-
公开(公告)号：US20180304231A1
公开(公告)日：2018-10-25
申请号：US15769400
申请日：2016-10-28
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Nils Norrman , Mattias Algotsson , Stefan D. Eriksson
CPC classification number: B01J20/24 , B01J20/28016 , B01J20/29 , B01J20/305 , C02F1/42
Abstract: The present invention relates to a method to improve chromatography beads. More closely, the invention relates to a novel method for production of dextran-containing porous media and chromatography media produced with this method. In the method, the chromatography media is subjected to dextranase-treatment leading to improved pressure-flow properties of the media.
-
公开(公告)号：US20180229152A1
公开(公告)日：2018-08-16
申请号：US15954545
申请日：2018-04-16
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Klaus Gebauer , Manoj Kumar Ramakrishna , Daniel Salomonsson , Per Uselius
CPC classification number: B01D15/22 , B01D15/1864 , B01D15/1885 , F16L55/00 , G01N30/461 , G01N30/466 , G01N30/6004 , Y10T29/49826
Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b) connected in a rigid housing (21; 61), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules in the rigid housing are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
-
公开(公告)号：US10041050B2
公开(公告)日：2018-08-07
申请号：US15355675
申请日：2016-11-18
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Patrik Adielsson , Tobias E. Soderman , Anna Akerblom
Abstract: The present invention relates to a method for endotoxin removal from a sample comprising the following steps: combining the sample comprising one or more target molecule(s) with a chromatography media comprising beads having an inner porous core functionalized with ligands capable of binding endotoxin and an outer porous layer without functional groups and a pore size small enough to exclude the target molecule from the inner core; and collecting the sample from the media, wherein the sample comprises an endotoxin level which is at least 75% less, preferably 90% less, than before the removal and the yield of the target molecule is at least 75%.
-
公开(公告)号：US20180127460A1
公开(公告)日：2018-05-10
申请号：US15564232
申请日：2016-04-04
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Martin Hall , Karolina Busson , Jean-Luc Maloisel , Helena Skoglar
IPC: C07K1/18 , B01D15/36 , B01D15/38 , B01D15/34 , C12N9/64 , C07K14/755 , C07K16/00 , C07K14/765 , C07K14/47 , B01J41/20
CPC classification number: C07K1/18 , A61K35/16 , A61K38/00 , A61K38/36 , A61K38/4846 , B01D15/34 , B01D15/363 , B01D15/3847 , B01J41/20 , C07K14/472 , C07K14/755 , C07K14/765 , C07K16/00 , C12N9/6424 , C12N9/644 , C12Y304/21022
Abstract: The present invention relates to the field of chromatography. More closely, the invention relates to a chromatographic method for purification of plasmaproteins, such as Factor VIII, von Willebrand factor and Factor IX. The chromatographic method is performed on a matrix comprising an inner porous core and outer porous lid surrounding said core.
-
公开(公告)号：US09950277B2
公开(公告)日：2018-04-24
申请号：US14290357
申请日：2014-05-29
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Klaus Gebauer
CPC classification number: B01D15/14 , B01D15/1864 , B01D15/1885 , B01D15/22 , G01N30/466 , G01N30/6039 , G01N30/6043 , G01N30/6091 , G01N2030/8881 , Y10T29/49826
Abstract: A parallel assembly (2; 11; 51) of chromatography column modules (3a,b,c; 13a,b,c; 53a,b,c, 90a, b), the assembly having one common assembly inlet (15; 55) and one common assembly outlet (17; 57), each column module comprising a bed space (29) filled with chromatography medium and each column module comprises integrated fluid conduits which when the column module is connected with other column modules are adapted to connect the bed space (29) of the column module with the assembly inlet (15; 55) and the assembly outlet (17; 57), wherein the total length and/or volume of the fluid conduit from the assembly inlet to one bed space together with the length and/or volume of the fluid conduit from the same bed space to the assembly outlet is substantially the same for all bed spaces and modules installed in the parallel assembly.
-
Patent Agency Ranking
公开(公告)号：US20170320919A1
公开(公告)日：2017-11-09
申请号：US15526895
申请日：2015-12-11
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Gustav Rodrigo , Mats Ander , Tomas Bjorkman
IPC: C07K14/195
CPC classification number: C07K14/195 , C07K1/22 , C07K16/00 , C07K2317/55 , C07K2317/569 , C07K2319/02
Abstract: The invention discloses kappa light chain-binding polypeptide comprising a mutated binding domain of Peptostreptococcus protein L, wherein at least one asparagine residue of a parental domain defined by, or having at least 95% or 98% sequence homology with, SEQ ID NO: 2-6 or 2 has been mutated to another amino acid residue which is not asparagine, proline or cysteine.
-
公开(公告)号：US20170219541A1
公开(公告)日：2017-08-03
申请号：US15329199
申请日：2015-07-06
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Klaus Gebauer , Mats Lundkvist , Bjorn Olovsson
CPC classification number: G01N30/6039 , B01D15/1864 , G01N30/465 , G01N30/468 , G01N30/6034 , G01N30/88 , G01N2030/027 , G01N2030/8881
Abstract: The invention discloses a flow control block for a stack of chromatography column modules, as well as a stack of chromatography modules comprising at least one flow control block. The flow control block is in a first position or configuration capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in parallel and in a second position or configuration it is capable of connecting two chromatography column modules, or a chromatography column module and an endpiece, in series.
-
公开(公告)号：US20160367966A1
公开(公告)日：2016-12-22
申请号：US15120845
申请日：2015-02-18
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Jean-Luc Maloisel , Karolina Busson , Karol Lacki , Bjorn Noren , Helena Skoglar
IPC: B01J20/32 , B01J20/28 , B01D15/20 , B01D15/30 , C12N1/20 , B01D15/12 , C07K1/22 , C07K14/765 , C07K14/77 , B01J20/286 , B01D15/36
CPC classification number: B01J20/3293 , B01D15/125 , B01D15/203 , B01D15/305 , B01D15/363 , B01J20/28019 , B01J20/286 , B01J20/3212 , B01J20/3219 , B01J20/3248 , B01J20/327 , B01J20/3278 , C07K1/22 , C07K14/765 , C07K14/77 , C12N1/20
Abstract: The invention discloses a separation matrix for purification of biological particles, comprising a plurality of particles having a porous core entity and a porous shell entity covering the core entity, wherein the core entity comprises at least 50 micromole/ml primary amines present on covalently attached ligands displaying at least two primary amines per ligand and the shell entity comprises less than 20 micromole/ml primary amines The invention further discloses a method of purifying biological particles and a method of manufacturing a separation matrix.
Abstract translation: 本发明公开了一种用于纯化生物颗粒的分离基质，其包含多个具有多孔核心实体和覆盖核心实体的多孔壳体的颗粒，其中核心实体包含共价连接的配体上存在的至少50微摩尔/ 每个配体显示至少两个伯胺，壳体包含少于20微摩尔/ ml伯胺本发明还公开了一种纯化生物颗粒的方法和一种制备分离基质的方法。
-
公开(公告)号：US11718643B2
公开(公告)日：2023-08-08
申请号：US14441129
申请日：2013-11-11
Applicant: GE HEALTHCARE BIOPROCESS R&D AB
Inventor： Jean-Luc Maloisel , Gustav Rodrigo , Bjorn Noren , Virendra Kumbhar
IPC: B01D15/32 , B01D15/36 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/286 , B01J20/289 , B01J20/32 , B01J41/20 , C07K1/16 , C07K1/36 , C07K16/00 , C07K16/06 , G01N33/544
CPC classification number: C07K1/165 , B01D15/327 , B01D15/363 , B01D15/3847 , B01J20/265 , B01J20/286 , B01J20/289 , B01J20/28016 , B01J20/3204 , B01J20/3208 , B01J20/3219 , B01J20/3251 , B01J20/3253 , B01J20/3255 , B01J20/3285 , B01J41/20 , C07K1/36 , C07K16/00 , C07K16/065 , G01N33/544 , B01D15/3809 , B01D15/3885 , B01J2220/52 , B01J2220/80 , B01D15/363 , B01D15/327
Abstract: The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five- or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.
-
公开(公告)号：US10815269B2
公开(公告)日：2020-10-27
申请号：US16115756
申请日：2018-08-29
Applicant: GE Healthcare BioProcess R&D AB
Inventor： Jean-Luc Maloisel , Gustav Rodrigo , Bjorn Noren , Virendra Kumbhar
IPC: B01D15/32 , B01D15/36 , B01D15/38 , B01J20/26 , B01J20/28 , B01J20/286 , B01J20/289 , B01J20/32 , B01J41/20 , C07K1/16 , G01N33/544 , C07K16/00 , C07K16/06 , C07K1/36
Abstract: The invention discloses a separation matrix which comprises a plurality of separation ligands, defined by the formula R1-L1-N(R3)-L2-R, immobilized on a support, wherein R1 is a five- or six-membered, substituted or non-substituted ring structure or a hydroxyethyl or hydroxypropyl group; L1 is either a methylene group or a covalent bond; R2 is a five-or six-membered, substituted or non-substituted ring structure; L2 is either a methylene group or a covalent bond; R3 is a methyl group; and wherein if R1 is a hydroxyethyl group and L1 is a covalent bond, R2 is a substituted aromatic ring structure or a substituted or non-substituted aliphatic ring structure.
-
-
-
-
-
-
-
-
-
Search Results
92
records
(took 0.019 seconds)
