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公开(公告)号：US20060068013A1
公开(公告)日：2006-03-30
申请号：US11152367
申请日：2005-06-15
Applicant: Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
Inventor： Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
CPC classification number: A61K47/42 , A61K9/7007 , A61K47/10 , A61K47/36 , A61L15/225 , A61L15/325 , A61L15/425 , A61L31/041 , A61L31/045 , A61L31/146 , C08L5/00 , C08L5/04 , C08L5/08 , C08L71/00 , C08L89/00 , C08L89/06 , C08L2205/02 , C08L2666/26 , C08L2666/14 , C08L2666/02
Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
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公开(公告)号：US06228393B1
公开(公告)日：2001-05-08
申请号：US09412584
申请日：1999-10-05
Applicant: Frank DiCosmo , Valerio DiTizio
Inventor： Frank DiCosmo , Valerio DiTizio
IPC: A61K9127
CPC classification number: A61L27/52 , A61K9/127 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/145 , A61L29/16 , A61L2300/406 , A61L2300/414 , A61L2300/42 , A61L2300/43 , A61L2300/436 , A61L2300/626
Abstract: The present invention is directed to a vehicle for effecting drug delivery from a solid substrate. Hydrogels loaded with liposomal therapeutic agents such as antibiotics are covalently bonded to the surface of substrates such as in-dwelling medical devices, such as implants, catheters, and the like. The present invention is particularly useful in the treatment and prevention of biofilm mediated infection often associated with the use of in-dwelling medical devices.
Abstract translation: 本发明涉及一种用于从固体基质进行药物递送的载体。 装载有脂质体治疗剂如抗生素的水凝胶共价结合到诸如植入物，导管等的诸如住院医疗装置的底物表面。 本发明特别可用于治疗和预防通常与使用住院医疗器械有关的生物膜介导的感染。
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公开(公告)号：US08920886B2
公开(公告)日：2014-12-30
申请号：US12892770
申请日：2010-09-28
Applicant: Hamed Abbasian , Pamela Chan , Valerio Ditizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
Inventor： Hamed Abbasian , Pamela Chan , Valerio Ditizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
CPC classification number: C08F2/48 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/10 , A61L2420/02 , C08J7/18 , C08L33/08 , C09D4/00 , C09D133/08
Abstract: One aspect of the present disclosure can include a method for grafting a coating polymer onto a surface of a device. The method can include the following steps: a) submerging the device into a photoinitiator solution; b) without first drying the device, submerging the device into a polymerizable solution; c) bubbling an oxygen-scavenging gas through the polymerizable solution; d) applying a UV light to the device to activate the photoinitiator, thereby grafting the coating polymer onto the device; and e) drying the device.
Abstract translation: 本公开的一个方面可以包括将涂覆聚合物接枝到设备的表面上的方法。 该方法可以包括以下步骤：a）将装置浸入光引发剂溶液中; b）没有首先干燥装置，将装置浸入可聚合溶液中; c）将氧气清除气体鼓泡通过可聚合溶液; d）向该装置施加UV光以激活光引发剂，从而将涂覆聚合物接枝到该装置上; 和e）干燥该装置。
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公开(公告)号：US08877256B2
公开(公告)日：2014-11-04
申请号：US12183426
申请日：2008-07-31
Applicant: Vyacheslav Dudnik , Yakeemovich Natali , Valerio DiTizio , Frank DiCosmo
Inventor： Vyacheslav Dudnik , Yakeemovich Natali , Valerio DiTizio , Frank DiCosmo
IPC: A61K33/38 , A61K31/555 , A61L31/10 , A61L15/18 , A01N25/34 , A61K31/785 , A01N59/16 , A61L15/46 , A61L27/30 , A61L27/54 , A61L29/10 , A61L29/16 , A61L31/08 , A61L31/16 , C08J7/06 , C08J7/18 , C09D5/14
CPC classification number: A61L15/18 , A01N25/34 , A01N59/16 , A61K31/785 , A61K33/38 , A61L15/46 , A61L27/306 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/80 , C08J7/06 , C08J7/18 , C08J2383/04 , C09B67/0083 , C09B67/0086 , C09D5/14 , A01N25/10 , A01N25/22 , A01N2300/00
Abstract: The invention is an antimicrobial photo-stable coating composition that deters photo-induced discoloration, does not stain tissue and can be applied to the surface of a variety of medical materials. The composition comprises in an aspect silver-PCA complex and dye.
Abstract translation: 本发明是抗微生物光稳定性涂料组合物，其阻止光诱导的变色，不会污染组织并且可以施加到各种医疗材料的表面。 该组合物在一方面包含银-PCA复合物和染料。
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公开(公告)号：US20110100294A1
公开(公告)日：2011-05-05
申请号：US12892799
申请日：2010-09-28
Applicant: Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
Inventor： Hamed Abbasian , Pamela Chan , Valerio DiTizio , Vyacheslav Dudnyk , Zhaopeng Li , Said Loloie , Natali Yakeemovich , Frank DiCosmo
CPC classification number: C08F2/48 , A61L27/34 , A61L29/085 , A61L31/10 , A61L2400/10 , A61L2420/02 , C08J7/18 , C08L33/08 , C09D4/00 , C09D133/08
Abstract: A system and method for photo-grafting a coating polymer onto the surface of a medical device are provided. The system comprises a plurality of stations including a novel grafting station. The system and method of the invention are both time- and resource-efficient. The system includes several stations, each station including a dipping tank. The system allows for the automated, semi-automated, or manual dipping of medical devices into the dipping tanks in a specified order, as desired, wherein at least one of the stations is a grafting station for photo-grafting the coating polymer onto the surface of the medical device. The system is modular, which allows for modification of the process as required, depending on the needs of the user. The system may comprise stations for incorporating an antimicrobial agent into the coating, and/or for rendering the coating lubricious.
Abstract translation: 提供了一种用于将涂层聚合物光刻接到医疗器械表面上的系统和方法。 该系统包括多个站，包括一个新颖的移植站。 本发明的系统和方法既时间又资源有效。 该系统包括几个站，每个站包括一个浸渍槽。 该系统允许根据需要以特定的顺序将医疗装置自动化，半自动化或手动地浸入浸渍罐中，其中至少一个站是用于将涂层聚合物光刻接合到表面上的接枝站 的医疗器械。 该系统是模块化的，这允许根据需要修改过程，具体取决于用户的需求。 该系统可以包括用于将抗微生物剂并入涂层中的站和/或用于使涂层润滑的站。
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Patent Agency Ranking
公开(公告)号：US20110097402A1
公开(公告)日：2011-04-28
申请号：US11664184
申请日：2005-06-15
Applicant: Valerio Ditizio , Frank Dicosmo , Yuehua Xiao
Inventor： Valerio Ditizio , Frank Dicosmo , Yuehua Xiao
IPC: A61K9/00 , A61K33/38 , A61K33/34 , A61K33/24 , A61K31/164 , A61K31/4355
CPC classification number: A61K47/42 , A61K9/7007 , A61K47/10 , A61K47/36 , A61L15/225 , A61L15/325 , A61L15/425 , A61L31/041 , A61L31/045 , A61L31/146 , C08L5/00 , C08L5/04 , C08L5/08 , C08L71/00 , C08L89/00 , C08L89/06 , C08L2205/02 , C08L2666/26 , C08L2666/14 , C08L2666/02
Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
Abstract translation: 本发明是基本上不粘的弹性明胶基体。 基质既不与伤口，组织和器官粘合，也具有弹性，使其柔韧。 基质是蛋白质，聚合物，交联剂和任选的增塑剂的冻干混合物。 本发明还提供了制造非粘性弹性明胶基质的方法。
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公开(公告)号：US20090035388A1
公开(公告)日：2009-02-05
申请号：US12183426
申请日：2008-07-31
Applicant: Vyacheslav Dudnik , Yakeemovich Natali , Valerio DiTizio , Frank DiCosmo
Inventor： Vyacheslav Dudnik , Yakeemovich Natali , Valerio DiTizio , Frank DiCosmo
CPC classification number: A61L15/18 , A01N25/34 , A01N59/16 , A61K31/785 , A61K33/38 , A61L15/46 , A61L27/306 , A61L27/54 , A61L29/106 , A61L29/16 , A61L31/088 , A61L31/16 , A61L2300/104 , A61L2300/404 , A61L2300/80 , C08J7/06 , C08J7/18 , C08J2383/04 , C09B67/0083 , C09B67/0086 , C09D5/14 , A01N25/10 , A01N25/22 , A01N2300/00
Abstract: The invention is an antimicrobial photo-stable coating composition that deters photo-induced discoloration, does not stain tissue and can be applied to the surface of a variety of medical materials. The composition comprises in an aspect silver-PCA complex and dye.
Abstract translation: 本发明是抗微生物光稳定性涂料组合物，其阻止光诱导的变色，不会污染组织并且可以施加到各种医疗材料的表面。 该组合物在一方面包含银-PCA复合物和染料。
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公开(公告)号：US20170290789A1
公开(公告)日：2017-10-12
申请号：US15484386
申请日：2017-04-11
Applicant: Frank DICOSMO
Inventor： Frank DICOSMO
CPC classification number: A61K31/155 , A01N47/44 , A61K47/02 , A61K47/10 , A61K47/36 , A61K47/38 , A61K47/42 , A61L26/0038 , A61L26/0066 , A61L2300/206 , A61L2300/404 , A61L2300/412
Abstract: An isotonic irrigation solution for wounds, surgical incisions and as a lavage, the irrigation solution comprising saline, antimicrobial, chelator, surfactant and collagenous biological enhancer.
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公开(公告)号：US20160317699A1
公开(公告)日：2016-11-03
申请号：US15141616
申请日：2016-04-28
Applicant: FRANK DICOSMO
Inventor： FRANK DICOSMO
CPC classification number: A61L15/585 , A61L15/225 , A61L15/26 , A61L15/44 , A61L15/46 , A61L15/58 , A61L2300/206 , A61L2300/404 , A61L2300/606 , A61L2300/608 , C08L83/04
Abstract: Silicone adhesive dressings that are antimicrobial and can include a backing layer are for use on wound areas and surgical incisions and as a protective dressing to cover, for example, indwelling therapeutic devices. The dressings include polyhexamethylene biguanide (PHMB) and ethylenediamine tetraacetic acid (EDTA) in a silicone layer as particulates, and optionally include glycerin.
Abstract translation: 抗微生物并且可以包括背衬层的硅胶粘合剂敷料可用于伤口区域和手术切口，并用作保护敷料以覆盖例如留置治疗装置。 敷料包括作为颗粒的硅氧烷层中的聚六亚甲基双胍（PHMB）和乙二胺四乙酸（EDTA），并且任选地包括甘油。
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公开(公告)号：US08361501B2
公开(公告)日：2013-01-29
申请号：US11152367
申请日：2005-06-15
Applicant: Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
Inventor： Valerio DiTizio , Frank DiCosmo , Yuehua Xiao
IPC: A61K9/70
CPC classification number: A61K47/42 , A61K9/7007 , A61K47/10 , A61K47/36 , A61L15/225 , A61L15/325 , A61L15/425 , A61L31/041 , A61L31/045 , A61L31/146 , C08L5/00 , C08L5/04 , C08L5/08 , C08L71/00 , C08L89/00 , C08L89/06 , C08L2205/02 , C08L2666/26 , C08L2666/14 , C08L2666/02
Abstract: The present invention is a substantially non-adhesive elastic gelatin matrix. The matrix is both non-adhesive to wounds, tissues and organs and is also elastic such that it is flexible. The matrix is a lyophilized mixture of protein(s), polymer(s), cross-linking agent(s) and optional plasticizer(s). The invention also provides methods for making the non-adhesive elastic gelatin matrix.
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