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公开(公告)号：US11932671B2
公开(公告)日：2024-03-19
申请号：US17245681
申请日：2021-04-30
IPC分类号： A61P37/04 , A61K39/095 , C07K14/22 , A61K39/00
CPC分类号： C07K14/22 , A61K39/095 , A61K2039/523 , A61K2039/55511 , A61K2039/70
摘要： Modified meningococcal fHbp polypeptides with increased stability.
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公开(公告)号：US20240082379A1
公开(公告)日：2024-03-14
申请号：US18256749
申请日：2021-12-10
IPC分类号： A61K39/095 , A61K39/02 , A61K39/102 , A61K39/104 , A61K39/108 , A61K39/112 , C12N15/70 , C12N15/74 , C12P1/04
CPC分类号： A61K39/095 , A61K39/0258 , A61K39/0275 , A61K39/099 , A61K39/102 , A61K39/104 , A61K39/1045 , A61K39/105 , A61K39/107 , C12N15/70 , C12N15/74 , C12P1/04
摘要： The present invention relates to the field of hyper-blebbing Gram-negative bacterial cells which are genetically modified by modifying the rpsA gene, the rpsA operon and/or 30S ribosomal protein S1 and to native outer membrane vesicles (nOMVs) obtained or obtainable from said genetically modified bacterial cells.
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公开(公告)号：US20240076318A1
公开(公告)日：2024-03-07
申请号：US18358350
申请日：2023-07-25
发明人： Stefania CAPONE , Antonella FOLGORI , Armin LAHM , Benjamin WIZEL
IPC分类号： C07K14/005 , A61K39/245 , C12N7/00
CPC分类号： C07K14/005 , A61K39/245 , C12N7/00 , A61K2039/70
摘要： The invention provides Epstein-Barr Virus antigen polynucleotides, polypeptides and vectors; as well as immunogenic compositions comprising the same. It includes the use of Epstein-Barr Virus antigen constructs to produce vaccines for treating and preventing Epstein-Barr Virus infections and Epstein-Barr Virus-associated diseases, such as multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus.
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公开(公告)号：US20240026407A1
公开(公告)日：2024-01-25
申请号：US18039514
申请日：2021-12-08
发明人： Murray BROWN , Edward CHAPMAN , Andrew COLLIS , Douglas FUERST , Joseph HOSFORD , Christopher MACDERMAID , James MORRISON
CPC分类号： C12P19/14 , C12N9/2445 , C12Y302/01021 , C12N9/2402 , C12Y302/0104 , A61K39/39 , A61K2039/55577
摘要： Methods for the enzymatic modification of saponins, products made thereby, uses of said products and also to other associated aspects. The saponins may be extracts of Quillaja species, such as extracts of Quillaja saponaria Molina.
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公开(公告)号：US20240000958A1
公开(公告)日：2024-01-04
申请号：US18252783
申请日：2021-11-12
CPC分类号： A61K47/646 , A61K39/092 , A61P31/04 , A61K2039/6037
摘要： The present invention is directed to a polysaccharide conjugate comprising or consisting of a one or more polysaccharide conjugated to a carrier polypeptide, wherein the carrier polypeptide is selected from the group consisting of (a) a Streptococcus pyogenes SpyAD (Spy0269, GAS40), a Streptococcus pyogenes SpyCEP (Spy0416, GAS57), or Streptococcus pyogenes SLO (Spy0167, GAS25); (b) CRM197; or (c) a variant, fragment and/or fusion of (a) or (b), improved conjugation methods, and uses of said conjugates for preventing or treating disease.
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公开(公告)号：US20230390381A1
公开(公告)日：2023-12-07
申请号：US18082456
申请日：2022-12-15
IPC分类号： A61K39/155 , A61K39/235 , A61K39/12
CPC分类号： A61K39/155 , A61K39/235 , A61K39/12 , A61K2039/5256
摘要： This disclosure provides immunogenic combinations that include a) an immunogenic component containing a peptide or polypeptide antigen of a respiratory pathogen; and b) an immunogenic component containing a nucleic acid encoding an antigen of the same respiratory pathogen, wherein the immunogenic components are formulated for concurrent, e.g., co-localized, administration. More specifically, the respiratory pathogen is respiratory syncytial virus (RSV). This disclosure also concerns provides the use of such immunogenic combinations, and methods for administering such immunogenic combinations to elicit an immune response specific for the respiratory pathogen.
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公开(公告)号：US20230381106A1
公开(公告)日：2023-11-30
申请号：US18231693
申请日：2023-08-08
发明人： Andrew GEALL
IPC分类号： A61K9/127 , A61K31/7088 , A61K39/00 , A61K39/12 , C12N15/86
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/7088 , A61K39/00 , A61K39/12 , C12N15/86 , C12N2770/36134 , A61K39/39
摘要： RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially a neutral surface charge at physiological pH and are effective for immunisation.
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公开(公告)号：US20230381105A1
公开(公告)日：2023-11-30
申请号：US18231692
申请日：2023-08-08
发明人： Andrew GEALL
IPC分类号： A61K9/127 , A61K39/12 , C12N15/86 , A61K31/7088 , A61K39/00
CPC分类号： A61K9/127 , A61K9/1272 , A61K39/12 , C12N15/86 , A61K31/7088 , A61K39/00 , A61K2039/55555 , C12N2760/18534 , A61K39/39
摘要： RNA encoding an immunogen is delivered in a liposome for the purposes of immunisation. The liposome includes lipids which have a pKa in the range of 5.0 to 7.6 and, preferably, a tertiary amine. These liposomes can have essentially a neutral surface charge at physiological pH and are effective for immunisation.
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公开(公告)号：US11827694B2
公开(公告)日：2023-11-28
申请号：US18173006
申请日：2023-02-22
发明人： Kurt Swanson , Philip R. Dormitzer
IPC分类号： C07K16/10 , A61K39/155 , A61K39/12 , C07K14/005 , A61K39/00
CPC分类号： C07K16/1027 , A61K39/12 , A61K39/155 , C07K14/005 , A61K39/00 , A61K2039/5252 , A61K2039/5256 , A61K2039/5258 , A61K2039/53 , A61K2039/55505 , A61K2039/55555 , A61K2039/55561 , A61K2039/55566 , A61K2039/55572 , C07K2317/76 , C07K2319/00 , C07K2319/21 , C07K2319/50 , C07K2319/73 , C12N2760/18522 , C12N2760/18534 , C12N2770/36143
摘要： The present invention relates to immunogenic compositions comprising RSV F protein, methods for preparing compositions that contain RSV F protein ecto-domain polypeptides, and to certain engineered RSV F proteins and nucleic acids that encode the engineered RSV F proteins. Compositions prepared using the methods can contain RSV F protein ecto-domain polypeptides in a predominant or single desired form and conformation. The invention also relates to methods for inducing an immune response to RSV F.
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公开(公告)号：US11813323B2
公开(公告)日：2023-11-14
申请号：US17849392
申请日：2022-06-24
发明人： Philip Dormitzer
IPC分类号： A61K39/155 , A61K39/12 , A61P31/14 , A61K39/00
CPC分类号： A61K39/155 , A61K39/12 , A61P31/14 , A61K2039/545 , A61K2039/55 , C12N2760/18634
摘要： The invention relates to an immunization regimen whereby an infant is protected against respiratory syncytial virus (RSV) through administration of a first anti-RSV immune response inducing composition to his or her mother during pregnancy, followed by administration of a second anti-RSV immune response inducing composition to the infant after birth.
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