公开(公告)号：US08955340B2

公开(公告)日：2015-02-17

申请号：US12685952

申请日：2010-01-12

Applicant: Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

Inventor： Aaron Burke ,  Michael Felo ,  Brian Pereira ,  Elias Noukas ,  Dennis Wong

IPC: F25D25/00 ,  B65B63/08 ,  F25D3/08 ,  F25D29/00 ,  A01N1/02

CPC classification number: F25D29/00 ,  A01N1/0263 ,  F25D2331/802 ,  F25D2400/28 ,  F25D2400/30 ,  F25D2600/06 ,  F25D2700/12 ,  Y10T29/53

Abstract: The biocontainer of the present invention provides a low cost, simple solution of many of the problems encountered during shipping, freezing and thawing of biopharmaceutical materials. The present invention enables a user to monitor the temperature profile of each biopharmaceutical container during the cryogenic process, so as to ensure the integrity of materials within each biocontainer by using a pre-installed and pre-sterilized temperature sensor. In some embodiments, the sensor assembly includes a wireless transmitter and is capable of transmitting information regarding the measured reading. In other embodiments, the sensor assembly includes a processing unit, which determines whether the temperature profile is acceptable. In a further embodiment, an indicator is included, such that the processing unit may indicate whether the biopharmaceutical material has been properly frozen. In other embodiments, the sensor assembly also includes a storage element, which is capable of storing various parameters during the freezing process.

Abstract translation: 本发明的生物容器提供了在生物药物材料的运输，冷冻和解冻期间遇到的许多问题的低成本，简单的解决方案。 本发明使得用户能够在低温过程期间监测每个生物药物容器的温度曲线，以便通过使用预先安装和预灭菌的温度传感器来确保每个生物容器内的材料的完整性。 在一些实施例中，传感器组件包括无线发射器，并且能够发送关于测量读数的信息。 在其他实施例中，传感器组件包括处理单元，其确定温度分布是否可接受。 在另一实施例中，包括指示器，使得处理单元可以指示生物药物材料是否已被适当地冷冻。 在其他实施例中，传感器组件还包括存储元件，其能够在冷冻过程期间存储各种参数。

公开(公告)号：US08922778B2

公开(公告)日：2014-12-30

申请号：US14065136

申请日：2013-10-28

Applicant: EMD Millipore Corporation

Inventor： Fedor Ilkov

IPC: G01N21/00 ,  G01N21/01 ,  G01N21/53 ,  G01N21/64 ,  G02B19/00

CPC classification number: G01N21/01 ,  G01N15/1434 ,  G01N15/1459 ,  G01N21/0303 ,  G01N21/05 ,  G01N21/53 ,  G01N21/6486 ,  G01N2015/1006 ,  G02B19/0028 ,  G02B19/0076

Abstract: In a particle analyzing apparatus including a capillary for passing through a fluid containing particles to be analyzed, an optical system is employed to collect fluorescent light emitted from particles or substances labeled to the particles with improved collection efficiency preserving resolution of the instrument. The optical system may include a first collection lens attached to the capillary and a first reflection element arranged adjacent to the first collection lens configured to reflect fluorescent light of one or more wavelengths. The optical system may include a second collection lens attached to the capillary and a second reflection element arranged adjacent to the second collection lens configured to reflect fluorescent light of one or more wavelengths.

Abstract translation: 在包括用于通过含有待分析颗粒的流体的毛细管的颗粒分析装置中，使用光学系统来收集从标记到颗粒的颗粒或物质发射的荧光，并且具有改善的收集效率，从而保持仪器的分辨率。 光学系统可以包括附接到毛细管的第一收集透镜和布置成与第一收集透镜相邻布置成反射一个或多个波长的荧光的第一反射元件。 光学系统可以包括附接到毛细管的第二收集透镜，以及被配置成反射一个或多个波长的荧光的与第二收集透镜相邻的第二反射元件。

公开(公告)号：US08906229B2

公开(公告)日：2014-12-09

申请号：US13116508

申请日：2011-05-26

Applicant: Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B01D65/00 ,  B01D15/08 ,  A61B9/00 ,  B01D15/10 ,  C12M1/00 ,  C12M1/12 ,  C12N1/02 ,  C12N1/34 ,  B01D61/18 ,  B01D61/20 ,  F04B43/08

CPC classification number: F17D1/00 ,  B01D61/18 ,  B01D61/20 ,  B01D61/30 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/58 ,  B30B7/00 ,  B30B9/22 ,  C12M47/12 ,  F04B43/08 ,  Y10T137/0318 ,  Y10T137/8593

Abstract: The invention concerns a device comprising: a base (2); a moveable or removable door (20), said device having a closed door position; and in the closed door position, a circuit (8) comprising a bag comprising two flexible films and conveying network connectors, and a press (9) comprising a first shell (16) disposed on said front face (5) of said base (2) and a second shell (17) disposed in said door (20); said bag being clamped between said first shell (16) and said second shell (17) in a state in which conduits of said network for conveying liquid are formed between said films.

Abstract translation: 本发明涉及一种装置，包括：基座（2）; 一个可移动或可拆卸的门（20），所述装置具有一个闭合的门位置; 并且在关闭的门位置，包括包括两个柔性膜和传送网络连接器的袋的电路（8）和包括设置在所述基座（2）的所述前表面（5）上的第一壳体（16）的压力机（9） ）和设置在所述门（20）中的第二壳（17）; 所述袋被夹在所述第一壳体（16）和所述第二壳体（17）之间，在所述薄膜之间形成用于输送液体的所述网络的导管的状态。

公开(公告)号：US08900454B2

公开(公告)日：2014-12-02

申请号：US13153809

申请日：2011-06-06

Applicant: Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

Inventor： Sebastien Cirou ,  Rene Reinbigler ,  Virginie Buisson ,  Jean-Louis Weissenbach

IPC: B01D17/12 ,  C12M1/12 ,  B65D43/26 ,  B30B5/00 ,  B01D61/18 ,  B01D61/20 ,  F04B43/08 ,  C12M1/00

CPC classification number: B01D33/00 ,  A61M1/16 ,  B01D15/08 ,  B01D61/18 ,  B01D61/20 ,  B01D61/243 ,  B01D2313/105 ,  B01D2313/125 ,  B01D2313/18 ,  B01D2313/58 ,  C12M47/12 ,  F04B43/08 ,  Y10T16/522 ,  Y10T137/8593 ,  Y10T137/86187 ,  Y10T137/86196

Abstract: The invention concerns a device comprising a base (2) and a door (20), said device having a closed door position in which a circuit (8) of the device comprises a bag comprising two flexible films and connectors of the conveying network, and a press (9) comprising a first shell (16) disposed on a front face (5) of said base (2) and a second shell (17) disposed in said door (20); and a hinge system hinging said door (20) relative to said base (2), and disposed only on one side of said door (20) so as to form lateral clearances between said door (20) and said base (2) over the rest of a perimeter of said door (20).

Abstract translation: 本发明涉及一种包括基座（2）和门（20）的装置，所述装置具有关闭的门位置，其中装置的电路（8）包括包括输送网络的两个柔性膜和连接器的袋，以及 包括设置在所述基座（2）的前表面（5）上的第一壳体（16）和设置在所述门（20）中的第二壳体（17）的压力机（9）。 以及铰链系统，其将所述门（20）相对于所述基座（2）铰接，并且仅设置在所述门（20）的一侧上，以便在所述门（20）和所述基座（2）之间形成横向间隙 所述门（20）的周边的其余部分。

公开(公告)号：US08895706B2

公开(公告)日：2014-11-25

申请号：US14298332

申请日：2014-06-06

Applicant: EMD Millipore Corporation

Inventor： Shari Spector ,  Robert Smith ,  Joe Orlando ,  Nanying Bian

IPC: A61K38/00 ,  A61K39/00 ,  C07K1/22 ,  C07K1/36

CPC classification number: C07K14/31 ,  B01D15/3809 ,  B01J20/286 ,  B01J20/3272 ,  B01J20/3274 ,  C07K1/22 ,  C07K16/1271 ,  C07K2319/21

Abstract: The present invention relates to chromatography matrices including ligands based on one or more domains of immunoglobulin-binding proteins such as, Staphylooccus aureus Protein A (SpA), as well as methods of using the same.

Abstract translation: 本发明涉及包括基于免疫球蛋白结合蛋白的一个或多个结构域的配体的色谱基质，例如金黄色葡萄球菌蛋白A（SpA），以及使用它们的方法。

公开(公告)号：US08885153B2

公开(公告)日：2014-11-11

申请号：US13461713

申请日：2012-05-01

Applicant: Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

Inventor： Richard Pittaro ,  Bruce Goldman ,  Ray Lefebvre ,  David A. King

IPC: G01N15/14

CPC classification number: G01N15/14 ,  G01N15/1429 ,  G01N15/1459 ,  G01N2015/1006 ,  G01N2015/1477 ,  G01N2015/1486

Abstract: A method of analyzing pulses from a flow cytometer in which particles in a fluid pass through an excitation volume of an electromagnetic radiation and interact with the electromagnetic radiation to generate signals in the form of pulses includes generating a time-dependent pulse indicative of the characteristics of one or more particles passing through the excitation volume of the electromagnetic radiation, determining a measurement window by selecting a portion of the pulse with a starting point and an ending point above a predetermined value, and calculating a first derivative of the pulse with respect to time over the measurement window.

Abstract translation: 一种分析来自流式细胞仪的脉冲的方法，其中流体中的颗粒通过电磁辐射的激发体积并与电磁辐射相互作用以产生脉冲形式的信号，包括产生指示时间相关脉冲的时间相关脉冲 一个或多个颗粒通过电磁辐射的激发体积，通过以高于预定值的起点和终点选择脉冲的一部分来确定测量窗口，并计算相对于时间的脉冲的一阶导数 在测量窗口上。

公开(公告)号：US08852884B2

公开(公告)日：2014-10-07

申请号：US13868263

申请日：2013-04-23

Applicant: EMD Millipore Corporation

Inventor： Christian Schann ,  Bruno Duquet ,  Abdel Hajila ,  Frederic Olivieri

IPC: G01N21/76 ,  C12Q1/24 ,  B05B15/04

CPC classification number: C12Q1/24 ,  B05B12/20 ,  G01N21/763

Abstract: The device for spraying a reagent onto a support (81) adapted to retain microorganisms on a predetermined surface (82), comprises a spraying bell (3) as well as a nozzle (71) for emitting a jet of droplets of said reagent into a spraying chamber (34) comprised by said bell (3), said device also comprising an absorbent pad (5) mounted against said bell (3) transversely to said jet and closing said chamber (34) from the opposite side to said nozzle (71) with the exception of a circular central opening (51) provided in said pad (5), the diameter of said central opening (51) being adapted to enable a portion of said jet, when said device faces said support (81) and is at a predetermined distance therefrom, to pass through said central opening (51) over its entire area and be deposited on the whole of said predetermined surface (82) of said support (81).

Abstract translation: 用于将试剂喷洒到适于将微生物保留在预定表面（82）上的支撑体（81）上的装置包括喷雾钟（3）以及喷嘴（71），用于将所述试剂的液滴喷射到 喷雾室（34），所述装置还包括一个吸收垫（5），该吸收垫（5）横向于所述射流安装在所述钟形（3）上，并从所述喷嘴（71）的相对侧关闭所述腔室 ），除了设置在所述垫（5）中的圆形中心开口（51）之外，所述中心开口（51）的直径适于使所述装置的一部分当所述装置面向所述支撑件（81）并且是 在其预定距离处穿过所述中心开口（51）遍及其整个区域并且沉积在所述支撑件（81）的整个所述预定表面（82）上。

公开(公告)号：US08753588B2

公开(公告)日：2014-06-17

申请号：US10961778

申请日：2004-10-08

Applicant: Kenneth G. Desilets ,  Stephane Jean Marie Olivier ,  Christopher A. Scott

Inventor： Kenneth G. Desilets ,  Stephane Jean Marie Olivier ,  Christopher A. Scott

IPC: B01D35/00

CPC classification number: B01L3/50255 ,  B01L2200/141 ,  B01L2300/0829 ,  B01L2400/049

Abstract: Underdrain design for a multiwell device that when fixed to the device (either as an integral or removable component thereof), allows for adequate venting during filtration, minimizes or prevents air lock, and has improved structural integrity. Also disclosed is a laboratory device designed particularly for a multiplate format that includes a plate or tray having a plurality of wells, and an underdrain in fluid communication with each of the plurality of wells. The underdrain can be a separate, removable piece, or can be an integral unitary structure with the plate or tray forming a one-piece design. The design is preferably in compliance with SBS format.

Abstract translation: 用于多孔设备的暗槽设计，当固定到设备（作为其整体或可移除部件）时，允许在过滤期间充分排气，最小化或防止气锁，并且具有改善的结构完整性。 还公开了一种特别设计用于多种格式的实验室装置，其包括具有多个孔的板或托盘，以及与多个孔中的每一个流体连通的暗槽。 下划线可以是单独的可拆卸件，或者可以是整体的单一结构，其中板或托盘形成一体式设计。 该设计优选地符合SBS格式。

公开(公告)号：US20140137386A1

公开(公告)日：2014-05-22

申请号：US14162823

申请日：2014-01-24

Applicant: EMD Millipore Corporation

Inventor： Stephane Olivier ,  Jerome Geyer ,  Gerard Muller

IPC: B23P19/04

CPC classification number: B23P19/04 ,  A61B17/3417 ,  A61B17/3421 ,  A61M5/158 ,  A61M5/162 ,  A61M25/06 ,  A61M25/065 ,  A61M2005/1623 ,  Y10T29/49826 ,  Y10T29/49892 ,  Y10T29/49895 ,  Y10T29/49897 ,  Y10T29/49899 ,  Y10T29/49947

Abstract: A take-off needle comprises a hollow lance having a distal end adapted to perform a insertion operation, said hollow lance being connected to at least one pipe provided with a spigot for it to be connected to a tube, and comprising a body for holding the hollow lance and pipe relative to each other such that the spigot projects from the holding body, said needle timber comprising two flanges held on respective sides of and spaced from the holding body by virtue of a spacer disposed between each flange and the holding body, said flanges extending in a longitudinal direction from the spigot to the vicinity of the proximal end of the hollow lance, the width of each flange being greater than the width of the portion of the holding body facing the flanges.

Abstract translation: 起飞针包括具有适于执行插入操作的远端的中空喷枪，所述中空喷枪连接到至少一个设置有插口的管子，以将其连接到管，并且包括用于保持 空心枪和管相对于彼此，使得插口从保持体突出，所述针木由包括设置在每个凸缘和保持体之间的间隔件而保持在保持体的相应侧面并与保持体间隔开的两个凸缘， 凸缘从纵向方向延伸到中空喷枪的近端附近，每个凸缘的宽度大于保持体面对凸缘的部分的宽度。

公开(公告)号：US08709790B2

公开(公告)日：2014-04-29

申请号：US13602331

申请日：2012-09-04

Applicant: Paul Ju-Sung Hung ,  Philip Janmin Lee

Inventor： Paul Ju-Sung Hung ,  Philip Janmin Lee

IPC: C12M1/34 ,  G01N33/543

CPC classification number: C12M23/12 ,  B01L3/5025 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0819 ,  B01L2300/10 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0655 ,  B29C65/002 ,  C12M23/16 ,  C12M29/10 ,  C12M29/14 ,  C12M41/00 ,  C12M41/48 ,  C12Q1/025 ,  F16K27/0236 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/0084 ,  G01N33/5008 ,  G01N33/54366 ,  G01N2035/00158 ,  Y10T137/2202

Abstract: A valved microfluidics device, microfluidics cell-culture device and system incorporating the devices are disclosed. The valved microfluidics device includes a substrate, a microchannel through which liquid can be moved from one station to another within the device, and a pneumatic microvalve adapted to be switched between open and closed states to control the flow of fluid through a microchannel. The microvalve is formed of three flexible membranes, one of which is responsive to pneumatic pressure applied to the valve and the other two of which deform to produce a more sealable channel cross-section. The cell culture device provides valving to allow controlled loading of cells into the individual well of the device, and exchange of cell-culture components in the wells.

Abstract translation: 公开了一种带阀的微流体装置，微流体细胞培养装置和结合装置的系统。 带阀的微流体装置包括基底，微通道，通过该微通道液体可以在装置内从一个站移动到另一个站;以及气动微型阀，其适于在打开和关闭状态之间切换以控制通过微通道的流体流动。 微型阀由三个柔性膜形成，其中一个柔性膜响应于施加到阀上的气压，另外两个变形以产生更可密封的通道横截面。 细胞培养装置提供阀门以允许将细胞控制加载到装置的个体井中，以及在孔中交换细胞培养组分。