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    Polymeric supports
    13.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5403902A

    公开(公告)日：1995-04-04

    申请号：US183063

    申请日：1994-01-18

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    IPC分类号： A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C12N11/08 ,  C08F26/06 ,  C08F220/10 ,  C08F220/54

    CPC分类号： C12N11/08 ,  A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/48

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1, the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基，芳基 具有5至12个环原子，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成含有4至 12个环原子，n为0或1的整数，所述吖内酯官能载体中含有0.1至99摩尔份的交联单体。

    Azlactone graft copolymers
    14.
    发明授权
    Azlactone graft copolymers 失效
    吖内酯接枝共聚物

    公开(公告)号：US5262484A

    公开(公告)日：1993-11-16

    申请号：US942352

    申请日：1992-09-09

    申请人： Patrick L. Coleman ,  Thomas A. Kotnour ,  Richard J. Rolando

    发明人： Patrick L. Coleman ,  Thomas A. Kotnour ,  Richard J. Rolando

    IPC分类号： C08F255/00 ,  C08L51/06 ,  C08F255/02 ,  A61K37/02 ,  C08F8/18 ,  C08F8/30 ,  C08F8/32 ,  C08F8/36 ,  C08F263/04 ,  C08F279/02 ,  C08L51/04 ,  G01N33/545

    CPC分类号： C08L51/06 ,  C08F255/00 ,  Y10T428/31692 ,  Y10T428/31696

    摘要： Graft copolymers and processes for the preparation thereof are provided. The copolymers comprise a base polymer having grafted thereto a monomeric 2-alkenyl azlactone. The surface properties of the graft copolymers can be modified by binding thereto nucleophilic reagents comprising further functional groups with desired properties. Further, the amount of azlactone available at the surface of a graft copolymer for binding to such nucleophilic reagents can be controlled by selecting a surface against which the graft copolymer is formed. The graft copolymers exhibit desirable thermoplastic, melt flow, and adhesion properties and are particularly useful for immobilizing proteins. Methods of immunoassay based on the immobilization of proteins are also disclosed. Another utility of the graft copolymers involves the compatibilizing of immiscible polymer blends.

    摘要翻译： 提供接枝共聚物及其制备方法。 共聚物包含接枝到其上的单体2-链烯基吖内酯的基础聚合物。 接枝共聚物的表面性质可以通过与包含具有所需性质的另外的官能团的亲核试剂结合来修饰。 此外，可以通过选择形成接枝共聚物的表面来控制在接枝共聚物的表面可用于结合这种亲核试剂的吖内酯的量。 接枝共聚物表现出所需的热塑性，熔体流动性和粘合性，并且特别可用于固定蛋白质。 还公开了基于蛋白质固定的免疫测定方法。 接枝共聚物的另一个用途是使不混溶的聚合物共混物相容化。

    Polymeric supports
    20.
    发明授权
    Polymeric supports 失效
    聚合物载体

    公开(公告)号：US5292840A

    公开(公告)日：1994-03-08

    申请号：US335835

    申请日：1989-04-10

    申请人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    发明人： Steven M. Heilmann ,  Jerald K. Rasmussen ,  Larry R. Krepski ,  Dean S. Milbrath ,  Patrick L. Coleman ,  Margaret M. Walker

    IPC分类号： B01J20/281 ,  A61K39/395 ,  B01J20/26 ,  C07K17/08 ,  C08F8/00 ,  C08F8/48 ,  C08F20/58 ,  C08F26/00 ,  C08F26/06 ,  C08J5/18 ,  C12N11/08 ,  G01N30/88 ,  C08F22/38

    CPC分类号： A61K39/39525 ,  B01J20/26 ,  C07K17/08 ,  C08F20/58 ,  C08F8/00 ,  C08F8/12 ,  C08F8/16 ,  C08F8/32 ,  C08F8/48 ,  C12N11/08 ,  C08F2800/10 ,  C08F2800/20 ,  C08F2810/20

    摘要： Azlactone-functional polymer supports are useful reactive supports for the attachment of functional materials to provide novel adduct beads. The adduct beads are useful as complexing agents, catalysts, polymeric reagents, chromatographic supports, and as enzyme- or other biologically active supports. Novel carboxylate-functional polymer beads, are intermediates in the preparation of the azlactone-functional beads.Azlactone-functional supports have units of the formula: ##STR1## wherein R.sup.1 is H or CH.sub.3,R.sup.2 and R.sup.3 independently can be an alkyl group having 1 to 14 carbon atoms, a cycloalkyl group having 3 to 14 carbon atoms, an aryl group having 5 to 12 ring atoms, an arenyl group having 6 to 26 carbon and 0 to 3 S, N, and nonperoxidic O heteroatoms, or R.sup.2 and R.sup.3 taken together with the carbon to which they are joined can form a carbocyclic ring containing 4 to 12 ring atoms, andn is an integer 0 or 1,the azlactone functional supports having 0.1 to 99 molar parts of crosslinking monomer incorporated therein.

    摘要翻译： 吖内酯官能聚合物载体是用于附着功能材料以提供新型加合珠的有用的反应性载体。 加合珠可用作络合剂，催化剂，聚合物试剂，色谱载体，以及酶或其它生物活性载体。 新型羧酸盐官能化聚合物珠粒是制备吖内酯官能团珠粒的中间体。 吖内酯官能载体具有下式的单元：（*化学结构*）V其中R 1为H或CH 3，R 2和R 3可独立地为具有1至14个碳原子的烷基，具有3至14个碳原子的环烷基， 具有5至12个环原子的芳基，具有6至26个碳和0至3个S，N和非过氧O的杂原子的芳基，或与其连接的碳一起的R 2和R 3可以形成碳环 含有4〜12个环原子，n为0或1的整数，所述吖内酯官能团的载体中含有0.1〜99摩尔份的交联单体。