ANALYSIS OF QUALITY CONTROL STRATEGY FOR LAB RESULTS
    186.
    发明申请
    USING PATIENT RISK IN ANALYSIS OF QUALITY CONTROL STRATEGY FOR LAB RESULTS 审中-公开
    使用患者风险分析质量控制策略的结果

    公开(公告)号：US20160320420A1

    公开(公告)日：2016-11-03

    申请号：US14702019

    申请日：2015-05-01

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： John Christopher Yundt-Pacheco ,  Lakshmi Kuchipudi ,  Curtis Alan Parvin

    IPC: G01N35/00

    CPC classification number: G01N35/00623 ,  G06F19/00 ,  G06F19/36 ,  G16H50/30

    Abstract: Methods, apparatuses, and systems are disclosed for analyzing quality control (QC) strategies that are applied to testing processes an analyte in order to meet an acceptable level of probability of patient harm that could result from incorrect test results. The measure of patient harm takes into account severity of patient harm, as well as its occurrence. Methods include calculating, based on the parameters of the QC strategies and the test apparatus, an expected number of incorrect final results E(Nuf) due to a test system failure. The value of E(Nuf) can be used as part of a calculation of a predicted level of probability patient harm. The ratio of the acceptable level of probability of patient harm to the predicted level of probability patient harm can determine the adequacy of the QC strategies.

    Abstract translation: 公开了用于分析用于测试分析物的质量控制（QC）策略的方法，装置和系统，以便满足可能由不正确的测试结果导致的可接受的患者伤害概率。 患者伤害的测量考虑到患者伤害的严重程度及其发生。 方法包括根据QC策略和测试设备的参数计算由于测试系统故障导致的不正确的最终结果E（Nuf）的预期数量。 E（Nuf）的值可以用作预测患者危害概率水平的计算的一部分。 患者伤害概率的可接受水平与预测的患者危害概率水平的比例可以确定QC策略的适当性。

    SAMPLE ANALYSIS SYSTEMS AND METHODS
    187.
    发明申请
    SAMPLE ANALYSIS SYSTEMS AND METHODS 审中-公开
    样本分析系统和方法

    公开(公告)号：US20160274097A1

    公开(公告)日：2016-09-22

    申请号：US15073518

    申请日：2016-03-17

    Applicant: Bio-Rad Laboratories, Inc,

    Inventor： Jan zur Megede

    IPC: G01N33/543

    CPC classification number: G01N33/54306 ,  B01L3/0241 ,  B01L3/5027 ,  B01L3/5088 ,  B01L2300/0861

    Abstract: Sample analysis systems and methods are provided. In one embodiment, the method may be achieved by applying a substance to a surface of a substrate having a first binding agent immobilized thereon; removing unbound material from at least a portion of the substrate having the substance applied thereon; applying a second binding agent to the surface of the substrate, wherein the second binding agent is optically labeled or unlabeled; removing unbound material from at least a portion of the substrate having the second binding agent applied thereon; responsive to detecting the optically labeled second binding agent bound to the substance, identifying the analyte present in the sample; and responsive to not detecting the optically labeled second binding agent bound to the substance, determining that the analyte is absent in the sample; wherein the applying the substance or second binding agent to the surface of the substrate steps are concurrent with the respective removing unbound material from at least a portion of the substrate steps. Systems and other methods are also described and illustrated.

    Abstract translation: 提供样品分析系统和方法。 在一个实施方案中，该方法可以通过将物质施加到其上固定有第一结合剂的基底的表面上来实现; 从其上施加有物质的基材的至少一部分去除未结合的材料; 将第二粘合剂施加到所述基底的表面，其中所述第二粘合剂是光学标记的或未标记的; 从其上施加有第二粘合剂的基材的至少一部分去除未结合的材料; 响应于检测与物质结合的光学标记的第二结合剂，鉴定样品中存在的分析物; 并且响应于不检测与物质结合的光学标记的第二结合剂，确定样品中不存在分析物; 其中将所述物质或第二粘合剂施加到所述基底台阶的表面与从所述基底步骤的至少一部分分离的去除未结合的材料同时进行。 还描述和示出了系统和其他方法。

    Multi-stage, regression-based PCR analysis system
    188.
    发明授权
    Multi-stage, regression-based PCR analysis system 有权
    多阶段回归分析系统

    公开(公告)号：US09442891B2

    公开(公告)日：2016-09-13

    申请号：US14043786

    申请日：2013-10-01

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Jeffrey Lerner

    IPC: G01N33/48 ,  G06F17/10 ,  G06F11/30

    CPC classification number: G06F17/10 ,  C12Q1/6851 ,  C12Q1/686 ,  C12Q2537/165 ,  C12Q2545/10 ,  C12Q2545/114 ,  C12Q2531/113

    Abstract: Systems and methods are provided for analyzing data to determine properties of a PCR processor other process exhibiting amplification or growth. Data representing an amplification can be distinguished from data representing a jump or other error. A modified sigmoid function containing a drift term may be used in determining the properties. A multi-stage functional fit of the amplification data can provide increased accuracy and consistency of one or more of the properties. A baseline of the amplification data can be determined by analyzing an integrated area of a first derivative function of the data. A reference quantitation value can also be determined from locations of maxima of different derivative functions of the amplification data, e.g., a weighted average of the maxima locations for the second and third derivatives may be used.

    Abstract translation: 提供了系统和方法用于分析数据以确定PCR处理器表现出放大或生长的其他过程的性质。 表示放大的数据可以与表示跳跃或其他错误的数据区分开。 可以使用包含漂移项的修改后的S形函数来确定属性。 扩增数据的多阶段功能拟合可以提供一种或多种性质的增加的精度和一致性。 可以通过分析数据的一阶导数函数的积分区域来确定放大数据的基线。 参考定量值也可以从放大数据的不同导数函数的最大值的位置确定，例如可以使用第二和第三导数的最大值位置的加权平均值。

    OPTIMIZED SPECTRAL MATCHING AND DISPLAY
    189.
    发明申请
    OPTIMIZED SPECTRAL MATCHING AND DISPLAY 审中-公开
    优化光谱匹配和显示

    公开(公告)号：US20160259792A1

    公开(公告)日：2016-09-08

    申请号：US15060260

    申请日：2016-03-03

    Applicant: Bio-Rad Laboratories, Inc.

    Inventor： Karl NEDWED ,  Ty ABSHEAR

    IPC: G06F17/30 ,  G06K9/52 ,  G06T11/20 ,  G06K9/62

    CPC classification number: G06F17/3053 ,  G01N21/35 ,  G01N21/552 ,  G01N2201/121 ,  G01N2201/127 ,  G01N2201/129 ,  G06F17/30554 ,  G06K9/4661 ,  G06K9/52 ,  G06K9/6215 ,  G06K9/6218 ,  G06K2209/05 ,  G06T11/203

    Abstract: Systems, methods, and apparatuses are provided for identifying an optimal spectral match and potentially display the compared spectra. A sample spectrum of a sample substance can be compared to reference spectra to identify matches, thereby determining possibilities for what the sample substance is. Correction parameter(s) may be used for the sample spectrum and/or the reference spectrum. Initial value(s) for the correction parameter(s) can be applied to the sample spectrum and/or a reference spectrum, and a similarity score can be determined. The value(s) for the correction parameter(s) can be updated and iteratively improved to provide an optimal similarity score that satisfies a convergence criterion. Data about the reference substances having optimal similarity scores that are above a threshold can be output to a user, e.g., the reference spectra can overlay the sample spectrum. A user can then make a final determination of which reference substance corresponds to the sample substance.

    Abstract translation: 提供系统，方法和装置用于识别最佳光谱匹配并潜在地显示所比较的光谱。 可以将样品物质的样品光谱与参考光谱进行比较以鉴定匹配，从而确定样品物质的可能性。 校正参数可用于样品光谱和/或参考光谱。 校正参数的初始值可以应用于采样频谱和/或参考频谱，并且可以确定相似性分数。 校正参数的值可以被更新和迭代地改进，以提供满足收敛准则的最佳相似度得分。 关于具有高于阈值的最佳相似性评分的参考物质的数据可以输出给用户，例如参考光谱可以覆盖样本光谱。 然后用户可以对哪个参考物质对应于样品物质进行最终确定。

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