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公开(公告)号：US20050139537A1
公开(公告)日：2005-06-30
申请号：US11037356
申请日：2005-01-19
Applicant: Chung-Jen Hou , Peter Konstantin , Yujing Yang
Inventor： Chung-Jen Hou , Peter Konstantin , Yujing Yang
IPC: B01D15/36 , B01D61/00 , B01D61/14 , B01D67/00 , B01D71/08 , B01D71/40 , B01J20/28 , B01J20/32 , B01J39/20 , B01J39/26 , B01J47/12 , C07K1/34 , C12M1/34 , C02F1/44
CPC classification number: B01D67/0088 , B01D15/362 , B01D61/00 , B01D61/007 , B01D61/14 , B01D67/0009 , B01D71/08 , B01D71/40 , B01D2323/12 , B01D2323/30 , B01D2325/14 , B01D2325/36 , B01J20/261 , B01J20/262 , B01J20/264 , B01J20/267 , B01J20/28035 , B01J20/2804 , B01J20/28078 , B01J20/2808 , B01J20/286 , B01J20/3208 , B01J20/3212 , B01J20/327 , B01J20/3274 , B01J20/3282 , B01J39/20 , B01J39/26 , B01J47/12 , B01J2220/44 , B01J2220/54 , C07K1/34 , Y10T436/143333
Abstract: The present invention provides, in certain embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating having fixed negative charges. The crosslinked coating can be prepared, e.g., from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- and/or N-(alkoxymethyl)-acrylamide, a hydrophilic unsaturated monomer, and an initiator. The present invention further provides, in some embodiments, a negatively charged microporous membrane comprising a porous substrate and a crosslinked coating prepared from a polymerized composition comprising an unsaturated monomer having an anionic group, an N-(hydroxymethyl)- or N-(alkoxymethyl)-acrylamide, a polysaccharide, and an initiator. The membranes of the present invention are suitable for use in ion exchange chromatography, for example, in the separation and purification of positively charged species such as proteins.
Abstract translation: 本发明在某些实施方案中提供了一种带负电荷的微多孔膜，其包含多孔基底和具有固定负电荷的交联涂层。 交联涂层可以例如由含有阴离子基团的不饱和单体，N-（羟甲基） - 和/或N-（烷氧基甲基） - 丙烯酰胺，亲水性不饱和单体和引发剂的聚合组合物制备。 在一些实施方案中，本发明进一步提供了一种带负电荷的微多孔膜，其包含多孔基材和由聚合组合物制备的交联涂层，所述聚合组合物包含具有阴离子基团的不饱和单体，N-（羟甲基） - 或N-（烷氧基甲基） - 丙烯酰胺，多糖和引发剂。 本发明的膜适用于离子交换色谱法，例如分离和纯化带正电荷的物质如蛋白质。
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公开(公告)号：US4791063A
公开(公告)日：1988-12-13
申请号：US758064
申请日：1985-07-23
Applicant: Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
Inventor： Kenneth C. Hou , Chung-Jen Hou , Haunn-Lin Chen
IPC: B01J20/28 , B01J20/32 , B01J39/22 , B01J41/16 , B01J47/12 , C08F251/00 , C08G81/02 , G01N30/38 , G01N30/60 , C12N1/00
CPC classification number: B01J20/28026 , B01J20/28028 , B01J20/28033 , B01J20/28052 , B01J20/3212 , B01J20/3248 , B01J20/3251 , B01J20/3255 , B01J39/22 , B01J41/16 , B01J47/123 , C08F251/00 , C08G81/02 , G01N2030/386 , G01N30/6091 , Y10S435/803
Abstract: Polyionene-transformed modified polymer-polysaccharide separation matrix and use thereof in removing contaminants of microorganism origin from biological liquids are disclosed.
Abstract translation: 公开了聚苯乙烯转化的改性聚合物 - 多糖分离基质及其在从生物液体中除去微生物来源污染物的用途。
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公开(公告)号：US20120029116A1
公开(公告)日：2012-02-02
申请号：US13267052
申请日：2011-10-06
Applicant: Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
Inventor： Rong-Chang Liang , John J. McNamara , Yurong Ying , Chung-Jen Hou
IPC: C09J163/04 , C07D303/40 , C09J11/06 , C09J163/02 , C09J163/00
CPC classification number: C08G59/245 , C08G59/3218 , C08L63/00 , C09J163/00 , C08L2666/22
Abstract: The invention provides an improvement to the useable lifetimes of phenolic-epoxy, phenolic-benzoxazine, phenolic-epoxy-benzoxazine mixtures and other phenolic mixtures through the use of protected phenolics, where a phenolic compound, polymer, or resin is released on demand by the addition of a deblocking agent.
Abstract translation: 本发明通过使用受保护的酚醛树脂来改进酚醛环氧树脂，酚 - 苯并恶嗪，酚 - 环氧 - 苯并恶嗪混合物和其它酚类混合物的使用寿命，其中根据需要释放酚类化合物，聚合物或树脂 加入去块剂。
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公开(公告)号：US07923488B2
公开(公告)日：2011-04-12
申请号：US11581302
申请日：2006-10-16
Applicant: Qianfei Xu , Chung-Jen Hou , Rong-Chang Liang
Inventor： Qianfei Xu , Chung-Jen Hou , Rong-Chang Liang
CPC classification number: C08G18/73 , C08G18/10 , C08G18/2875 , C08G18/3271 , C08G18/3825 , C08G18/4854 , C08G18/755 , C08G18/8058 , C08G18/808 , C08G59/686 , C08L63/00 , C09J163/00 , H05K3/323 , Y10T428/31511
Abstract: An epoxy composition for applications such as one-part adhesives, coatings, prepreg and molding compounds that includes leuco dyes, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, N-alkyl-N-arylamino-, N-alkylamino- or N-arylamino- functional group on one of the aromatic rings, as a co- catalyst or co-curing agent. The use of the leuco dye co-catalyst provides improved curing speed of the epoxy composition comprising a latent curing agent/catalyst such as imidazole microcapsules while maintaining the shelf-life stability. The epoxy may also include a secondary co-catalyst that includes a urea, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, N-alkyl-N-arylamino- or dicycloalkylamino- functional group. Secondary cocatalysts of low mobility at the storage conditions are particularly preferred. The improved epoxy composition is implemented as adhesives for manufacturing an anisotropic conductive film (ACF) and also for connecting, encapsulating, or packaging of electronic devices.
Abstract translation: 用于诸如单份粘合剂，涂料，预浸料和模塑料的应用的环氧组合物，其包括无色染料，特别是包含N，N-二烷基氨基 - ，N，N-二芳基氨基 - ，N-烷基-N-芳基氨基 - ，N- 一个芳环上的N-烷基氨基或N-芳基氨基官能团，作为助催化剂或共固化剂。 使用无色染料助催化剂提供包含潜在性固化剂/催化剂如咪唑微胶囊的环氧组合物的改进的固化速度，同时保持保质期的稳定性。 环氧树脂还可以包括辅助助催化剂，其包括尿素，特别是包含N，N-二芳基氨基 - ，N，N-二芳基氨基 - ，N-烷基-N-芳基氨基 - 或二环烷基氨基官能团的那些。 在储存条件下的低迁移率的二级助催化剂是特别优选的。 改进的环氧组合物被实施为用于制造各向异性导电膜（ACF）的粘合剂以及用于电子器件的连接，封装或封装的粘合剂。
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公开(公告)号：US20100075438A1
公开(公告)日：2010-03-25
申请号：US12576076
申请日：2009-10-08
Applicant: Winston Z. Ho , Chung-Jen Hou
Inventor： Winston Z. Ho , Chung-Jen Hou
IPC: G01N33/566
CPC classification number: G01N33/545 , C08F2/50 , C08F8/00 , C08F220/18 , C08L63/00 , C08L63/10 , C12Q1/6813 , C12Q1/6846 , G01N27/745 , G03F7/038 , G03F7/085 , G03F7/26 , C12Q2563/155 , C12Q2563/107
Abstract: The present invention relates to substrates for biological testing produced from photo-curable epoxy compositions which further include carboxyl-containing monomers such as acrylic acid, 2-carboxyethyl acrylic acid, 4-vinylbenzoic acid, or 3-Acrylamido-3-methyl-1-butanoic acid, or glycidyl methacrylate, etc. The photo-curable compositions may be used to cast films or fabricate beads, magnetic beads, or magnetic beads containing nickel barcodes. The resulting various kinds of films, beads, magnetic beads, or magnetic beads containing nickel barcodes may find use in clinical or biological applications.
Abstract translation: 本发明涉及由可光固化环氧组合物生产的生物测试用基材，其进一步包括含羧基的单体如丙烯酸，2-羧乙基丙烯酸，4-乙烯基苯甲酸或3-丙烯酰氨基-3-甲基-1- 丁酸或甲基丙烯酸缩水甘油酯等。可光固化组合物可用于流延膜或制造珠粒，磁珠或含有镍条形码的磁珠。 得到的各种膜，珠，磁珠或含有镍条形码的磁珠可用于临床或生物应用。
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Patent Agency Ranking
公开(公告)号：US07223341B2
公开(公告)日：2007-05-29
申请号：US11480977
申请日：2006-07-06
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
Abstract translation: 本发明提供了具有约25mg / ml或更大的蛋白结合能力的带正电荷的微多孔膜，其包含亲水性多孔基底和向膜提供固定的正电荷的交联涂层。 本发明还提供一种带正电的微多孔膜，其包括多孔基材和包含阳离子阳离子基团的交联涂层。 本发明的膜可用于各种应用，包括离子交换层析，大分子转移，以及生物分子如蛋白质，核酸，内毒素等的检测，过滤和纯化。
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公开(公告)号：US06851561B2
公开(公告)日：2005-02-08
申请号：US10891098
申请日：2004-07-15
Applicant: Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
Inventor： Xiaosong Wu , Chung-Jen Hou , Jayesh Dharia , Peter Konstantin , Yujing Yang
IPC: B01D15/36 , B01D61/00 , B01D61/14 , B01D63/14 , B01D67/00 , B01D69/02 , B01D69/10 , B01D69/12 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01J20/28 , B01J41/12 , B01J41/20 , B01J47/12 , B01D63/06 , B01D71/56
CPC classification number: B01D67/0088 , B01D15/361 , B01D15/363 , B01D61/00 , B01D61/14 , B01D69/02 , B01D69/10 , B01D69/125 , B01D71/40 , B01D71/44 , B01D71/60 , B01D71/82 , B01D2325/16 , B01D2325/30 , B01D2325/36 , B01J20/28033 , B01J20/28035 , B01J20/3272 , B01J20/3282 , B01J41/12 , B01J41/13 , B01J41/20 , B01J47/12 , C12N15/1017 , G01N33/54393
Abstract: The present invention provides a positively charged microporous membrane having a protein binding capacity of about 25 mg/ml or greater comprising a hydrophilic porous substrate and a crosslinked coating that provides a fixed positive charge to the membrane. The present invention further provides a positively charged microporous membrane comprising a porous substrate and a crosslinked coating comprising pendant cationic groups. The membranes of the present invention find use in a variety of applications including ion-exchange chromatography, macromolecular transfer, as well as detection, filtration and purification of biomolecules such as proteins, nucleic acids, endotoxins, and the like.
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公开(公告)号：US5980746A
公开(公告)日：1999-11-09
申请号：US966261
申请日：1997-11-07
Applicant: Charles Gelman , Peter Konstantin , Wilfrid Klaus Wixwat , Yujing Yang , Chung-Jen Hou
Inventor： Charles Gelman , Peter Konstantin , Wilfrid Klaus Wixwat , Yujing Yang , Chung-Jen Hou
IPC: B01D67/00 , B01D71/20 , B01D71/26 , B01D71/56 , B01D71/68 , C08J5/18 , C08J9/36 , G01N33/544 , G01N33/545 , G01N33/548 , B01D39/18 , B01D71/10
CPC classification number: B01D67/0088 , B01D67/0018 , B01D71/20 , B01D71/68 , G01N33/544 , G01N33/545 , G01N33/548 , B01D2323/12 , B01D2325/02 , B01D2325/36 , Y10T428/249959
Abstract: The present invention provides a membrane comprising (a) polymer solids comprising 60 wt. % or more of a fully synthetic organic polymer and optionally about 40 wt. % or less of a polymer of natural origin and (b) a cellulose compound which allows for the detection of a biological molecule of interest, wherein the cellulose compound is uniformly distributed throughout the surface of the membrane. The present invention also provides methods of preparing and using such membranes.
Abstract translation: 本发明提供一种膜，其包含（a）聚合物固体，其包含60wt。 完全合成的有机聚合物的％或更多，任选地约40wt。 ％以下的天然来源的聚合物和（b）允许检测感兴趣的生物分子的纤维素化合物，其中所述纤维素化合物均匀分布在膜的整个表面。 本发明还提供了制备和使用这种膜的方法。
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公开(公告)号：US09255922B2
公开(公告)日：2016-02-09
申请号：US12576076
申请日：2009-10-08
Applicant: Winston Z. Ho , Chung-Jen Hou
Inventor： Winston Z. Ho , Chung-Jen Hou
IPC: C08F8/00 , C08F2/50 , G01N33/545 , C08F220/18 , C12Q1/68 , G03F7/26
CPC classification number: G01N33/545 , C08F2/50 , C08F8/00 , C08F220/18 , C08L63/00 , C08L63/10 , C12Q1/6813 , C12Q1/6846 , G01N27/745 , G03F7/038 , G03F7/085 , G03F7/26 , C12Q2563/155 , C12Q2563/107
Abstract: The present invention relates to substrates for biological testing produced from photo-curable epoxy compositions which further include carboxyl-containing monomers such as acrylic acid, 2-carboxyethyl acrylic acid, 4-vinylbenzoic acid, or 3-Acrylamido-3-methyl-1-butanoic acid, or glycidyl methacrylate, etc. The photo-curable compositions may be used to cast films or fabricate beads, magnetic beads, or magnetic beads containing nickel barcodes. The resulting various kinds of films, beads, magnetic beads, or magnetic beads containing nickel barcodes may find use in clinical or biological applications.
Abstract translation: 本发明涉及由可光固化环氧组合物生产的生物测试用基材，其进一步包括含羧基的单体如丙烯酸，2-羧乙基丙烯酸，4-乙烯基苯甲酸或3-丙烯酰氨基-3-甲基-1- 丁酸或甲基丙烯酸缩水甘油酯等。可光固化组合物可用于流延膜或制造珠粒，磁珠或含有镍条形码的磁珠。 得到的各种膜，珠，磁珠或含有镍条形码的磁珠可用于临床或生物应用。
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公开(公告)号：US20080090943A1
公开(公告)日：2008-04-17
申请号：US11581302
申请日：2006-10-16
Applicant: Qianfei Xu , Chung-Jen Hou , Rong-Chang Liang
Inventor： Qianfei Xu , Chung-Jen Hou , Rong-Chang Liang
IPC: C08L63/00
CPC classification number: C08G18/73 , C08G18/10 , C08G18/2875 , C08G18/3271 , C08G18/3825 , C08G18/4854 , C08G18/755 , C08G18/8058 , C08G18/808 , C08G59/686 , C08L63/00 , C09J163/00 , H05K3/323 , Y10T428/31511
Abstract: An epoxy composition for applications such as one-part adhesives, coatings, prepreg and molding compounds that includes leuco dyes, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, or cycloalkylamino-functional group on one of the aromatic rings, as a co-catalyst or co-curing agent. The use of the leuco dye co-catalyst provides improved curing speed of the epoxy composition comprising a latent curing agent/catalyst such as Novacure imidazole microcapsules while maintaining the shelf-life stability. The epoxy may also include a secondary co-catalyst that includes amides and lactams, particularly those comprising a N,N-dialkylamino-, N,N-diarylamino-, or dicycloalkylamino-functional group. Secondary cocatalysts of low mobility at the storage conditions, such as those with a long chain substitutent, dimeric or oligomeric amides or lactams, are particularly preferred. The improved epoxy composition is implemented as adhesives for manufacturing an anisotropic conductive film (ACF) and also for connecting, encapsulating, or packaging of electronic devices.
Abstract translation: 用于诸如单份粘合剂，涂料，预浸料和模塑料的应用的环氧组合物，其包括无色染料，特别是包含N，N-二烷基氨基 - ，N，N-二芳基氨基 - 或环烷基氨基官能团的那些 芳环，作为助催化剂或共固化剂。 无色染料助催化剂的使用提供包含潜在性固化剂/催化剂如Novacure咪唑微胶囊的环氧组合物的改进的固化速度，同时保持保质期的稳定性。 环氧树脂还可以包括包含酰胺和内酰胺的次级助催化剂，特别是那些包含N，N-二烷基氨基 - ，N，N-二芳基氨基 - 或二环烷基氨基官能团的助催化剂。 在储存条件下的低迁移率的二级助催化剂，例如具有长链取代基，二聚或低聚酰胺或内酰胺的二级助催化剂是特别优选的。 改进的环氧组合物被实施为用于制造各向异性导电膜（ACF）的粘合剂以及用于电子器件的连接，封装或封装的粘合剂。
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